Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33492 | Target Info | |||
| Target Name | Tyrosyl-DNA phosphodiesterase 1 (TDP1) | ||||
| Synonyms |
Tyr-DNA phosphodiesterase 1
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| Target Type | Patented-recorded Target | ||||
| Gene Name | TDP1 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 188 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Camptothecin
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|
Phase 3 | Compound Info | ||
| Synonyms |
camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat
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| Activity |
IC50 ~ 111000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-[7-fluoro-1-(4-methylphenyl)-3,9-dioxo-3,9-dihydrochromeno[2,3-c]pyrrol-2(1H)-yl]-4-methyl-1,3-thiazole-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590542; BDBM50378678; STK516176; AKOS001491490; AKOS016305511; CCG-119214; MCULE-7147520804; NCGC00182479-01; Z57905725
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| Activity |
IC50 = 50120 nM
|
[2] | |||
| Compound Name |
{Imidazo[1,2-a]pyridin-2-yl}methyl 1H,2H,3H-cyclopenta[b]quinoline-9-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591966; ZINC8008113; BDBM50378677; AKOS033664578; MCULE-5666553025; NCGC00182451-01; Z19180148
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| Activity |
IC50 = 50120 nM
|
[2] | |||
| Compound Name |
CID 71458831
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170138; BDBM50397356; methyl 3-[(Z)-(2-oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoate
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| Activity |
IC50 = 51000 nM
|
[3] | |||
| Compound Name |
5,11-Dioxo-6-(2-amino-1-ethyl)-11H-indeno[1,2-c] isoquinoline hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188130; NSC725669; NSC-725669
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| Activity |
IC50 = 55300 nM
|
[4] | |||
| Compound Name |
Chembl4160427
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL21630177; BDBM50450518
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|
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| Activity |
IC50 = 58000 nM
|
[5] | |||
| Compound Name |
Schembl22364348
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809831; BDBM50172724
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| Activity |
IC50 ~ 60000 nM
|
[6] | |||
| Compound Name |
2-[(6-Methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312914; BDBM50425048; BDBM60991; US9402842, 14
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|
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| Activity |
IC50 = 61000 nM
|
[7] | |||
| Compound Name |
(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)-carbamic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3657598; BDBM140515; US8912213, 14; (6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)carbamic acid
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| Activity |
IC50 = 61000 nM
|
[8] | |||
| Compound Name |
2-[3-(Dimethylamino)propyl]-3,4-(1,2-phenylenecarbonyl)-1,2-dihydro-2,6-naphthyridine-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809043; SCHEMBL19372729; BDBM50172717; J3.605.556A
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|
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| Activity |
IC50 = 63000 nM
|
[6] | |||
| Compound Name |
2-[3-(Dimethylamino)propyl]-3,4-(1,2-phenylenecarbonyl)-1,2-dihydro-2,7-naphthyridine-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581877; SCHEMBL19372728; BDBM50090918; J3.605.557J
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|
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| Activity |
IC50 = 63000 nM
|
[6] | |||
| Compound Name |
[4-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170149; SCHEMBL14860901; BDBM50397340
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|
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| Activity |
IC50 = 69000 nM
|
[3] | |||
| Compound Name |
(2-Oxo-1-phenyl-2-piperidin-1-ylethyl) (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590804; BDBM50378680; NCGC00182459-01
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|
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| Activity |
IC50 = 70790 nM
|
[2] | |||
| Compound Name |
(5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-3-phenyl-2-sulfanylideneimidazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170158; BDBM50397331
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|
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| Activity |
IC50 = 74000 nM
|
[3] | |||
| Compound Name |
(5Z)-5-(Pyridin-4-ylmethylidene)-4-sulfanylidene-1,3-thiazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170142; SCHEMBL14860989; BDBM50397351
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|
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| Activity |
IC50 = 75000 nM
|
[3] | |||
| Compound Name |
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170125; SCHEMBL14860934; SCHEMBL14860937; BDBM50397316; ZINC95552627
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| Activity |
IC50 = 76000 nM
|
[3] | |||
| Compound Name |
(5Z)-5-[(2,5-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170126; SCHEMBL14860975; SCHEMBL14860979; BDBM50397315; ZINC95553343
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|
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| Activity |
IC50 = 76000 nM
|
[3] | |||
| Compound Name |
(4S,4As,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
NSC50352; CHEMBL2010387; SCHEMBL13782609; CTK9A0466; BDBM136693; MCULE-2757726313; US8865686, Table 1, Compound 5; NCI60_004211; DB-055941; FT-0603513; SW197115-3
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|
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| Activity |
IC50 = 84000 nM
|
[9] | |||
| Compound Name |
Methyl 4-{[4-(3-cyclopropyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxyphenoxy]methyl}benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590803; BDBM50378679; AKOS034403593; MCULE-1096473832; NCGC00182447-01; Z48988173
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| Activity |
IC50 = 89130 nM
|
[2] | |||
| Compound Name |
6-[3-(Dimethylamino)propyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809255; SCHEMBL19372726; BDBM50172685
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|
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| Activity |
IC50 = 90000 nM
|
[6] | |||
| Compound Name |
(2E)-6-Acetyl-2-[1-[2-(dimethylamino)ethylamino]ethylidene]-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104897; BDBM50232839
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2E)-6-Acetyl-7,9-dihydroxy-8,9b-dimethyl-2-[1-(3-morpholin-4-ylpropylamino)ethylidene]dibenzofuran-1,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087033; BDBM50232840
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(-)-Usnic acid
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Investigative | Compound Info | ||
| Synonyms |
(+)-Usniacin; (S)-Usnic acid; (9bR)-2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-3(9bH)-one; (S)-usnate; MFCD00016878; (9bS)-2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzofuran-1-one; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3(2H,9bH)-dione; MLS006011829; CHEMBL461903; (+)-Usniacin (D-Usnic acid); 2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one; CHEMBL1454474; SCHEMBL10076307; SCHEMBL14029477; DTXSID40977181; DTXSID001019955; HMS3655H16; ZINC135467; ALBB-015483; TNP00338; (+)-Usnic acid from Usnea dasypoga; BDBM50232841; CU0011; LMPK13060002; s2252; SBB006458; STK523900; ZINC53007741; AKOS005174867; CCG-208150; CCG-208515; MCULE-2548080738; MCULE-2648148615; SMP1_000308; NCGC00017388-01; NCGC00017388-02; NCGC00017388-03; NCGC00017388-05; NCGC00142542-01; NCGC00142542-02; SC-19718; SMR003325592; AB0109671; B3661; R1338; SW219509-1; V0974; C10101; Q27105250; UNII-0W584PFJ77 component WEYVVCKOOFYHRW-GOSISDBHSA-N; (9bS)-2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one; 3(9bH)-dibenzofuranone, 2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyl-, (9bR)-
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[[4-(Dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carbonyl]amino]-3-hydroxybutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650154; BDBM136694; US8865686, Table 1, Compound 6
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|
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| Activity |
IC50 = 106000 nM
|
[9] | |||
| Compound Name |
4-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-4-oxobutanoic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312889
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| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,7]naphthyridine-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809548; SCHEMBL19372559; BDBM50172713
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
16-Methoxy-15-(3-morpholin-4-ylpropoxy)-20-(3-morpholin-4-ylpropyl)-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261815; SCHEMBL17183601; BDBM50016177
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|
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| Activity |
IC50 ~ 111000 nM
|
[12] | |||
| Compound Name |
6-[3-(Dimethylamino)propyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809424; SCHEMBL19372718; BDBM50172705
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| Activity |
IC50 = 111000 nM
|
[6] | |||
| Compound Name |
4-Bromo-N-[4-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059749; SCHEMBL17599839; BDBM50388581
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|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
10-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422403; BDBM50082048
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| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
N-[4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059430; SCHEMBL16698877; BDBM50388564
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
20-[3-(Dimethylamino)propyl]-11,19-dioxo-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13(18),14,16-heptaene-16-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312905; SCHEMBL16312485; BDBM50425056
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| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809688; SCHEMBL19372556; BDBM50172692
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
10-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422404; BDBM50082049
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| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
8-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422396
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|
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| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
9-Hydroxy-2,3,8-trimethoxy-6-(3-morpholin-4-ylpropyl)indeno[1,2-c]isoquinoline-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177791; SCHEMBL16710312; BDBM50081948
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| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
6-[(2R)-2,3-Dihydroxypropyl]-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127447; BDBM50449151
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| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
6-(3-Hydroxypropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172300; SCHEMBL16312062; BDBM50425059
Click to Show/Hide
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| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
5-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-5-oxopentanoic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312890
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| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
6-(3-Azidopropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312898; SCHEMBL16312059; BDBM50425064
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059278; BDBM50388556
Click to Show/Hide
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[12-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059533; BDBM50388607
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809626; SCHEMBL19372722; BDBM50172694
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
N-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059429; BDBM50388563
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 57521911
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059760; BDBM50388589
Click to Show/Hide
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059432; BDBM50388566
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[2-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057231; BDBM50388618
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808575; SCHEMBL19372717; BDBM50172711
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
CID 57521693
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059750; BDBM50388610; 4-bromo-N-[5-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]benzenesulfonamide
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)-5,11-dioxoindeno[1,2-c]isoquinoline-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312902; BDBM50425058
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
4-Bromo-N-[10-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059755; SCHEMBL17599801; BDBM50388585
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
9-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422401; BDBM50082045
Click to Show/Hide
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| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
6-(3-Hydroxypropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121622; SCHEMBL16286357; BDBM50388594; STL523935; ZINC27187670; AKOS030487350; 6-(3-hydroxypropyl)indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
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||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 57521489
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059690; BDBM50388576; N-[8-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)octyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Methyl 2-[[16-methoxy-20-(3-morpholin-4-ylpropyl)-11,19-dioxo-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaen-15-yl]oxy]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261819; SCHEMBL17183594; BDBM50016169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[12] | |||
| Compound Name |
20-(2,3-Dihydroxypropyl)-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127435; BDBM50449163
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
3-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-3-oxopropanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[8-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)octyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059282; BDBM50388617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803651
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063011; BDBM50257104
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
Schembl21803662
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099136; BDBM50257122
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
CID 71546826
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312885; BDBM50425074
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
Schembl21803683
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085641; BDBM50257127
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
8-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
2-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-2-oxoacetic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312887
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
4-Bromo-N-[3-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059748; SCHEMBL17599904; BDBM50388580
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
n,n'-Dibenzoylcystine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264425; 2-benzamido-3-[(2-benzamido-2-carboxyethyl)disulfanyl]propanoic acid; NSC114532; MLS001049003; SCHEMBL6411060; DTXSID90947990; HMS2267O19; EINECS 246-640-6; BDBM50179184; AKOS030492639; MCULE-7080605342; NSC-114532; NCGC00246209-01; SMR000387015; N,N'-Bis[hydroxy(phenyl)methylidene]cystine; 3,3'-disulfanediylbis{2-[(phenylcarbonyl)amino]propanoic acid}
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[16] | |||
| Compound Name |
6-(7-Hydroxyheptyl)indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057325; BDBM50388597
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
(5Z)-1-Benzyl-5-[(4-fluorophenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170164; BDBM50397325
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[3] | |||
| Compound Name |
15,16-Dimethoxy-20-[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127440; BDBM50449158
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
(5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957774; SCHEMBL1249438; BDBM50397323
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[3] | |||
| Compound Name |
6-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-6-oxohexanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
20-[(2R)-2,3-Dihydroxypropyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127437; BDBM50449161
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810067; SCHEMBL19372716; BDBM50172498
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]-3-iodoindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581863; BDBM50090917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[17] | |||
| Compound Name |
N-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059277; BDBM50388616
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
15,16-Dimethoxy-20-[(2R,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127444; BDBM50449154
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
N-[10-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059692; BDBM50388577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581878; SCHEMBL19372724; BDBM50172722
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]-3-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059538; BDBM50388574
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
4-Bromo-N-[9-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059754; SCHEMBL17599820; BDBM50388611
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(6-Hydroxyhexyl)indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057324; BDBM50388596
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[6-(3-Aminopropyl)-11-hydroxy-5-oxo-11H-indeno[1,2-c]isoquinolin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172215; SCHEMBL16312078; BDBM50425060
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
4-Bromo-N-[2-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059695; SCHEMBL17599902; BDBM50388579
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808668; SCHEMBL19372725; BDBM50172718
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
CID 71546177
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312911; BDBM50425081; methyl 4-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-4-oxobutanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
CID 57521588
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059694; BDBM50388578; N-[12-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803696
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079995; BDBM50257100
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810072; SCHEMBL19372723; BDBM50172719
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
n,n'-Bis(phenylacetyl)cystine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-3198; MLS002637673; CHEMBL576840; NSC3198; DTXSID30277622; HMS3078K07; BDBM50179183; NSC144285; NSC-144285; SMR001547197; 3,3'-Dithiobis[2-[(phenylacetyl)amino]propanoic acid]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[16] | |||
| Compound Name |
Schembl21803682
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087581; BDBM50237808
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-6-(3-imidazol-1-ylpropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422388; SCHEMBL18319733
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
4-Sulfanyl-5-[(E)-[6-(tetrazol-5-ylidene)cyclohexa-2,4-dien-1-ylidene]methyl]-3H-1,3-thiazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170146; SCHEMBL14862808; SCHEMBL14862809; BDBM50397347
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[3] | |||
| Compound Name |
(5E)-5-(1H-Indol-5-ylmethylene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170161; ALBB-008486; BDBM50397328; STK505460; AKOS005214295; (5E)-5-(1H-indol-5-ylmethylidene)-3-phenyl-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[3] | |||
| Compound Name |
N-[4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059536; BDBM50388573
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 71544698
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312901; BDBM50425063; 8-methoxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
Schembl21803687
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094373; BDBM50257125
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
N-[10-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059531; SCHEMBL17599844; BDBM50388569
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
3-Benzyl-5-hydroxy-4-[(E)-indol-5-ylidenemethyl]-1H-imidazole-2-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170165; BDBM50397324
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[3] | |||
| Compound Name |
7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl 4-methylbenzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057330; BDBM50388601
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl 4-methylbenzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057329; BDBM50388600
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
5-Fluoro-14-methoxy-9-(3-morpholin-4-ylpropyl)-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072994; BDBM50257090
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
6-(Furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928103; SCHEMBL18010798; BDBM50161990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[18] | |||
| Compound Name |
3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl 4-methylbenzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057326; BDBM50388598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059281; BDBM50388559
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(5-Hydroxypentyl)indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141955; SCHEMBL16699480; BDBM50388614; 6-(5-Hydroxypentyl)-11H-indeno[1,2-c]isoquinoline-5(6H),11-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
9-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422400; BDBM50082044
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
5,6-Dihydro-6-(4-hydroxy-1-butyl)-5,11-diketo-11H-indeno[1,2-c]isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL139888; SCHEMBL4219938; BDBM50388595; 6-(4-hydroxybutyl)indeno[1,2-c]isoquinoline-5,11-dione; 6-(4-Hydroxybutyl)-11H-indeno[1,2-c]isoquinoline-5(6H),11-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
3-[(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino]-3-oxopropanoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312915; SCHEMBL16312054; BDBM50425078; 3-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-3-oxopropanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[6-(3-Azidopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172296; SCHEMBL16312051; BDBM50425062
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
2-((6-(3-((Tert-Butoxycarbonyl)amino)propyl)-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312895; BDBM50425066
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
(Z)-4-((2,4-Dioxothiazolidin-5-ylidene)methyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929274; 4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid; 4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic Acid; 4-{[(5Z)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE]METHYL}BENZOIC ACID; SCHEMBL5672232; BBL030324; BDBM50359685; STK113864; ZINC12504753; AKOS000287973; VS-09743; ST50157955; EN300-12921; AB00677693-01; 4-(2,4-Dioxothiazolidine-5-ylidenemethyl)benzoic acid; F1950-0169
Click to Show/Hide
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||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl 4-methylbenzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057327; BDBM50388599
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
3-Nitro-6-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127449; BDBM50449149
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
6-(2-Hydroxyethyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC339705; MLS002701832; CHEMBL123218; 6-(2-hydroxyethyl)indeno[1,2-c]isoquinoline-5,11-dione; 6-(2-Hydroxyethyl)-5H-indeno(1,2-c)isoquinoline-5,11(6H)-dione; NSC 339705; SCHEMBL16312042; CTK5E9053; DTXSID40231295; ZINC1578555; BDBM50388593; STL523979; AKOS030487573; NSC-339705; NCI60_003019; SMR001565425; DS-005788; 5H-Indeno[1,11(6H)-dione, 6-(2-hydroxyethyl)-; 6-(2-Hydroxyethyl)-5 H-indeno[1,2-c]isoquinoline-5,11(6 H)-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803655
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103520; BDBM50257099
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
CID 57521807
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059757; BDBM50388587; 4-bromo-N-[12-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
20-[(2S)-2,3-Dihydroxypropyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127436; BDBM50449162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
4-Bromo-N-[7-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059752; SCHEMBL17599845; BDBM50388583
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803677
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063586; BDBM50257101
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
16-Methoxy-15-[3-(4-methylpiperazin-1-yl)propoxy]-20-(3-morpholin-4-ylpropyl)-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261816; SCHEMBL17183600; BDBM50016171
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[12] | |||
| Compound Name |
3-Nitro-6-[(2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexyl]indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127452; BDBM50449146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
N-[9-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059530; BDBM50388568
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[2-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059276; BDBM50388603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 57521803
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059753; BDBM50388584; 4-bromo-N-[8-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)octyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059535; SCHEMBL17599861; BDBM50388572
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
15,16-Dimethoxy-20-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127443; BDBM50449155
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
Methyl 3-[(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino]-3-oxopropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312910; SCHEMBL17599915; BDBM50425082; methyl 3-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-3-oxopropanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[11-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059532; BDBM50388570
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[11-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059427; SCHEMBL16698960; BDBM50388562
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
(Z)-5-((1H-Indol-5-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170120; BDBM50397322
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
7-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422393; BDBM50082034
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
CID 57522032
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057319; BDBM50388606; N-[3-(2,3-dimethoxy-5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
2-[(6-Methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312894; BDBM50425067
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
CID 57521912
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059761; BDBM50388590; N-[3-(3-nitro-5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059433; BDBM50388619
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Methyl 2-[(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312909; BDBM50425083; methyl 2-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-2-oxoacetate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
15,16-Dimethoxy-20-[(2S,3R,4R)-2,3,4,5-tetrahydroxypentyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127441; BDBM50449157
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
CID 57522034
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057321; BDBM50388592; 6-[11-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Bromopropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312897; SCHEMBL16312055; BDBM50425065; 6-(3-Bromopropyl)-5,6-dihydro-8-methoxy-3-nitro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
16-Methoxy-20-(3-morpholin-4-ylpropyl)-15-prop-2-enoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261811; SCHEMBL17183599; BDBM50016173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[12] | |||
| Compound Name |
N-[5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059431; BDBM50388565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
7-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422394; BDBM50082035
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
N-[7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059539; SCHEMBL17599878; BDBM50388575
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
8-Hydroxy-6-(3-imidazol-1-ylpropyl)-2,3,9-trimethoxyindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177788; BDBM50081947
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809703; SCHEMBL19372727; BDBM50172710
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
CID 71546179
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312913; BDBM50425079; methyl 6-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-6-oxohexanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
6-(2,3-Dihydroxypropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127446; BDBM50449152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
1,2,3,4-Tetrahydro-6-(2-furanyl)isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792752; SCHEMBL18010809; BDBM50161991; J3.621.124E
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[18] | |||
| Compound Name |
9-Hydroxy-6-(3-imidazol-1-ylpropyl)-2,3,8-trimethoxyindeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177790; BDBM50081949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
Ethyl 2-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312892; BDBM50425068
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[8-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)octyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059434; BDBM50388567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
5-Fluoro-14-methoxy-9-[3-(4-methylpiperazin-1-yl)propyl]-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068761; BDBM50257121
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
CID 71546178
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312912; BDBM50425080; methyl 5-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-5-oxopentanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059280; BDBM47063; US8912213, 84
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[3-(11,20-Dioxo-5,7-dioxa-12-azapentacyclo[11.7.0.02,10.04,8.014,19]icosa-1(13),2,4(8),9,14,16,18-heptaen-12-yl)propyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059759; BDBM50388612
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
4-Bromo-N-[6-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059751; SCHEMBL17599863; BDBM50388582
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 57522035
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057322; BDBM50388613; 6-[12-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[10-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059284; BDBM50388561
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[6-(3-Hydroxypropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172218; SCHEMBL16312076; BDBM50425061
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
CID 57521909
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059758; BDBM50388588; N-[3-(3-nitro-5,11-dioxo-9-phenylindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 71546514
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312569; BDBM50425075
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
Schembl21803652
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070873; BDBM50257124
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
Schembl21803664
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076362; BDBM50257119
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
8-Hydroxy-9-methoxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
N-[5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059537; BDBM50388608
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 71546350
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312916; BDBM50425077
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059279; BDBM50388557
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803665
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101133; BDBM50257126
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[15] | |||
| Compound Name |
9-Hydroxy-8-methoxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422387; SCHEMBL18320288
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[13] | |||
| Compound Name |
N-[2-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059534; BDBM50388571
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
2-[[11-Hydroxy-16-methoxy-20-(3-morpholin-4-ylpropyl)-19-oxo-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaen-15-yl]oxy]acetohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261820; SCHEMBL17183592; BDBM50016170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[12] | |||
| Compound Name |
CID 71546351
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312917; BDBM50425076
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808629; SCHEMBL19372555; BDBM50172716
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl 4-methylbenzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057328; BDBM50388615
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
N-[9-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059691; SCHEMBL17599792; BDBM50388605
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581876; SCHEMBL19372720; BDBM50172723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
CID 57521806
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059756; BDBM50388586; 4-bromo-N-[11-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809052; SCHEMBL19372721; BDBM50172654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
N-[12-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059428; BDBM50388604
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 57522033
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057320; BDBM50388591; 6-[10-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]indeno[1,2-c]isoquinoline-5,11-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
CID 57521587
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059693; BDBM50388609; N-[11-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
15,16-Dimethoxy-20-[(2R,3S,4R)-2,3,4,5-tetrahydroxypentyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127438; BDBM50449160
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[14] | |||
| Compound Name |
(4Z)-4-[[4-[Bis(2-cyanoethyl)amino]phenyl]methylidene]-5-oxo-1-(4-sulfophenyl)pyrazole-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3813826; BDBM50179250; ZINC16942051
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[16] | |||
| Compound Name |
CID 71544702
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312903; BDBM50425057; 6-(3-morpholin-4-ylpropyl)-5,11-dioxoindeno[1,2-c]isoquinoline-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[11] | |||
| Compound Name |
N-[9-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059283; BDBM50388560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
4-(Dimethylamino)-1,6,10,11,12a-pentahydroxy-N-(2-hydroxyethyl)-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650155; BDBM136695; US8865686, Table 1, Compound 7
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[9] | |||
| Compound Name |
2-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170133; SCHEMBL14860994; BDBM50397344
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[3] | |||
| Compound Name |
6-[[4-(Dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650156; BDBM136696; US8865686, Table 1, Compound 8
Click to Show/Hide
|
||||
| Activity |
IC50 = 141000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 18 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Framycetin
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Neomycin; neomycin; NEOMYCIN B; Soframycin; Actiline; Mycifradin; Fradiomycin; Soframycine; Framycetinum; Framycetine; Framicetina; Neomas; Fradiomycinum; Antibiotique; Nivemycin; Actilin; Neolate; Enterfram; Myacyne; Framygen; Caswell No 595; Vonamycin powder V; Neomycin B sulfate; Neomin; Neomcin; Fradiomycin B; Neo-Rx; Neomicina [DCIT]; Framycetinum [INN-Latin]; PIMAVECORT; Neobrettin; Neo-Fradin; 119-04-0; Neomycine [INN-French]; Neomycinum [INN-Latin]; Framycetine [INN-French]; Framicetina [INN-Spanish]; USAF CB-19; Endomixin; Fraquinol; Myacine; Myciguent; NMY; Neobiotic; Neomicina; Neomycinum; Tuttomycin; VONAMYCIN; NEOMYCIN AND POLYMYXIN B SULFATES; NEOMYCIN SULFATE; Neomycin solution; Soframycin Ophthalmic; Antibiotic 10676; Antibiotic produced by Streptomyces decaris Neomycin B; Framycetin (INN); Soframycin (TN); Framycetin [INN:BAN:DCF]; Sofra-Tulle (TN); BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG; BDG-(1-4)NEB-(5-1)RIB-(3-1)NED; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-O-beta-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy
Click to Show/Hide
|
||||
| Activity |
IC50 = 8000000 nM
|
[4] | |||
| Compound Name |
AG490
Click to Show/Hide
|
Terminated | Compound Info | ||
| Synonyms |
(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 133550-30-8; AG-490; Tyrphostin B42; Tyrphostin AG 490; AG 490; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; Tyrphostin AG490; tyrphostin AG-490; AG-490 (Tyrphostin B42); alpha-Cyano-(3,4-dihydroxy)-N-benzylcinnamide; N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 134036-52-5; (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; CHEMBL56543; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; (2E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE; SMR001230665
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tyrphostin 46; Tyrphostin A46; AG 99; Tyrphostin B40; 122520-85-8; alpha-Cyano-(3,4-dihydroxy)cinnamide; AG-99; 3,4-Dihydroxy-alpha-cyanocinnamamide; UNII-ARL2OF9022; CHEMBL296407; ARL2OF9022; 118409-59-9; Tyrphostin AG 99; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; NSC666250; NSC-666250; 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-; (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide; Tyrphostin AG99; 3,4-Dihydroxy-alpha-cyanocinnamide; NSC 666250; Tocris-0497; Tyrphostin deriv. 40; BiomolKI_000013; AC1NS5AR
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
2-(3,4,5-Trihydroxy-benzylidene)-malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tyrphostin A25; Tyrphostin 25; 118409-58-8; Tyrphostin-25; (3,4,5-Trihydroxybenzylidene)-malononitrile; NSC 676484; 2-(3,4,5-Trihydroxybenzylidene)malononitrile; alpha-Cyano-(3,4,5-trihydroxy)cinnamonitrile; AG 82; ((3,4,5-Trihydroxyphenyl)methylene)propanedinitrile; NSC676484; 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile; NCGC00016046-02; RG-50875; 158129-55-6; Propanedinitrile, ((3,4,5-trihydroxyphenyl)methylene)-; Propanedinitrile,2-[(3,4,5-trihydroxyphenyl)methylene]-; Tyrphostin A 25
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170124; SCHEMBL14860944; SCHEMBL14860947; BDBM50397317; ZINC95553327
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[3] | |||
| Compound Name |
Sodium;2-[(Z)-(2-oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170136
Click to Show/Hide
|
||||
| Activity |
IC50 = 280000 nM
|
[3] | |||
| Compound Name |
4-[(Z)-(5-Oxo-1-phenyl-2-sulfanylideneimidazolidin-4-ylidene)methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170159; BDBM50397330
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
2-Cyano-3-(4-fluorophenyl)-2-propenethioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170151; ZINC243944; BDBM50397338; AKOS003238650; AF-399/32977006; 2-Propenethioamide, 2-cyano-3-(4-fluorophenyl)-, (E)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
2-Propenethioamide, 3-(4-bromophenyl)-2-cyano-, (E)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170153; ZINC1925590; BDBM50397336; 2-(4-Bromobenzylidene)-3-amino-3-thioxopropanenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
N-[4-[(E)-3-Amino-2-cyano-3-sulfanylideneprop-1-enyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170155; BDBM50397334
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
2-Propenethioamide, 2-cyano-3-(4-nitrophenyl)-, (E)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170152; ZINC135344; BDBM50397337; AKOS003676701; 2-Cyano-3-(4-nitrophenyl)acrylthiamide; ST028521; (2E)-2-(aminothioxomethyl)-3-(4-nitrophenyl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
(5Z)-5-[(4-Fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496786; (Z)-5-(4-Fluorobenzylidene)thiazolidine-2,4-dione; 5-[(4-Fluorobenzylidene]-2,4-thiazolidinedione; 5-[(4-fluorophenyl)methylene]-1,3-thiazolidine-2,4-dione; 5-[(Z)-(4-fluorophenyl)methylidene]-1,3-thiazolane-2,4-dione; SCHEMBL2539685; SCHEMBL2539691; thiazolidine-2,4-dione, 18a; BDBM26640; (Z)-5-(4-Fluorobenzylidene)-1,3-thiazolidine-2,4-dione; ZINC1027467; BDBM50368684; MFCD00449418; STK044824; AKOS001078562; MS-0336; ST025547; AB00077831-01; 5-[(Z)-4-Fluorobenzylidene]-2,4-thiazolidinedione; J-016355; 5-[4-FLUOROBENZYLIDENE]-2,4-THIAZOLIDINEDIONE; 2,4-Thiazolidinedione, 5-[(4-fluorophenyl)methylene]-; (5Z)-5-(4-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
5-(4-Fluoro-benzylidene)-3-phenyl-2-thioxo-imidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170160; ZINC1468132; BDBM50397329; STK809091; AKOS001666057; SR-01000492873; SR-01000492873-1; (5Z)-5-(4-fluorobenzylidene)-3-phenyl-2-thioxoimidazolidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
2-Cyano-3-(2-naphthyl)thioacrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170157; BDBM50397332
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
(E)-2-Cyano-3-(1H-indol-5-yl)prop-2-enethioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170156; BDBM50397333
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
4-[(Z)-(3-Benzyl-5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170163; BDBM50397326
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG 30; Tyrphostin AG 30; Tyrphostin AG30; AG-30; (E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid; alpha-Cyano-(3,4-dihydroxy)cinnamic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (E)-; Tyrphostin AG-30; Tyrphostin AG-43; Tyrophostin AG 30; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; alpha-Cyano-3,4-dihydroxycinnamic acid; (2E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)ACRYLIC ACID; CHEMBL73820; BDBM4352; ZINC3871432; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI); HSCI1_000132; MFCD09739079; AKOS000146224; benzylidenemalononitrile (BMN) deriv. 36; BS-15011; HY-118532; CS-0066283; 520C790; J-004814; (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 2-propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 333000 nM
|
[3] | |||
| Compound Name |
Achromycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Sanclomycine; Bristacycline; Abramycin; Tetraverine; Bristaciclina; Robitet; Steclin; Lemtrex (base); Democracin; Bristaciclin .alpha.; Liquamycin, veterinary; Polycycline, antibiotic; Agromicina; Ambramicina; Ambramycin; Biocycline; Cefracycline; Criseociclina; Cyclomycin; Hostacyclin; Lexacycline; Mericycline; Neocycline; Omegamycin; Orlycycline; Polycycline; Purocyclina; Roviciclina; Tetradecin; Vetacyclinum; Ciclibion; Copharlan; Panmycin; Tetrabon; Tetracyn; Tetrafil; Veracin; Tetracycline I; SK-Tetracycline; Tetracycline II; Tetra-Co; Piracaps (base); Centet (base); Abricycline; Enterocycline; Limecycline; Medocycline; Micycline; Resteclin; Amycin; Cytome; Vetquamycin-324 (free base); Bio-tetra; (-)-Tetracycline; Cefracycline suspension; T-125; Tetracycline (internal use); SR-01000311198; Acromicina; Dispatetrin; Tetracyclinbase; Tetraseptine; Ibicyn; Tetra-Proter; NSC108579; 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide; Talsutin (Salt/Mix); Dumocyclin (Salt/Mix); component of Tetrastatin; Mysteclin-F (Salt/Mix); Bristacycline (Salt/Mix); MLS001183730; SCHEMBL2614976; SCHEMBL4092221; CHEMBL1315061; CHEMBL1970834; SCHEMBL16245310; CTK6H9492; CTK8G3384; Achromycin, naphthacene derivative; BDBM136690; HMS2232B22; BBL022898; MFCD00066847; STK177206; AKOS000715021; AKOS022060566; MCULE-9174708419; US8865686, Table 1, Compound 1; NCGC00018244-02; NCGC00181125-01; NCGC00188941-01; NCI60_000202; SMR000677914; FT-0696567; H3043; SR-01000311198-1; SR-01000311198-2
Click to Show/Hide
|
||||
| Activity |
IC50 = 785000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2). J Med Chem. 2017 Apr 27;60(8):3275-3288. | ||||
| REF 2 | Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores. Bioorg Med Chem. 2010 Jan 1;18(1):182-9. | ||||
| REF 3 | 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. J Med Chem. 2012 Oct 25;55(20):8671-84. | ||||
| REF 4 | Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. J Med Chem. 2012 May 10;55(9):4457-78. | ||||
| REF 5 | Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents. J Med Chem. 2018 Nov 21;61(22):9908-9930. | ||||
| REF 6 | Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons. J Med Chem. 2016 Apr 28;59(8):3840-53. | ||||
| REF 7 | US patent application no. 9402842B2, Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors | ||||
| REF 8 | US patent application no. 8912213B2, Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors | ||||
| REF 9 | US patent application no. 8865686B2, Tetracycline compounds as tyrosyl-DNA phosphodiesterase I inhibitors | ||||
| REF 10 | Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin. J Nat Prod. 2016 Nov 23;79(11):2961-2967. | ||||
| REF 11 | Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1). J Med Chem. 2013 Jan 10;56(1):182-200. | ||||
| REF 12 | Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors. J Med Chem. 2014 May 22;57(10):4324-36. | ||||
| REF 13 | Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors. J Med Chem. 2015 Apr 9;58(7):3188-208. | ||||
| REF 14 | Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776). J Med Chem. 2014 Feb 27;57(4):1495-512. | ||||
| REF 15 | Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I. J Med Chem. 2017 Jul 13;60(13):5364-5376. | ||||
| REF 16 | Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3232-3236. | ||||
| REF 17 | Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore. J Med Chem. 2015 May 14;58(9):3997-4015. | ||||
| REF 18 | Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2). J Med Chem. 2016 Mar 24;59(6):2734-46. | ||||
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