Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61744 | Target Info | |||
| Target Name | Phosphodiesterase 4A (PDE4A) | ||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Type 4A cAMP phosphodiesterase; PDE46; DPDE2
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| Target Type | Successful Target | ||||
| Gene Name | PDE4A | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 26 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
AC1M1SP5
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Patented | Compound Info | ||
| Synonyms |
3-(2-methoxyphenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one; 850915-31-0; AC1M1SP5; SCHEMBL16200721; CHEMBL3913943; BDBM86646; ZINC2719834; AKOS024584906; MCULE-4663000139; BC11-38-4; SR-01000120201; SR-01000120201-1; F0579-0260; 3-(2-methoxyphenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 = 60000 nM
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[1] | |||
| Compound Name |
BC11-28
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Patented | Compound Info | ||
| Synonyms |
BDBM86641; 7-(4-fluorophenyl)-N-(2-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; AC1MM8WN; Oprea1_524381; CHEMBL2132713; SCHEMBL14998917; BDBM60812; HMS1911I05; ZINC2713985; STK859438; AKOS002104616; MCULE-7713625102; BC11-28; NCGC00138975-01; ST50069829; EU-0095146; US9173884, BC11-28; SR-01000567887; SR-01000567887-1; K405-0344; 7-(4-fluorophenyl)-N-(2-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidin-4-amine; [7-(4-fluorophenyl)-5-phenylpyrrolo[3,2-e]pyrimidin-4-yl](2-methylphenyl)amine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
CI-930
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
CI-930; CI 930; 86798-59-6; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-5-methyl-; AC1MIBTH; CHEMBL440593; SCHEMBL6052113; CTK5F7194; BDBM14362; AEZZPAQOEUQNBB-UHFFFAOYSA-N; 90791-23-4 (hydrochloride); BDBM50225945; LS-187480; LS-186812; 6-[4-(1-Imidazolyl)phenyl]-5-methyl-3-oxo-2,3,4,5-tetrahydropyridazine; 3-(4-imidazol-1-ylphenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
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| Activity |
Ki ~ 50000 nM
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[2] | |||
| Compound Name |
ZAPRINAST
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Terminated | Compound Info | ||
| Activity |
Ki ~ 50000 nM
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[2] | |||
| Compound Name |
4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL434332
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| Activity |
Ki ~ 50000 nM
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[2] | |||
| Compound Name |
4-[2-[4-(2-Oxo-2-hydroxyethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL418231; BDBM50113420; {4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-acetic acid
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| Activity |
IC50 = 58000 nM
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[3] | |||
| Compound Name |
4-Imino-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-3(4H)-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1402123; MLS000779421; HMS2748E22; BDBM50426301; STK720894; AKOS003594740; MCULE-4636067337; SMR000416123; 4-Imino-7-methyl-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-ylamine
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| Activity |
Ki = 66000 nM
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[4] | |||
| Compound Name |
(Z)-2-(1-(3,3-Dimethylcyclohex-1-en-1-yl)ethylidene)hydrazinecarboximidamide acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312699; AKOS030512373
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| Activity |
Ki = 69000 nM
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[4] | |||
| Compound Name |
7-Amino-1-(2,5-dimethoxyphenyl)-3-propylpyrido[2,3-d]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082465; SCHEMBL6645502; BDBM50260354; J3.655.005H; (aS)-7-Amino-1-(2,5-dimethoxyphenyl)-3-propyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
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| Activity |
IC50 = 70000 nM
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[5] | |||
| Compound Name |
N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972355; SCHEMBL14999000; BDBM86639; HMS1786A16; ZINC3293408; AKOS034464439; BC11-15; MCULE-3880495348; Z56898051
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| Activity |
IC50 = 70000 nM
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[1] | |||
| Compound Name |
4-[2-[4-(2-Methylbenzoylaminosulfonyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL287114; BDBM50113423
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| Activity |
IC50 = 75000 nM
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[3] | |||
| Compound Name |
4-[2-(4-Carboxyphenyl)-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL32153; BDBM50113426; 4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-benzoic acid
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| Activity |
IC50 = 77000 nM
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[3] | |||
| Compound Name |
4-[2-(4-Chlorophenyl)-2-[2-fluoro-3-(cyclopentyloxy)-4-methoxyphenyl]ethyl]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL284479; BDBM50113413; 4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-2-fluoro-4-methoxy-phenyl)-ethyl]-pyridine
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| Activity |
IC50 = 98000 nM
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[3] | |||
| Compound Name |
Chlortetracycline
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Investigative | Compound Info | ||
| Synonyms |
AUREOMYCIN; Chlorotetracycline; 7-Chlorotetracycline; Clortetraciclina; Chlortetracyclinum; UNII-WCK1KIQ23Q; Biomycin; WCK1KIQ23Q; Aureomykoin; Chrysomykine; Acronize; Aureocina; Biomitsin; Duomycin; Flamycin; Uromycin; Biomycin a; CTC (abtibiotic); Tri-chlortetracycline; MFCD00864876; Aureomycin A-377; Caswell No. 219B; Aureomycin (TN); Chlortetracycline [INN:BAN]; Chlortetracyclinum [INN-Latin]; Clortetraciclina [INN-Spanish]; Chlormax; EINECS 200-341-7; EPA Pesticide Chemical Code 006301; Aueromycin; Spectrum_000727; Spectrum_001315; Chlortetracycline (INN); Prestwick0_000145; Prestwick1_000145; Prestwick2_000145; Spectrum2_000802; Spectrum3_000348; Spectrum4_001001; Spectrum4_001791; Spectrum5_000461; Spectrum5_001870; SCHEMBL3110; SCHEMBL62861; BSPBio_002015; KBioGR_001461; KBioGR_002364; KBioSS_001207; KBioSS_001795; DivK1c_000253; SPBio_000663; SPBio_002189; CHEMBL404520; SCHEMBL4099094; CHEMBL1622557; DTXSID9022811; SCHEMBL19981439; HMS500M15; HY-B1327A; KBio1_000253; KBio2_001207; KBio2_001795; KBio2_003775; KBio2_004363; KBio2_006343; KBio2_006931; KBio3_001235; NINDS_000253; RKL10090; LMPK07000004; ZINC19701769; ZINC100154659; ZINC100302624; CCG-269531; DB09093; MCULE-9900766267; IDI1_000253; NCGC00178862-01; NCGC00178862-04; SBI-0051312.P003; CS-0013541; C06571; D07689; 90565-EP2270015A1; 90565-EP2272510A1; 90565-EP2272834A1; 90565-EP2301929A1; 90565-EP2301935A1; 90565-EP2305674A1; AB00643434_03; 864C876; Q417948; Q-200843
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| Activity |
IC50 = 100000 nM
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[4] | |||
| Compound Name |
(11S)-5-Anilino-8-methyl-11-(phenylmethoxymethyl)-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3771202; BDBM50150133
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatricyclo[7.4.0.02,6]trideca-2,5,9-trien-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770646; BDBM50150125
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
2-[4-[3,5-Bis(cyclopropylmethoxy)phenyl]-2-ethyl-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319809; BDBM50072193; 2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-7-(2-hydroxy-ethoxy)-quinazolin-6-yloxy]-ethanol
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955950; SCHEMBL16200699; BDBM86643; ZINC2719706; AKOS024584760; MCULE-1273250191; BC11-38-1; EU-0022193; SR-01000120181; SR-01000120181-1; F0579-0062
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950652; SCHEMBL16200731; BDBM86645; ZINC2459466; AKOS024584842; MCULE-6274932978; BC11-38-3; EU-0088907; SR-01000120189; SR-01000120189-1; F0579-0160
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
BDBM86640; Maybridge4_000373; Oprea1_392751; CHEMBL3974407; SCHEMBL14998934; BDBM60808; HMS1522A21; ZINC134330; CCG-51916; BC11-19; MCULE-1137806289; IDI1_030955; NCGC00177650-01; US9173884, BC11-19; SR-01000641186-1; BRD-K04557143-001-01-6
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
7-Benzyloxy-4-(3,5-bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-methoxy-quinazoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99470; BDBM50072202
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
(11R,15S)-5-Anilino-3-[[4-(4-fluorophenyl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-5,9-dien-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3771172; BDBM50150261
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
2-[4-[(3R)-3-Methyl-2-oxo-1,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312697; BDBM50426303; ZINC19200427
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| Activity |
Ki = 115000 nM
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[4] | |||
| Compound Name |
5,5-Dimethyl-3-(piperazin-1-ylmethyl)imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312698; SCHEMBL15557144; 5,5-dimethyl-3-(piperazin-1-ylmethyl)imidazolidin-2,4-dione; BDBM50426302; ZINC19199934; AKOS000777329
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| Activity |
Ki = 131000 nM
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[4] | |||
| Compound Name |
3-Methoxy-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3222273; BDBM50496801
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| Activity |
IC50 = 199000 nM
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[8] | |||
| Compound Name |
Click to Show/Hide
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Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9173884B2, Inhibitors of phosphodiesterase 11 (PDE11) | ||||
| REF 2 | 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. J Med Chem. 2005 Feb 24;48(4):1237-43. | ||||
| REF 3 | Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. | ||||
| REF 4 | Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model. J Med Chem. 2013 Feb 28;56(4):1715-22. | ||||
| REF 5 | Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor. Bioorg Med Chem. 2017 Aug 15;25(16):4506-4511. | ||||
| REF 6 | Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016 Feb 11;59(3):1149-64. | ||||
| REF 7 | Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2891-6. | ||||
| REF 8 | Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A. Medchemcomm. 2013 Feb 1;4(2):443-449. | ||||
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