Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75440 | Target Info | |||
| Target Name | Translocator protein (TSPO) | ||||
| Synonyms |
Peripheral-type benzodiazepine receptor; Peripheral benzodiazepine receptor; PKBS; PBR; Mitochondrial benzodiazepine receptor; MBR; BZRP
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | TSPO | ||||
| Biochemical Class | Cholesterol/porphyrin uptake translocator | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 51 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nitrazepam
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Alodorm; Apodorm; Benzalin; Calsamin; Calsmin; Cerson; Dormalon; Dumolid; Eatan; Epibenzalin; Epinelbon; Eunoctin; Eunoktin; Gerson; Hipnax; Hipsal; Ibrovek; Imadorm; Imeson; Imesont; Ipersed; Magadon; Megadon; Mitidin; Mogadan; Mogadon; Mogadone; Nelbon; Nelmat; Neozepam; Neuchlonic; Nitrados; Nitravet; Nitrazadon; Nitrazep; Nitrazepamum; Nitrempax; Nitrenpax; Nitrodiazepam; Noctesed; Novanox; Pacisyn; Paxisyn; Pelson; Persopit; Radedorm; Relact; Remnos; Serenade; Somitran; Somnased; Somnibel; Somnite; Sonebon; Sonnolin; Surem; Trazenin; Unisomnia; Aliud Brand of Nitrazepam; Allphar Brand of Nitrazepam; Alphapharma Brand of Nitrazepam; Alpharma Brand of Nitrazepam; Alter Brand of Nitrazepam; CSP Brand of Nitrazepam; DDSA Brand of Nitrazepam; Dermatech Brand of Nitrazepam; Desitin Brand of Nitrazepam; Dormicum Brand of Nitrazepam; Eatan N; ICN Brand of Nitrazepam; Neuraxpharm Brand of Nitrazepam; Nitrazepam AL; Norgine Brand of Nitrazepam; Pfleger Brand of Nitrazepam; Protea Brand of Nitrazepam; Rhoxalpharma Brand of Nitrazepam; Sandoz nitrazepam; Scheurich Brand of Nitrazepam; Sonebon Tofraniln A; Taurus Brandof Nitrazepam; United Drug Brand of Nitrazepam; Wernigerode Brand of Nitrazepam; LA 1; S 2000; Alodorm (TN); Apo-nitrazepam tablets BP; Apodorm (TN); Arem (TN); Benzalin (TN); Cavodan (TN); Ct-Arzneimittel Brand of Nitrazepam; Dima (TN); Dormalon (TN); Dormicum (anticonvulsant); Dormigen (TN); Dormin-5; Dormo-Puren; Dumolid (TN); Eatan N (TN); Eunoctin (TN); Hypnotex (TN); ISOPROPYLACETATE/NITRAZEPAM; Imeson (TN); Insoma (TN); Insomin (TN); Ipersed (TN); LA 1 (VAN); Mitidin (TN); Mogadan (TN); Mogadon (TN); N-Desmethylnimetazepam; Nitavan (TN); Nitepam (TN); Nitrados (TN); Nitrapan (TN); Nitravet (TN); Nitrazadon (TN); Nitrazep (TN); Nitrazepam (TN); Nitrazepam Capsules BP 1993 (TN); Nitrazepam Oral Suspension BP 1993 (TN); Nitrazepam Tablets BP 1993 (TN); Nitrazepam-10; Nitrazepam-5; Nitrazepam-neuraxpharm; Nitrazepamum [INN-Latin]; Nitrazepan (TN); Nitrazepol (TN); Nitredon (TN); Nitrosun (TN); Novanox (TN); Numbon (TN); Onirema (TN); Ormodon (TN); Pacisyn (TN); Paxadorm (TN); Pelson (TN); Pelsonfilina (TN); Protraz (TN); Radedorm (TN); Remnos (TN); Rhoxal-nitrazepam; Ro 4-5360; Ro 5-3059; Ro 53-60; Serenade (TN); Somnibel N (TN); Somnipar (TN); Somnite (TN); Sonebon (TN); Sonotrat (TN); Surem (TN); Tri (TN); Unisomnia (TN); Dormo-Puren (TN); Nitrazepam (JP15/USAN/INN); Nitrazepam [USAN:INN:BAN:JAN]; 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000000 nM
|
[1] | |||
| Compound Name |
Clonazepam
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepamum; Clonex; Clonopin; Iktorivil; Kenoket; Klonopin; Landsen; Lktorivil; Lonazep; Melzap; Paxam; Ravotril; Rivatril; Rivoril; Rivotril; Solfidin; Klonopin Rapidly Disintegrating; DF2374250; RO4023; Ro 4023; Ro 54023; Alti-Clonazepam; Clonazepamum [INN-Latin]; Klonopin (TN); Ravotril (TN); Rivatril (TN); Rivotril (TN); Ro 4-8180; Ro 5-4023; Ro-5-4023; Clonazepam (JP15/USP/INN); Clonazepam [USAN:INN:BAN:JAN]; Ro 5-4023/B-7; 1,3-Dihydro-5-(o-chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one; 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one; 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 555904257.3 nM
|
[1] | |||
| Compound Name |
Delorazepam
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Delorazepam; Chlordemethyldiazepam; 2894-67-9; B1, Benzodiazepine; Cl-DMDZ; Delorazepam [INN]; Clordesmetildiazepam; 2-Chloronordiazepam; 2'-chloronordiazepam; EN [Anticonvulsant]; Ro 5-3027; Delorazepamum [INN-Latin]; 7-chloro-5-(2-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; NSC 169895; Clordesmetildiazepam [Spanish]; UNII-O91W32476G; RV-12165; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-; EINECS 220-771-9; BRN 0754062; CHEMBL268254; DEA No. 2754; CHIFCDOIPRCHCF-UHFFFAOYSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 = 555904257.3 nM
|
[1] | |||
| Compound Name |
RO-054520
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL13095; 844-11-1; 5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; RO-054520; AC1L4W0W; SCHEMBL11858895; CTK5F2279; DTXSID00233371; ZINC3650317; BDBM50019250; AKOS030555310; Ro-05-4520; 5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; 1-Methyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 71449632.61 nM
|
[1] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(1,1-dimethylethyl)-1,3-dihydro-5-phenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140487; BDBM50422184; ZINC13651902; Ro-201310; Ro-20-1310; 1-tert-Butyl-7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 1-tert-butyl-7-chloro-1,3-dihydro-5-phenyl-; 1-(1,1-Dimethylethyl)-7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 1-(1,1-dimethylethyl)-7-chloro-1,3-dihydro-5-phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 1614358.56 nM
|
[1] | |||
| Compound Name |
7-Amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150977; 7-Amino Nimetazepam; SCHEMBL2925930; 7-amino-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one; DTXSID40632349; BDBM50422187; ZINC13651894; Ro-053418; Ro-5-3418; Ro-05-3418; CS-0130618; 7-amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; 7-amino-5-phenyl-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; 7-Amino-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 2172701.18 nM
|
[1] | |||
| Compound Name |
Motrazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-36YG4ZMR69; 36YG4ZMR69; 1-(methoxymethyl)-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one; Motrazepamum; Motrazepam [INN]; Motrazepamum [INN-Latin]; NSC 313451; CHEMBL146817; SCHEMBL2110471; DTXSID40183649; ZINC4216987; BDBM50422188; NSC313451; 2,3-Dihydro-1-(methoxymethyl)-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on; NSC-313451; Ro-069098; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-(methoxymethyl)-7-nitro-5-phenyl-; Ro-06-9098; Ro 06-9098-000; Ro-06-9098/000; Q15409377; 2H-1, 1,3-dihydro-1-(methoxymethyl)-7-nitro-5-phenyl-; 1,3-dihydro-1-methoxymethyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-1-(methoxymethyl)-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 2328091.26 nM
|
[1] | |||
| Compound Name |
7-Aminonitrazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-amino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; UNII-1A49O337AZ; CHEMBL147144; 7-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1A49O337AZ; 7-Amino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one; Ro 5-3072; Nitrazepam-M 7-amino; BRN 0535813; Ro-05-3072; 7-Aminonitrazepam solution; SCHEMBL15435607; CTK3I9195; DTXSID20197749; 2H-1,4-Benzodiazepin-2-one, 7-amino-1,3-dihydro-5-phenyl-; 7-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; ZINC2570182; BDBM50422186; AKOS000112248; Ro-053072; 7-Aminonitrazepam 0.1 mg/ml in Acetonitrile; 7-Aminonitrazepam 1.0 mg/ml in Acetonitrile; 7-amino-5-phenyl-3H-1,4-benzodiazepin-2-ol; Q27252146; (Z)-7-amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; 7-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
Click to Show/Hide
|
||||
| Activity |
IC50 = 2588212.92 nM
|
[1] | |||
| Compound Name |
1H-1,4-Benzodiazepine-7-carbonitrile, 2,3-dihydro-1-methyl-2-oxo-5-phenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL275115; 2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-7-carbonitrile; BRN 0757698; Ro 5-4528; Ro-5-4528; Oprea1_514225; 5-25-08-00121 (Beilstein Handbook Reference); QHII-066; SCHEMBL11262318; CTK1C2864; DTXSID70188445; 1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine-7-carbonitrile; ZINC2026540; BDBM50083882; Ro-054528; Ro-05-4528; 1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-7-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 2630267.99 nM
|
[1] | |||
| Compound Name |
1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one; 5-Phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one; 5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; 5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 5-Phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-phenyl-; CHEMBL13458; UNII-4JHQ7M3460; 4JHQ7M3460; 5-PHENYL-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE; Ro-05-2921; (Z)-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; EINECS 220-781-3; NSC656624; CLOZAPINEN-OXIDE; PubChem12793; Maybridge1_006686; Oprea1_710885; MLS001182241; 2,3-Dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine; SCHEMBL1365706; CTK4G2520; HMS560H20; ZINC86336; DTXSID30183178; HMS2851L21; CS-D0048; KS-00002BC2; ANW-66675; BDBM50083899; MFCD00277779; AKOS000638525; CCG-244429; MCULE-2013823654; MS-3038; NSC-656624; Ro-052921; Ro-5-2921; SS-4716; NCGC00246645-01; SMR000567904; DB-031642; FT-0645216; ST50031451; Z5821; 5-phenyl-1H,3H-benzo[f]1,4-diazepin-2-one; 2,3Dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one; 898D080; SR-01000499023; 2,3-Dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one; 2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine; J-517912; SR-01000499023-1; 2H-1,4-Benzodiazepin-2-one,1,3-dihydro-5-phenyl-; 5-Phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
Click to Show/Hide
|
||||
| Activity |
IC50 = 2857590.54 nM
|
[1] | |||
| Compound Name |
1-Tert-butyl-5-(2-fluorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345284; Ro-22-4683; BDBM50422185
Click to Show/Hide
|
||||
| Activity |
IC50 = 3334264.13 nM
|
[1] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-(hydroxyamino)-1-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358955; Ro-20-7736; SCHEMBL11773114; DTXSID40204484; BDBM50408007; 5-(2-fluorophenyl)-7-(hydroxyamino)-1-methyl-3H-1,4-benzodiazepin-2-one; Ro-207736; 5-(2-Fluorophenyl)-1,3-dihydro-7-(hydroxyamino)-1-methyl-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-5-(2-fluorophenyl)-7-hydroxyamino-1-methyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 10423174.29 nM
|
[1] | |||
| Compound Name |
7-Aminoclonazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Aminoclonazepam; Chloraminazepam; UNII-17D6640Q7Y; 7-Amino-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-amino-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one; CHEMBL1273; 17D6640Q7Y; 7-Aclz; 2H-1,4-Benzodiazepin-2-one,7-amino-5-(2-chlorophenyl)-1,3-dihydro-; Clonazepam-M 7-amino; 7-Aminoclonazepam solution; SCHEMBL11453747; CTK4J1412; DTXSID90197913; ZINC2569743; BDBM50408036; Ro 5-461; 2H-1,4-Benzodiazepin-2-one, 7-amino-5-(2-chlorophenyl)-1,3-dihydro-; AKOS030255929; AS-6122; Ro-054619; Ro-05-4619; 7-Aminoclonazepam 0.1 mg/ml in Acetonitrile; 7-Aminoclonazepam 1.0 mg/ml in Acetonitrile; Q-200879; (1R,5R)-3-N-Cbz-3,6-Diazabicyclo[3.2.0]heptane; Q27251904; 7-amino-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-ol; (E)-7-amino-5-(2-chlorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 13335214.32 nM
|
[1] | |||
| Compound Name |
7-Aminoflunitrazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Amino-flunitrazepam; UNII-7T03QW0G7C; 7-amino-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; 7T03QW0G7C; CHEMBL151121; Ro 20-1815; 7-amino-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one; Flunitrazepam-M 7-amino; 7-Aminoflunitrazepam solution; SCHEMBL11072824; CTK8D9548; DTXSID40187682; ZINC2569742; BDBM50408031; Ro-201815; 2H-1,4-Benzodiazepin-2-one, 7-amino-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-; Ro-20-1815; (Chloromethyl)(dimethyl)(pentadecyloxy)silane; 7-Aminoflunitrazepam 0.1 mg/ml in Acetonitrile; 7-Aminoflunitrazepam 1.0 mg/ml in Acetonitrile; Q27268805; (E)-7-amino-5-(2-fluorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one; 7-amino-1,3-dihydro-1-methyl-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 7-amino-5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-amino-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 15381546.4 nM
|
[1] | |||
| Compound Name |
1,7-Dichloro-3-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150925; BDBM50408039; Ro-067263; Ro-06-7263
Click to Show/Hide
|
||||
| Activity |
IC50 = 20417379.45 nM
|
[1] | |||
| Compound Name |
2-Oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-7-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348694; BDBM50408033; ZINC13651898; Ro-205397; Ro-20-5397
Click to Show/Hide
|
||||
| Activity |
IC50 = 23280912.58 nM
|
[1] | |||
| Compound Name |
7-Fluoro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RO-053061; CHEMBL13290; SCHEMBL2615409; CTK4F7966; DTXSID50181070; ZINC1841121; BDBM50408016; Ro-5-3061; Ro 05-3061; Ro-05-3061; 2H-1,4-Benzodiazepin-2-one, 7-fluoro-1,3-dihydro-5-phenyl-; 2H-1,4-Benzodiazepin-2-one,7-fluoro-1,3-dihydro-5-phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 25003453.62 nM
|
[1] | |||
| Compound Name |
5-Phenyl-7,8-dichloro-1-methyl-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150639; Ro-22-6762; BDBM50040701; ZINC13651920; 7,8-Dichloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 25003453.62 nM
|
[1] | |||
| Compound Name |
7-Ethyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348664; Ro-20-2533; BDBM50408021; ZINC13651896; Ro-202533
Click to Show/Hide
|
||||
| Activity |
IC50 = 27797132.68 nM
|
[1] | |||
| Compound Name |
5-(2-Fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepine-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150784; SCHEMBL11256869; BDBM50408020; Ro-202541; Ro-20-2541; 5-(o-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepine-7-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 33342641.28 nM
|
[1] | |||
| Compound Name |
8-Chloro-5-(2,6-difluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151548; DTXSID70877923; BDBM50408013; ZINC13651918; Ro-076198; Ro-07-6198; 1,4-BENZDIAZEPIN-2-ONE-5(26F-PH)8CL
Click to Show/Hide
|
||||
| Activity |
IC50 = 35727283.82 nM
|
[1] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(2-hydroxyethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N(sup 1)-(2-Hydroxyethyl)flurazepam; N-1-(Hydroxyethyl)flurazepam; Ro-07-2750; 2-Hydroxyethylflurazepam; UNII-2Z6WHH283E; 7-chloro-5-(2-fluorophenyl)-1-(2-hydroxyethyl)-3H-1,4-benzodiazepin-2-one; 2Z6WHH283E; CHEMBL435684; Ro 7-2750; Flurazepam, hydroxyethyl; 1-(2-Hydroxyethyl)flurazepam; Flurazepam, (N-hydroxyethyl)-; SCHEMBL11679711; DTXSID10175152; ZINC2016364; BDBM50408009; Ro-072750; 2-Hydroxyethylflurazepam 0.1 mg/ml in Methanol; 2-Hydroxyethylflurazepam 1.0 mg/ml in Methanol; Q27255842
Click to Show/Hide
|
||||
| Activity |
IC50 = 40831938.63 nM
|
[1] | |||
| Compound Name |
5-Phenyl-7-ethenyl-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346836; BDBM50040705; ZINC13651897; Ro-205747; Ro-20-5747; 5-Phenyl-7-vinyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 41686938.35 nM
|
[1] | |||
| Compound Name |
1,3-Dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147024; SCHEMBL8547651; DTXSID70877685; BDBM50408026; ZINC13651900; Ro-054336; Ro-05-4336; 1,4-BENZODIAZPIN-2-ONE,5-(2-F PH); 5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one; 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 47643098.68 nM
|
[1] | |||
| Compound Name |
5-(2-Fluorophenyl)-8-methyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346213; BDBM50408023; ZINC13651919; Ro-208895; Ro-20-8895
Click to Show/Hide
|
||||
| Activity |
IC50 = 52601726.64 nM
|
[1] | |||
| Compound Name |
5-(2,6-Difluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151386; BDBM50408022; ZINC13651904; Ro-074419; Ro-07-4419
Click to Show/Hide
|
||||
| Activity |
IC50 = 52601726.64 nM
|
[1] | |||
| Compound Name |
7-Acetyl-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151179; SCHEMBL8933492; DTXSID00878105; BDBM50408025; ZINC13651899; Ro-203053; Ro-20-3053; 14-BENZODIAZPN2-ON,5(2-F PH)7ACETYL; 7-ACETYL-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-1,4-BENZODIAZEPIN-2-ONE; 7-acetyl-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 55590425.73 nM
|
[1] | |||
| Compound Name |
7-Fluoro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150738; SCHEMBL4817228; BDBM50408038; ZINC13651887; Ro-054865; Ro-5-4865; Ro-05-4865; 7-Fluoro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 58884365.54 nM
|
[1] | |||
| Compound Name |
5-(2-Fluorophenyl)-8-chloro-7-methyl-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL356411; BDBM50040702; ZINC13651922; Ro-208552; Ro-20-8552; 8-Chloro-5-(2-fluoro-phenyl)-7-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 71449632.61 nM
|
[1] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-phenyl-7-(trifluoromethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ro5-2904; RO-052904; BRN 0758865; Ro 5-2904; Triflunordazepam; 1,3-Dihydro-5-phenyl-7-trifluoromethyl-2H-1,4-benzodiazepin-2-one; UNII-8CS486VL3D; 5-24-04-00415 (Beilstein Handbook Reference); CHEMBL13039; 8CS486VL3D; SCHEMBL7322754; CTK8H7030; DTXSID70177394; ZINC2038727; 5-phenyl-7-(trifluoromethyl)-1,3-dihydro-1,4-benzodiazepin-2-one; BDBM50408024; Ro-5-2904; Ro-05-2904; Q7339204
Click to Show/Hide
|
||||
| Activity |
IC50 = 76913044.03 nM
|
[1] | |||
| Compound Name |
Nordazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Nordiazepam; desmethyldiazepam; Dealkylprazepam; Norprazepam; N-Demethyldiazepam; 1-Demethyldiazepam; N-Desmethyldiazepam; N-Deoxydemoxepam; N1-Desmethyldiazepam; Calmday; Demethyldiazepam; Desalkylprazepam; Madar; Stilny; Nordazepamum; N-Deoxydemoxapam; Ro 5-2180; N-Descyclopropylmethylprazepam; Nordazepam [INN]; A 101; NSC 46078; UNII-67220MCM01; CHEMBL523; Vegesan; Nordazepam (INN); NSC631619; 67220MCM01; NCGC00168263-01; Demadar; Praxadium; Nordaz; Lomax; Sopax; Nordazepam CIV; Nordazepamum [INN-Latin]; CCRIS 9181; EINECS 214-123-4; BRN 0751823; Desoxydemoxepam; DEA No. 2838; Calmday (TN); Ro 52180; Diazepam-M N-desmethyl; Diazepam EP Impurity A; Nordazepam (Nordiazepam); ChemDiv1_028362; MixCom6_000554; DSSTox_CID_28926; DSSTox_RID_83192; DSSTox_GSID_49000; Oprea1_578139; SCHEMBL78453; 5-24-04-00291 (Beilstein Handbook Reference); MLS001173623; DivK1c_000979; DTXSID2049000; CTK6H1721; HMS503C19; HMS667J04; KBio1_000979; NINDS_000979; HMS2272B05; NSC46078; ZINC1249069; Tox21_113493; BDBM50027835; NSC-46078; STK560158; Desmethyldiazepam, analytical standard; WLN: T67 GMV JN IHJ CG KR; AKOS000636746; AKOS005486646; DB14028; MCULE-2705262252; NSC-631619; IDI1_000979; Desmethyldiazepam; Oxazepam intermediate; SMR000238153; 2H-1, 1,3-dihydro-7-chloro-5-phenyl-; 2H-1, 7-chloro-1,3-dihydro-5-phenyl-; DB-040846; 5-phenyl-7-chloro-1,4-benzodiazepin-2-one; 7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-ol; C07486; D08283; 7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-one; Nordazepam (Nordiazepam) 0.1 mg/ml in Methanol; Nordazepam (Nordiazepam) 1.0 mg/ml in Methanol; 088N115; 3h-1,4-benzodiazepin-2-ol, 7-chloro-5-phenyl-; A801929; Q3180288
Click to Show/Hide
|
||||
| Activity |
IC50 = 106414301.8 nM
|
[1] | |||
| Compound Name |
7-Fluoro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151984; BDBM50408028; ZINC13651888; Ro-056820; Ro-5-6820; Ro-05-6820
Click to Show/Hide
|
||||
| Activity |
IC50 = 135207256.3 nM
|
[1] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1,3-dimethyl-7-nitro-, (R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ro 11-6893; CHEMBL345301; 3-Methylflunitrazepam; SCHEMBL11068726; CTK8E0338; DTXSID80985588; BDBM50408030; (3R)-5-(2-fluorophenyl)-1,3-dimethyl-7-nitro-3H-1,4-benzodiazepin-2-one; Ro 11-6896; Ro-11-6893; 5-(2-Fluorophenyl)-1,3-dimethyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 142889395.9 nM
|
[1] | |||
| Compound Name |
7-Chloro-5-(2,6-dichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ro-22-3294; CHEMBL276821; BDBM50026855; ZINC13651908
Click to Show/Hide
|
||||
| Activity |
IC50 = 142889395.9 nM
|
[1] | |||
| Compound Name |
7-Chloro-5-(2,6-dichlorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9689; DTXSID40877930; BDBM50026859; Ro-075220; Ro-7-5220; Ro-07-5220; 1,4-BENZODIAZPN2-ON,1-ME-5(26CLPH)7CL; 7-Chloro-5-(2,6-dichloro-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 181970085.9 nM
|
[1] | |||
| Compound Name |
7-Azido-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341902; Ro-14-3074; BDBM50408029; Ro-143074
Click to Show/Hide
|
||||
| Activity |
IC50 = 188799134.9 nM
|
[1] | |||
| Compound Name |
3,7-Dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148490; BDBM50408034; Ro-207078; Ro-20-7078
Click to Show/Hide
|
||||
| Activity |
IC50 = 188799134.9 nM
|
[1] | |||
| Compound Name |
1-Methyl-5-(2-fluorophenyl)-7-fluoro-1,3-dihydro-2h-1,4-benzodiazepine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85481; DTXSID60877937; BDBM50408015; ZINC13651889; Ro-056822; Ro-5-6822; Ro-05-6822; 1,4-BENZODIAZEPIN-2-ONE,7-FLUORO-5-(2-FLUOROPHEN
Click to Show/Hide
|
||||
| Activity |
IC50 = 195884467.4 nM
|
[1] | |||
| Compound Name |
7-Chloro-5-(2,6-difluorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346673; BDBM50408008; Ro-074065; Ro-07-4065; 7-chloro-5-(2,6-difluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 243781081.8 nM
|
[1] | |||
| Compound Name |
5-(2-Chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358422; SCHEMBL8360460; BDBM50408010; ZINC13651901; Ro-054608; Ro-05-4608
Click to Show/Hide
|
||||
| Activity |
IC50 = 263026799.2 nM
|
[1] | |||
| Compound Name |
5-(2-Fluorophenyl)-7,8-dichloro-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443823; DTXSID50877921; BDBM50040706; ZINC13651921; Ro-208065; Ro-20-8065; 1,4-BENZDAZEPIN-2-ON-5(2F-PH)-7,8-DICL; 7,8-Dichloro-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 277971326.8 nM
|
[1] | |||
| Compound Name |
(3R)-7-Chloro-5-(2-fluorophenyl)-3-methyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150323; BDBM50408012; ZINC13651912
Click to Show/Hide
|
||||
| Activity |
IC50 = 285759054.3 nM
|
[1] | |||
| Compound Name |
7-Nitro-5-[2-(trifluoromethyl)phenyl]-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-6NIM4Z45PY; 6NIM4Z45PY; CHEMBL314775; Ro-5-3590; DTXSID70877928; BDBM50408027; Ro-053590; Ro-05-3590; 1,4-BENZODIAZPN2-ON,5(2CF3PH)7NO2; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-(2-(trifluoromethyl)phenyl)-; 7-Nitro-5-(alpha,alpha,alpha-trifluoro-o-tolyl)-3H-benzodiazepin-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 285759054.3 nM
|
[1] | |||
| Compound Name |
7-Chloro-5-(2-chloro-6-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148526; BDBM50408006; ZINC13651907; Ro-075193; Ro-07-5193
Click to Show/Hide
|
||||
| Activity |
IC50 = 333426412.8 nM
|
[1] | |||
| Compound Name |
5-(2-Fluorophenyl)-7-iodo-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-K3141VKX05; Ro-7-9957; CHEMBL358426; K3141VKX05; Ro 7-9957; CTK8D4539; DTXSID80877939; 5-(2-fluorophenyl)-7-iodo-1-methyl-3H-1,4-benzodiazepin-2-one; ZINC5996068; BDBM50408017; Ro-079957; Ro-07-9957; 1,4-BENZDAZEPIN-2-ON-1ME-5(2FPH)-7I; Q27281882; 7-Iodo-1,3-dihydro-1-methyl-5(2'-fluorophenyl) -2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 345143739.3 nM
|
[1] | |||
| Compound Name |
7-Bromo-5-(2,6-difluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL356900; Ro-13-3780; BDBM50408019; Ro-133780
Click to Show/Hide
|
||||
| Activity |
IC50 = 416869383.5 nM
|
[1] | |||
| Compound Name |
5-(2-Chlorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
METHYLCLONAZEPAM; ID 690; Clonazepam, methyl; 5-(2-chlorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one; ID-690; RO-054082; Methyl Clonazepam; N-Methylclonazepam; Methylclonazpam; Clonazepam, methylated; Ro 5-4082; Ro 05-4082; CHEMBL269232; SCHEMBL11063876; CTK5A3320; DTXSID60203777; 5-(2-Chlorophenyl)-1-methyl-7-nitro-(1,4)-benzodiazepin-2-one; 5-(o-Chlorophenyl)-1-methyl-7-nitro-(1,4)-benzodiazepin-2-one; BDBM50408040; ZINC13651892; AKOS030242431; Ro-05-4082; SC-89745; 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-1-methyl-7-nitro-; 5-(o-chlorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 454988060.2 nM
|
[1] | |||
| Compound Name |
Norfludiazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
norflurazepam; Norflutoprazepam; 7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one; Descarbethoxyloflazepate; 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one; N-Desalkyl-2-oxoquazepam; CM 7116; 5-(2-Fluorophenyl)-7-chloro-1,4-benzodiazepin-2-one; Ro 5-3367; Sch 17514; 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-; UNII-X9U41NXR6M; N-Desalkylflurazepam; CHEMBL974; Norfludiazepam; Norflurazepam; X9U41NXR6M; MLS000028851; 7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(2-FLUOROPHENYL)-; SMR000058397; (E)-7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one; EINECS 220-748-3; BRN 0754061; Flurazepam-N-desalkyl; N-Desalkyl flurazepam; Flurazepam, des-alkyl; N-Desalkylflutoprazepam; Opera_ID_747; N-1-desalkyl-flurazepam; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-; Flurazepam M (des-alkyl); 5-24-04-00319 (Beilstein Handbook Reference); Flurazepam Related Compound F; MLS001146946; SCHEMBL5177297; Flurazepam M (N-1-des-alkyl); CTK4G2304; DTXSID30183057; HMS2236J07; HMS3371H16; Norfludiazepam, analytical standard; ZINC1433338; ANW-63210; BDBM50408014; MFCD00083443; AKOS015854231; Ro-053367; NCGC00247051-01; NCGC00247051-02; Ro-05-3367; AC-11173; DS-18402; SC-77672; DB-047480; FT-0634532; KS-00001019; 886F659; W-107024; Q27293739; 7-chloro-5-(2-fluorophenyl)- 1,4-Benzodiazepin-2-one; 5-(2-FLUOROPHENYL)-7-CHLORO-1,4-BENZODIAZEPIN-2-ON; 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2one; 7-Chloro-5-(2-fluorophenyl)-1H-benzo-[e][1,4]diazepin-2(3H)-one; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-; 7-chloro-1,3-dihydro-5 -(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro- (8CI)
Click to Show/Hide
|
||||
| Activity |
IC50 = 500034535 nM
|
[1] | |||
| Compound Name |
7-Chloro-5-(2,6-difluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151574; Ro-07-3953; SCHEMBL7323441; DTXSID10877922; BDBM50408011; ZINC13651905; Ro-073953; 1,4-BENZDIAZEPIN-2-ONE-5(26F-PH)7CL; 1,3-dihydro-7-chloro-5-(2,6-difluorophenyl)-2H-1,4-benzodiazepin-2-one; 7-chloro-1,3-dihydro-5-(2,6-difluorophenyl)-2H-1,4-benzodiazepin-2-one; 7-chloro-5-(2,6-difluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one; 7-chloro-5-(2,6-difluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 625172692.8 nM
|
[1] | |||
| Compound Name |
Norflunitrazepam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Desmethylflunitrazepam; N-Desmethylflunitrazepam; UNII-055XLQ0YQ6; RO 5-4435; 5-(2-Fluorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-fluorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one; CHEMBL87369; 055XLQ0YQ6; 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-nitro-; Demethylflunitrazepam; EINECS 219-878-3; Fonazepam;Norflunitrazepam; Flunitrazepan, N-desmethyl; SCHEMBL7308583; N-Desmethylflunitrazepam solution; DTXSID30180268; BDBM50408035; ZINC13651891; Ro-054435; Ro-05-4435; Desmethylflunitrazepam 0.1 mg/ml in Methanol; Desmethylflunitrazepam 1.0 mg/ml in Methanol; Q27236089; 5-(2-fluorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; (E)-5-(2-fluorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one; 5-(2-Fluorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one #; 7-nitro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 666806769.2 nM
|
[1] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-, (R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149268; Ro 11-3624; Meclonazepam, (R)-isomer; Ro 11-3624/001; CTK3E8544; BDBM50408037; (3R)-5-(2-Chlorophenyl)-3-methyl-7-nitro-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 833681184.6 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem. 1996 Dec 20;39(26):5246-56. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.