Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20709 | Target Info | |||
| Target Name | Muscarinic acetylcholine receptor M4 (CHRM4) | ||||
| Synonyms |
M4 receptor; CHRM4
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | CHRM4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 89 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Carbachol
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Carbach; Carbacholin; Carbacholine; Carbacholinum; Carbacholum; Carbacol; Carbacolina; Carbacolo; Carbamiotin; Carbamoylcholine; Carbastat; Carbochol; Carbocholin; Carbocholine; Carbyl; Carcholin; Coletyl; Doryl; Jestryl; Karbachol; Lentin; Lentine; Miostat; Moryl; Rilentol; Vasoperif; CARBACHOL CHLORIDE; Carbachol hydrochloride; Carbacholine chloride; Carbacholini chloridum; Carbacholinium chloratum; Carbacholum chloratum; Carbacolo [DCIT]; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamoylcholine chloride; Carbamylcholine chloride; Choline carbamate chloride; Choline chloride carbamate; Choline chlorine carbamate; Isopto Carbachol; Karbachol [Czech]; Karbamoylcholin chlorid; Karbamoylcholin chlorid [Czech]; Lentine [French]; Mistura C; C 4382; TL 457; C-1770; Carbacholum [INN-Latin]; Carbacol [INN-Spanish]; Carbamic acid, ester with choline chloride; Carbamoylcholine-hydrochloride; Carbastat (TN); Carboptic (TN); Choline chloride, carbamate; Doryl (VAN); Doryl (pharmaceutical); Gamma-Carbamoyl choline chloride; Isopto Carbachol (TN); Miostat (TN); Carbachol [INN:BAN:JAN]; Choline, chloride carbamate(ester); Choline, chloride, carbamate; P. V. Carbachol; Carbachol (JAN/USP/INN); Choline, chloride, carbamate, hydrochloride; Ethanaminium, 2-(aminocarbonyl)oxy-N,N,N-trimethyl-, chloride; Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride (1:1); (2-Carbamoyloxy-ethyl)-trimethyl-ammonium; (2-Carbamoyloxy-ethyl)-trimethyl-ammonium(Carbachol); (2-Carbamoyloxyethyl)trimethylammonium chloride; (2-Hydroxyethyl)trimethyl ammonium chloride carbamate; (2-Hydroxyethyl)trimethylammonium chloride carbamate; (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride; 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride; 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride; 2-carbamoyloxyethyl(trimethyl)azanium chloride
Click to Show/Hide
|
||||
| Activity |
EC50 = 60000 nM
|
[1] | |||
| Compound Name |
Arecoline
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
arecoline; Arecholine; Arecaline; 63-75-2; Methylarecaiden; Methylarecaidin; Arecolin; Arekolin; Arecoline base; Arecaidine methyl ester; Arecholin; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester; Methyl N-methyltetrahydronicotinate; C8H13NO2; N-Methyltetrahydronicotinic acid, methyl ester; Methyl 1,2,5,6-tetrahydro-1-methylnicotinate; UNII-4ALN5933BH; NSC 56321; Methyl N-methyl-1,2,5,6-tetrahydronicotinate; CCRIS 7688
Click to Show/Hide
|
||||
| Activity |
Ki = 60000 nM
|
[2] | |||
| Compound Name |
6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489576; BDBM50263936
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476990; BDBM50263413; 2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-[1,4'']bipiperidinyl-1''-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518747; BDBM50263371
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490597; BDBM50263889; 1-(1''-Benzyl-[1,4'']bipiperidinyl-4-yl)-5-chloro-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490598; BDBM50263890; 4-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521914; BDBM50263893
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477821; SCHEMBL5476466; BDBM50263372; 1-[1''-(2-Chloro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478034; BDBM50263411; 1-[1''-(2-Nitro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(E)-Tert-butyl 6-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyleneamino)indoline-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240021; BDBM50206176
Click to Show/Hide
|
||||
| Activity |
Ki = 50000 nM
|
[4] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523657; BDBM50263837; 5-Chloro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491818; BDBM50263937
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491208; BDBM50263886; 2-[4-(5-Chloro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-[1,4'']bipiperidinyl-1''-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490797; BDBM50263892; 6-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515489; BDBM50263410; 5-Chloro-1-[1''-(2-chloro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522451; BDBM50263891; 5-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Tbpb
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; CHEMBL522460; GTPL3258; SCHEMBL5473311; BCP13406; TBPB, >=98% (HPLC); BDBM50263887; ZINC40423557; AKOS026750197; CS-3517; NCGC00390669-01; DA-41854; HY-14562; QC-11734; FT-0746315; Y6339; A14205; BRD-K86989957-001-01-7; Q27088942; 1-(1''-(2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1''-2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1a?(2-Methylbenzyl)-1,4a?bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478662; SCHEMBL5486679; BDBM50263370; 1-(1''-(2-(trifluoromethyl)benzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-[1''-(2-Trifluoromethyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL514689; BDBM50263412; 5-Chloro-1-[1''-(2-nitro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(5-Methylfuran-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(5-methyl-2-furyl)pyrrolidine; 2-(5-Methyl-2-furanyl)pyrrolidine; Pyrrolidine, 2-(5-methyl-2-furanyl)-; CHEMBL505086; SCHEMBL2710474; 2-Methyl-5-(2-pyrrolidinyl)furan; BBL021170; STK893876; AKOS001476809; 2-(5-Methyl-furan-2-yl)-pyrrolidine; MCULE-7088447028; DA-27999; BB 0249581; FT-0745190; EN300-79349; K-1273; Z1238477877
Click to Show/Hide
|
||||
| Activity |
Ki = 51286.14 nM
|
[6] | |||
| Compound Name |
Trimethyl-[[(2R)-5,5,6,6-tetramethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593861
Click to Show/Hide
|
||||
| Activity |
Ki = 53703.18 nM
|
[7] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-N-methyl-1-(3-pyridinylmethylene)-1H-indene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21328; BDBM50219349
Click to Show/Hide
|
||||
| Activity |
Ki = 54954.09 nM
|
[8] | |||
| Compound Name |
Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450729; BDBM50412424; ZINC40835745
Click to Show/Hide
|
||||
| Activity |
Ki = 56234.13 nM
|
[6] | |||
| Compound Name |
Trimethyl-[[(2R,6S)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594803
Click to Show/Hide
|
||||
| Activity |
Ki = 57543.99 nM
|
[7] | |||
| Compound Name |
(2R)-1-Methyl-2-(5-methylfuran-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461709; BDBM50412423
Click to Show/Hide
|
||||
| Activity |
Ki = 58884.37 nM
|
[6] | |||
| Compound Name |
5-(1-Ethyl-4-phenyl-3,6-dihydro-2H-pyridin-3-yl)-3-pentyl-1,2,4-oxadiazole;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332405
Click to Show/Hide
|
||||
| Activity |
IC50 = 63337.5 nM
|
[9] | |||
| Compound Name |
1-[3-[4-[9-[[4-(1-Methyl-1,2,5,6-tetrahydropyridine-3-yl)-1,2,5-thiadiazole-3-yl]oxy]nonyl]piperidino]propyl]-3,4-dihydro-2(1H)-quinolinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354069; BDBM50030224
Click to Show/Hide
|
||||
| Activity |
EC50 = 66069.34 nM
|
[10] | |||
| Compound Name |
1-(4-(Methylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391191; BDBM50206161
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[4] | |||
| Compound Name |
Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227378; BDBM50003015
Click to Show/Hide
|
||||
| Activity |
Ki = 69183.1 nM
|
[11] | |||
| Compound Name |
2-Furan-2-yl-1-methylpyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460470; SCHEMBL13162083; 2-Furan-2-yl-1-methyl-pyrrolidine
Click to Show/Hide
|
||||
| Activity |
Ki = 69183.1 nM
|
[6] | |||
| Compound Name |
6-Methoxy-1-(1-methyl-4-nitro-1H-pyrrol-2-yl)-4,9-dihydro-3H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241099; BDBM50206185
Click to Show/Hide
|
||||
| Activity |
Ki = 70000 nM
|
[4] | |||
| Compound Name |
2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391353; BDBM50435313
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[12] | |||
| Compound Name |
6-Methoxy-1-(3-methoxyphenyl)-4,9-dihydro-3H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241082; BDBM50206188
Click to Show/Hide
|
||||
| Activity |
Ki = 78000 nM
|
[4] | |||
| Compound Name |
Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461502; BDBM50412425; ZINC40861610
Click to Show/Hide
|
||||
| Activity |
Ki = 79432.82 nM
|
[6] | |||
| Compound Name |
Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228144; BDBM50003014
Click to Show/Hide
|
||||
| Activity |
Ki = 87096.36 nM
|
[11] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168223; BDBM50474495
Click to Show/Hide
|
||||
| Activity |
Ki = 87096.36 nM
|
[13] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404557
Click to Show/Hide
|
||||
| Activity |
Ki = 87096.36 nM
|
[7] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595022
Click to Show/Hide
|
||||
| Activity |
Ki = 87096.36 nM
|
[7] | |||
| Compound Name |
2-(Furan-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(2-furyl)pyrrolidine; 2-Furan-2-yl-pyrrolidine; Pyrrolidine, 2-(2-furyl)-; CHEMBL461087; Pyrrolidine, 2-(2-furanyl)-; 2-pyrrolidin-2-ylfuran; 2-(2-Furanyl)pyrrolidine; 2-(2-Furyl)pyrrolidine; 2-(Furan-2-yl)pyrrolidine; 2-(2-Furanyl)pyrrolidine; Oprea1_525509; SCHEMBL2349663; (?)-2-(2-Furanyl)pyrrolidine; CTK5G7373; KS-00001OWO; (RS)-2-furan-2-yl-pyrrolidine; DTXSID60394917; (+/-)-2-(2-Furanyl)pyrrolidine; BBL020479; BDBM50412416; MFCD02663415; SBB025605; STK134526; AKOS005168094; MCULE-6604305404; PS-3493; VP60214; (S)-5-AMINOMETHYLPYRROLIDIN-2-ONE; DB-019508; BB 0249484; FT-0642156; ST45134019; EN300-74367; A26468; B-1535; 086F898; Z1335657438
Click to Show/Hide
|
||||
| Activity |
Ki = 87096.36 nM
|
[6] | |||
| Compound Name |
(2R)-2-(Furan-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461088; Pyrrolidine, 2-(2-furanyl)-, (2R)-; ZINC3732225; BDBM50412429; AKOS006329719
Click to Show/Hide
|
||||
| Activity |
Ki = 89125.09 nM
|
[6] | |||
| Compound Name |
(4-Methylpiperazin-1-yl)-[(3E)-3-(pyridin-4-ylmethylidene)inden-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424214; BDBM50219397
Click to Show/Hide
|
||||
| Activity |
Ki = 89125.09 nM
|
[8] | |||
| Compound Name |
Trimethyl-[[(2R,5R)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594376
Click to Show/Hide
|
||||
| Activity |
Ki = 93325.43 nM
|
[7] | |||
| Compound Name |
1-(2-(Propylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241100; BDBM50206189
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[4] | |||
| Compound Name |
1-(2-(Methylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241279; BDBM50206164
Click to Show/Hide
|
||||
| Activity |
Ki = 95000 nM
|
[4] | |||
| Compound Name |
N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391367; SCHEMBL975152; BDBM50435331; AKOS032990511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441756
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
6,7,8,9-Tetrahydro-[1,2,5]thiadiazolo[3,4-h]isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL15936; [1,2,5]Thiadiazolo[3,4-h]isoquinoline, 6,7,8,9-tetrahydro; SCHEMBL7810242; BDBM50062157; 6,7,8,9-Tetrahydro-2-thia-1,3,8-triaza-cyclopenta[a]naphthalene
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[15] | |||
| Compound Name |
Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309717
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441760
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391366; SCHEMBL974224; BDBM50435332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441750
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441757
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441752
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312346; BDBM50426242
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441751
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500313; BDBM50256181
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309715
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593864
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Esaprazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Cyclohexyl-2-piperazin-1-yl-acetamide; Exaprazole; N-cyclohexyl-2-piperazin-1-ylacetamide; N-cyclohexyl-2-(piperazin-1-yl)acetamide; N-Cyclohexyl-1-piperazineacetamide; UNII-38QSU0IB5L; 1-Piperazineacetamide, N-cyclohexyl-; Hexaprazol; 38QSU0IB5L; 1-Piperazineacetamide,N-cyclohexyl-; MFCD00865680; hexaprazole; NCGC00160434-01; DSSTox_CID_26147; DSSTox_RID_81379; DSSTox_GSID_46147; Esaprazole [INN]; Esaprazola; Esaprazolum; Esaprazolum [INN-Latin]; Esaprazola [INN-Spanish]; BRN 0785765; Prazol; N-cyclohexyl-2-piperazin-1-ylacetamide dihydrochloride; 5-23-02-00264 (Beilstein Handbook Reference); MLS004754470; SCHEMBL931007; CHEMBL1983100; DTXSID0046147; CTK5C0914; ALBB-013043; Tox21_111808; 7294AE; BDBM50435343; ZINC19737386; AKOS000209735; Tox21_111808_1; MCULE-8782683340; NE28840; N-cyclohexyl-2-(1-piperazinyl)acetamide; NCGC00160434-02; AS-44244; SMR002529465; n-(cyclohexyl-2-piperazin-1-yl)-acetamide; FT-0678584; EN300-68725; AE-641/00334033; AE-641/30178021; SR-01000883686; SR-01000883686-1; 1-piperazineacetamide, N-cyclohexyl-, dihydrochloride; BRD-K92426617-001-01-4; Q27256807; Z234896745
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311547; BDBM50426233
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
N-Isopropyl-1-piperazineacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
n-isopropyl-2-(piperazin-1-yl)acetamide; N-isopropyl-2-piperazin-1-ylacetamide; 2-piperazin-1-yl-N-propan-2-ylacetamide; 2-(piperazin-1-yl)-N-(propan-2-yl)acetamide; CHEMBL2391356; 1-Piperazineacetamide, N-(1-methylethyl)-; N-(methylethyl)-2-piperazinylacetamide; EINECS 254-676-9; NSC379438; SCHEMBL255190; CTK4I2048; KS-00003TBM; DTXSID10192925; N-isopropyl-2-piperazinoacetamide; 2-piperazinyl-N-isopropylacetamide; N-isopropyl-1-piperazine acetamide; piperazinoacetic acid isopropylamide; ALBB-006203; 2503AE; BDBM50435342; MFCD00005969; SBB027314; STK501255; ZINC19942920; AKOS000264275; MCULE-4117297184; NSC-379438; VP70271; N-Isopropyl-1-piperazineacetamide, 95%; TS-02582; 1-Piperazineacetamide,N-(1-methylethyl)-; N-Isopropyl-2-(1-piperazinyl)acetamide #; DB-049493; BB 0259628; FT-0639584; ST45024241; EN300-18601; W-6183
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441754; SCHEMBL21541688; (5S)-5-[(dimethylamino)methyl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403029
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[18] | |||
| Compound Name |
[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441758
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL279105; BDBM50062158; 1,4-Dimethyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391352; BDBM50435314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
[(2R,6R)-6-Ethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042401
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391382; SCHEMBL974621; BDBM50435316
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1,7-Di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]heptane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336478; BDBM50107714; 3,3'-(Heptamethylenebisoxy)bis[4-(1-methyl-1,2,5,6-tetrahydropyridine-3-yl)-1,2,5-thiadiazole]
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
[(2R,5R,6S)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608985
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391374; BDBM50435324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Trimethyl-[[(2R,5S)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593443
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Naphthalen-1-ylethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312347; BDBM50426241
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220553; BDBM50194316; (5R,2''S)-5[1''-methylpyrrolidin-2''-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359597
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441753
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
1,8-Di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]octane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141452; BDBM50107698; 3,3'-(Octamethylenebisoxy)bis[4-(1-methyl-1,2,5,6-tetrahydropyridine-3-yl)-1,2,5-thiadiazole]
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1,6-Di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]hexane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142126; BDBM50107708; 3,3'-(Hexamethylenebisoxy)bis[4-(1-methyl-1,2,5,6-tetrahydropyridine-3-yl)-1,2,5-thiadiazole]
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441759
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594802
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391368; SCHEMBL976125; BDBM50435329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391357; SCHEMBL1024404; BDBM50435341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441755
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441761
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
[(2R,5R,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593871
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-2-(Furan-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451335; Pyrrolidine, 2-(2-furanyl)-, (2S)-; SCHEMBL6181015; ZINC2582574; BDBM50412428
Click to Show/Hide
|
||||
| Activity |
Ki = 102329.3 nM
|
[6] | |||
| Compound Name |
1-[3-(4-Butylpiperidino)propyl]-3,4-dihydroquinoline-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
77-LH-28-1; CHEMBL3354065; 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one; GTPL3271; SCHEMBL4100746; DTXSID90437063; BDBM50030196; ZINC38410698; NCGC00370712-03; Q4643539; (1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1h)-quinolinone); 1-[3-(4-Butyl-piperidin-1-yl)-propyl]-3,4-dihydro-1H-quinolin-2-one; 1-[3-(4-Butyl-piperidin-1-yl)propyl]-3,4-dihydro-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 120226.44 nM
|
[10] | |||
| Compound Name |
4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255692
Click to Show/Hide
|
||||
| Activity |
Ki = 162181.01 nM
|
[18] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Pyrrolidine, 2-(5-methyl-2-furanyl)-, (2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458416; ZINC4234800; BDBM50412426; AKOS006329069
Click to Show/Hide
|
||||
| Activity |
Ki = 208929.61 nM
|
[6] | |||
| Compound Name |
1-(3-Methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241098; CBDivE_002501; Oprea1_059264; Oprea1_176873; 1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; ALBB-020107; BDBM50206193; MFCD00543776; STL525958; AKOS004912312; MCULE-2723125937; 1-(3-Methoxyphenyl)-1,2,3,4-tetrahydro-beta-carboline; 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-(3-methoxyphenyl)-
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[4] | |||
| Compound Name |
2-Fluoro-6-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241280; BDBM50206186
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[4] | |||
| Compound Name |
1-Phenyl-2,3,4,9-tetrahydro-1H-beta-carboline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 1-Phenyl-tetrahydrocarboline; CHEMBL241083; CMLDBU00002587; CMLD2_000054; Oprea1_201098; Oprea1_407648; SCHEMBL274149; DTXSID40276762; ALBB-008773; BDBM50206179; STK505562; AKOS000558803; AKOS016050245; CCG-102255; MCULE-6546088378; NCGC00017826-02; AS-66675; FT-0673838; R4816; 1,2,3,4-Tetrahydro-1-phenyl-beta-carboline; 1-Phenyl-1,2,3,4-tetrahydro-beta-carboline; 1-Phenyl-2,3,4,9-tetrahydro-1H-b-carboline; SR-05000001242; 1-Phenyl-2,3,4,9-tetrahydro-1H-beta-carboline #; SR-05000001242-1; 1-PHENYL-1H,2H,3H,4H,9H-PYRIDO[3,4-B]INDOLE; 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-phenyl-
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. J Med Chem. 1998 Jul 2;41(14):2524-36. | ||||
| REF 2 | C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists. J Med Chem. 2003 May 22;46(11):2216-26. | ||||
| REF 3 | Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5439-42. | ||||
| REF 4 | M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds. Bioorg Med Chem Lett. 2007 May 1;17(9):2649-55. | ||||
| REF 5 | Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5443-7. | ||||
| REF 6 | Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. J Med Chem. 2008 Jul 10;51(13):3905-12. | ||||
| REF 7 | Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation. Bioorg Med Chem. 2009 Dec 15;17(24):8174-85. | ||||
| REF 8 | Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. Bioorg Med Chem Lett. 2001 May 7;11(9):1241-3. | ||||
| REF 9 | Identification and characterization of m1 selective muscarinic receptor antagonists1. J Med Chem. 1999 Feb 11;42(3):356-63. | ||||
| REF 10 | Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1). J Med Chem. 2014 Nov 13;57(21):9065-77. | ||||
| REF 11 | Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. Bioorg Med Chem Lett. 2008 Jan 15;18(2):614-8. | ||||
| REF 12 | Synthesis and biological evaluation of Esaprazole analogues showing 1 binding and neuroprotective properties in vitro. Bioorg Med Chem. 2013 Jun 1;21(11):3334-47. | ||||
| REF 13 | Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. J Med Chem. 2003 Feb 27;46(5):856-67. | ||||
| REF 14 | Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6481-5. | ||||
| REF 15 | Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity. J Med Chem. 1998 Jan 1;41(1):109-16. | ||||
| REF 16 | Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3255-9. | ||||
| REF 17 | Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists. J Med Chem. 2013 Feb 28;56(4):1693-703. | ||||
| REF 18 | Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. | ||||
| REF 19 | 1,4-dioxane, a suitable scaffold for the development of novel M1 muscarinic receptor antagonists. J Med Chem. 2012 Feb 23;55(4):1783-7. | ||||
| REF 20 | Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists. J Med Chem. 2001 Dec 20;44(26):4563-76. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.