Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12808 | Target Info | |||
| Target Name | Protein kinase C alpha (PRKCA) | ||||
| Synonyms |
Protein kinase C alpha type; PRKACA; PKCalpha; PKCA; PKC-alpha; PKC-A
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| Target Type | Successful Target | ||||
| Gene Name | PRKCA | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 176 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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|
Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Imatinib
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Approved | Compound Info | ||
| Synonyms |
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Niclosamide
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Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Genistein
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Phase 2/3 | Compound Info | ||
| Synonyms |
Bonistein; GEN; Genestein; Genisteol; Genisterin; Prunetol; Sophoricol; Differenol A; G 6649; G10000; IN1327; NPI 031L; STO514; TNP00151; GENISTEIN (ENDOCRINE DISRUPTER); Lactoferrin-genistein; PTI G4660 (Genistein); PTI-G4660; SIPI 807-1; C.I. 75610; SIPI-9764-I; ENDOCRINE DISRUPTOR (GENISTEIN) (SEE ALSO GENISTEIN (446-72-0)); 4 inverted exclamation marka,5,7-Trihydroxyisoflavone; ,5,7-Trihydroxyisoflavone; 4',5, 7-Trihydroxyisoflavone; 4',5,7-Trihydroxy isoflavone; 4',5,7-Trihydroxyisoflavone; 4,5,7-Trihydroxyiso-flavone; 4,6,7-Trihydroxyisoflavone; 5,7,4'-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
MK-3281
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Phase 1 | Compound Info | ||
| Synonyms |
MK-3281; UNII-3593C180JO; CHEMBL1233524; 3593C180JO; (7r)-14-Cyclohexyl-7-{[2-(Dimethylamino)ethyl](Methyl)amino}-7,8-Dihydro-6h-Indolo[1,2-E][1,5]benzoxazocine-11-Carboxylic Acid; MK3281; cyclohexyl-[2-dimethylaminoethyl(methyl)amino][ ]carboxylic acid; SCHEMBL3073622; BDBM50335314; 1187645-92-6
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| Activity |
IC50 = 59000 nM
|
[5] | |||
| Compound Name |
L-751250
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Preclinical | Compound Info | ||
| Synonyms |
Purvalanol B; 212844-54-7; PURVALANOL; Purvalanol B(NG-95); (R)-2-chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzoic acid; (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL; CHEMBL23254; CHEBI:49840; NG 95; NG-95; C20H25ClN6O3; 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid; J-502183; PVB
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
NSC-73306
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
BMS-645737
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Investigative | Compound Info | ||
| Synonyms |
651744-16-0; BMS-645737; BMS645737; 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; UNII-86H6HFH34L; 86H6HFH34L; CHEMBL261592; 6-(5-methyl-1,3,4-oxadiazol-2-yl)-n-{2-methyl-1h-pyrrolo[2,3-b]pyridin-5-yl}-5-(propan-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo-[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; C20H20N8O
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
aloisine A
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Investigative | Compound Info | ||
| Synonyms |
ALOISINE A; 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; 496864-16-5; RP107; 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE; CHEMBL75680; 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine; RP-107; ALH; 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol; 1ung; SCHEMBL80147; BDBM7377; GTPL5924; AC1NS169; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol; CHEBI:93641; CTK8D4068; DTXSID30416115; HMS3229A14; RM-39; BCP26893; ZINC2540737; ACT06534; IN1539; HSCI1_000219; MFCD04973541; AKOS005145972; CCG-206814; DB07364; RTC-063070; AJ-39131
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
8-chloro-quinoline-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL436817; Cyanoquinoline, 11; SCHEMBL6071997; BDBM21898; CHEBI:94979; BRD-K00088062-001-01-3; 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1H-imidazole-5-ylmethyl)amino]-8-chloro-3-quinolinecarbonitrile
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL7827; SCHEMBL3355884; 62845-10-7; 3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one; CTK2B1467; ZINC23489; DTXSID10445847; BDBM50074745; AKOS030553076; 5,7-Dihydroxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3-(3-chlorophenyl)-5,7-dihydroxy-
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
CGP-191
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL122243; 1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; pyrazolopyrimidine deriv. 1; CGP-191; AC1NS35Q; SCHEMBL2360645; BDBM3003; AKOS028111796; 129852-40-0; 1,3-diphenylpyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1,3-diphenyl-; 1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (11)
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
TYRPHOSTIN AG-1478
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Investigative | Compound Info | ||
| Synonyms |
AG-1478; 153436-53-4; Tyrphostin AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 175178-82-2; Tyrphostin AG-1478; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; AG 1478; AG1478; TYRPHOSTIN; 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-; UNII-SUH0SEZ9HY; SUH0SEZ9HY; AG-1478 hydrochloride; AG-1478 (Tyrphostin AG-1478); CHEMBL7917; CHEBI:75404; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine; NSC-693255; AK-63142; N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine; BRD6408; BRD-6408; SR-01000076156; NSC693255
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Ro-4396686
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5809947; CHEMBL606964
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| Activity |
IC50 ~ 125000 nM
|
[12] | |||
| Compound Name |
3-{[2-(3-Thienyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL481248; BDBM50259638
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
3-Hydroxy-2-[4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dimethylbenzoyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL87075
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
9-(Azetidin-3-ylamino)-1-cyclopropyl-3,5-dihydro-1H-[1,2,4]triazino[3,4-c][1,4]benzoxazin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356462; BDBM50049432
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
2-[2,6-Dihydroxy-4-[[(3R,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]-methylcarbamoyl]benzoyl]-3-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2310935; BDBM50450311
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| Activity |
IC50 ~ 50000 nM
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[18] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
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| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779202; SCHEMBL897210; BDBM50344664; 6,6-dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
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| Activity |
IC50 ~ 50000 nM
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[21] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
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| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-2,4-difluoro-N-methoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL194498; SCHEMBL5605870; BDBM50168403
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| Activity |
IC50 ~ 50000 nM
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[22] | |||
| Compound Name |
3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466496; SCHEMBL4365652; BDBM50259376; DB07234; Q27096459; 3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
CID 49806721
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (S)-1-(4-hydroxy-benzoylamino)-indan-2-yl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL367457; BDBM50289210
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| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxadiazol-2-yl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL365318; BDBM50168387
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| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
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| Activity |
IC50 = 50000 nM
|
[24] | |||
| Compound Name |
2-N-(2-Aminoethyl)-9-ethyl-6-N-[3-(trifluoromethyl)phenyl]purine-2,6-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL534909
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| Activity |
IC50 = 50000 nM
|
[25] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
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| Activity |
IC50 ~ 50000 nM
|
[26] | |||
| Compound Name |
[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 3,5-dihydroxy-4-(8-hydroxy-4-oxo-3H-phthalazin-1-yl)benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313902
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
Modified Benzophenone Carboxylic Acid, Balanol Analog 37
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55890; BDBM3237
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| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095873; SCHEMBL4482804; BDBM50317750
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| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
3-Hydroxy-2-[4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylphenyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL85129
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 3,5-dihydroxy-4-[2-hydroxy-6-[(2,2,2-trifluoroacetyl)amino]benzoyl]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91932
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
3,5-Dihydro[1,2,4]triazino[3,4-C][1,4]benzoxazin-2(1h)-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1968515; (1,2,4)Triazino(3,4-c)(1,4)benzoxazin-2(1H)-one, 3,5-dihydro-; 3,5-Dihydro-(1,2,4)triazino(3,4-c)(1,4)benzoxazin-2(1H)-one; Kinome_3625; 3,5-dihydro-1H-[1,2,4]triazino[3,4-c][1,4]benzoxazin-2-one; SCHEMBL15798857; DTXSID60161121; BDBM50049435; ZINC19926414; Q27453440
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid tetrahydro-furan-2-ylmethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370266; BDBM50168392
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| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468125; 3-{[2-(2-Fluorophenyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione; SCHEMBL4371574; BDBM50259601
Click to Show/Hide
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
3-{[2-(2-Furyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL519113; SCHEMBL4366875; BDBM50259637; 3-[[2-(furan-2-yl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
Click to Show/Hide
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
Acyclic Balanol Analog 13b
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Investigative | Compound Info | ||
| Synonyms |
BDBM3196; CHEMBL150422
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| Activity |
IC50 ~ 50000 nM
|
[29] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-1-(4-hydroxy-benzoylamino)-indan-2-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444877; BDBM50289209
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
6-(5-Methyl-1,3,4-oxadiazol-2-yl)-5-propan-2-yl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258694; BDBM50377357
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602472; BDBM50306684; CH-5234152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
Modified Benzophenone Carboxylic Acid, Balanol Analog 38
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3238; CHEMBL299987
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[30] | |||
| Compound Name |
[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 3-methanesulfonyl-propyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195218; SCHEMBL5605704; BDBM50168389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 4-[2-(2-aminoethoxy)-6-hydroxybenzoyl]-3,5-dihydroxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316088
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
9-(Azetidin-3-ylamino)-1-phenyl-3,5-dihydro-1H-[1,2,4]triazino[3,4-c][1,4]benzoxazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356463; BDBM50049431
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]oxadiazol-2-yl]-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino}-2,4-difluoro-N-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195903; SCHEMBL5605694; BDBM50168402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
2-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylphenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315545
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 4-(2-acetamido-6-hydroxybenzoyl)-3,5-dihydroxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329178
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
1-[(Z)-10-(4-Amino-2-methylquinolin-1-ium-1-yl)dec-5-enyl]-2-methylquinolin-1-ium-4-amine;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2112065; BDBM50473218
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[31] | |||
| Compound Name |
3,13-Diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tetracosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20,23-decaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332575; Imide Analog 12; BDBM14187; 11H-Naphtho[2,1-a]carbazole-5,6-dicarbimide; 6H,14H-naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(5H,7H)-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 52750 nM
|
[32] | |||
| Compound Name |
1,1'-Hexamethylenebis(4-amino-2-methylquinolinium)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113332; Quinolinium,1,1'-(1,6-hexanediyl)bis[4-amino-2-methyl-, diiodide (9CI); ACMC-1C0G3; CTK4B4221; BDBM50473217; 1-[6-(4-amino-2-methylquinolin-1-ium-1-yl)hexyl]-2-methylquinolin-1-ium-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 54000 nM
|
[31] | |||
| Compound Name |
5,21-Dihydroxy-13-(methylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277667; BDBM50076940
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[33] | |||
| Compound Name |
13-(Dimethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278071; BDBM50076939
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[33] | |||
| Compound Name |
13-Methyl-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC692356; CHEMBL326711; BDBM50060400; NSC-692356; NCI60_033122; methyl-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl][?]dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12-hexopyranosyl-12,13-dihydro-6-methyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[34] | |||
| Compound Name |
2-Cyano-N-[5,21-dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278526; BDBM50076929
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[33] | |||
| Compound Name |
5,21-Dihydroxy-13-(propylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21096; BDBM50076936
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[33] | |||
| Compound Name |
9-[3,4-Dihydroxy-6-(hydroxymethyl)-5-methoxyperhydropyran-2-yl]-7,10-dichloro-2-hydroxyindolo[2,3-a]3-pyrrolino[3,4-c]carbazole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138039; BDBM50054432; dichloro-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-hydroxy-[?]dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[35] | |||
| Compound Name |
4,N*1*-Dimethyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21215; SCHEMBL15159937; BDBM50287095; N1,4-dimethyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[36] | |||
| Compound Name |
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CGP-53716; CGP53716;CGP 53716; CHEMBL20926; cgp53716; SCHEMBL9782; BCP34642; BDBM50240407; MFCD00945675; VCC347042; AK688902; BS-15548; N-(4-Methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide; N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide; N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[2] | |||
| Compound Name |
[3-Hydroxy-2-(4-phenylmethoxyphenyl)propyl] 2-phenylacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3632675
Click to Show/Hide
|
||||
| Activity |
IC50 = 73900 nM
|
[37] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75049; SCHEMBL2461344; BDBM50051319; 5,6-dimethyl-N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[38] | |||
| Compound Name |
(5R,6S)-9-Dodecyl-6-hydroxymethyl-1,7-dioxa-spiro[4.4]nonane-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28120; BDBM50041392
Click to Show/Hide
|
||||
| Activity |
Ki = 75300 nM
|
[39] | |||
| Compound Name |
2-(2-Amino-ethyl-amino)-6-(3-cyano-phenyl-amino)-9-ethyl-9H-purine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557975; SCHEMBL5839390
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[25] | |||
| Compound Name |
Hydrazinecarboxamide, N-(5,7,12,13-tetrahydro-5,7-dioxo-6H-indolo(2,3-a)pyrrolo(3,4-c)carbazol-6-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142141; 1-amino-3-(dioxo[?]yl)urea; DTXSID70939752; BDBM50054434; 6-(4-Semicarbazido)-6,7,12,13-tetrahydro-5,7-dioxoindolo[2,3-a] pyrrolo[3,4-c]-carbazole; 6-[(Hydrazinocarbonyl)amino]-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[35] | |||
| Compound Name |
6-Hydroxy-12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140891; SCHEMBL8317372; ZINC6582860; BDBM50054422; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-6-hydroxy-; 6-hydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 79200 nM
|
[35] | |||
| Compound Name |
2-Methoxy-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418010; SCHEMBL9666; BDBM50287096; VCC863136; 2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
13-Methyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117114; BDBM50060401; methyl-(3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)[?]dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[34] | |||
| Compound Name |
N-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278287; SCHEMBL5972157; BDBM50287089
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[36] | |||
| Compound Name |
[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 3,5-dihydroxy-4-(2-hydroxybenzoyl)benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88466
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[15] | |||
| Compound Name |
(6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-m-tolyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307062; SCHEMBL2460990; BDBM50051300
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-[4-[[5-[3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064537; SCHEMBL14604035
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
4-N-(3-Chlorophenyl)-3-N-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 22; BDBM3021; CHEMBL122245; SCHEMBL8125731; 3-((4-Methoxybenzyl)amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 4-(3-Chloro-phenylamino)-3-(4-methoxy-benzylamino)-1H-pyrazolo[3,4-d]-pyrimidine; N-(4-Methoxybenzyl)-N'-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72393; SCHEMBL2459255; BDBM50051306; N-(3-Bromophenyl)-5,6,7,8-tetrahydro-9H-pyrimido[4,5-b]indol-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391119; BDBM50435040
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
[3,4,5-Triacetyloxy-6-(13-methyl-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)oxan-2-yl]methyl acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332728; BDBM50060402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
CID 71578744
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391101; BDBM50435025; N-[4-[5-[(3-cyanophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3,5-difluorophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391117; BDBM50435038
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Phenyl-(6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433305; SCHEMBL2461588; BDBM50051310
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-[[4-(4-Methoxyphenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391131; SCHEMBL14604069; BDBM50435029
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[[4-(3,5-Difluorophenyl)phenyl]methylsulfanyl]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391124; SCHEMBL14604425; BDBM50435018
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Cyclapolin 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin-9; CHEMBL476124; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide; 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide; SCHEMBL5055142; CTK8I6133; AOB5979; ZINC2577648; BDBM50263697; AKOS024457436; HY-15159; CS-0003792; 7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide; 2-(aminocarbonyl)-7-nitro-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-3-olate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 6-amino-1,11-dichloro-12,13-dihydro-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335122; 6-Amino-1,11-dichloro-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 6-amino-1,11-dichloro-12,13-dihydro-; amino(dichloro)[?]dione; DTXSID30939753; BDBM50054435; 6-Amino-1,11-dichloro-6,7,12,13-tetrahydro-5,7-dioxoindolo[2,3-a] pyrrolo[3,4-c]-carbazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-[4-[5-[[4-(2-Cyanophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391102; BDBM50435024
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-Amino-9-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyperhydropyran-2-yl]-7,10-dichloroindolo[2,3-a]3-pyrrolino[3,4-c]carbazole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138757; BDBM50054437; amino-dichloro-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl][?]dione
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||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-Benzoyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277430; BDBM50287092
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
6-(Formylamino)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343990; N-(dioxo[?]yl)formamide; BDBM50054436; 6-Formamido-6,7,12,13-tetrahydro-5,7-dioxoindolo[2,3-a] pyrrolo[3,4-c]-carbazole; Formamide, (5,7,12,13-tetrahydro-5,7-dioxo-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-6-yl)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423288; SCHEMBL19556857; BDBM50240406; N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
3-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391132; SCHEMBL14604396; BDBM50435031
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20252; SCHEMBL9837; BDBM50287091; VCC051689; Naphthalene-2-carboxylic acid [4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3-fluoro-phenyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308582; SCHEMBL2460989; BDBM50051307; N-(3-fluorophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-[(4-Phenylphenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391099; SCHEMBL14604409; BDBM50435027; AKOS000905896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Rebeccamycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-Y96MQM21V9; CHEMBL370100; Y96MQM21V9; NSC 359079; BRN 4732638; NSC359079; SCHEMBL24695; CTK8G2916; DTXSID70239880; BDBM50162287; ZINC28520217; AKOS030213234; DB14729; HY-19825; CS-0016893; C19701; Q7301989; UNII-Y96MQM21V9 component QEHOIJJIZXRMAN-QZQSLCQPSA-N; Rebeccamycin, solid, >=98% (HPLC), from Saccharothrix aerocolonigenes
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
2-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064536; SCHEMBL14604399; BDBM50389082
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[4-Chloro-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278630; BDBM50287094
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
4-N-(3-Chlorophenyl)-3-N-[(3-methoxyphenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 21; BDBM3020; CHEMBL123189; SCHEMBL8123060; 3-((3-Methoxybenzyl)amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 4-(3-Chloro-phenylamino)-3-(3-methoxy-benzylamino)-1H-pyrazolo[3,4-d]-pyrimidine; N-(3-Methoxybenzyl)-N'-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-(5-Benzylsulfanyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391100; BDBM50435026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine; JR9RZF7KDS; UNII-JR9RZF7KDS; CHEMBL278103; 4-methyl-3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-; N-(5-Amino-o-tolyl)-4-(3-pyridyl)-2-pyrimidinamine; N-(5-Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine; 4-Methyl-N3-[4-(3-Pyridinyl)-2-Pyrimidinyl]-1,3-Benzenediamine; 4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline; 1,3-Benzenediamine, 4-methyl-N3-(4-(3-pyridinyl)-2-pyrimidinyl)-; 4-Methyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine; N-(5-Amino-2-methylphenyl)-4-(3-pridyl)-2-pyrimidineamine; Imatinib amine; 4-Methyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 4-Methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; 6-METHYL-N1-[4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL]BENZENE-1,3-DIAMINE; zlchem 1354; Imatinib amine [USP]; PubChem18212; Imatinib EP Impurity F; ACMC-209d7r; SCHEMBL2392; KSC174K2P; BEN021; CTK0H4527; DTXSID30433443; ZLE0132; Imatinib related compound F [USP]; ACT04895; BCP22918; AC-619; ANW-21397; BDBM50287097; CA0157; MFCD09028125; VCC489937; ZINC21985310; AKOS015888614; AC-2147; ACN-026829; CCG-310976; CS-W014568; DS-0284; LS41060; MCULE-2150821496; QC-1118; 112GI007; AK-23922; AT-20154; BR-23922; SC-19340; AB0005260; A3351; AM20050827; FT-0647597; FT-0655675; FT-0696298; VU0549314-1; M-1404; 460A101; Q-100177; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimid; F9995-0188; 3-[[4-(3-Pyridinyl)pyrimidine-2-yl]amino]-4-methylaniline; n-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine; N-(5-Amino-2-methyl phenyl)-4-(3-pyridyl)-2-pyrimidineamine; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2- pyrimidineamine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine; 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl; 4-Methyl-N-3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 4-methyl-N~3~-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; 4-Methyl-N3-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine; 4-methyl-N3-[4-(3-piridinyl)-2-pirimidinyl]-1,3-benzendiamine; 4-Methyl-N3-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-phenylenediamine; 6-Methyl-N-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 6-Methyl-N1-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,2-diamine; N-(5-amino-2-methyl phenyl)-4-(3-pyridinyl)2-pyrimidine-amine; N-(5-amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidine-amine; 4-Methyl-N~3~-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391129; BDBM50435023
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
12-(4-O-Methyl-beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350557; SCHEMBL6738264; BDBM50472525; 12-(4-O-methyl- -D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
2-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391118; SCHEMBL14603900; BDBM50435039
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Formamide, (1,11-dichloro-5,7,12,13-tetrahydro-5,7-dioxo-6H-indolo(2,3-a)pyrrolo(3,4-c)carbazol-6-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL139266; CTK0H8242; DTXSID90939754; N-[dichloro(dioxo)[?]yl]formamide; BDBM50054427; 6-(Formylamino)-1,11-dichloro-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 6-Formamido-1,11-dichloro-6,7,12,13-tetrahydro-5,7-dioxoindolo[2,3-a] pyrrolo[3,4-c]-carbazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
2-[[4-(2-Nitrophenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391133; BDBM50435032
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
pi-103 (Hydrochloride)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PI 103 HYDROCHLORIDE; PI-103 Hydrochloride; CHEMBL538346; PI103 hydrochloride; PubChem22442; C19H16N4O3.ClH; C19H16N4O3.HCl; DTXSID30587490; 3971AH; ABP000093; HY-10115A; LT0082; AKOS024457341; CS-0760; SB10966; 3-(4-Morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol hydrochloride; PI 103 hydrochloride;PI103 hydrochloride; W-5452; PI-103 - CAS 371935-74-9
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
Dichloroarcyriaflavin A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL139517; Rebeccamycin aglycon; rebeccamycin aglycone; dichloro-arcyriaflavin A; SCHEMBL8123086; BDBM50054421; C19699; Q27225728; 1,11-Dichloro-12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
4-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2390958; SCHEMBL14604141; BDBM50435030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
1,11-Dichloro-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335822; AC1LACOU; SCHEMBL9268981; BDBM50054418; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 1,11-dichloro-6,7,12,13-tetrahydro-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-(3-Chlorophenyl)-9H-pyrimido[4,5-b]indol-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306315; SCHEMBL7497652; ZINC3815156; BDBM50051308; (3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
Xanthohumol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
UNII-T4467YT1NT; T4467YT1NT; 2',4,4'-trihydroxy-6'-methoxy-3'-prenylchalcone; XANTHOHUMO; 2',4,4'-Trihydroxy-3'-prenyl-6'-methoxychalcone; SCHEMBL143683; CHEMBL253896; MEGxp0_000104; ACon1_001634; DTXSID00893171; Xanthohumol(Random Configuration); HMS3886H19; BCP18498; ZINC5158937; 0397AC; BDBM50384998; LMPK12120294; MFCD00210576; s7889; AKOS016010098; CCG-268086; DB15359; MCULE-7307777782; SMP2_000278; NCGC00180304-01; AC-31276; BS-17392; SC-11144; W2672; C16417; Q408088; BRD-K77390737-001-01-6; Q27166535; Xanthohumol, primary pharmaceutical reference standard; Xanthohumol from hop (Humulus lupulus), >=96% (HPLC)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
6-(2-Hydroxyethyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435422; BDBM50054433; 6-(2-Hydroxyethyl)6,7,12,13-tetrahydro-5,7-dioxoindolo[2,3-a] pyrrolo[3,4-c]-carbazole; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-6-(2-hydroxyethyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391125; SCHEMBL14604165; BDBM50435019
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
4-Chloro-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21162; SCHEMBL9677; BDBM50287090; VCC374125; 4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(Methoxycarbonylmethyl)-5-hydroxy-7-methoxy-3-(3-chlorophenyl)quinoline-4(1H)-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL7866; SCHEMBL8601752; BDBM50074742; [3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-quinolin-1-yl]-acetic acid methyl ester
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391120; BDBM50435033
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
4-(3-Chlorophenylamino)-5,6-dimethyl-7H-pyrrolo(2,3-d)pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CGP-59326; UNII-YP9UZR062O; YP9UZR062O; CHEMBL306081; N-(3-chlorophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 1H-Pyrrolo(2,3-d)pyrimidin-4-amine, N-(3-chlorophenyl)-5,6-dimethyl-; 4-(3-chlorophenylamino)-5,6-dimethyl-7h-pyrrolo[2,3-d]pyrimidine; TRX-13; 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-(3-chlorophenyl)-5,6-dimethyl-; SCHEMBL2463632; CTK0E4305; DTXSID30169619; 4-(m-chloroanilino)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine; BDBM50051317; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, N-(3-chlorophenyl)-5,6-dimethyl-; Q27294641; (3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-(2H-1,3-Benzodioxol-5-yl)-5-[({[1,1'-biphenyl]-4-yl}methyl)sulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064531; SCHEMBL14604056; ZINC5019100; BDBM50389086; AKOS000875105; MCULE-8962558919; Z19456538
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3030; CHEMBL334026; 4-(3-chlorophenoxy)-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine; N-(3-Chlorophenyl)-4-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064515; SCHEMBL16944474; BDBM50389080
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-chromen-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL7339; BDBM50074741; 5-Hydroxy-7-methoxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391122; BDBM50435035
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
5,7-Dihydroxy-3-(3-chlorophenyl)quinoline-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266995; SCHEMBL8574541; CTK0J0190; DTXSID00445174; BDBM50074743; 3-(3-Chlorophenyl)-5,7-dihydroxyquinolin-4(1H)-one; 3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-one; 4(1H)-Quinolinone, 3-(3-chlorophenyl)-5,7-dihydroxy-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1,11-Dichloro-7-hydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422107; dichloro(hydroxy)[?]one; BDBM50054419; 5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 1,11-dichloro-6,7,12,13-tetrahydro-7-hydroxy-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-(3-Bromophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74722; SCHEMBL2461158; CTK0E4304; DTXSID20442569; BDBM50051312; (3-Bromo-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine; 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-(3-bromophenyl)-5,6-dimethyl-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N-[5,21-Dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138203; BDBM50054430; N-[dichloro-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-dioxo-[?]yl]formamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
2-[4-[[5-[(3R)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064538; SCHEMBL14603965; BDBM50389084
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064532; SCHEMBL14604002; BDBM50389079
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin 1; 2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-3-oxide; SCHEMBL5062617; CHEMBL1222044; CTK2H1083; DTXSID10429521; 7-nitro-3-oxido-5-(trifluoromethylsulfanyl)-1,3-benzothiazol-3-ium-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391126; SCHEMBL14604054; BDBM50435020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[4-[[5-[(3S)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064539; SCHEMBL14603830; BDBM50389078
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
6-Methyl-12-(4-O-methyl--D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350560; SCHEMBL6730339; BDBM50471650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
(3-Chloro-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75177; SCHEMBL2461340; BDBM50051297; N-(3-Chlorophenyl)-5,6,7,8-tetrahydro-9H-pyrimido[4,5-b]indol-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N-{4-Methyl-3-[4-(1-oxy-pyridin-3-yl)-pyrimidin-2-ylamino]-phenyl}-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21079; SCHEMBL3048286; BDBM50287098; N-[4-methyl-3-[[4-(1-oxidopyridin-1-ium-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-m-tolyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307026; SCHEMBL2459209; BDBM50051304; 5,6-dimethyl-N-(3-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
5-Fluoro-2-[4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391098; BDBM50435028
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098682; BDBM50242512
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD153035; PD-153035; pd 153035; UNII-TC62B68RSL; 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE; AG-1517; SU 5271; 4-(3-bromophenylamino)-6,7-dimethoxyquinazoline; AG 1517; NSC-669364; PD-153035 free base; SU-5271; TC62B68RSL; CHEMBL29197; 153436-54-5 (free base); (3-Bromophenyl)(6,7-dimethoxyquinazolin-4-yl)amine; 4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline; C16H14BrN3O2; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline; SR-01000597835; WHI-P-79; InSolution PD 153035; GI 230329A; PubChem22449; Tocris-1037; SCHEMBL9423; AG-1517 HCl; BDBM3032; LSPANGZZENHZNJ-UHFFFAOYSA-; AOB6127; DTXSID80165328; ZINC600292; BCP00569; EX-A1235; KS-00000I0V; ANW-48127; HSCI1_000100; MFCD00934896; QC-948; s6546; AKOS003676410; BCP9001062; CS-0143; DS-1673; VZ27722; NCGC00024956-01; NCGC00024956-02; NCGC00024956-04; NCGC00024956-18; NCGC00024956-19; AC-32897; AK-50931; AM808088; BR-50931; HY-14346; SC-27623; AB0022472; DB-028592; FT-0643505; W3343; PD 153035(AG-1517); K00043; N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-; S-7071; J-009016; J-523873; SR-01000597835-2; 4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-; BRD-K26603252-001-01-9; Q27163047; PD 153035 - CAS 153436-54-5; PD 153035; SU 5271; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-(3-Chlorophenyl)-5-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311129; SCHEMBL2462441; BDBM50051302; (3-Chloro-phenyl)-(5-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-Methyl-5-hydroxy-7-methoxy-3-(3-chlorophenyl)quinoline-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7819; SCHEMBL8576451; BDBM50074740; 3-(3-chlorophenyl)-5-hydroxy-7-methoxy-1-methylquinolin-4-one; 3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1H-quinolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5,21-Dichloro-3-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-13-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350558; BDBM50471651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
8-Bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-1,2,3-triazol-4-ylmethyl)amino]quinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyanoquinoline, 51; BMCL193485 Compound 8; CHEMBL230232; SCHEMBL4961707; BDBM21925; 8-bromo-4-(3-chloro-4-fluoroanilino)-6-(2H-triazol-4-ylmethylamino)quinoline-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064534; SCHEMBL14604288; BDBM50389081
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391128; SCHEMBL14603927; BDBM50435021
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-{9-[3,4-Dihydroxy-6-(hydroxymethyl)-5-methoxyperhydropyran-2-yl]-1,3-dioxoindolo[2,3-a]3-pyrrolino[3,4-c]carbazol-2-yl}carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137907; BDBM50054431; N-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-dioxo-[?]yl]formamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
4-Methyl-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20867; SCHEMBL9820; BDBM50175491; VCC643561; 4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391121; BDBM50435034
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[4-Methyl-3-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21078; BDBM50287087
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Methyl 4-[[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064520; BDBM50389085
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-Amino-9-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyperhydropyran-2-yl]indolo[2,3-a]3-pyrrolino[3,4-c]carbazole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137842; BDBM50054438; amino-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl][?]dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064535; SCHEMBL14604060; BDBM50389083
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
3-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391130; SCHEMBL14603849; BDBM50435022
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[(4-phenylphenyl)methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391123; SCHEMBL14604095; BDBM50435036
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
4'-({[5-(2H-1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-[1,1'-biphenyl]-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064533; BDBM50389087; ZINC22415373; AKOS033887643; MCULE-8760820046; Z237995644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
5-Hydroxy-7-methoxy-3-(3-chlorophenyl)quinoline-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440453; SCHEMBL8574371; BDBM50074744; 3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391127; SCHEMBL14603718; BDBM50435037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21263; BDBM50076932
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[33] | |||
| Compound Name |
4-Amino-1-decyl-2-methylquinolin-1-ium iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113334; SCHEMBL2337776; N-Decyl-4-aminoquinaldinium iodide; BDBM50473220; AKOS033582222; MCULE-9801253905; Z1763257479
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[31] | |||
| Compound Name |
(+)-(1R,3R)-1-(3-Hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952210; Ro-4383596; SCHEMBL5772118; BDBM50363957; 7-anilino-1-[(1R,3R)-3-hydroxycyclopentyl]-3-(4-methoxyphenyl)-4H-pyrimido[4,5-d]pyrimidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[48] | |||
| Compound Name |
Ferruginoside C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL506920; BDBM50269515
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[49] | |||
| Compound Name |
(2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,2,4,5-tetrahydro-benzo[e][1,4]diazepin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283673; Benzolactam V7; BDBM50077649
Click to Show/Hide
|
||||
| Activity |
Ki = 127000 nM
|
[50] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428453; BDBM50076930
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[33] | |||
| Compound Name |
1-[(E)-Dec-5-enyl]-2-methylquinolin-1-ium-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113333; BDBM50473215
Click to Show/Hide
|
||||
| Activity |
IC50 = 137000 nM
|
[31] | |||
| Compound Name |
(1R)-2-[2,6-Dihydroxy-4-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]cyclohexane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313550
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
(1S)-2-[2,6-Dihydroxy-4-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]cyclohexane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 3,5-dihydroxy-4-(1-hydroxynaphthalene-2-carbonyl)benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91412
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
2-[[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88454
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
8-Hydroxy-6-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonyl-9-oxoxanthene-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329437
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 4-(2,6-dihydroxybenzoyl)-3,5-dimethoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
2-(N-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]anilino)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88962
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[15] | |||
| Compound Name |
Heptanoic acid (2S,3R)-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26671; BDBM50041396; Heptanoic acid (2beta-hydroxymethyl-5-oxotetrahydrofuran)-3alpha-yl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 187000 nM
|
[39] | |||
| Compound Name |
p38 MAP Kinase Inhibitor IX
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259922; Kinome_3519; SCHEMBL16576573; CTK8G2239; BDBM50376226; 4-methyl-N-(1,2-oxazol-3-yl)-3-[(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
Click to Show/Hide
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||||
| Activity |
IC50 = 188000 nM
|
[51] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 29 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Resveratrol
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
Click to Show/Hide
|
||||
| Activity |
EC50 = 5780000 nM
|
[52] | |||
| Compound Name |
phorbol 12-myristate 13-acetate
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Synonyms |
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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||||
| Activity |
EC50 = 1700000 nM
|
[52] | |||
| Compound Name |
AR-A014418
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
487021-52-3; GSK-3beta Inhibitor VIII; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; A Inhibitor VIII; N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA; UNII-87KSH90Q6D; AR-AO 14418; SN 4521; AR-A 014418; CHEMBL259850; 87KSH90Q6D; N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AK175829; C12H12N4O4S; N-(4-Methoxybenzyl)-N& -(5-nitro-1,3-thiazol-2-yl)urea; AR 014418; GSK 3be
Click to Show/Hide
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||||
| Activity |
IC50 > 100000000 nM
|
[53] | |||
| Compound Name |
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541643
Click to Show/Hide
|
||||
| Activity |
IC50 = 466000 nM
|
[43] | |||
| Compound Name |
TRISMETHOXYRESVERATROL
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
22255-22-7; trans-Trimethoxyresveratrol; (E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene; (E)-3,5,4'-Trimethoxystilbene; 3,4',5-trimethoxy-trans-stilbene; 3,4',5-trimethoxystilbene; 3,5,4'-trimethoxystilbene; TRIMETHOXYSTILBENE; TRISMETHOXYRESVERATROL; E-Resveratrol trimethyl ether; CHEMBL296411; 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene; trans-3,4',5-trimethoxystilbene; GDHNBPHYVRHYCC-SNAWJCMRSA-N; (E)-3,4',5-Trimethoxystilbene; 5-[2-(4-Methoxyphenyl)Ethenyl]-1,3-Dimethoxy Benzene
Click to Show/Hide
|
||||
| Activity |
EC50 = 1560000 nM
|
[52] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277008; BDBM50076922
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|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
13-(Ethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277011; BDBM50076942
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
3-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]propanenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283766; BDBM50076938
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|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282436; BDBM50076943
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277039; BDBM50076921
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277408; BDBM50076924
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
5,21-Dihydroxy-13-(2-hydroxyethylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20811; BDBM50076920
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-(dimethylamino)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278757; BDBM50076934
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
13-(2,3-Dihydroxypropylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266182; BDBM50076935
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
13-Amino-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21265; BDBM50076923
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21221; BDBM50076927
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|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
N-(4-Pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57553; SCHEMBL1465; BDBM50045528; VCC415532; 4-(3-Pyridinyl)-N-(3-aminophenyl)pyrimidin-2-amine; N-(3-aminophenyl)-4-(3-pyridyl)-2-pyrimidine-amine; 3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 210000 nM
|
[2] | |||
| Compound Name |
Tetradecanoic acid (2R,3R)-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28285; BDBM50041405; ZINC43598580; Tetradecanoic acid (2alpha-hydroxymethyl-5-oxotetrahydrofuran)-3alpha-yl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[39] | |||
| Compound Name |
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(2-Methyl-5-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine; N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine; n-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidineamine; CHEMBL20426; 2-Pyrimidinamine, N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-; (2-Methyl-4-nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; MFCD02179269; N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine; 2-Pyrimidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-; 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine; SCHEMBL1550; ACMC-1C66W; KSC527I5D; N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimid; PYR402; SCHEMBL13597737; CTK4C7451; DTXSID50443544; ACT04899; BCP12559; N-(2-methyl-5-nitro-phenyl)-4-pyridin-3-yl-pyrimidin-2-amine; ANW-41942; BDBM50287093; VCC987289; ZINC21298122; AKOS015909809; AC-2148; ACN-026830; MCULE-9226886591; QC-1117; 112GI008; AK-47893; DS-14539; SC-47708; AB0005259; AM20050826; FT-0654432; M2584; X2637; VU0549313-1; M-8440; 460M098; A809314; J-008922; 2-(2-methyl-5-nitroanilino)-4-(3-pyridinyl)pyrimidine; F9995-0184; N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-pyrimidine-amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine; N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinylamine; N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine; (2-Methyl-5-nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; N-(2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl)pyrimidin-2-amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2 pyrimidine amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidine amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[36] | |||
| Compound Name |
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163772; BDBM50395892
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[54] | |||
| Compound Name |
Acetic acid (2S,3R)-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28341; BDBM50041406; Acetic acid (2beta-hydroxymethyl-5-oxotetrahydrofuran)-3alpha-yl ester
Click to Show/Hide
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||||
| Activity |
Ki > 1700000 nM
|
[39] | |||
| Compound Name |
5,5'-(1E)-1,2-Ethenediylbis-1,2,3-benzenetriol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819531; 5-[(E)-2-(3,4,5-trihydroxyphenyl)ethenyl]benzene-1,2,3-triol; 3,3',4,4',5,5'-hexahydroxy-trans-stilbene; SCHEMBL4608754; 4,3',5'-Trihydroxyresveratrol; BDBM50351474; ZINC38393465; AKOS015915175; Stilbene-3,3',4,4',5,5'-hexaol; AC-24225; AS-66882; (E)-3,3',4,4',5,5'-Hexahydroxystilbene; 5-[(E)-2-(3,4,5-trihydroxyphenyl)vinyl]benzene-1,2,3-triol; 5-[(1E)-2-(3,4,5-trihydroxyphenyl)ethenyl]benzene-1,2,3-triol
Click to Show/Hide
|
||||
| Activity |
EC50 = 2980000 nM
|
[52] | |||
| Compound Name |
1-Methyl-4-amino-2-methylquinolinium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113335; Maq iodide; 1-MAQ; 4-amino-N,2-dimethylquinolinium iodide; SCHEMBL336306; BDBM50473213; 1,2-dimethylquinolin-1-ium-4-amine;iodide; Quinolinium, 4-amino-1,2-dimethyl-, iodide
Click to Show/Hide
|
||||
| Activity |
IC50 = 3590000 nM
|
[31] | |||
| Compound Name |
5-[(E)-2-(4-Hexadecoxyphenyl)ethenyl]benzene-1,3-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819528; BDBM50351475
Click to Show/Hide
|
||||
| Activity |
EC50 = 5040000 nM
|
[52] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824332; BDBM50352494
Click to Show/Hide
|
||||
| Activity |
IC50 = 24200000 nM
|
[53] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824334; BDBM50352493
Click to Show/Hide
|
||||
| Activity |
IC50 > 100000000 nM
|
[53] | |||
| Compound Name |
1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824539; BDBM50352491
Click to Show/Hide
|
||||
| Activity |
IC50 > 100000000 nM
|
[53] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824540; BDBM50352492
Click to Show/Hide
|
||||
| Activity |
IC50 > 100000000 nM
|
[53] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 = 220000 nM
|
[55] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61. | ||||
| REF 2 | Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives. Bioorg Med Chem Lett. 1997 Jan 21;7(2):187-92. | ||||
| REF 3 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 4 | Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones. J Med Chem. 1999 Mar 25;42(6):1018-26. | ||||
| REF 5 | Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2011 Jan 13;54(1):289-301. | ||||
| REF 6 | Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. | ||||
| REF 7 | Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem. 2009 May 28;52(10):3191-204. | ||||
| REF 8 | Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]t... Bioorg Med Chem Lett. 2008 May 1;18(9):2985-9. | ||||
| REF 9 | Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. | ||||
| REF 10 | Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304. | ||||
| REF 11 | Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40(22):3601-16. | ||||
| REF 12 | Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. | ||||
| REF 13 | Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. | ||||
| REF 14 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 15 | Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits. J Med Chem. 2002 Jun 6;45(12):2624-43. | ||||
| REF 16 | Discovery of selective and orally bioavailable protein kinase C (PKC) inhibitors from a fragment hit. J Med Chem. 2015 Jan 8;58(1):222-36. | ||||
| REF 17 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 18 | Novel PKC inhibitory analogs of balanol with replacement of the ester functionality. Bioorg Med Chem Lett. 1995 Sep 7;5(17):2015-20. | ||||
| REF 19 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 20 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
| REF 21 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 22 | Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors. J Med Chem. 2005 Jun 16;48(12):3991-4008. | ||||
| REF 23 | Synthesis and protein kinase C inhibitory activities of indane analogs of balanol. Bioorg Med Chem Lett. 1996 Apr 23;6(8):973-8. | ||||
| REF 24 | Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. | ||||
| REF 25 | 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. | ||||
| REF 26 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 27 | Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements. Bioorg Med Chem Lett. 1995 Aug 17;5(16):1839-42. | ||||
| REF 28 | Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. | ||||
| REF 29 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. J Med Chem. 1996 Dec 20;39(26):5215-27. | ||||
| REF 30 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 31 | Inhibition of protein kinase C(alpha) by dequalinium analogues: dependence on linker length and geometry. J Med Chem. 2000 Apr 6;43(7):1413-7. | ||||
| REF 32 | Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3835-9. | ||||
| REF 33 | Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506. Bioorg Med Chem Lett. 1999 May 3;9(9):1219-24. | ||||
| REF 34 | Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group. J Med Chem. 1997 Oct 10;40(21):3456-65. | ||||
| REF 35 | Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties. J Med Chem. 1996 Oct 25;39(22):4471-7. | ||||
| REF 36 | Phenylamino-pyrimidine (PAP) - derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors. Bioorg Med Chem Lett. 1996 Jun 4;6(11):1221-6. | ||||
| REF 37 | Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands. Medchemcomm. 2015;6:547-54. | ||||
| REF 38 | 4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem. 1996 Jun 7;39(12):2285-92. | ||||
| REF 39 | Protein kinase C. Modeling of the binding site and prediction of binding constants. J Med Chem. 1994 Apr 29;37(9):1326-38. | ||||
| REF 40 | Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3alpha. J Med Chem. 2012 May 10;55(9):4407-24. | ||||
| REF 41 | Structure-based optimization of oxadiazole-based GSK-3 inhibitors. Eur J Med Chem. 2013 Mar;61:26-40. | ||||
| REF 42 | Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. | ||||
| REF 43 | Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2438-42. | ||||
| REF 44 | Inverse Virtual Screening allows the discovery of the biological activity of natural compounds. Bioorg Med Chem. 2012 Jun 1;20(11):3596-602. | ||||
| REF 45 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 46 | Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. | ||||
| REF 47 | Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles. J Med Chem. 2007 Sep 20;50(19):4728-45. | ||||
| REF 48 | RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation. Bioorg Med Chem. 2005 Aug 15;13(16):4835-41. | ||||
| REF 49 | Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. | ||||
| REF 50 | Synthesis and protein kinase C binding activity of benzolactam-V7. Bioorg Med Chem Lett. 1999 May 17;9(10):1371-4. | ||||
| REF 51 | Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2652-7. | ||||
| REF 52 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. Bioorg Med Chem. 2011 Sep 15;19(18):5321-33. | ||||
| REF 53 | Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5610-5. | ||||
| REF 54 | Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. | ||||
| REF 55 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. J Med Chem. 2016 Oct 27;59(20):9277-9294. | ||||
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