Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26463 | Target Info | |||
| Target Name | DNA polymerase alpha catalytic p180 (POLA1) | ||||
| Synonyms |
POLA; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha catalytic subunit
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| Target Type | Discontinued Target | ||||
| Gene Name | POLA1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(4-Chlorobenzyl)-2-[(2-hydroxyethoxy)methyl]-8-(morpholin-4-ylmethyl)-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095387; SCHEMBL6707923; BDBM50318170; N-[(4-chlorophenyl)methyl]-(2-hydroxyethoxymethyl)-(morpholinomethyl)-oxo-[?]carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Chlorobenzyl)-2-(2-hydroxyethyl)-8-(4-morpholinylmethyl)-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097364; SCHEMBL6666985; CTK4I0528; DTXSID80333222; BDBM50318169; PHA-529311; N-[(4-chlorophenyl)methyl]-(2-hydroxyethyl)-(morpholinomethyl)-oxo-[?]carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(3As,4S,7R,7aR)-1,6-diethyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydro-3H-indene-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL210764; BDBM50184763
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2-Cyclopropylethyl)-3-(1,1-Dioxido-2h-1,2,4-Benzothiadiazin-3-Yl)-6-Fluoro-4-Hydroxyquinolin-2(1h)-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL372357; AGN-PC-00BRN0; SCHEMBL5089690; SCHEMBL21067365; CTK4J0316; DTXSID80468720; BDBM50181559; ZINC100036569; DB08278; DA-18387; Q27097501
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3,5-Dihydroxy-naphthalene-2-carboxylic acid 4-chloro-benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL292775; BDBM50091980; N-(4-Chlorobenzyl)-3,5-dihydroxynaphthalene-2-carboxamide; (3,5-Dihydroxy(2-naphthyl))-N-[(4-chlorophenyl)methyl]carboxamide; N-[(4-chlorophenyl)methyl]-3,5-dihydroxy-naphthalene-2-carboxamide
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| Activity |
IC50 = 63000 nM
|
[4] | |||
| Compound Name |
Plakevulin A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL210842; BDBM50184762; Q15425264
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| Activity |
IC50 = 66000 nM
|
[2] | |||
| Compound Name |
N-Acetyl-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy]phosphonamidic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236424; BDBM50001208
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| Activity |
EC50 = 70000 nM
|
[5] | |||
| Compound Name |
N-[[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236418; BDBM50001142
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| Activity |
EC50 = 80000 nM
|
[5] | |||
| Compound Name |
N~2~-(3,4-Dichlorophenyl)-9H-purine-2,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
NSC681687; CHEMBL53605; BDBM50034955; NSC-681687; NCI60_029180; N-(3,4-Dichlorophenyl)-9H-purine-2,6-diamine; N2-(3,4-dichlorophenyl)-9H-purine-2,6-diamine; N~2~-(3,4-Dichlorophenyl)-9H-purine-2,6-diamine; N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine
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| Activity |
IC50 = 85000 nM
|
[6] | |||
| Compound Name |
N-(4-Chlorobenzothiazole-2-yl)-3-hydroxy-7-methoxynaphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL65137; BDBM50091990; ZINC00588024; N-(4-Chlorobenzothiazol-2-yl)(3-hydroxy-7-methoxy(2-naphthyl))carboxamide; 3-Hydroxy-7-methoxy-naphthalene-2-carboxylic acid (4-chloro-benzothiazol-2-yl)-amide; N-(4-chloro-1,3-benzothiazol-2-yl)-3-hydroxy-7-methoxy-naphthalene-2-carboxamide
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| Activity |
IC50 = 93000 nM
|
[4] | |||
| Compound Name |
6H-Purin-6-one, 2-((3,4-dichlorophenyl)amino)-1,9-dihydro-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL51613; 6H-Purin-6-one,2-[(3,4-dichlorophenyl)amino]-1,9-dihydro-; 6H-Purin-6-one, 2-[(3,4-dichlorophenyl)amino]-1,9-dihydro-; ACMC-20mqvl; CTK4B3711; DTXSID70924668; BDBM50013091; 2-(3,4-dichloroanilino)-1,9-dihydropurin-6-one; 2-(3,4-Dichlorophenylamino)-9H-purin-6(1H)-one; 2-((3,4-Dichlorophenyl)amino)-1H-purin-6(9H)-one; 2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-one; 2-[(3,4-Dichlorophenyl)imino]-3,9-dihydro-2H-purin-6-ol
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
{[({2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy}methyl)(hydroxy)phosphoryl]oxy}phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1652468; BDBM50335555
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Dihydroxyphosphoryl (((2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl)methoxy-hydroxy-phosphoryl) hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
PSI-7409; UNII-T90A75S60M; CHEMBL486231; T90A75S60M; GS 461203; GS-461203; 2'F-2'C-Me-UTP; SCHEMBL14666156; RO2433-TP; PSI 7409; BDBM50333129; ZINC45484499; CS-6532; Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-; HY-15745; Q27289825; (2'R)-2'-deoxy-2'-fluoro-2'-methyluridine-5'-triphosphate; beta-D-2''-deoxy-2''-fluoro-2''-C-methyluridine triphosphate
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
[({[2-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)ethoxy]methyl}(hydroxy)phosphoryl)oxy]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1652466; BDBM50335553
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
1-[(2-Amino-4-chloro-5-methylphenyl)sulfonyl]-L-proline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL210593; 1-(2-AMINO-4-CHLORO-5-METHYLPHENYLSULFONYL)PYRROLIDINE-2-CARBOXYLIC ACID; BDBM50187225; DB07273; Q27096500; (2S)-1-(2-amino-4-chloro-5-methyl-phenyl)sulfonylpyrrolidine-2-carboxylic acid; (S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylic acid; 1-[(2-Amino-4-chloro-5-methylphenyl)sulfonyl]pyrrolidine-2alpha-carboxylic acid
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
5-Methyluridine triphosphate
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Investigative | Compound Info | ||
| Synonyms |
ribothymidine triphosphate; CHEMBL220940; 5-methyluridine 5'-(tetrahydrogen triphosphate); 5-methyluridine 5'-triphosphate; D-rTTP; SCHEMBL625179; BDBM50205415; 5-Methyluridine 5'-triphosphoric acid; .beta.-D-5-Methyl uridine 5'-triphosphate
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
[[(2R,3R,4R,5S)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287609; SCHEMBL3699139; BDBM50021053
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
[[(2S,3R,5S)-5-(4-Amino-2-oxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092835; L-FdCTP; BDBM50408425; 2',3'-Deoxy-3'-fluoro-5'-cytidine triphosphate, .beta.-L
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
[({[({2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy}methyl)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1652469; BDBM50335556
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[[2-Chloro-6-methoxy-5-(trifluoromethyl)naphthalene-1-carbonyl]-methoxycarbonylamino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL84384; SCHEMBL9489492; BDBM50150371; [(2-Chloro-6-methoxy-5-trifluoromethyl-naphthalene-1-carbonyl)-methoxycarbonyl-amino]-acetic acid; 2-[[2-chloro-6-methoxy-5-(trifluoromethyl)naphthalene-1-carbonyl]-methoxycarbonyl-amino]acetic acid; Glycine, N-[[2-chloro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-(methoxycarbonyl)-; N-[[2-Chloro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-(methoxycarbonyl)glycine
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
[[(2S,3R,5S)-5-(2,4-Dioxopyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092834; L-FdUTP; BDBM50408428; 2',3'-Deoxy-3'-fluoro-5'-uridine triphosphate, .beta.-L
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-Hydroxy-7-methoxy-N-[(4-nitrophenyl)methyl]naphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62295; BDBM50091988; N-(4-Nitrobenzyl)-3-hydroxy-7-methoxynaphthalene-2-carboxamide; (3-Hydroxy-7-methoxy(2-naphthyl))-N-[(4-nitrophenyl)methyl]carboxamide; 3-Hydroxy-7-methoxy-naphthalene-2-carboxylic acid 4-nitro-benzylamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3,5-Dihydroxy-N-[(4-nitrophenyl)methyl]naphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL66652; BDBM50091985; N-(4-Nitrobenzyl)-3,5-dihydroxynaphthalene-2-carboxamide; (3,5-Dihydroxy(2-naphthyl))-N-[(4-nitrophenyl)methyl]carboxamide; 3,5-Dihydroxy-naphthalene-2-carboxylic acid 4-nitro-benzylamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[[(2R,3R,5R)-5-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-3-hydroxyoxolan-2-yl]methoxy-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350438
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| Activity |
Ki = 156000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 26 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cholesterol
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Investigative | Compound Info | ||
| Synonyms |
cholesterol; 57-88-5; Cholesterin; Cholest-5-en-3beta-ol; Cholesteryl alcohol; Cholestrin; Dusoran; Cordulan; Dusoline; Cholesterine; Hydrocerin; Cholestrol; Kathro; Dythol; Lanol; Super hartolan; Provitamin D; Cholesterol base H; Lidinite; Nimco cholesterol base H; Lidinit; Wool alcohols B. P.; (-)-Cholesterol; Tegolan (VAN); Cholest-5-en-3-beta-ol; 5:6-Cholesten-3beta-ol; Tegolan; 3beta-Hydroxycholest-5-ene; 5-Cholesten-3beta-ol; Cholest-5-en-3-ol (3beta)-; 3-beta-Hydroxycholest-5-ene; (3beta)-cholest-5-en-3-ol; CCRIS 2834; Dastar; HSDB 7
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
[[(2S,3R,5S)-5-(4-Amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483492; L-FMetdCTP (19); Beta-L-FMetCdR triphosphate; BDBM50408427; 5-Methyl-2',3'-deoxy-3'-fluoro-5'-cytidine triphosphate, .beta.-L
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| Activity |
IC50 > 200000 nM
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[10] | |||
| Compound Name |
[[(2S,3R,5S)-3-Fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092833; L-FTTP; BDBM50408426; 2',3'-Deoxy-3'-fluoro-5'-thymidine triphosphate, .beta.-L
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| Activity |
IC50 > 200000 nM
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[10] | |||
| Compound Name |
Remdesivir triphosphate
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Investigative | Compound Info | ||
| Synonyms |
GS-441524 Triphosphate; GS-443902; CHEMBL2016761; RDV-TP; AEL0YED4SU; UNII-AEL0YED4SU; R-32-GS-441524; SCHEMBL10120881; BCP32801; EX-A3055; BDBM50236025; HY-126303; CS-0101780
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| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
Bicyclic pyrimidinone, (R)-22b
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL408479; BDBM22695
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| Activity |
IC50 > 200000 nM
|
[16] | |||
| Compound Name |
[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-N-(pyridine-3-carbonyl)phosphonamidic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236422; BDBM50001206
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| Activity |
EC50 = 250000 nM
|
[5] | |||
| Compound Name |
N-[[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236417; BDBM50001141
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| Activity |
EC50 = 350000 nM
|
[5] | |||
| Compound Name |
N-[(2S)-1-Acetylpyrrolidine-2-carbonyl]-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy]phosphonamidic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236425; BDBM50001209
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| Activity |
EC50 = 410000 nM
|
[5] | |||
| Compound Name |
Dihydrocholesterol
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Investigative | Compound Info | ||
| Synonyms |
beta-Cholestanol; 5alpha-Cholestan-3beta-ol; Zymostanol; 5alpha-Cholestanol; CHOLESTANOL; Cholestan-3beta-ol; Dihydrocholesterin; Cholestan-3-ol, (3beta,5alpha)-; 5-alpha-Cholestan-3-beta-ol; Cholestan-3-ol, (3b,5a)-; 3beta-Hydroxy-5alpha-cholestane; 3beta-Cholestanol; UNII-8M308U816E; MFCD00066413; NSC 18188; (5alpha)-cholestan-3beta-ol; (3beta,5alpha)-cholestan-3-ol; 8M308U816E; Epicholestanol; Cholestan-3-ol, (3.beta.,5.alpha.)-; Cholestanol (VAN); 3beta-Hydroxycholestane; 5alpha-Dihydrocholesterol; Cholestan-3-ol, (3.beta.)- #; 5a-Cholestanol; Cholestan-3b-ol; EINECS 201-315-8; 3b-Hydroxycholestane; 5a-Dihydrocholesterol; 5a-Cholestan-3b-ol; 3b-Hydroxy-5a-cholestane; bmse000541; (3b,5a)-Cholestan-3-ol; SCHEMBL133951; (5 )-cholestan-3 -ol; (+)-Dihydrocholesterol solution; CHEMBL1289436; CTK3E8365; 5^a-Cholestan-3^b-ol, 98%; DTXSID40883258; ZINC4262223; ANW-41621; LMST01010077; s5123; 5alpha-Cholestan-3beta-ol, >=95%; Cholestane, 3beta-hydroxy-, 5alpha-; AKOS016036214; ACN-048867; CCG-268506; AS-58118; HY-107819; CS-0030696; Q27159255; 1814DD66-70FE-4610-86FB-FA8455101768; Cholestanol, United States Pharmacopeia (USP) Reference Standard; Cholestanol solution, certified reference material, 10 mg/mL in chloroform
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
1-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138039
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(2S)-1-Acetyl-N-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236420; BDBM50001204
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| Activity |
EC50 > 500000 nM
|
[5] | |||
| Compound Name |
N-[(2S)-2-Acetamido-3-phenylpropanoyl]-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy]phosphonamidic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236426; BDBM50001210
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| Activity |
EC50 > 500000 nM
|
[5] | |||
| Compound Name |
N-[[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236419; BDBM50001143
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|
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| Activity |
EC50 > 500000 nM
|
[5] | |||
| Compound Name |
[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-N-(pyridine-4-carbonyl)phosphonamidic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236423; BDBM50001207
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| Activity |
EC50 > 500000 nM
|
[5] | |||
| Compound Name |
2-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188403; SCHEMBL9456417; BDBM50153118
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(beta-D-2'',3''-Dideoxy-5''-F-cytidine-5''-triphosphate)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630222; BDBM50333127
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| Activity |
IC50 > 500000 nM
|
[17] | |||
| Compound Name |
2-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185640; SCHEMBL9456505; BDBM50153114
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| Activity |
IC50 > 500000 nM
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[14] | |||
| Compound Name |
[[(2R,3R,4R,5R)-4-Chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069349; SCHEMBL16480833; BDBM50261285
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| Activity |
IC50 > 500000 nM
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[18] | |||
| Compound Name |
1-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364431; BDBM50153112
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| Activity |
IC50 > 500000 nM
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[14] | |||
| Compound Name |
[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-N-benzoylphosphonamidic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236421; BDBM50001205
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| Activity |
EC50 > 500000 nM
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[5] | |||
| Compound Name |
1-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL189088; BDBM50153108
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| Activity |
IC50 > 500000 nM
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[14] | |||
| Compound Name |
(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186373; SCHEMBL15694752; BDBM50153109
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| Activity |
IC50 > 500000 nM
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[14] | |||
| Compound Name |
2-[(3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethylhexyl)-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-3-yloxy]ethanol
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL875595; CHEMBL3138442
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| Activity |
IC50 > 500000 nM
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[14] | |||
| Compound Name |
[[(2R,3S,5R)-5-(6-Amino-8-bromopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL178078; BDBM50118822
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| Activity |
Ki = 548000 nM
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[13] | |||
| Compound Name |
2,4-Pyrimidinediamine, 6-chloro-N4-(3,4-dichlorophenyl)-
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Investigative | Compound Info | ||
| Synonyms |
NSC43273; CHEMBL53912; NSC 43273; 6-chloro-n4-(3,4-dichlorophenyl)pyrimidine-2,4-diamine; DTXSID00222780; ZINC1675992; BDBM50034961; NSC-43273; AKOS019303096; 2-amino-4-chloro-6-(3',4'-dichloroanilino)pyrimidine; N'-(3,4-Dichlorophenyl)-6-chloro-2,4-pyrimidinediamine; 6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4-diamine
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| Activity |
IC50 > 1000000 nM
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[6] | |||
| Compound Name |
6H-Purin-6-one, 1,9-dihydro-2-((3-ethyl-4-methylphenyl)amino)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL16026; 6H-Purin-6-one,2-[(3-ethyl-4-methylphenyl)amino]-1,9-dihydro-; BRN 5442163; N(sup 3)-(3-Ethyl-4-methylphenyl)guanine; 1,9-Dihydro-2-((3-ethyl-4-methylphenyl)amino)-6H-purin-6-one; ACMC-20m7in; 2-(3-ethyl-4-methylanilino)-3,7-dihydropurin-6-one; SCHEMBL18231630; CTK4A3255; DTXSID20146671; BDBM50013093; 2-(3-ethyl-4-methyl-anilino)-1,9-dihydropurin-6-one; 2-(3-Ethyl-4-methylphenylamino)-9H-purin-6(1H)-one; 2-((3-Ethyl-4-methylphenyl)amino)-1H-purin-6(9H)-one; 2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin-6-one; 6H-Purin-6-one, 2-[(3-ethyl-4-methylphenyl)amino]-1,9-dihydro-
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| Activity |
Ki = 1760000 nM
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[19] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility. Bioorg Med Chem Lett. 2010 May 15;20(10):3039-42. | ||||
| REF 2 | Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2877-81. | ||||
| REF 3 | 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem. 2006 Feb 9;49(3):971-83. | ||||
| REF 4 | Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2079-81. | ||||
| REF 5 | N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs. Bioorg Med Chem. 2014 Apr 1;22(7):2133-40. | ||||
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| REF 7 | GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53(7):2777-84. | ||||
| REF 8 | 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture. J Med Chem. 2017 Jul 13;60(13):5424-5437. | ||||
| REF 9 | Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem. 2006 Jun 1;49(11):3052-5. | ||||
| REF 10 | Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. J Med Chem. 1998 Jun 4;41(12):2040-6. | ||||
| REF 11 | Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents. ACS Med Chem Lett. 2014 Apr 10;5(6):679-84. | ||||
| REF 12 | Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4221-4. | ||||
| REF 13 | Enhancement of nucleoside cytotoxicity through nucleotide prodrugs. J Med Chem. 2002 Sep 26;45(20):4505-12. | ||||
| REF 14 | Molecular design of cholesterols as inhibitors of DNA polymerase alpha. J Med Chem. 2004 Sep 23;47(20):4971-4. | ||||
| REF 15 | Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. | ||||
| REF 16 | Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors. J Med Chem. 2008 Feb 28;51(4):861-74. | ||||
| REF 17 | PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. | ||||
| REF 18 | The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-alpha-chloro-2'--C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4323-4330. | ||||
| REF 19 | Synthesis, cell growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogues. J Med Chem. 1987 Jan;30(1):109-16. | ||||
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