Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35734 | Target Info | |||
| Target Name | Soluble epoxide hydrolase (EPHX2) | ||||
| Synonyms |
Bifunctional epoxide hydrolase 2
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| Target Type | Clinical trial Target | ||||
| Gene Name | EPHX2 | ||||
| Biochemical Class | Ether bond hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 68 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
ROLIPRAM
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|
Phase 2 | Compound Info | ||
| Synonyms |
61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Adeo; Rolipram [USAN:INN]; 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone; (R,S)-rolipram; ZK-62711; CHEMBL63; EINECS 262-771-1; BRN 1588548; MLS000069691; CHEBI:104872; HJORMJIFDVBMOB-UHFFFAOYSA-N; 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone; [3H]rolipram
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
ASTRAGALIN
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Investigative | Compound Info | ||
| Synonyms |
Astragalin; 480-10-4; Astragaline; kaempferol-3-glucoside; Kaempferol 3-O-glucoside; Kaempferol 3-glucoside; Kaempferol-3-O-glucoside; asragalin; Kaempferol-3-beta-monoglucoside; Kaempferol-3-D-glucoside; Kaempferol-3-beta-glucopyranoside; UNII-APM8UQ3Z9O; 3,4',5,7-Tetrahydroxyflavone-3-glucoside; Kaempferol 3-O-beta-D-glucopyranoside; 3-Glucosylkaempferol; Kaempferol 3-O-beta-D-glucoside; APM8UQ3Z9O; 4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-; CHEMBL233930; CHEBI:30200
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Aloe-emodin
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Investigative | Compound Info | ||
| Synonyms |
Aloe-emodin; Aloe emodin; 481-72-1; Aloeemodin; Aloe-emodine; Rhabarberone; EMODINE; 3-Hydroxymethylchrysazin; 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione; 3-Hydroxymethylchrysazine; 1,8-Dihydroxy-3-hydroxymethylanthraquinone; 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; NSC 38628; 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione; UNII-C8IYT9CR7C; 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-; CCRIS 3526; EINECS 207-571-7; C8IYT9CR7C; 3-(Hydroxymethyl)chrysazin; BRN 2059062; CHEMBL40275; CHEBI:2607
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| Activity |
Ki = 52200 nM
|
[3] | |||
| Compound Name |
N-Cycloheptyl-1-(4-nitrophenyl)sulfonylpiperidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933509; BDBM50360333
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
Methyl (1S)-7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236513; BDBM50004204
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2,6-Dichlorophenyl)-3-(1-propionylpiperidin-4-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258668; SCHEMBL2733881; BDBM50327841; 1-(2,6-dichlorophenyl)-3-(1-propanoylpiperidin-4-yl)urea
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4130292
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274230
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| Activity |
IC50 = 50248 nM
|
[6] | |||
| Compound Name |
1-(2,6-Diisopropyl-phenyl)-3-[4-(4-fluoro-phenoxy)-cyclohexyl]-urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217942; SCHEMBL3192284; SCHEMBL3192290; BDBM50194506
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| Activity |
IC50 = 50500 nM
|
[7] | |||
| Compound Name |
1-[3-(Trifluoromethyl)phenyl]-1H-pyrazol-4-ol
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Investigative | Compound Info | ||
| Synonyms |
1-[3-(trifluoromethyl)phenyl]pyrazol-4-ol; CHEMBL3402236; 1-(3-(Trifluoromethyl)phenyl)-1H-pyrazol-4-ol; SCHEMBL2413147; CTK8A0694; ZINC168857; KS-00001W0J; 9603AE; BDBM50068108; KM1855; MFCD03791208; SBB097257; AKOS005070310; MCULE-4295381373; 1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-ol; 3W-0219; Q27454533; 1-[3-(Trifluoromethyl)phenyl]-1H-pyrazol-4-ol, AldrichCPR
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| Activity |
IC50 = 52000 nM
|
[8] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-3-methyl-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375967; BDBM50192977
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
6-{[(Butylamino)carbonyl]amino}nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099593; ZINC5792807; BDBM50444539; MCULE-9800258385; AI-204/31694061
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| Activity |
IC50 = 57000 nM
|
[10] | |||
| Compound Name |
10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-hydroxymethyl-9(10H)-anthrone
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Investigative | Compound Info | ||
| Synonyms |
aloin; Alloin; Aloin A; Aloin, curaco; Aloin, Cape; Aloin(mixture of A&B); CHEMBL497001; 10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)anthracen-9(10H)-one; 10-(1',5'-Anhydroglucosyl)aloe-emodin-9-anthrone; 10-(1,5'-Anhydroglucosyl)aloe-emodin-9-anthrone; SCHEMBL4974144; 10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; HY-N6013; BDBM50269016; AKOS015895347; CCG-230807; DB15477; SMP1_000011; AI3-19097; CS-0032167; Q-100153; Q27140379; 1,8- Dihydroxy-3-hydroxymethyl-10-beta-D-glucopyranosyl-9-anthron; 9(10H)-Anthracenone, 10-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-; 1,8-Dihydroxy-3-(hydroxymethyl)-10-(beta-D-glucopyranosyl)anthracene-9(10H)-one; cent-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone
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| Activity |
Ki = 57300 nM
|
[3] | |||
| Compound Name |
Chembl4128031
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274271
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| Activity |
IC50 = 57393 nM
|
[6] | |||
| Compound Name |
13-(2-(n-Butylamino)-2-oxoacetamido)tridec-8(Z)-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL559453; SCHEMBL13193162; BDBM50295086
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| Activity |
IC50 = 58712 nM
|
[11] | |||
| Compound Name |
Chembl4203677
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456389
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| Activity |
IC50 = 60900 nM
|
[12] | |||
| Compound Name |
4-Benzyl-1,3-dihydroquinoxalin-2-one
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Investigative | Compound Info | ||
| Synonyms |
4-Benzyl-3,4-Dihydroquinoxalin-2(1h)-One; CHEMBL2094355; DNDI1416972; 4-benzyl-1,2,3,4-tetrahydroquinoxalin-2-one; Oprea1_758378; CTK8B8140; DTXSID80353960; HMS1724D22; ZINC226275; KS-00000I1I; ANW-59396; BDBM50002348; MFCD02641650; AKOS001042804; FS-3635; MB02434; MP-1981; AK-38466; AB0063879; DB-059492; FT-0723963; Z3854; SR-01000433747; SR-01000433747-1; Q27465199
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| Activity |
IC50 = 61000 nM
|
[13] | |||
| Compound Name |
Dibenzyl sulfoxide
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Investigative | Compound Info | ||
| Synonyms |
Benzyl sulfoxide; Dibenzylsulfoxide; Tardiol D; Dibenzyl sulphoxide; Sulfoxide, dibenzyl; (Sulfinylbis(methylene))dibenzene; benzylsulfinylmethylbenzene; Bis(phenylmethyl) sulfoxide; NSC 55; Benzene, 1,1'-[sulfinylbis(methylene)]bis-; UNII-554PDF1275; (phenylmethanesulfinylmethyl)benzene; MLS002637483; CHEMBL190496; BENZENE, 1,1'-(SULFINYLBIS(METHYLENE))BIS-; 554PDF1275; Benzyl sulfoxide, 98+%; phenyl[benzylsulfinyl]methane; EINECS 210-668-7; BRN 2049262; Dibenzylsulfoxyd; Benzyl sulfoxide (6CI,8CI); AI3-62190; Benzyl sulphoxide; Preventol CI 5; 1,1'-(sulfinyldimethanediyl)dibenzene; 1,1'-[sulfinylbis(methylene)]dibenzene; PubChem10867; DIBENZYL-SULFOXIDE; SULFOXIDE,DIBENZYL; ACMC-1BHE8; benzylsulfinyl-methyl-benzene; NSC55; WLN: R1SO&1R; Benzil-related compound, 61; 4-06-00-02651 (Beilstein Handbook Reference); SCHEMBL340372; sulfinylbis(methylene)dibenzene; [(Benzylsulfinyl)methyl]benzene; NSC-55; DTXSID8022088; BDBM22781; CTK5B4360; ZINC13562; (phenylmethyl)sulfinylmethylbenzene; [(Benzylsulfinyl)methyl]benzene #; KS-00000WW4; ANW-34063; MFCD00004782; SBB058830; [(phenylmethane)sulfinylmethyl]benzene; AKOS004907768; MCULE-2824076855; Benzene,1'-[sulfinylbis(methylene)]bis-; NCGC00246832-01; AC-16487; AS-61321; SC-47271; SMR001547021; 1,1'-[sulfinylbis(methylene)]bis-benzene; Benzene,1,1'-[sulfinylbis(methylene)]bis-; D0001; FT-0624664; ST51038544; A833587; AE-641/05560032; Q5805477; Z316995896
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| Activity |
IC50 = 70000 nM
|
[14] | |||
| Compound Name |
5-(4-Bromobenzyl)-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
NS19504; 5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine; NS 19504; CHEMBL3233606; 2-Thiazolamine, 5-[(4-bromophenyl)methyl]-; 5-(4-Bromobenzyl)thiazol-2-amine; 5-[(4-bromophenyl)methyl]-1,3-thiazole-2-ylamine; Oprea1_137648; SCHEMBL14341905; CTK5I7396; ZINC137444; BCP33054; BDBM50002342; MFCD01910159; SBB084108; STL120345; AKOS000122195; MCULE-9560179760; NE60827; BS-13920; SC-31384; 5-[(4-Bromophenyl)methyl]-2-thiazolamine; DS-016494; HY-110153; CS-0033014; N-235; NS 19504;NS-19504; ST50077632; EN300-02544; 5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine.; Q27465201; Z57330027; F2121-0157
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| Activity |
IC50 = 70000 nM
|
[13] | |||
| Compound Name |
Methyl 2-(3-cyclohexylureido)acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL66518; Glycine, N-[(cyclohexylamino)carbonyl]-, methyl ester; BDBM50143930; AKOS008961458; (3-Cyclohexyl-ureido)-acetic acid methyl ester
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| Activity |
IC50 = 70000 nM
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[9] | |||
| Compound Name |
1-Adamantan-1-yl-3-[2-(4-piperazin-1-yl-butoxy)-phenyl]-urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1632461; BDBM50333065
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| Activity |
IC50 = 72770 nM
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[15] | |||
| Compound Name |
2-(4-Methoxyphenyl)imidazo[1,2-a]pyridine
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Investigative | Compound Info | ||
| Synonyms |
2-(4-Methoxy-phenyl)-imidazo[1,2-a]pyridine; CHEMBL1594316; 4-imidazo[1,2-a]pyridin-2-ylphenyl methyl ether; Oprea1_383328; Oprea1_532298; MLS000712762; SCHEMBL9293443; CTK5A7154; ZINC68612; HMS1610N18; HMS2769J13; BBL020189; BDBM50444540; CCG-17505; KM0121; MFCD00478756; STK827935; 2-(p-Anisyl)imidazo[1,2-a]pyridine; AKOS000547556; MCULE-4595674066; KS-0000386M; NCGC00245504-01; SMR000282529; DB-098161; ST50008654; 4P-071; AE-848/36049002; SR-01000448503; SR-01000448503-1; 2-(4-METHOXY-PHENYL)IMIDAZO[1,2-A]PYRIDINE; F0913-0558; 1-(4-hydroimidazo[1,2-a]pyridin-2-yl)-4-methoxybenzene
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| Activity |
IC50 = 75000 nM
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[10] | |||
| Compound Name |
Methyl 3-[(cyclohexylcarbamoyl)amino]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308642; beta-Alanine, N-[(cyclohexylamino)carbonyl]-, methyl ester; BDBM50143931; ZINC13493756; AKOS006040290; MCULE-4772870275; 3-(3-Cyclohexyl-ureido)-propionic acid methyl ester; Z56110124
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| Activity |
IC50 = 78000 nM
|
[16] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-3-(4-hydroxy-phenyl)-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218954; BDBM50192993
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| Activity |
IC50 = 80000 nM
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[9] | |||
| Compound Name |
7-Methoxy-2-(trifluoromethyl)-4H-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
4H-1-Benzopyran-4-one, 7-methoxy-2-(trifluoromethyl)-; 7-methoxy-2-(trifluoromethyl)chromen-4-one; CHEMBL3099591; 7-methoxy-2-trifluoromethylchromone; CDS1_004102; CBMicro_023686; MixCom6_000710; DivK1c_005142; CTK1E0617; DTXSID00357920; WT870; ZINC437880; BDBM50444536; CCG-10914; MFCD00760804; STK074790; AKOS001704383; DS-6436; MCULE-9210328196; KS-000001A4; AK114291; BIM-0023812.P001; X5672; Q-9355; SR-01000513684; SR-01000513684-1; 2-(Trifluoromethyl)-7-methoxy-4H-1-benzopyran-4-one; 578-84-7 7-methoxy-2-(trifluoromethyl)-4H-chromen-4-one
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| Activity |
IC50 = 91000 nM
|
[10] | |||
| Compound Name |
(4-Bromo-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
2-(4-bromo-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid; CHEMBL3402239; 2-(4-Bromo-3-cyclopropyl-pyrazol-1-yl)acetic acid; 2-(4-bromo-3-cyclopropylpyrazol-1-yl)acetic acid; 2-(4-bromo-3-cyclopropylpyrazolyl)acetic acid; CTK7J4952; ZINC2538713; BBL104329; BDBM50068105; MFCD04970945; SBB022446; STK349806; AKOS000311154; MCULE-7660397181; ST065622; EN300-92418; Q27454546; Z2106593039
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| Activity |
IC50 = 91000 nM
|
[8] | |||
| Compound Name |
2-(Pyridin-3-yl)-1H-benzo[d]imidazole
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Investigative | Compound Info | ||
| Synonyms |
2-(3-Pyridyl)benzimidazole; 2-pyridin-3-yl-1H-benzimidazole; 2-(3-Pyridyl)-1H-benzimidazole; 2-(pyridin-3-yl)-1H-1,3-benzodiazole; 1H-Benzimidazole, 2-(3-pyridinyl)-; 2-(3-Pyridinyl)-1H-benzimidazole; 2-(3-Pyridyl)-Benzimidazole; 2-Pyridin-3-yl-1H-benzoimidazole; 2-(pyridin-3-yl)-1H-benzimidazole; MFCD00022665; CHEMBL83103; MLS000736696; 2-Pyridin-3-Yl-1~{h}-Benzimidazole; SMR000178379; NSC62610; LDHA Inhibitor, 10; NCIOpen2_000049; MLS000553255; SCHEMBL1519746; Benzimidazole, 2-(3-pyridyl)-; CTK4A8426; ZINC50724; DTXSID40289655; HMS2507G10; ALBB-017632; KS-00000YW5; 1H-Benzimidazole,2-(3-pyridinyl)-; 2327AA; BDBM50078827; g 514; NSC-62610; SBB045204; STK729686; AKOS000275318; GS-5888; MCULE-6140871503; 2-(3-pyridyl)-1H-1,3-benzimidazole; 2-(3-Pyridyl)-1H-benzimidazole, 97%; SY045485; DB-060540; ST4020042; BB 0219593; EU-0035673; FT-0656645; R1468; 2-(3-PYRIDYL)-1H-BENZIMIDAZOLE 97; EN300-48617; AE-848/30862034; SR-01000407186; J-003018; J-018292; SR-01000407186-1; F0349-4134
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| Activity |
IC50 = 91000 nM
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[10] | |||
| Compound Name |
1-Adamantan-1-yl-3-(2-(3-(piperazin-1-yl)propoxy)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1632453; BDBM50333074
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| Activity |
IC50 = 97460 nM
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[15] | |||
| Compound Name |
[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220029; BDBM50192995
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
(S)-2-(2-(3-Cyclohexylureido)acetamido)-3-(1H-imidazol-5-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL426881; BDBM50192949
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
(S)-2-(2-(3-Cyclohexylureido)acetamido)-3-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219694; BDBM50192939; AKOS025627785
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
(S)-2-(2-(3-Cyclohexylureido)acetamido)pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219024; BDBM50192950
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
9-Heptadecanone
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Investigative | Compound Info | ||
| Synonyms |
Heptadecan-9-one; Di-n-octyl ketone; Dioctyl ketone; Dioctylketone; Pelargone; Octyl ketone; MFCD00009573; CHEMBL2398215; 9-Oxoheptadecane; NSC 7336; EINECS 208-734-5; BRN 1707117; bis-octyl ketone; Di-n-Octylketone; ACMC-209lc2; 4-01-00-03396 (Beilstein Handbook Reference); SCHEMBL342685; CTK1G9724; DTXSID50202310; NSC7336; NSC-7336; 6065AH; ANW-31920; BDBM50436157; LMFA12000196; ZINC85831823; AKOS009031334; MCULE-9065183097; KS-000012K0; AS-56674; DB-052455; FT-0621663; EN300-21560; A-8959; Z1245792988
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-(3-Chloro-phenoxycarbonyloxy)-butyric acid pentyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL192243; BDBM50167036
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Pentyl N-[2-[(3-chlorophenyl)carbamoylamino]ethyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL66796; SCHEMBL1065058; BDBM50143929; {2-[3-(3-Chloro-phenyl)-ureido]-ethyl}-carbamic acid pentyl ester
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-3-hydroxy-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL373902; BDBM50192945
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-4-methylsulfanyl-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL424747; BDBM50192937
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-3-methyl-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216220; BDBM50192970
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-[6-(3-Cyclohexyl-ureido)-hexanoylamino]-5-guanidino-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219747; BDBM50192992
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-[2-(3-Chloro-phenyl)-acetoxy]-butyric acid pentyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195542; BDBM50167051; ZINC13644453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(S)-2-(6-(3-Cyclohexylureido)hexanamido)pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387334; BDBM50192994
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(1-Adamantyl)piperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3222125; BDBM50496755; AKOS009216134
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[18] | |||
| Compound Name |
(S)-2-[2-(3-Cyclohexyl-ureido)-acetylamino]-5-guanidino-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219023; BDBM50192932
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-{2-[3-(3-Chloro-phenyl)-ureido]-ethyl}-3-pentyl-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302664; SCHEMBL1063491; BDBM50143910; ZINC13560467; 1-(3-chlorophenyl)-3-[2-(pentylcarbamoylamino)ethyl]urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-2-((S)-2-(6-(3-Cyclohexylureido)hexanamido)-3-phenylpropanamido)succinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219498; BDBM50192941
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-Cyclohexyl-3-(2-hydroxymethyl-phenyl)-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192136; ZINC6884554; BDBM50167046; AKOS005964138; MCULE-6818138482; ST51026911; (cyclohexylamino)-N-[2-(hydroxymethyl)phenyl]carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-Cyclohexyl-N-(2-hydroxymethyl-phenyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191982; BDBM50167039; AKOS008975182
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218354; BDBM50192972
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-(2-(3-Cyclohexylureido)acetamido)-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219693; BDBM50192959; AKOS026961267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-4-methyl-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219151; BDBM50192985
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-3-(3H-imidazol-4-yl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216219; BDBM50192971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-((S)-2-(6-(3-Cyclohexylureido)hexanamido)-3-phenylpropanamido)pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265624; BDBM50192946
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(3-Chlorophenyl)carbamoylamino]ethyl]heptanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63945; SCHEMBL1061303; BDBM50143932; Heptanoic acid {2-[3-(3-chloro-phenyl)-ureido]-ethyl}-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-5-guanidino-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219141; BDBM50192934
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
6-[(Adamantan-1-ylcarbamoyl)amino]hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219094; Urea-based compound, 16; SCHEMBL12932218; BDBM25735; 1-(Adamantane-1-yl)-3-(5-carboxypentyl)urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-(3-Chloro-phenoxycarbonylamino)-butyric acid pentyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364020; BDBM50167038
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-3-hydroxy-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219528; BDBM50192929
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-(6-(3-Cyclohexylureido)hexanamido)-3-(1H-imidazol-5-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219596; BDBM50192979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-1-[6-(3-Adamantan-1-yl-ureido)-hexanoyl]-pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218353; BDBM50192948
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Di-n-octyl Sulfone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
di-n-octylsulfone; 1-octylsulfonyloctane; n-Octyl Sulfone; DIOCTYL SULFONE; Octane, 1,1'-sulfonylbis-; CHEMBL2398217; (octylsulfonyl)octane; 1,1'-sulfonyldioctane; 1-(octylsulfonyl)octane; ACMC-209p8u; SCHEMBL394809; CTK2G6685; DTXSID40396570; 2-methoxy-4'-methyldiphenyl ether; ANW-36988; BDBM50436155; MFCD00039760; SBB060124; ZINC59636862; AKOS015839961; MCULE-1608935298; DB-056198; D3161; FT-0636578; ST51046359
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-succinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375839; BDBM50192962
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Dioctyl sulfide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Di-n-octyl sulfide; Octane, 1,1'-thiobis-; Octyl sulfide; 1-octylsulfanyloctane; n-Octyl sulfide; Di-n-octylsulfide; 1-(Octylsulfanyl)octane; Dioctyl thioether; 9-Thiaheptadecane; DIOCTYLSULFANE; UNII-KWB0X6Z9EG; KWB0X6Z9EG; octylthiooctane; MFCD00009566; NSC 65459; Dioctyl sulphide; 1-(octylthio)octane; Di-n-octyl thioether; Octane,1'-thiobis-; Bis(1-octyl) sulfide; Octyl sulfide (8CI); Dioctyl sulfide, 96%; 1-(1-Octylthio)octane; ACMC-2097bo; NCIOpen2_003245; SCHEMBL23901; KSC203A2F; CHEMBL2398216; DTXSID1062594; CTK1A3022; KS-00000YKJ; LOXRGHGHQYWXJK-UHFFFAOYSA-; (n-C8H17)2S; NSC65459; EINECS 220-259-5; ANW-13762; BDBM50436156; NSC-65459; SBB060668; ZINC96272027; AKOS015897571; MCULE-5901093421; AS-57046; SC-49102; 1 inverted exclamation mark -thiobis-octan; AI3-12172; DB-047046; FT-0625207; O0108; ST51046805; A818668; Q27282471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(S)-2-[6-(3-Adamantan-1-yl-ureido)-hexanoylamino]-pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220028; BDBM50192933
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-Cyclohexyl-2-(2-hydroxymethyl-phenyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195797; BDBM50167037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-(1-Methyl-1H-pyrazol-4-yl)-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233605; 2-(1-methyl-1H-pyrazol-4-yl)-1H-1,3-benzodiazole; SCHEMBL16756598; CTK6I3835; ZINC9337925; BDBM50001940; AKOS009107074; MCULE-9274364112; EN300-26311; Q27465196; Z221592824
Click to Show/Hide
|
||||
| Activity |
IC50 = 127000 nM
|
[13] | |||
| Compound Name |
2-(Furan-2-yl)benzo[d]oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(furan-2-yl)-1,3-benzoxazole; 2-(2-Furyl)benzoxazole; CHEMBL3099679; Benzoxazole, 2-(2-furanyl)-; SCHEMBL2223897; CTK3B6808; DTXSID30359093; ZINC532763; 4051AC; ANW-62093; BDBM50444532; AKOS003264756
Click to Show/Hide
|
||||
| Activity |
IC50 = 133000 nM
|
[10] | |||
| Compound Name |
3-(4-(Benzyloxy)phenyl)propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-[4-(benzyloxy)phenyl]-1-propanol; 3-[4-(benzyloxy)phenyl]propan-1-ol; 3-(4-phenylmethoxyphenyl)propan-1-ol; CHEMBL3402237; Benzenepropanol,4-(phenylmethoxy)-; 3-[4-(benzyloxy)phenyl)-1-propanol; 3-(4-benzyloxyphenyl)propanol; SCHEMBL1563277; 3-[p-(benzyloxy)phenyl]propanol; CTK5B3230; DTXSID20377286; 3-(4-benzyloxyphenyl)propan-1-ol; ZINC2511828; 6706AE; BDBM50068107; KM0512; MFCD03791226; SBB099599; AKOS005068141; KS-00001Y02; 3-[4-(phenylmethoxy)phenyl]propan-1-ol; DA-04409; FT-0680475; 5W-0218; J-510634; Q27454534
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[8] | |||
| Compound Name |
N-[2-(Morpholin-4-yl)phenyl]thiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233609; Oprea1_512225; ZINC153993; BDBM50002352; CCG-48721; AKOS001320542; HR-0379; MCULE-7207710828; SR-01000638239-1; Q27465202
Click to Show/Hide
|
||||
| Activity |
IC50 = 171000 nM
|
[13] | |||
| Compound Name |
4-[2,5-Dimethyl-1-(tetrahydrofuran-2-ylmethyl)-1H-pyrrol-3-yl]-1,3-thiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233608; 4-[2,5-dimethyl-1-(oxolan-2-ylmethyl)-1H-pyrrol-3-yl]-1,3-thiazol-2-amine; 4-[2,5-dimethyl-1-(oxolan-2-ylmethyl)pyrrol-3-yl]-1,3-thiazol-2-amine; CTK7E1731; BDBM50002351; AKOS000349666; MCULE-9515649565; NE20849; EN300-09955; SR-01000058435; J-514230; SR-01000058435-1; Z48847575; 4-(2,5-Dimethyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-3-yl)thiazol-2-amine; 4-{2,5-dimethyl-1-[(oxolan-2-yl)methyl]-1H-pyrrol-3-yl}-1,3-thiazol-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Fuberidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Fubridazole; Fuberidatol; 1H-Benzimidazole, 2-(2-furanyl)-; Fuberidazol; Furidazol; Furidazole; Fuberisazol; Voronit; Voronite; 2-(2-Furyl)benzimidazole; Bayer 33172; 2-(2-Furyl)-1H-benzimidazole; Benzimidazole, 2-(2-furyl)-; 2-(2-Furanyl)-1H-benzimidazole; BAY 33172; W VII/117; 2-(furan-2-yl)-1H-benzimidazole; UNII-RXD450F6C7; NSC 72670; B-33172; 2-benzimidazol-2-ylfuran; 2-(furan-2-yl)-1H-benzo[d]imidazole; 2-(2'-Furyl)-benzimidazole; CHEMBL201094; RXD450F6C7; Furidazole; NSC 72670;Voronit;BAY 33172; Fuberidazole [BSI:ISO]; 2-Furan-2-yl-1H-benzoimidazole; EINECS 223-404-0; 2-(2-Furanyl)-1H-benzimidazole (9CI); DSSTox_CID_21995; DSSTox_RID_79898; DSSTox_GSID_41995; SCHEMBL23174; 2-(furan-2-yl)-benzimidazole; DTXSID4041995; CTK3I9124; Fuberidazole, analytical standard; ZINC40234; 2-(Fur-2-yl)-1H-benzimidazole; 2-(2-Furyl)-1H-benzimidazole #; ALBB-017849; NSC72670; Tox21_301574; 2279AE; BBL023354; BDBM50180740; MFCD00055496; NSC-72670; SBB083945; STK741597; WLN: T56 BM DNJ C- BT5OJ; 2-(2-furyl)-1H-1,3-benzimidazole; AKOS000591107; Fuberidazole 10 microg/mL in Methanol; MCULE-1895628564; NCGC00255946-01; ST065434; BB 0219597; R1859; C18737; Fuberidazole, PESTANAL(R), analytical standard; AE-641/02605022; SR-01000393557; Q5506905; SR-01000393557-1; F0346-3053; Pesticide6_Fuberidazole_C11H8N2O_2-(2-Furyl)-1H-benzimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 207000 nM
|
[10] | |||
| Compound Name |
1-Cyclohexyl-3-(5-hydroxy-pentyl)-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66499; BDBM50143940
Click to Show/Hide
|
||||
| Activity |
IC50 = 253000 nM
|
[16] | |||
| Compound Name |
3-[(Cyclohexylcarbamoyl)amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304297; 3-([(Cyclohexylamino)carbonyl]amino)propanoic acid; 3-(3-Cyclohexylureido)propanoic acid; beta-Alanine, N-[(cyclohexylamino)carbonyl]-; SCHEMBL14606844; ZINC8754395; BDBM50143908; MFCD08442982; AKOS000126195; CCG-295168; MCULE-7264919171; NE49965; 3-(3-Cyclohexyl-ureido)-propionic acid; b-Alanine, N-[(cyclohexylamino)carbonyl]-; EN300-26981; Z235342985
Click to Show/Hide
|
||||
| Activity |
IC50 = 358000 nM
|
[16] | |||
| Compound Name |
Methyl (5-methyl-4-phenyl-1,3-thiazol-2-yl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099678; Cambridge id 5704524; ZINC995592; BDBM50444533; STK448772; AKOS003254506; MCULE-5240197706; ST50916369; SR-01000217738; SR-01000217738-1; methoxy-N-(5-methyl-4-phenyl(1,3-thiazol-2-yl))carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 379000 nM
|
[10] | |||
| Compound Name |
1-Cyclohexyl-3-(3-hydroxypropyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL70175; Cambridge id 7102564; HMS1588D08; ZINC2546465; BDBM50143911; AKOS008967532; MCULE-4907075210; 1-Cyclohexyl-3-(3-hydroxy-propyl)-urea; N-CYCLOHEXYL-N'-(3-HYDROXYPROPYL)UREA; Z57283933
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
Tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Boc-3-amino-1,2,3,4-tetrahydroquinoline; Tert-butyl N-(1,2,3,4-tetrahydroquinolin-3-yl)carbamate; (1,2,3,4-TETRAHYDRO-QUINOLIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER; CHEMBL3402238; tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate; SCHEMBL464351; KS-00000FSF; DTXSID10403523; 1124AB; ANW-73554; BDBM50068106; MFCD02181058; AKOS000164155; AKOS016843526; ACN-045306; CS-W006318; MB02356; AK-49037; DS-14863; SC-82370; FT-0765003; Z-5931; 2-METHYL-1,2-OXAPHOSPHOLAN-5-ONE2-OXIDE; (1,2,3,4-Tetrahydro-quinolin-3-yl)-carbamic acid t; Boc-3-amino-1,2,3,4-tetrahydroquinoline, AldrichCPR; tert-Butyl 1,2,3,4-tetrahydroquinolin-3-yl-carbamate; Z2350907433; (1,2,3,4-tetrahydro-quinoline-3-yl)-carbamic acid tert-butyl ester; (1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 580000 nM
|
[8] | |||
| Compound Name |
N-[(1-Methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402234; (1-Methyl-1H-pyrazol-3-ylmethyl)-phenethyl-amine; [(1-methylpyrazol-3-yl)methyl](2-phenylethyl)amine; CTK6I2524; ZINC2536461; BDBM50068110; SBB021590; STK312236; AKOS000307054; MCULE-8668257847; ST45091267; (1-methyl-1 h-pyrazol-3-ylmethyl)-phenethyl-amine; (1-Methyl-1 H -pyrazol-3-ylmethyl)-phenethyl-amine; Q27454528; (1-methyl-1 h-pyrazol-3-ylmethyl)-phenethyl-amine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[8] | |||
| Compound Name |
1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-[3-(Trifluoromethyl)pyrid-2-yl]piperazine; 1-(3-(trifluoromethyl)pyridin-2-yl)piperazine; 1-(3-Trifluoromethyl-pyridin-2-yl)-piperazine; 1-[3-(trifluoromethyl)-2-pyridyl]piperazine; CHEMBL45663; MFCD00114705; 1-(3-trifluoromethylpyridin-2-yl)piperazine; 1-[3-(trifluoromethyl)-2-pyridinyl]piperazine; [3-(trifluoromethyl)-2-pyridyl]piperazine; 1-(3-(trifluoromethyl)-2-pyridyl)piperazine; 1-(3-(trifluoromethyl)pyrid-2-yl)piperazine; 1-[3-(Trifluoromethyl)pyridine-2-yl]piperazine; SCHEMBL233710; CTK5F8316; DTXSID701007523; ZINC2159227; ANW-54905; BBL102605; BDBM50027018; GS0771; SBB055620; STL556408; AKOS000142502; AS-5557; MCULE-4245620170; KS-00003H37; SC-82013; 1-(3-trifluoromethyl-2-pyridyl)piperazine; 1-(3trifluoromethylpyridin-2-yl)piperazine; DB-025580; diethyl?4-chloropyridine-2,6-dicarboxylate; (3-trifluoromethyl-pyridin-2-yl)-piperazine; 1-(3-trifluoromethyl-2-pyridinyl)piperazine; FT-0607115; ST50949999; 1-[3-(trifluoromethyl)-2-pyridyl] piperazine; 1-[3-(trifluoromethyl)pyrid-2-yl]-piperazine; 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine; Z-0023; 1-(3-(trifluoromethyl)-pyridin-2-yl)piperazine; 394T636; A813902; A842124; A1-00488; Q27454532; 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[8] | |||
| Compound Name |
N-Methyl-N-(3-pyridin-3-ylbenzyl)amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-methyl-1-(3-pyridin-3-ylphenyl)methanamine; N-Methyl-1-[3-(Pyridin-3-Yl)phenyl]methanamine; CHEMBL3402235; Benzenemethanamine,N-methyl-3-(3-pyridinyl)-; N-Methyl-1-(3-(pyridin-3-yl)phenyl)methanamine; methyl({[3-(pyridin-3-yl)phenyl]methyl})amine; SCHEMBL1038487; CTK5F4555; DTXSID60427638; KS-00003QQ0; ZINC3880944; BDBM50068109; MFCD07368550; SBB092342; AKOS006150828; PS-5144; methyl[(3-(3-pyridyl)phenyl)methyl]amine; N-Methyl[3-(pyridin-3-yl)phenyl]methylamine; Y4274; J-523699; N-Methyl-N-(3-pyridin-3-ylbenzyl)amine, AldrichCPR; Q27453695
Click to Show/Hide
|
||||
| Activity |
IC50 = 2200000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 2018 Apr 26;61(8):3541-3550. | ||||
| REF 2 | Anti-inflammatory components of Euphorbia humifusa Willd. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1895-900. | ||||
| REF 3 | Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe. Bioorg Med Chem. 2015 Oct 15;23(20):6659-65. | ||||
| REF 4 | Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Jan 1;22(1):601-5. | ||||
| REF 5 | US patent application no. 9296693B2, Acyl piperidine inhibitors of soluble epoxide hydrolase | ||||
| REF 6 | Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2302-2313. | ||||
| REF 7 | Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5773-7. | ||||
| REF 8 | Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening. Bioorg Med Chem. 2015 May 15;23(10):2310-7. | ||||
| REF 9 | Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5439-44. | ||||
| REF 10 | Exploring the chemical space of multitarget ligands using aligned self-organizing maps. ACS Med Chem Lett. 2013 Oct 23;4(12):1169-72. | ||||
| REF 11 | 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. | ||||
| REF 12 | Inhibition Potential of Cycloartane-Type Glycosides from the Roots of Cimicifuga dahurica against Soluble Epoxide Hydrolase. J Nat Prod. 2017 Jun 23;80(6):1867-1875. | ||||
| REF 13 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg Med Chem. 2014 Apr 15;22(8):2427-34. | ||||
| REF 14 | Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3818-21. | ||||
| REF 15 | Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2010 Dec 9;53(23):8376-86. | ||||
| REF 16 | Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem. 2004 Apr 8;47(8):2110-22. | ||||
| REF 17 | Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. | ||||
| REF 18 | Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase. Medchemcomm. 2012 Mar 1;(3):379-384. | ||||
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