Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58992 | Target Info | |||
| Target Name | Opioid receptor delta (OPRD1) | ||||
| Synonyms |
OPRD; Delta-type opioid receptor; Delta opioid receptor; DOR-1; D-OR-1
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|
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| Target Type | Successful Target | ||||
| Gene Name | OPRD1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 89 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-benzhydryl-4-isopropylpiperidin-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233721; 1-benzhydryl-4-isopropylpiperidin-4-ol
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|
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| Activity |
Ki = 52825 nM
|
[1] | |||
| Compound Name |
1-benzhydryl-4-tert-butylpiperidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL234771; 1-benzhydryl-4-tert-butylpiperidin-4-ol
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|
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| Activity |
Ki = 56600 nM
|
[1] | |||
| Compound Name |
1-benzhydryl-4-cyclopropylpiperidin-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398039; 1-benzhydryl-4-cyclopropylpiperidin-4-ol
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|
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| Activity |
Ki = 130550 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(1R)-2-carbamoyl-1-(furan-2-yl)prop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163916; BDBM50395060
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|
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| Activity |
Ki = 50010 nM
|
[2] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(1S)-2-carbamoyl-1-(furan-3-yl)prop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163917; BDBM50395059
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|
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| Activity |
Ki = 50930 nM
|
[2] | |||
| Compound Name |
N-[1-[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]piperidin-4-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880598; CHEMBL3695261; BDBM133858; US8846929, 23
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|
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| Activity |
Ki = 52099 nM
|
[3] | |||
| Compound Name |
4-(1-Cyclooctylpiperidin-4-yl)-6-morpholin-4-yl-1H-quinoxaline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1270546; CHEMBL3665436; BDBM116213; US8637502, 47
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|
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| Activity |
Ki = 52100 nM
|
[4] | |||
| Compound Name |
3-[(3S)-3-Aminopyrrolidin-1-yl]-1-(1-cyclooctylpiperidin-4-yl)quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852883; CHEMBL3695273; BDBM133870; US8846929, 39
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|
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| Activity |
Ki = 52574 nM
|
[3] | |||
| Compound Name |
N-[(3S)-1-[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]pyrrolidin-3-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880326; CHEMBL3698754; BDBM133890; US8846929, 59
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|
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| Activity |
Ki = 53164 nM
|
[3] | |||
| Compound Name |
4-(1-Cyclooctylpiperidin-4-yl)-N-hydroxy-3-oxoquinoxaline-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880822; CHEMBL3698781; BDBM133919; US8846929, 95
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|
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| Activity |
Ki = 53540 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-4H-pyrido[2,3-b]pyrazine-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852393; CHEMBL3665435; BDBM116212; US8637502, 66
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|
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| Activity |
Ki = 54760 nM
|
[4] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-[(3S)-3-hydroxypyrrolidin-1-yl]quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3698763; SCHEMBL13221989; BDBM133899; US8846929, 68
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|
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| Activity |
Ki = 54999 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(3-oxopiperazin-1-yl)quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853526; CHEMBL3698848; BDBM133987; US8846929, 18
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|
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| Activity |
Ki = 55229 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(1S)-2-carbamoyl-1-phenylprop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163921; BDBM50395068
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|
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| Activity |
Ki = 56010 nM
|
[2] | |||
| Compound Name |
4-[(2S)-3-{Benzyl[(2S)-1-(4-hydroxyphenyl)-3-(methylamino)propan-2-yl]amino}-2-(dimethylamino)propyl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378173; BDBM50188183
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|
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| Activity |
IC50 = 56703 nM
|
[5] | |||
| Compound Name |
N-[(3R)-1-[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]pyrrolidin-3-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695271; SCHEMBL13221964; BDBM133868; US8846929, 37
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|
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| Activity |
Ki = 56989 nM
|
[3] | |||
| Compound Name |
N-[(E)-(2,3-Dihydroxyphenyl)methylideneamino]-4-[(4,6-dimethylpyrimidin-2-yl)sulfanylmethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000336744; SMR000244059; MLS002635856; BDBM5343; CHEMBL1996281; CHEMBL3695231; BDBM12180; BDBM12181; cid_6508320; SR-01000031220; US8846929, 116; SR-01000031220-1
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|
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| Activity |
Ki = 57741 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-[(1-methylsulfonylpiperidin-4-yl)amino]quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880607; CHEMBL3695284; BDBM133881; US8846929, 50
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|
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| Activity |
Ki = 59230 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]-1-phenylprop-2-enyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163920; BDBM50395069
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|
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| Activity |
Ki = 59290 nM
|
[2] | |||
| Compound Name |
3-Butyl-8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
spiropiperidine analogue, 13; CHEMBL514606; BDBM26892
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|
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| Activity |
Ki = 59420 nM
|
[6] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(prop-2-enylamino)quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852818; CHEMBL3698850; BDBM133989; US8846929, 24
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|
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| Activity |
Ki = 60848 nM
|
[3] | |||
| Compound Name |
8-[Bis(2-chlorophenyl)methyl]-3-(3-methylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
spiropiperidine analogue, 21; CHEMBL475497; BDBM26900
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|
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| Activity |
Ki = 60980 nM
|
[6] | |||
| Compound Name |
N-[1-[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]piperidin-4-yl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880588; CHEMBL3695266; BDBM133863; US8846929, 30
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|
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| Activity |
Ki = 61698 nM
|
[3] | |||
| Compound Name |
2-[4-(1-Cyclooctylpiperidin-4-yl)-2,3-dioxoquinoxalin-1-yl]acetonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL551174; CHEMBL3665433; BDBM116210; US8637502, 44
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|
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| Activity |
Ki = 65660 nM
|
[4] | |||
| Compound Name |
Methyl (2S,4R)-1-[4-(1-cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]-4-hydroxypyrrolidine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695264; SCHEMBL10269499; BDBM133861; US8846929, 28
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|
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| Activity |
Ki = 66315 nM
|
[3] | |||
| Compound Name |
Diethyl (3S)-1-[2-[[4-[(1R,5S)-8-cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-3-oxoquinoxalin-2-yl]amino]ethyl]pyrrolidine-3,4-dicarboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3698810; SCHEMBL13222069; BDBM133948; US8846929, 329
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|
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| Activity |
Ki = 67102 nM
|
[3] | |||
| Compound Name |
3-Oxo-4-[(1R,5S)-8-(4-propan-2-ylcyclohexyl)-8-azabicyclo[3.2.1]octan-3-yl]quinoxaline-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853105; SCHEMBL853106; SCHEMBL853490; CHEMBL3698879; BDBM14165; US8846929, 253; US8846929, 255
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|
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| Activity |
Ki = 68750 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-5H-pyrido[2,3-b][1,4]diazepine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1269815; CHEMBL3665441; BDBM116218; US8637502, 67
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|
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| Activity |
Ki = 72400 nM
|
[4] | |||
| Compound Name |
[(3R)-1-[4-[(1R,5S)-8-Cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-3-oxoquinoxalin-2-yl]pyrrolidin-3-yl]-methylcarbamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3698897; BDBM15580; US8846929, 284
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|
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| Activity |
Ki = 72511 nM
|
[3] | |||
| Compound Name |
8-Cyclohexylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240001; BDBM50204780
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|
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| Activity |
Ki = 73655 nM
|
[7] | |||
| Compound Name |
Grandisine G
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611496
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|
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| Activity |
IC50 = 75400 nM
|
[8] | |||
| Compound Name |
(S)-N-(1-(2-Amino-3-(thiazol-4-yl)propanoyl)piperidin-4-yl)-N-phenylpropionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390667; BDBM50206650
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|
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| Activity |
Ki = 76000 nM
|
[9] | |||
| Compound Name |
(2S)-1-{[(2S,5S)-5-(Hydroxymethyl)pyrrolidin-2-yl]carbonyl}pyrrolidine-2-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
2-cyanopyrrolidine 10h; CHEMBL210665; SCHEMBL5376412; BDBM11064
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|
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| Activity |
Ki = 76337 nM
|
[3] | |||
| Compound Name |
(4R,4Ar,6R,7R,7aR,12bS)-6-fluoro-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2418742; BDBM50493043
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|
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| Activity |
EC50 = 79000 nM
|
[10] | |||
| Compound Name |
(2S)-1-[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880324; CHEMBL3695276; BDBM133873; US8846929, 42
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|
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| Activity |
Ki = 81321 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(2,3-dihydroxypropylamino)quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852487; CHEMBL3698851; BDBM133990; US8846929, 25
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|
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| Activity |
Ki = 82251 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(1S)-2-carbamoyl-1-naphthalen-1-ylprop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163918; BDBM50395058
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|
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| Activity |
Ki = 84680 nM
|
[2] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(1S)-2-carbamoyl-1-naphthalen-2-ylprop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163919; BDBM50395057
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|
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| Activity |
Ki = 84850 nM
|
[2] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-[2,3-dihydroxypropyl(methyl)amino]quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880403; CHEMBL3698760; BDBM133896; US8846929, 65
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|
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| Activity |
Ki = 85587 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(1,3-dihydroxypropan-2-ylamino)quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880619; CHEMBL3698762; BDBM133898; US8846929, 67
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|
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| Activity |
Ki = 86219 nM
|
[3] | |||
| Compound Name |
Elaeocarpine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608813; (6aR,12bR)-11-methyl-1,2,3,5,6,6a,12a,12b-octahydrochromeno[2,3-g]indolizin-12-one
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| Activity |
IC50 = 86400 nM
|
[11] | |||
| Compound Name |
13-[2-Amino-3-(4-hydroxy-3-nitro-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL412569; BDBM50000804
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| Activity |
IC50 = 90000 nM
|
[12] | |||
| Compound Name |
(S)-(1,2,3,5,6,8a-Hexahydroindolizin-8-yl)(2-hydroxy-6-methylphenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1076554; BDBM50313163
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| Activity |
Ki = 94000 nM
|
[13] | |||
| Compound Name |
(2S)-2-[[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]amino]-3-hydroxypropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880592; CHEMBL3695269; BDBM133866; US8846929, 33
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|
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| Activity |
Ki = 96003 nM
|
[3] | |||
| Compound Name |
4-(2-(Aminomethyl)phenyl)-1-(cycloheptylmethyl)piperidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL233535; BDBM50210197
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|
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| Activity |
Ki = 99505 nM
|
[1] | |||
| Compound Name |
Chembl4169199
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Investigative | Compound Info | ||
| Synonyms |
BDBM50340644
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|
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(7-bromo-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319088; BDBM50497847
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(2-hydroxyethylamino)quinoxalin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853229; CHEMBL3698835; BDBM133974; US8846929, 3
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(5-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319081; BDBM50497855
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|
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
10-(Dimethylamino)-1,9-dimethyltricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL301421; BDBM50050478; 10-Dimethylamino-1,9-dimethyl-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-trien-4-ol
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
1-(2-Bromo-4-methylphenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325716; BDBM50055965
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|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(4R,4Ar,6R,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2418741; BDBM50493044
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|
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| Activity |
EC50 = 100000 nM
|
[10] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(7-bromo-2-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319091; BDBM50497846
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|
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-5,7-dihydro-4H-indazol-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325841; BDBM50055964
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178725
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178733; BDBM50398700
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
2-[2-[[4-[(1R,5S)-8-Cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-3-oxoquinoxalin-2-yl]amino]ethylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853283; CHEMBL3639941; BDBM13042; US8846929, 226
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(+)-18-Methoxycoronaridine HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554230
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
2-((4-Hydroxy-4-phenylpiperidin-1-yl)(phenyl)methyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437742; BDBM50210382
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Tyr-Gly-Pro-Phe-Leu-Arg-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369370; CHEMBL292337; BDBM50128089
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(2R)-2-Acetamido-6-amino-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178728
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(2R)-2-Acetamido-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178730
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(2R)-2-Acetamido-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178729
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
4-[(1R,5S)-8-Cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-N-hydroxy-3-oxoquinoxaline-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852647; CHEMBL3695242; BDBM12729; US8846929, 127
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(5-bromo-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319087; BDBM50497851
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Spiro[benzo[b]furan-3(2h),4'-piperidin]-7-ol,1'-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297281; BDBM50070949; ZINC29481386; 1''-methylspiro[2,3-dihydrobenzo[b]furan-3,4''-(hexahydropyridine)]-7-ol
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319080; BDBM50497854
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
4-[(1R,5S)-8-Cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-3-oxo-N-(6-oxo-1H-pyridin-3-yl)quinoxaline-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853749; SCHEMBL853944; CHEMBL3695237; CHEMBL3695239; BDBM12265; BDBM12373; US8846929, 122; US8846929, 124
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]amino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880523; CHEMBL3695281; BDBM133878; US8846929, 47
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(3-oxopyrazolidin-1-yl)quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852488; CHEMBL3695234; BDBM12221; US8846929, 119
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(3,4-Dichloro-phenyl)-N-methyl-N-(5-oxo-2-pyrrolidin-1-yl-cyclohexyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74010; BDBM50000785; 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-5-oxo-2beta-(1-pyrrolidinyl)cyclohexyl]acetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178726
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
13-[2-Amino-3-(3-amino-4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78365; BDBM50000808
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(4S,7S,13S)-13-[[(2R,3R)-2-Amino-3-(4-hydroxyphenyl)butanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80626; BDBM50000809
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(1S,13R)-4-Hydroxy-1,13-dimethyl-10-(oxolan-2-ylmethyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL280958; BDBM50083924
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[24] | |||
| Compound Name |
(S)-2-{(2S,3S)-2-[(S)-2-[((S)-1-{(S)-2-[(Adamantane-1-carbonyl)-amino]-6-amino-hexanoyl}-pyrrolidine-2-carbonyl)-amino]-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372106; SCHEMBL9540762; BDBM50281811
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
Chembl4164452
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50340645
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(2R)-2-Acetamido-6-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178727
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(2R,5S,8R)-5-Benzyl-2-(1H-indol-3-ylmethyl)-3,6,10,14-tetraoxo-1,4,7,11-tetrazacyclotetradecane-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178731; BDBM50398702
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
Chembl4172330
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50340647
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(5-nitro-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319089; BDBM50497852
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Chembl4159127
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50340646
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
N-[1-(2-Pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1,3-benzothiazole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393999; BDBM50061373
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[26] | |||
| Compound Name |
5-Methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393993; BDBM50061375
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[26] | |||
| Compound Name |
Methyl 2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228736; BDBM50210381
Click to Show/Hide
|
||||
| Activity |
Ki = 121800 nM
|
[20] | |||
| Compound Name |
Methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl}acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
spiropiperidine analogue, 22; CHEMBL516077; BDBM26901
Click to Show/Hide
|
||||
| Activity |
Ki = 122080 nM
|
[6] | |||
| Compound Name |
8-[Bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241272; spiropiperidine analogue, 2; BDBM26949
Click to Show/Hide
|
||||
| Activity |
Ki = 150385 nM
|
[6] | |||
| Compound Name |
3-(Cyclohexylmethyl)-8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
spiropiperidine analogue, 17; CHEMBL515554; BDBM26896
Click to Show/Hide
|
||||
| Activity |
Ki = 187050 nM
|
[6] | |||
| Compound Name |
8-[Bis(2-chlorophenyl)methyl]-3-butyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
spiropiperidine analogue, 20; CHEMBL475496; BDBM26899
Click to Show/Hide
|
||||
| Activity |
Ki = 192050 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 24 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S,E)-(2,3,5,6,7,9a-Hexahydro-1H-pyrrolo[1,2-a]azepin-9-yl)(2-hydroxy-6-methylphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080674; BDBM50313167
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[13] | |||
| Compound Name |
(2-Hydroxy-6-methylphenyl)-[(8S)-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1082013; BDBM50313166; (S)-(2-hydroxy-6-methylphenyl)(2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)methanone
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[13] | |||
| Compound Name |
(S)-(1,2,3,5,6,8a-Hexahydroindolizin-8-yl)(2-hydroxyphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080153; BDBM50313165
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[13] | |||
| Compound Name |
(S)-(1,2,3,5,6,8a-Hexahydroindolizin-8-yl)(2-methoxy-6-methylphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080152; BDBM50313164
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[13] | |||
| Compound Name |
Methyl 2-[[4-(1-cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]amino]-3-hydroxypropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880599; CHEMBL3695280; BDBM133877; US8846929, 46
Click to Show/Hide
|
||||
| Activity |
Ki = 518930 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852913; CHEMBL3698843; BDBM133982; US8846929, 12
Click to Show/Hide
|
||||
| Activity |
Ki = 519741 nM
|
[3] | |||
| Compound Name |
4-[1-(1-Ethylcyclooctyl)piperidin-4-yl]-3-oxoquinoxaline-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL854042; CHEMBL3889570
Click to Show/Hide
|
||||
| Activity |
Ki = 524333 nM
|
[3] | |||
| Compound Name |
4-[(1R,5S)-9-(1-Adamantyl)-9-azabicyclo[3.3.1]nonan-3-yl]-3-oxoquinoxaline-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3698893; SCHEMBL13221775; BDBM15340; US8846929, 263
Click to Show/Hide
|
||||
| Activity |
Ki = 525570 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-[[(2R)-2,3-dihydroxypropyl]amino]quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880729; CHEMBL3695288; BDBM133885; US8846929, 54
Click to Show/Hide
|
||||
| Activity |
Ki = 528011 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-[[(2S)-2,3-dihydroxypropyl]amino]quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3698750; SCHEMBL13221986; BDBM133886; US8846929, 55
Click to Show/Hide
|
||||
| Activity |
Ki = 530892 nM
|
[3] | |||
| Compound Name |
Ethyl 4-[(1R,5S)-8-cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-3-oxoquinoxaline-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL852474; SCHEMBL852991; CHEMBL3698884; BDBM14833; US8846929, 153
Click to Show/Hide
|
||||
| Activity |
Ki = 530900 nM
|
[3] | |||
| Compound Name |
3-[(1-Acetylpiperidin-4-yl)amino]-1-(1-cyclooctylpiperidin-4-yl)quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880327; CHEMBL3695283; BDBM133880; US8846929, 49
Click to Show/Hide
|
||||
| Activity |
Ki = 531427 nM
|
[3] | |||
| Compound Name |
Ethyl 2-[[4-(1-cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3698752; SCHEMBL13221987; BDBM133888; US8846929, 57
Click to Show/Hide
|
||||
| Activity |
Ki = 532394 nM
|
[3] | |||
| Compound Name |
4-[(1S,5R)-9-Cyclooctyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl]-3-oxoquinoxaline-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853708; CHEMBL3698882; BDBM14328; US8846929, 249
Click to Show/Hide
|
||||
| Activity |
Ki = 533100 nM
|
[3] | |||
| Compound Name |
4-[(1R,5S)-8-(1-Adamantyl)-8-azabicyclo[3.2.1]octan-3-yl]-3-oxoquinoxaline-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695245; CHEMBL3695246; SCHEMBL13221533; SCHEMBL13221535; BDBM12867; BDBM12979; BDBM14925; US8846929, 130; US8846929, 131; US8846929, 247
Click to Show/Hide
|
||||
| Activity |
Ki = 533800 nM
|
[3] | |||
| Compound Name |
1-[1-(1-Adamantyl)piperidin-4-yl]-3-[[(2R)-2,3-dihydroxypropyl]amino]quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880606; CHEMBL3698777; BDBM133913; US8846929, 89
Click to Show/Hide
|
||||
| Activity |
Ki = 535200 nM
|
[3] | |||
| Compound Name |
3-Oxo-4-[1-(1-propylcyclooctyl)piperidin-4-yl]quinoxaline-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853205; CHEMBL3698894; BDBM15351; US8846929, 239
Click to Show/Hide
|
||||
| Activity |
Ki = 537763 nM
|
[3] | |||
| Compound Name |
1-(1-Cyclooctylpiperidin-4-yl)-3-(1,3-dihydroisoindol-2-yl)quinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL854532; CHEMBL3698849; BDBM133988; US8846929, 19
Click to Show/Hide
|
||||
| Activity |
Ki = 545749 nM
|
[3] | |||
| Compound Name |
2-[[4-[(1R,5S)-8-Cyclooctyl-8-azabicyclo[3.2.1]octan-3-yl]-3-oxoquinoxalin-2-yl]-(2-hydroxyethyl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853077; CHEMBL3698876; BDBM14162; US8846929, 231
Click to Show/Hide
|
||||
| Activity |
Ki = 547704 nM
|
[3] | |||
| Compound Name |
2-[[4-(1-Cyclooctylpiperidin-4-yl)-3-oxoquinoxalin-2-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL880568; CHEMBL3695268; BDBM133865; US8846929, 32
Click to Show/Hide
|
||||
| Activity |
Ki = 548766 nM
|
[3] | |||
| Compound Name |
13-[2-Amino-3-(4-hydroxy-3-methoxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309596; BDBM50000807
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[12] | |||
| Compound Name |
10-Amino-9-(hydroxymethyl)-1-methyltricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409026; BDBM50050484; 10-Amino-9-hydroxymethyl-1-methyl-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-trien-4-ol
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[16] | |||
| Compound Name |
9-(Hydroxymethyl)-1-methyl-10-(methylamino)tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57879; BDBM50050480; 9-Hydroxymethyl-1-methyl-10-methylamino-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-trien-4-ol
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[16] | |||
| Compound Name |
10-(Dimethylamino)-9-(hydroxymethyl)-1-methyltricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299460; BDBM50050477; 10-Dimethylamino-9-hydroxymethyl-1-methyl-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-trien-4-ol
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| Activity |
Ki > 1000000 nM
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[16] | |||
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| References | Top | ||||
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| REF 1 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. | ||||
| REF 2 | A new class of highly potent and selective endomorphin-1 analogues containing alpha-methylene--aminopropanoic acids (map). J Med Chem. 2012 Jul 12;55(13):6224-36. | ||||
| REF 3 | US patent application no. 8846929B2, Substituted-quinoxaline-type piperidine compounds and the uses thereof | ||||
| REF 4 | US patent application no. 8637502B2, 2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating pain | ||||
| REF 5 | Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4331-8. | ||||
| REF 6 | Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1164-7. | ||||
| REF 7 | Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2281-4. | ||||
| REF 8 | Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. J Nat Prod. 2006 Sep;69(9):1295-9. | ||||
| REF 9 | Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2161-5. | ||||
| REF 10 | Access to 7-analogs of codeine with mixed / agonist activity via 6,7-alpha-epoxide opening. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4870-4. | ||||
| REF 11 | Indolizidine alkaloids with delta-opioid receptor binding affinity from the leaves of Elaeocarpus fuscoides. J Nat Prod. 2007 May;70(5):872-5. | ||||
| REF 12 | Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity. J Med Chem. 1992 Jun 26;35(13):2384-91. | ||||
| REF 13 | Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1601-3. | ||||
| REF 14 | Constraining Endomorphin-1 by ,alpha-Hybrid Dipeptide/Heterocycle Scaffolds: Identification of a Novel -Opioid Receptor Selective Partial Agonist. J Med Chem. 2018 Jul 12;61(13):5751-5757. | ||||
| REF 15 | Synthesis of tripeptides containing D-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception. J Med Chem. 2014 Aug 14;57(15):6861-6. | ||||
| REF 16 | Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids. J Med Chem. 1996 May 10;39(10):1956-66. | ||||
| REF 17 | Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists. Bioorg Med Chem. 2014 Sep 1;22(17):4694-703. | ||||
| REF 18 | Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus. J Med Chem. 2012 Nov 26;55(22):10292-6. | ||||
| REF 19 | Synthesis of enantiomerically pure (+)- and (-)-18-methoxycoronaridine hydrochloride and their preliminary assessment as anti-addictive agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):473-6. | ||||
| REF 20 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. | ||||
| REF 21 | Structure-activity relationships of dynorphin a analogues modified in the address sequence. J Med Chem. 2003 May 22;46(11):2104-9. | ||||
| REF 22 | C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1813-8. | ||||
| REF 23 | Selective reversible and irreversible ligands for the kappa opioid receptor. J Med Chem. 1992 Jun 12;35(12):2243-7. | ||||
| REF 24 | Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. | ||||
| REF 25 | Neurotensin receptor binding and antinociceptive activity for lipophilic Nalpha-amido neurotensin(9-13) analogs. Bioorg Med Chem Lett. 1993 Oct;3(10):2055-60. | ||||
| REF 26 | Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists. Bioorg Med Chem Lett. 2015 Feb 15;25(4):887-92. | ||||
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