Target Poor or Non Binder(s) Information

Target General Information

Target ID

T13491

Target Info

Target Name

Solute carrier family 29 member 1 (SLC29A1)

Synonyms

SLC29A1; Nucleoside transporter, es-type; Nucleoside transporter 1; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; ENT1

Click to Show/Hide

Target Type

Successful Target

Gene Name

SLC29A1

UniProt ID

Q99808

Poor Binders of This Target (in total, 18 binders)

Download

Top

Compound Name

Uridine

Click to Show/Hide

Approved

Compound Info

Synonyms

uridine; 58-96-8; Uridin; Uracil riboside; beta-Uridine; d-uridine; CHEBI:16704; b-Uridine; UNII-WHI7HQ7H85; Urd; AI3-52690; EINECS 200-407-5; WHI7HQ7H85; MLS000069625; Uracil-1-beta-d-ribofuranoside; C9H12N2O6; DRTQHJPVMGBUCF-XVFCMESISA-N; SMR000058222; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione

Click to Show/Hide

Activity

Ki = 51000 nM

[1]

Compound Name

9-Butyl-6-(pyridin-2-ylmethylsulfanyl)purin-2-amine

Click to Show/Hide

Investigative

Compound Info

Synonyms

MLS002667467; CHEMBL261798; NSC51473; CTK4B7362; DTXSID40287535; HMS3080G18; ZINC1682633; BDBM50412047; NSC-51473; SMR001557233; 9-Butyl-6-((pyridin-2-ylmethyl)thio)-9H-purin-2-amine; 9H-Purin-2-amine,9-butyl-6-[(2-pyridinylmethyl)thio]-

Click to Show/Hide

Activity

IC50 = 52480.75 nM

[2]

Compound Name

9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL406191; SRI 1215; NSC 39368; Inosine, 6-S-ethyl-6-thio-; SCHEMBL6470152; 9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl- (8CI)(9CI); BDBM50412072; (2R,3R,4S,5R)-2-(6-ethylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-(Ethylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Click to Show/Hide

Activity

IC50 = 57543.99 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-(2-Amino-6-butan-2-ylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL261797; BDBM50412060

Click to Show/Hide

Activity

IC50 = 63095.73 nM

[2]

Compound Name

9-Isobutyl-6-propylsulfanyl-9H-purin-2-ylamine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL408881; NSC48719; CTK5A6055; DTXSID10287047; ZINC1680986; BDBM50412032; NSC-48719; 9-isobutyl-6-(propylthio)-9H-purin-2-amine; 9H-Purin-2-amine,9-(2-methylpropyl)-6-(propylthio)-

Click to Show/Hide

Activity

IC50 = 63095.73 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-(4-Chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL328824; SCHEMBL4019484; BDBM50090853; 4-Chloro-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine; 7-(beta-D-Ribofuranosyl)-5-iodo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-iodo-7-beta-D-ribofuranosyl-

Click to Show/Hide

Activity

IC50 = 77624.71 nM

[2]

Compound Name

[2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl] thiohypoiodite

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL429510; BDBM50412068

Click to Show/Hide

Activity

IC50 = 81283.05 nM

[2]

Compound Name

9h-Purin-2-amine, 9-propyl-6-[(2-pyridinylmethyl)thio]-

Click to Show/Hide

Investigative

Compound Info

Synonyms

MLS002667466; CHEMBL405642; NSC51471; CTK5A6058; DTXSID20287533; HMS3080A16; ZINC1682631; BDBM50412027; NSC-51471; SMR001557232; 9-Propyl-6-((pyridin-2-ylmethyl)thio)-9H-purin-2-amine

Click to Show/Hide

Activity

IC50 = 91201.08 nM

[2]

Compound Name

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-phenylsulfanylpurin-9-yl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL263131; BDBM50412039

Click to Show/Hide

Activity

IC50 = 91201.08 nM

[2]

Compound Name

N-(2-Phenylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL265928; SCHEMBL9667926; ZINC4353492; BDBM50412022; STK944721; AKOS005655367; CCG-330027; MCULE-4673269423; Z204264128; 1h-pyrazolo[3,4-d]pyrimidin-4-amine,n-(2-phenylethyl)-

Click to Show/Hide

Activity

IC50 = 100000 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-(5-Bromo-4-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL258982; BDBM50412021; 7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-(methylthio)-7-beta-D-ribofuranosyl-

Click to Show/Hide

Activity

IC50 = 114815.36 nM

[2]

Compound Name

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-[(2-methylnaphthalen-1-yl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL410477; BDBM50412064

Click to Show/Hide

Activity

IC50 = 114815.36 nM

[2]

Compound Name

N-(3-Methoxybenzyl)adenosine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL225786; Adenosine, N-[(3-methoxyphenyl)methyl]-; SCHEMBL638672; CTK0G8104; BDBM50411991; 6-(-3-methoxybenzylamino)-9-beta-d-ribofuranosylpurine

Click to Show/Hide

Activity

IC50 = 114815.36 nM

[2]

Compound Name

9-Butyl-6-(propan-2-ylsulfanyl)-9h-purin-2-amine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL259774; NSC47780; CTK5A6054; DTXSID40286806; ZINC1679430; BDBM50412061; NSC-47780; 9-butyl-6-(isopropylthio)-9H-purin-2-amine; 9-butyl-6-isopropylsulfanyl-9H-purin-2-ylamine

Click to Show/Hide

Activity

IC50 = 120226.44 nM

[2]

Compound Name

6-Isopropylsulfanyl-9-propyl-9H-purin-2-ylamine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL407471; NSC47778; CTK5A6056; DTXSID80286805; ZINC1679428; BDBM50412031; NSC-47778; 6-(isopropylthio)-9-propyl-9H-purin-2-amine; 9H-Purin-2-amine,6-[(1-methylethyl)thio]-9-propyl-

Click to Show/Hide

Activity

IC50 = 144543.98 nM

[2]

Compound Name

S-Ethyl-6-thio-guanosine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL408045; BDBM50412044

Click to Show/Hide

Activity

IC50 = 162181.01 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-(2-Amino-6-propan-2-ylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL408943; BDBM50412067

Click to Show/Hide

Activity

IC50 = 190546.07 nM

[2]

Compound Name

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[4-(1-piperidyl)pyrrolo[2,3-d]pyrimidin-7-yl]tetrahydrofuran-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL262874; BDBM50412053; 7H-Pyrrolo[2,3-d]pyrimidine, 4-(1-piperidinyl)-7-beta-D-ribofuranosyl-

Click to Show/Hide

Activity

IC50 = 194984.46 nM

[2]

Click to Show/Hide the Information of All Poor Binders

Non Binders of This Target (in total, 19 non binders)

Download

Top

Compound Name

5'-iodotubercidin

Click to Show/Hide

Investigative

Compound Info

Synonyms

5-Iodotubercidin; 24386-93-4; 5-iodotubericidin; 7-Deaza-7-iodoadenosine; 7-iodo-7-deazaadenosine; 7-iodotubercidin; (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL; CHEMBL99203; CHEBI:40167; 5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; NSC 113939; 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,5-iodo-7-b-D-ribofuranosyl-; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 5-iodo-7-beta-D-ribofuranosyl-

Click to Show/Hide

Activity

IC50 = 229086.77 nM

[2]

Compound Name

Phlorizin

Click to Show/Hide

Investigative

Compound Info

Synonyms

Phlorizin; Phloridzin; 60-81-1; Phlorhizin; Phlorizoside; Floridzin; Phlorrhizin; Phloretin 2'-glucoside; Phlorrhizen; Phloridzosid; Phlorizine; UNII-CU9S17279X; Phloretin-2'-O-beta-glucoside; AI3-19835; NSC 2833; Phloridzin dihydrate; EINECS 200-487-1; Phloretin-2'-beta-glucoside; CHEBI:8113; CHEMBL245067; IOUVKUPGCMBWBT-QNDFHXLGSA-N; CU9S17279X; 2'-(beta-D-Glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 1-[2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; 1-Propanone, 1-(2-(b

Click to Show/Hide

Activity

Ki > 1000000 nM

[3]

Compound Name

6-Methylthioguanosine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL259960; SCHEMBL1979457; BDBM50412028; (2R,3R,4S,5R)-2-(2-amino-6-methylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(2-amino-6-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Click to Show/Hide

Activity

IC50 = 204173.79 nM

[2]

Compound Name

9H-Purin-2-amine, 9-butyl-6-(methylthio)-

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL259986; NSC40667; 9H-Purine, 2-amino-9-butyl-6-(methylthio)-; CTK4C5051; DTXSID60285154; ZINC1672212; BDBM50412035; NSC-40667; 9-butyl-6-(methylthio)-9H-purin-2-amine; 9H-Purin-2-amine,9-butyl-6-(methylthio)-

Click to Show/Hide

Activity

IC50 = 218776.16 nM

[2]

Compound Name

6-Methylmercaptopurine riboside

Click to Show/Hide

Investigative

Compound Info

Synonyms

METHYLTHIOINOSINE; 6-Methylthiopurine riboside; 6-Methylmercaptopurine ribonucleoside; 6-Methyl MP-riboside; 6-Methylthioinosine; Methylmercaptopurine riboside; 6-Methyl MP riboside; Me6MPR; 6-Methyl-9-ribofuranosylpurine-6-thiol; 6-MMPR; 6-S-methyl-6-thioinosine; UNII-Y5G39SHR0V; 6-(Methylthio)purine ribonucleoside; 6-(Methylthio)-9-beta-D-ribofuranosyl-9H-purine; Y5G39SHR0V; 2-HYDROXYMETHYL-5-(6-METHYLSULFANYL-PURIN-9-YL)-TETRAHYDRO-FURAN-3,4-DIOL; Inosine, 6-S-methyl-6-thio-; CHEMBL388931; Inosine, 6-(methylthio)-; 6-(methylsulfanyl)-9-beta-D-ribofuranosyl-9H-purine; MFCD00022826; beta-D-Ribosyl-6-methylthiopurine; NCI-C04784; NSC 40774; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-methylsulfanylpurin-9-yl)oxolane-3,4-diol; SQ 21977; Purine-6-thiol, 6-methyl-9-ribofuranosyl-; EINECS 206-442-2; BRN 0042871; AI3-50295; 9H-Purine, 6-(methylthio)-9beta-D-ribofuranosyl-; 9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-; 6-Methylmercapto-9-(b-D-ribofuranosyl)purine; 6MMPr; S-methyl-6-thioinosine; 6-SMe-PuR; 9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-, dihydrate; 9-BETA-D-RIBOFURANOSYL-6-METHYLTHIOPURINE; 4-26-00-01992 (Beilstein Handbook Reference); SCHEMBL672035; 6-Methylmercaptopurine-riboside; DTXSID5030454; CTK8F7173; ZINC519128; BDBM50412071; AKOS027320756; DB02896; 6-Methylmercapto-9-(beta-D-ribofuranosyl) purine; 9H-Purine, 6-(methylthio-9-beta-D-ribofuranosyl-; Q27093868; 6-(Methylthio)-9-; A-D-ribofuranosyl-9H-purine, 98%

Click to Show/Hide

Activity

IC50 = 229086.77 nM

[2]

Compound Name

N-(3-Methylbutyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL405374; NSC-11607; NCIStruc1_000318; NCIStruc2_000074; NCI11607; ZINC3953840; BDBM50412023; CCG-37799; NCGC00013123; STK944726; AKOS005655382; MCULE-8974020719; NCGC00013123-02; NCGC00096244-01; NCI60_000364; N-isopentyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; Z237578948

Click to Show/Hide

Activity

IC50 = 234422.88 nM

[2]

Compound Name

(1R,13R,14S,15R)-7-(6-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL259855; BDBM50376972

Click to Show/Hide

Activity

IC50 = 245470.89 nM

[2]

Compound Name

N-Isopropyladenosine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL260167; BDBM50411980; n6-2-propyl adenosine; CHEMBL605864; SCHEMBL6347442; BDBM50368128; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(propan-2-ylamino)purin-9-yl]oxolane-3,4-diol

Click to Show/Hide

Activity

IC50 = 257039.58 nM

[2]

Compound Name

6-Methylsulfanyl-9-tetrahydropyran-2-yl-9H-purine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL258880; NSC33184; CTK4B7360; DTXSID50283740; BDBM50412040; NSC-33184; AKOS015904707; 6-Methylmercapto-9-tetrahydropyranylpurine; 6-(methylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine; 6-(methylsulfanyl)-9-tetrahydro-2H-pyran-2-yl-9H-purine; 9H-Purine,6-(methylthio)-9-(tetrahydro-2H-pyran-2-yl)-

Click to Show/Hide

Activity

IC50 = 275422.87 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-[6-[(4-Tert-butylphenyl)sulfanylmethyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL258660; BDBM50412001

Click to Show/Hide

Activity

IC50 = 331131.12 nM

[2]

Compound Name

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(4-methoxypyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL403715; SCHEMBL17816361; BDBM50412020; ZINC29057889; 4-Methoxy-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 4-methoxy-7-beta-D-ribofuranosyl-

Click to Show/Hide

Activity

IC50 = 338844.16 nM

[2]

Compound Name

7H-Pyrrolo[2,3-d]pyrimidine-4-thiol, 7-beta-D-ribofuranosyl-

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL439437; BDBM50412019; 7-.beta.-D-ribofuranosylpyrrolo[2,3-d]pyrimidine-4-thione; 7-(beta-D-Ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-4-thiol; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(4-sulfanylpyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol

Click to Show/Hide

Activity

IC50 = 389045.14 nM

[2]

Compound Name

1-[2-[2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]sulfanylphenyl]ethanone

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL258879; BDBM50412024

Click to Show/Hide

Activity

IC50 = 446683.59 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-[2-Amino-6-(3-methyl-5-nitroimidazol-4-yl)sulfanylpurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL408942; BDBM50412057

Click to Show/Hide

Activity

IC50 = 575439.94 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-[6-[2-[2-[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]ethoxy]ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL260057; BDBM50411981

Click to Show/Hide

Activity

IC50 = 912010.84 nM

[2]

Compound Name

1-(2-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

compound 16 [PMID: 19097778]; CHEMBL482331; GTPL8837; BDBM50255978; Q27076287

Click to Show/Hide

Activity

Ki > 1000000 nM

[3]

Compound Name

(1R,13R,14S,15R)-7-(8-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL258729; BDBM50376970

Click to Show/Hide

Activity

IC50 = 1737800.83 nM

[2]

Compound Name

(1R,13R,14S,15R)-7-(5-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)-11,16-dioxa-2,4,6,9-tetrazatetracyclo[11.2.1.02,10.03,8]hexadeca-3(8),4,6,9-tetraene-14,15-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL260281; BDBM50376973

Click to Show/Hide

Activity

IC50 = 7413102.41 nM

[2]

Compound Name

(2R,3R,4S,5R)-2-[2-Amino-6-[(6-methylpyridin-2-yl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL260406; BDBM50412029

Click to Show/Hide

Activity

IC50 = 11481536.21 nM

[2]

Click to Show/Hide the Information of All Non Binders

References

Top

REF 1

Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22.

REF 2

Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008 Apr 1;16(7):3848-65.

REF 3

Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Prof. Feng ZHU

Prof. Yuzong CHEN