Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53904 | Target Info | |||
| Target Name | HIF-prolyl hydroxylase 1 (HPH-1) | ||||
| Synonyms |
Prolyl hydroxylase domain-containing protein 1; PHD1; Hypoxia-inducible factor prolyl hydroxylase 1; HPH-3; HIF-PH1; HIF-PH; Estrogen-induced tag6; Estrogen-induced tag 6; Egl nine homolog 2; EIT6; EIT-6
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| Target Type | Successful Target | ||||
| Gene Name | EGLN2 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID25468267-Compound-46
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Patented | Compound Info | ||
| Activity |
IC50 = 54000 nM
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[1] | |||
| Compound Name |
5-(3-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062958
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
3-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100311
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| Activity |
IC50 = 61000 nM
|
[2] | |||
| Compound Name |
4-(8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074542
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| Activity |
IC50 = 80000 nM
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[2] | |||
| Compound Name |
N-[(3-Hydroxypyridin-2-Yl)carbonyl]glycine
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Investigative | Compound Info | ||
| Synonyms |
2-[(3-hydroxypyridin-2-yl)formamido]acetic acid; CHEMBL1256568; 2-(3-Hydroxypicolinamido)Acetic Acid; N-[(3-Hydroxy-2-pyridinyl)carbonyl]-glycine; SCHEMBL704958; 2-[(3-hydroxypyridine-2-carbonyl)amino]acetic Acid; AOB5401; 3-hydroxypyridine-2-carbonylglycine; BDBM50328019; ZINC33978615; AKOS010147143; MCULE-6903676397; NE44030; N-(3-Hydroxy-2-pyridylcarbonyl)glycine; AS-16890; Glycine, N-[(3-hydroxy-2-pyridinyl)carbonyl]-; [(3-Hydroxy-pyridine-2-carbonyl)-amino]-acetic acid; Q27463096; Z1492781232
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| Activity |
IC50 = 91090 nM
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[3] | |||
| Compound Name |
4-[8-(Dimethylamino)octyl-hydroxyamino]-4-oxobutanoic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215587
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
5-(3-Methylphenyl)-[1,2,4]triazolo[1,5-a]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089970
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1229308; CHEMBL1215519; NCDM-32; BDBM50324535; BRD-K37429342-003-01-4; 3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propanoicAcid Hydrochloride
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
5-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062115
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-({9-[Butyl(Methyl)]Amino}Nonanoyl(Hydroxy)Amino)Propanoicacid HCl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215588
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215519
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-[10-(Dimethylamino)decanoyl-hydroxyamino]propanoic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215520
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
7-(2,4-Dichlorophenyl)pyrazolo[1,5-a]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068390
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-[8-(Dimethylamino)octanoyl-hydroxyamino]propanoic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215518
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-[Acetyl(hydroxy)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215449; 3-(N-Hydroxyacetamido)Propanoic Acid; SCHEMBL10045696; BDBM50324531; AKOS006387734
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2,5-Pyridinedicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
Isocinchomeronic acid; PYRIDINE-2,5-DICARBOXYLIC ACID; 2,5-pyridinedicarboxylicacid; UNII-4K1KGR926X; Pyridinedicarboxylic acid-(2,5); CHEMBL88972; 4K1KGR926X; 2,5-Pyridinedicarboxylic acid, 98%; Pyridine 2,5-dicarboxylate; NSC 177; EINECS 202-834-2; PubChem12991; 2,5-Dicarboxy-pyridine; AI3-19238; 6-carboxy-nicotinic acid; pyridine carboxylate, 6b; ACMC-2097nz; ISOCINCHLOMERONIC ACID; SCHEMBL70231; KSC174Q6D; NSC177; ZINC5284; Pyridine 2,5-dicarboxylic acid; DTXSID3059210; BDBM26114; CTK0H4861; KS-00000IKW; pyridine-2,5- dicarboxylic acid; NSC-177; ACT07453; ANW-14205; BBL011510; MFCD00006297; SBB003886; STL146625; AKOS000119637; ACN-051112; FG-0457; MCULE-4931082325; MP-0263; NCGC00336418-01; AK-41175; BR-41175; SC-22647; DB-002412; AM20050593; FT-0610502; FT-0674189; FT-0674190; FT-0674191; P0552; ST50307920; AB00376873-03; W-204355; Q27120714; F0001-0013
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| Activity |
Ki > 300000 nM
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[5] | |||
| Compound Name |
2-(3-Hydroxyphenyl)-2-mercaptoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256567; BDBM50328018
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| Activity |
IC50 = 500000 nM
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[3] | |||
| Compound Name |
Salicyluric acid
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Investigative | Compound Info | ||
| Synonyms |
2-Hydroxyhippuric acid; Salicylurate; o-Hydroxyhippuric acid; N-Salicyloylglycine; Salicyloylglycine; Glycine, N-(2-hydroxybenzoyl)-; 2-(2-hydroxybenzamido)acetic acid; N-(2-Hydroxybenzoyl)glycine; N-o-Hydroxybenzoylglycine; HIPPURIC ACID, o-HYDROXY-; 2-Hydroxybenzoylglycine; 2-hydroxy hippuric acid; o-Hydroxyhippurate; N-(2-Hydroxybenzoyl)-glycine; UNII-5BR3P7J05U; NSC-87566; NSC 524135; 2-[(2-hydroxybenzoyl)amino]acetic acid; NSC87566; ortho-Hydroxyhippuric acid; (2-Hydroxybenzoyl)glycine; CHEMBL586; 5BR3P7J05U; Salicyluric Acid (50-80-%); ((2-hydroxybenzoyl)amino)acetic acid; [(2-Hydroxybenzoyl)amino]acetic acid; 2-Hydroxyhippurate; 2-[(2-hydroxyphenyl)formamido]acetic acid; WLN: QV1MVR BQ; ortho-Hydroxyhippurate; 2-Hydroxyhippuric acid, 95%; Salicylursaure; o-hydroxy-hippuric acid; Glycine, N-salicyloyl-; 2-Hydroxybenzoylaminoacetic acid; 2-[(2-hydroxyphenyl)carbonylamino]acetic acid; EINECS 207-661-6; NSC 87566; BRN 2213833; o-hydroxy-Hippurate; PubChem19001; 2-hydroxybenzoylaminoacetate; Hippuric acid, 2-hydroxy-; NCIStruc1_000217; NCIStruc2_000217; Oprea1_189845; Oprea1_844373; 4-10-00-00172 (Beilstein Handbook Reference); SCHEMBL570541; (2-hydroxybenzamido)acetic acid; Glycine,N-(2-hydroxybenzoyl)-; CTK4J0981; KS-00002ACU; [(2-Hydroxybenzoyl)amino]acetate; DTXSID70197592; ZINC125017; NCI87566; BDBM50328021; CCG-36270; MFCD00002695; NCGC00013916; NSC524135; SBB000337; (2-Hydroxy-benzoylamino)-acetic acid; (2-hydroxybenzoyl amino)-acetic acid; (2-hydroxy-benzoyl amino)-acetic acid; AKOS000126862; ZINC299805499; ZINC575410688; MCULE-5194764394; NSC-524135; PS-5117; Glycine, N-(2-hydroxybenzoyl)- (9CI); NCGC00013916-02; NCGC00097025-01; NCI60_041936; ST013863; o-Hydroxyhippuric acid, analytical standard; HY-113295; CS-0059539; FT-0612609; C07588; J-006172; Q2214314; 4DD455E5-CFA8-4AFD-B0A3-267800311FA5
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| Activity |
IC50 > 1000000 nM
|
[3] | |||
| Compound Name |
Picolinoylglycine
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Investigative | Compound Info | ||
| Synonyms |
2-(picolinamido)acetic acid; 2-(pyridin-2-ylformamido)acetic acid; 2-[(pyridin-2-yl)formamido]acetic acid; [(pyridin-2-ylcarbonyl)amino]acetic acid; CHEMBL221255; N-(pyridin-2-ylcarbonyl)glycine; N-[(pyridin-2-yl)carbonyl]glycine; SCHEMBL1219736; BDBM50328020; MFCD08444886; ZINC20284658; AKOS000133442; MCULE-4073681274; NE13896; EN300-83280; Q27162068; Z228588744
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| Activity |
IC50 > 1000000 nM
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[3] | |||
| Compound Name |
(1-Hydroxy-2,5-dioxo-pyrrolidin-3-yl)-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL284271; SCHEMBL1411797; BDBM50126536; 2-(1-hydroxy-2,5-dioxopyrrolidin-3-yl)acetic acid
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| Activity |
IC50 = 1000000 nM
|
[6] | |||
| Compound Name |
2-(3-Hydroxyphenyl)-2-oxo-ethanoic acid
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Investigative | Compound Info | ||
| Synonyms |
(3-hydroxyphenyl)(oxo)acetic acid; CHEMBL1230698; 2-(3-hydroxyphenyl)-2-oxoacetic acid; 3-Oxyphenylglyoxylsaure; 3-hydroxyphenylglyoxylic acid; SCHEMBL9187064; 2-(3-Hydroxyphenyl)glyoxylic acid; BDBM50328017; Q27457086
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| Activity |
IC50 > 1000000 nM
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[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Lysine demethylases inhibitors. J Med Chem. 2011 Dec 22;54(24):8236-50. | ||||
| REF 2 | 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672. | ||||
| REF 3 | Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6125-8. | ||||
| REF 4 | Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone de... J Med Chem. 2010 Aug 12;53(15):5629-38. | ||||
| REF 5 | Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem. 2008 Nov 27;51(22):7053-6. | ||||
| REF 6 | Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4. | ||||
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