Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T09538 | Target Info | |||
| Target Name | Alkaline phosphatase tissue-nonspecific (ALPL) | ||||
| Synonyms |
TNSALP; Liver/bone/kidney isozyme; Alkaline phosphatase, tissue-nonspecific isozyme; Alkaline phosphatase liver/bone/kidney isozyme; AP-TNAP
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| Target Type | Successful Target | ||||
| Gene Name | ALPL | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 68 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Phenylalanine
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|
Approved | Compound Info | ||
| Synonyms |
Endophenyl; Fenilalanina; Phe; Phenylalanine; Phenylalaninum; Fenilalanina [Spanish]; Phenylalaninum [Latin]; Antibiotic FN 1636; CB 3208; NCI9959; Alpha-Aminohydrocinnamic acid; Beta-Phenylalanine; L-Antibiotic FN 1636; L-PHENYLALININE; N-Formylmelphalan; Phenylalanine (VAN); H-Phe-OH; L-Phenylalanine (JP15); Phenylalanine (USP/INN); Phenylalanine [USAN:INN:JAN]; Beta-Phenyl-L-alanine; N-Formyl-L-sarcolysin; N-Formyl-L-p-sarcolysin; L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine; L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI); (2S)-2-amino-3-phenylpropanoic acid; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; (S)-2-Amino-3-phenylpropionic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminohydrocinnamic acid; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; 3-Phenyl-L-alanine; 3-Phenylalanine; 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid
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| Activity |
IC50 = 100100 nM
|
[1] | |||
| Compound Name |
PMID28870136-Compound-48
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Patented | Compound Info | ||
| Activity |
Ki = 82000 nM
|
[2] | |||
| Compound Name |
N-[(3-Methoxyphenyl)methyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115158; BDBM50447458; MLS-0454662.0001; MLS-0454662.0002
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| Activity |
IC50 = 74000 nM
|
[3] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(2-methyl-1-imidazolyl)ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589756; MLS-0315852.0001; BDBM41889; cid_25067491; MLS-0315852.0002; Q27165250; 1-(3,4-dihydroxyphenyl)-2-(2-methylimidazol-1-yl)ethanone; 1-(3,4-dihydroxyphenyl)-2-(2-methyl-1-imidazolyl)ethanone;hydrochloride; 1-(3,4-dihydroxyphenyl)-2-(2-methylimidazol-1-yl)ethanone;hydrochloride; 1-[3,4-bis(oxidanyl)phenyl]-2-(2-methylimidazol-1-yl)ethanone;hydrochloride
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| Activity |
IC50 = 78300 nM
|
[4] | |||
| Compound Name |
N-(4-Cyanophenyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115160; BDBM50447456; MLS-0454665.0001; MLS-0454665.0002
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| Activity |
IC50 = 81000 nM
|
[3] | |||
| Compound Name |
Levamisole hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
Levamisole HCl; Ergamisol; (-)-Tetramisole hydrochloride; Tramisole; Decaris; Tramisol; Niratic hydrochloride; Stimamizol hydrochloride; (-)-Tetramisole; Niratic-puron hydrochloride; Levamisol hydrochloride; NSC-177023; Levamisole (hydrochloride); Spartakon; R 12,564; UNII-DL9055K809; R 12564; R-12,564; MFCD00012675; DL9055K809; Ascaridil; Dekaris; Levacide; Levadin; Levasole; Solaskil; Meglum; Nilverm forte; Worm-chek; Ripercol-L; Citarin L; L-Tetramisole hydrochloride; 16595-80-5 (HCL); DSSTox_CID_27518; DSSTox_RID_82391; DSSTox_GSID_47518; Levamisole hydrochloride, 99+%; Levomysol hydrochloride; KW 2LE-T; SMR001230807; KW-2-LE-T; NSC177023; SR-01000075969; EINECS 240-654-6; R-12564; LEV hydrochloride; Ergamisol (TN); NCGC00094446-03; Prestwick_294; Levamisole hydrochloride [USAN:USP]; Levamisole HCl(Ergamisol); Ergamisol (TN) (Janssen); CHEMBL1770; SCHEMBL19226; BMK1-H6; Levamisole Hydrochloride,(S); MLS002153440; MLS002222198; MLS002695941; SPECTRUM1503245; Levamisole hydrochloride (USP); ((-)-Tetramisole hydrochloride; DTXSID7047518; CTK8B8704; KS-00000GHI; HMS1568F05; HMS1922M11; BCP13755; Levamisole Hydrochloride (Ergamisol); Tox21_111282; Tox21_500690; ANW-61085; CCG-40301; s1939; (-)-Levamisole hydrochloride solution; AKOS015951350; Tox21_111282_1; EBD2199095; KW-2299; LP00690; MCULE-7118728152; NE43217; SB18744; NCGC00094046-01; NCGC00261375-01; NCGC00263461-01; AC-23973; AS-13370; HY-13666; SC-26016; AB0013424; EU-0100690; L0231; (-)-Tetramisole hydrochloride, >=99% (GC); C07906; D00750; L 9756; R 12654; J-010244; J-521642; SR-01000075969-1; SR-01000075969-6; Q27107205; Z1550648764
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| Activity |
Ki = 93000 nM
|
[5] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylamino)-1-(3,4-dihydroxyphenyl)ethanone;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597837; MLS-0315849.0001; BDBM46050; cid_25067485; 2-(1H-benzimidazol-2-ylamino)-1-[3,4-bis(oxidanyl)phenyl]ethanone;hydrochloride
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| Activity |
IC50 = 93800 nM
|
[4] | |||
| Compound Name |
N-[2-(3,4-Dimethoxyphenyl)ethyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115137; BDBM50447426; MLS-0463435.0001
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| Activity |
IC50 = 96000 nM
|
[3] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115118; BDBM50447452; MLS-0454670.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(2-Methoxyphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115138; BDBM50447425; MLS-0463427.0001; MLS-0463427.0002
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(5,6-dimethyl-1-benzimidazolyl)ethanone;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602242; MLS-0315851.0001; BDBM46052; cid_25067489; 1-(3,4-dihydroxyphenyl)-2-(5,6-dimethylbenzimidazol-1-yl)ethanone;hydrochloride; 1-[3,4-bis(oxidanyl)phenyl]-2-(5,6-dimethylbenzimidazol-1-yl)ethanone;hydrochloride
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-[(2-Oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115127; BDBM50447441; MLS-0463440.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N~1~-Benzyl-N~3~-[(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)sulfonyl]-beta-alaninamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1363800; MLS001096066; HMS2934J21; BDBM50447440; ZINC15936486; MCULE-2934274102; SMR000631056; MLS-0454552.0001; N~1~-benzyl-N~3~-[(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)sulfonyl]-beta-alaninamide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(4-Methoxyphenyl)methyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115159; BDBM50447457; MLS-0454663.0001; MLS-0454663.0002; MLS-0454663.0003
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(3-Fluorophenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115142; BDBM50447421; MLS-0463428.0001; MLS-0463428.0002
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(2-Chlorophenyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115146; BDBM50447417
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4286917
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Investigative | Compound Info | ||
| Synonyms |
BDBM50464729
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-(4-Cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115153; BDBM50447462
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[(2-Oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115133; BDBM50447430; MLS-0463432.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-(4-Hydroxyphenyl)ethyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115139; BDBM50447424; MLS-0463437.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3-Cyanophenyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114959; BDBM50447455; MLS-0454666.0001; MLS-0454666.0002
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115125; BDBM50447443; MLS-0454688.0001; MLS-0454688.0002; MLS-0454688.0003
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(4-Methylphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115129; BDBM50447437; MLS-0463417.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(3-Chlorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115135; BDBM50447428; MLS-0463441.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115123; BDBM50447446; MLS-0463431.0001
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N,N-Dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
AB00540133; CHEMBL1570441; BDBM45772; cid_16749996; ML086; ML 086 (CID-1674999); MLS-0390838.0001; MLS-0390838.0002; BRD-K19922318-001-01-4; Q27204764; 3-(3-keto-1,2-benzothiazol-2-yl)-N,N-dimethyl-benzamide; N,N-dimethyl-3-(3-oxidanylidene-1,2-benzothiazol-2-yl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[(2,4-Dimethoxyphenyl)methyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114960; BDBM50447454; MLS-0454664.0001
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(2-ethyl-1-imidazolyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL607856; MLS-0315848.0001; BDBM41888; cid_25067483; ZINC45389565; MLS-0315848.0002; Q27164770; 1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone; 1-(3,4-dihydroxyphenyl)-2-(2-ethyl-1-imidazolyl)ethanone;hydrochloride; 1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone;hydrochloride; 1-[3,4-bis(oxidanyl)phenyl]-2-(2-ethylimidazol-1-yl)ethanone;hydrochloride
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
1-[(2,4-Dimethoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115150; BDBM50447465
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N~1~-(1,3-Benzodioxol-5-ylmethyl)-N~3~-[(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)sulfonyl]-beta-alaninamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115122; BDBM50447447; ZINC20994445; MCULE-9480439179; MLS-0454551.0001; MLS-0454551.0002; MLS-0454690.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115136; BDBM50447427
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115124; BDBM50447445; MLS-0454691.0001
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-[(3-Fluorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112615; BDBM50447444; MLS-0463433.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(2,5-Dimethylphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115154; BDBM50447461
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115151; BDBM50447464
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Chembl4289495
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Investigative | Compound Info | ||
| Synonyms |
BDBM50464737
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[(4-Chlorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115128; BDBM50447438; MLS-0463420.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(2,5-Dimethylphenyl)-3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]propionamide
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Investigative | Compound Info | ||
| Synonyms |
MLS001096094; CHEMBL1322977; SMR000631039; MLS003873802; BDBM76214; cid_24790980; HMS2956L24; ZINC15936482; MCULE-1478474528; SMR002530429; MLS-0369427.0001; MLS-0454687.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N~1~-(3,4-Dimethylphenyl)-N~3~-[(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)sulfonyl]-beta-alaninamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1347946; MLS001096134; HMS2956A15; BDBM50447439; ZINC15936473; MCULE-8625819578; SMR000631043; MLS-0366922.0001; N~1~-(3,4-dimethylphenyl)-N~3~-[(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)sulfonyl]-beta-alaninamide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[(2-Keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-o-anisyl-propionamide
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Investigative | Compound Info | ||
| Synonyms |
MLS001096065; CHEMBL1470091; SMR000631046; BDBM76212; cid_24790972; HMS2934P23; ZINC15936487; MCULE-7582922280; MLS-0371302.0001; MLS-0463418.0001; AB00835013-06
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[3-(1,3-Benzodioxol-5-yl)propyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115126; BDBM50447442
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-(4-Methoxyphenyl)ethyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115140; BDBM50447423; MLS-0463436.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(3-Cyanophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115120; BDBM50447449; MLS-0454684.0001
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4289643
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Investigative | Compound Info | ||
| Synonyms |
BDBM50464742
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(4-methyl-1-pyrazolyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL610781; cid_25199538; BDBM50309565; MLS-0390945.0001; MLS-0390945.0002; BRD-K23027438-001-01-1; Q27164144; 1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-pyrazol-1-yl)ethanone
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(3,4-Dimethoxyphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115155; BDBM50447460
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(4-Hydroxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115132; BDBM50447431
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(2-phenyl-1-imidazolyl)ethanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608722; MLS-0315847.0001; BDBM46049; cid_25067481; 1-(3,4-dihydroxyphenyl)-2-(2-phenylimidazol-1-yl)ethanone;hydrochloride; 1-[3,4-bis(oxidanyl)phenyl]-2-(2-phenylimidazol-1-yl)ethanone;hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[(2,4-Dimethoxyphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115143; BDBM50447420; MLS-0463424.0001; MLS-0463424.0002
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(2,5-Dimethylphenyl)-3-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115130; BDBM50447435
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Isoproterenone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Aludrone; N-Isopropylnoradrenalone; 1-(3,4-dihydroxyphenyl)-2-(propan-2-ylamino)ethanone; S 35179; ACETOPHENONE, 3',4'-DIHYDROXY-2-(ISOPROPYLAMINO)-; 1-(3,4-DIHYDROXYPHENYL)-2-[(1-METHYLETHYL)AMINO]ETHAN-1-ONE; UNII-299T6A9WRP; 299T6A9WRP; CHEMBL598662; 1-(3,4-Dihydroxyphenyl)-2-((1-methylethyl)amino)ethan-1-one; 1-(3,4-DIHYDROXYPHENYL)-2-((1-METHYLETHYL)AMINO)ETHANONE; EINECS 204-461-0; NSC 163353; BRN 2105828; 1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]ethanone; MLS-0315678.0001; 3,4-Dihydroxy-alpha-isopropylaminoacetophenone; 3',4'-Dihydroxy-2-(isopropylamino)acetophenone; 1-(3,4-dihydroxyphenyl)-2-(propan-2-ylamino)ethanone;hydrochloride; Ethanone, 1-(3,4-dihydroxyphenyl)-2-((1-methylethyl)amino)-; 4-14-00-00835 (Beilstein Handbook Reference); SCHEMBL9768178; 4-(isopropylaminoacetyl)catechol; BDBM46041; cid_2830496; CTK4B2284; DTXSID90153099; BBL029136; NSC163353; STL372881; ZINC53193262; AKOS015955777; MCULE-3317742925; NSC-163353; Isoprenaline EP Impurity A; Isoproterenone; ST50977324; Acetophenone,4'-dihydroxy-2-(isopropylamino)-; 3,4-Dihydroxy-.alpha.-isopropylaminoacetophenone; A804709; 1-(3,4-dihydroxyphenyl)-2-(isopropylamino)ethanone; 3',4'-Dihydroxy-alpha-(isopropylamino)acetophenone; Ethanone,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]-; 1-(3,4-DIHYDROXY-PHENYL)-2-ISOPROPYLAMINO-ETHANONE; 1-[3,4-bis(oxidanyl)phenyl]-2-(propan-2-ylamino)ethanone; 1-(3,4-dihydroxyphenyl)-2-[(methylethyl)amino]ethan-1-one; Ethanone,1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]-; 1-(3,4-dihydroxyphenyl)-2-(isopropylamino)ethanone;hydrochloride; 1-(3,4-dihydroxyphenyl)-2-[(propan-2-yl)amino]ethan-1-one, 3; 1-[3,4-bis(oxidanyl)phenyl]-2-(propan-2-ylamino)ethanone;hydrochloride; Ethanone, 1-(3,4-dihydroxyphenyl)-2-((1-methylethyl)amino)- (9CI)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(2,4-Dimethoxyphenyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115141; BDBM50447422; MLS-0463422.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3,4-Dimethoxyphenyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115148; MLS003873804; BDBM50447415; SMR002530431; MLS-0466802.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115144; BDBM50447419; MLS-0463429.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(2-Methylphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115147; BDBM50447416; MLS-0463426.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(2-Chlorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115134; BDBM50447429; MLS-0463438.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(1,2,4-triazol-4-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602448; MLS-0315850.0001; BDBM46051; cid_25067487; 1-(3,4-dihydroxyphenyl)-2-(1,2,4-triazol-4-yl)ethanone;hydrochloride; 1-[3,4-bis(oxidanyl)phenyl]-2-(1,2,4-triazol-4-yl)ethanone;hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[2-(1,3-Benzodioxol-5-yl)ethyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115117; BDBM50447453; MLS-0454668.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-(1-imidazolyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349641; MLS-0315813.0002; 1-(3,4-dihydroxyphenyl)-2-imidazol-1-ylethanone; cid_52780; MLS002460467; BDBM41887; cid_25067472; Ethanone, 1-(3,4-dihydroxyphenyl)-2-(1H-imidazol-1-yl)-; HMS2218C04; HMS3329J09; NCGC00247370-01; SMR001382684; MLS-0315813.0001; MLS-0315813.0003; Q27163870; 1-(3,4-dihydroxyphenyl)-2-imidazol-1-ylethanone;hydrochloride; 1-(3,4-dihydroxyphenyl)-2-(1-imidazolyl)ethanone;hydrochloride; 1-(3,4-dihydroxyphenyl)-2-imidazol-1-yl-ethanone;hydrochloride; 1-[3,4-bis(oxidanyl)phenyl]-2-imidazol-1-yl-ethanone;hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-Cyanophenyl)-3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS001096095; CHEMBL1349252; SMR000631049; BDBM76215; cid_24790981; HMS2941H24; ZINC15936481; MCULE-5454902391; MLS-0372220.0001; MLS-0466803.0001; N-(3-cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(4-Fluorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1711225; MLS001096085; HMS2938G24; BDBM50447436; SMR000631048; MLS-0454556.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(4-Methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115121; MLS003873803; BDBM50447448; SMR002530430; MLS-0454683.0001; MLS-0454683.0002
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[(2-Keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-m-anisyl-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS001096075; CHEMBL1727453; SMR000631047; MLS003873800; BDBM76213; cid_24790974; HMS2930O04; ZINC15936485; MCULE-7773644553; SMR002530427; MLS-0370484.0001; MLS-0454682.0001; MLS-0454682.0002; MLS-0454682.0003; AB00847224-06
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[(3-Methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115149; BDBM50447412
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(3,4-Dimethoxyphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115145; BDBM50447418; MLS-0463430.0001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(2-Fluorophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115131; BDBM50447432
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(3-Cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115152; BDBM50447463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(1,3-Benzodioxol-5-yl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115156; BDBM50447459
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4287345
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467827
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
Chembl4292898
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Investigative | Compound Info | ||
| Synonyms |
ZINC8991072; BDBM50467819; STK619692; AKOS005553286; (3Z)-3-(3-chlorobenzylidene)-2,3-dihydro-4H-1,2-benzothiazin-4-one 1,1-dioxide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
Chembl4283809
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467822
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
Chembl4287568
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50467830
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
Chembl4280348
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467818
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||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Coumarin sulfonates: New alkaline phosphatase inhibitors; in vitro and in silico studies. Eur J Med Chem. 2017 May 5;131:29-47. | ||||
| REF 2 | Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Bioorg Med Chem Lett. 2009 Jan 1;19(1):222-5. | ||||
| REF 3 | Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett. 2014 Feb 1;24(3):1000-1004. | ||||
| REF 4 | Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem. 2010 Jan 15;18(2):573-9. | ||||
| REF 5 | Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2297-301. | ||||
| REF 6 | 2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study. Eur J Med Chem. 2018 Jan 20;144:116-127. | ||||
| REF 7 | Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4308-11. | ||||
| REF 8 | Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. Eur J Med Chem. 2018 Nov 5;159:282-291. | ||||
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