Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10191 | Target Info | |||
| Target Name | T-cell surface glycoprotein CD4 (CD4) | ||||
| Synonyms |
T-cell surface antigen T4/Leu-3
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| Target Type | Successful Target | ||||
| Gene Name | CD4 | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[[5-[1-[3-[[(1S)-1-Carboxy-2-phenylethyl]carbamoyl]-5-chloro-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoyl]amino]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138122
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| Activity |
EC50 ~ 62000 nM
|
[1] | |||
| Compound Name |
5-[1-[3-Carboxy-5-[(3-carboxy-4-methoxybenzoyl)amino]-4-methoxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-[(3-carboxy-4-methoxybenzoyl)amino]-2-methoxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138342
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| Activity |
EC50 ~ 66000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[3-Chloro-5-[1-[3-chloro-5-[[(1S)-1,3-dicarboxypropyl]carbamoyl]-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-2-hydroxybenzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138374
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| Activity |
EC50 = 69600 nM
|
[1] | |||
| Compound Name |
5-[1-[3-Carboxy-4-[(4-carboxyphenyl)methoxy]-5-chlorophenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]butyl]-2-[(4-carboxyphenyl)methoxy]-3-chlorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138378
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| Activity |
EC50 = 70400 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[3-Chloro-5-[1-[3-chloro-5-[[(1S)-1,3-dicarboxypropyl]carbamoyl]-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]butyl]-2-hydroxybenzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138360
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| Activity |
EC50 = 73000 nM
|
[1] | |||
| Compound Name |
5-[1-[3-Carboxy-4-[[4-(carboxymethyl)phenyl]methoxy]-5-chlorophenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-2-[[4-(carboxymethyl)phenyl]methoxy]-3-chlorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138119
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| Activity |
EC50 = 83800 nM
|
[1] | |||
| Compound Name |
5-[1-[3-Carboxy-4-[[4-(3-carboxyphenyl)phenyl]methoxy]-5-chlorophenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-2-[[4-(3-carboxyphenyl)phenyl]methoxy]-3-chlorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138133
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| Activity |
EC50 ~ 95000 nM
|
[1] | |||
| Compound Name |
5-[1-[3-Carboxy-4-[[4-(4-carboxyphenyl)phenyl]methoxy]-5-chlorophenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-2-[[4-(4-carboxyphenyl)phenyl]methoxy]-3-chlorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138383
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[[5-[1-[3-(2-Carboxyethylcarbamoyl)-5-chloro-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3137853
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| Activity |
EC50 = 120000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[3-Chloro-5-[1-[3-chloro-5-[[(1S)-1,2-dicarboxyethyl]carbamoyl]-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-2-hydroxybenzoyl]amino]butanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138117
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| Activity |
EC50 = 122000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[5-[1-[3-[[(1S)-1-Carboxy-3-methylbutyl]carbamoyl]-5-chloro-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoyl]amino]-4-methylpentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138094
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| Activity |
EC50 ~ 125000 nM
|
[1] | |||
| Compound Name |
2-[[5-[1-[3-(Carboxymethylcarbamoyl)-5-chloro-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]butyl]-3-chloro-2-hydroxybenzoyl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3137855
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| Activity |
EC50 ~ 125000 nM
|
[1] | |||
| Compound Name |
2-[[5-[1-[3-(Carboxymethylcarbamoyl)-5-chloro-4-hydroxyphenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoyl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3137848; BDBM50451176
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| Activity |
EC50 ~ 125000 nM
|
[1] | |||
| Compound Name |
5-[1-[3-Carboxy-4-[[4-(2-carboxyphenyl)phenyl]methoxy]-5-chlorophenyl]-4-[(3S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-2-[[4-(2-carboxyphenyl)phenyl]methoxy]-3-chlorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138438
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| Activity |
EC50 ~ 125000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. J Med Chem. 2001 Mar 1;44(5):703-14. | ||||
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