Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78356 | Target Info | |||
| Target Name | Thromboxane-A synthase (TBXAS1) | ||||
| Synonyms |
Thromboxane A2 synthase; TXS; TXA synthase; Cytochrome P450 5A1; CYP5A1; CYP5
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| Target Type | Clinical trial Target | ||||
| Gene Name | TBXAS1 | ||||
| Biochemical Class | Intramolecular oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Indomethacin
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Approved | Compound Info | ||
| Synonyms |
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Isbogrel
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Discontinued in Preregistration | Compound Info | ||
| Synonyms |
Antexan; A-66900; CV-4151
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Sulotroban
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Terminated | Compound Info | ||
| Synonyms |
BM-13177; SKF-95587
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| Activity |
IC50 = 94100 nM
|
[3] | |||
| Compound Name |
1-[2-(4-Sulphamoylphenoxy)ethyl]imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414614; SCHEMBL10748344; BDBM50026009; 4-(2-imidazol-1-ylethoxy)benzenesulfonamide; 4-(2-Imidazol-1-yl-ethoxy)-benzenesulfonamide; Benzenesulfonamide, 4-[2-(1H-imidazol-1-yl)ethoxy]-
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[2-(4-Nitrophenoxy)ethyl]imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL34511; 1-(2-(4-nitrophenoxy)ethyl)-1H-imidazole; 1-[2-(4-Nitrophenoxy)ethyl]-1H-imidazole; 1H-Imidazole, 1-[2-(4-nitrophenoxy)ethyl]-; SCHEMBL76423; DTXSID50876318; BDBM50025997; DS-021128; 1-(2-(P-NO2PHENOXY)ETHYL)IMIDAZOLE; 1-(2-(4-nitrophenoxy)-ethyl)-1H-imidazole; 1-[2-(4-nitro-phenoxy)ethyl]-1H-imidazole; 1-[2-(4-Nitro-phenoxy)-ethyl]-1H-imidazole
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[5-Chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
PF-4693627; CHEMBL2325079; PF 4693627; SCHEMBL2031399; BDBM50426967; ZINC72315303; NCGC00386681-01; NCGC00386681-02; HY-125415; CS-0091336; PF 04693627
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-(2,2-Dimethyl-propyl)-5-pyridin-3-ylmethyl-1H-pyrrol-2-yl]-2-methyl-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL262055; BDBM50017907
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| Activity |
IC50 = 78000 nM
|
[5] | |||
| Compound Name |
(6-{2-[(E)-Phenyl-pyridin-3-yl-methoxyimino]-pentyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL12020; BDBM50284381
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| Activity |
IC50 = 85000 nM
|
[6] | |||
| Compound Name |
5-[[(E)-(4-Pyrimidinyl)phenylmethylene]aminooxy]valeric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL335841; DTXSID80878002; BDBM50053781; ZINC13759459; RIDOGREL,4-PYRIMIDINYLVALERIC ANALOG; 5-[1-Phenyl-1-pyrimidin-4-yl-meth-(Z)-ylideneaminooxy]-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
5-[[(E)-alpha-(4-Pyrimidinyl)-3-(trifluoromethyl)benzylidene]aminooxy]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341426; DTXSID40878144; BDBM50053785; RIDOGREL,4-PYRIMIDINYL-M-TRIFLUOROMETHYLPHENYL-V; 5-[1-Pyrimidin-4-yl-1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylideneaminooxy]-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-[[[(Alphae)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131088; BDBM50053766; ZINC13759453; 5-[1-Phenyl-1-pyridazin-3-yl-meth-(Z)-ylideneaminooxy]-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-[[(Z)-(2-Pyrimidinyl)phenylmethylene]aminooxy]valeric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL129935; BDBM50053779; ZINC27326289; 5-[1-Phenyl-1-pyrimidin-2-yl-meth-(E)-ylideneaminooxy]-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
7-Phenyl-7-pyridin-2-yl-hept-6-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101870; BDBM50026541
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-(3',4'-Dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
pf-9184; CHEMBL1087267; C21H14Cl2N2O4S; AOB4734; SYN5102; BDBM50313205; AKOS027470312; ZINC101331153; PF 9184; NCGC00402263-03; AS-16466; HY-19622; CS-0015995; FT-0699578
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
5-[Pyridazin-3-yl-(3-trifluoromethyl-phenyl)-methyleneaminooxy]-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL130365; BDBM50053770; 5-[[(E)-(3-Pyridazinyl)[3-(trifluoromethyl)phenyl]methylene]aminooxy]valeric acid; 5-[[(Z)-(3-Pyridazinyl)[3-(trifluoromethyl)phenyl]methylene]aminooxy]valeric acid
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
5-[[[(Alphaz)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341211; BDBM50053753; ZINC13759455; 5-[1-Phenyl-1-pyridazin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
5-[[(Z)-(4-Pyrimidinyl)phenylmethylene]aminooxy]valeric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL132043; BDBM50053765; ZINC13759460; 5-[1-Phenyl-1-pyrimidin-4-yl-meth-(E)-ylideneaminooxy]-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
(Z)-6-[(2S,4S,5R)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
ICI 192605; CHEMBL30024; Ici-192605; ICI 192,605; Tocris-0837; (4Z)-rel-; SCHEMBL1894938; HMS3411P03; HMS3675P03; ZINC3782896; BDBM50034747; MFCD00673936; AKOS024458666; NCGC00024816-01; SR-01000597453; SR-01000597453-1; UNII-FQ9418XA31 component WHUIENZXNGAHQI-GKZDNZBASA-N; 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(6-{2-[(E)-Phenyl-pyridin-4-yl-methoxyimino]-propyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL12032; BDBM50284380
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| Activity |
IC50 = 210000 nM
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[6] | |||
| Compound Name |
{6-[4-(Phenyl-pyridin-3-yl-methyl)-pyrazol-1-ylmethyl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL11779; SCHEMBL8413356; BDBM50284385
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| Activity |
IC50 = 320000 nM
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[6] | |||
| Compound Name |
(Z)-7-[(2R,3R)-3-[(E,3R)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288251; BDBM50405184
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| Activity |
IC50 = 470000 nM
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[10] | |||
| Compound Name |
(Z)-7-[(2R,3S)-3-[(E,3R)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288453; BDBM50405181
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| Activity |
IC50 = 560000 nM
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[10] | |||
| Compound Name |
Imidazole
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Investigative | Compound Info | ||
| Synonyms |
1H-Imidazole; Glyoxaline; Imidazol; Iminazole; Miazole; 1,3-Diazole; Glyoxalin; Imutex; 1,3-Diaza-2,4-cyclopentadiene; Pyrro(b)monazole; USAF EK-4733; Pyrro[b]monazole; Formamidine, N,N'-vinylene-; Glioksal [Polish]; Glioksal; Methanimidamide, N,N'-1,2-ethenediyl-; CCRIS 3345; AI3-24703; UNII-7GBN705NH1; NSC 60522; BRN 0103853; N,N'-vinyleneformamidine; MFCD00005183; CHEMBL540; 7GBN705NH1; DTXSID2029616; N,N'-1,2-ethenediylmethanimidamide; Imidazole, 99%; Imidazole, ACS reagent; DSSTox_CID_9616; DSSTox_RID_78788; DSSTox_GSID_29616; Imidazole, 99+%, crystalline; 1H-imidazol; Imidazole (8CI); NSC51860; Imidazole, puriss. p.a., >=99.5% (GC); EINECS 206-019-2; NSC 51860; Immidazole; imidazole-; 1-H-imidazole; Imidazole, Reagent; {Pyrro[b]monazole}; 1,4-cyclopentadiene; Imidazole, ACS grade; ACMC-1CPAG; 1H-Imidazole (9CI); Formamidine,N'-vinylene-; bmse000096; bmse000790; WLN: T5M CNJ; EC 206-019-2; NCIStruc1_001975; NCIStruc2_000693; Imidazole, LR, >=99%; 5-23-04-00191 (Beilstein Handbook Reference); KSC203M9T; MLS001055465; BDBM7882; Imidazole-buffered saline (5X); CTK1A3699; HSDB 8449; 1,3-Diaza-2,4-cyclopentadiene-; Imidazole, ReagentPlus(R), 99%; ZINC901039; Imidazole, for synthesis, 99.5%; BCP26547; HY-D0837; KS-000002NA; NSC60522; Methanimidamide,N'-1,2-ethenediyl-; Tox21_201504; Tox21_303345; ANW-26483; BBL009685; NSC-60522; s6006; SBB040815; STK362967; AKOS000120177; AM82000; CS-5135; DB03366; MCULE-1410806694; Imidazole, BioUltra, >=99.5% (GC); NCGC00090984-01; NCGC00090984-02; NCGC00257344-01; NCGC00259055-01; 2,4-Diazonia-2,4-cyclopentadiene-1-ide; AK-76381; BP-11451; SC-18719; SMR000057825; ST097249; 1,3-Diaza-2,4-cyclopentadiene;Glyoxaline; Imidazole, SAJ special grade, >=99.0%; Imidazole, Vetec(TM) reagent grade, 98%; DB-002018; Imidazole, 0.5M buffer solution, pH 6.0; Imidazole, 0.5M buffer solution, pH 7.0; Imidazole, 0.5M buffer solution, pH 7.5; FT-0627179; FT-0670295; I0001; I0014; I0288; I0290; Imidazole, >=99% (titration), crystalline; Imidazole Zone Refined (number of passes:30); Imidazole, ACS reagent, >=99% (titration); 2519-EP0930075A1; 2519-EP1441224A2; 2519-EP2269977A2; 2519-EP2269978A2; 2519-EP2269985A2; 2519-EP2269990A1; 2519-EP2269991A2; 2519-EP2269992A1; 2519-EP2270002A1; 2519-EP2270006A1; 2519-EP2270008A1; 2519-EP2270010A1; 2519-EP2270011A1; 2519-EP2270014A1; 2519-EP2270015A1; 2519-EP2270113A1; 2519-EP2270505A1; 2519-EP2272509A1; 2519-EP2272510A1; 2519-EP2272516A2; 2519-EP2272517A1; 2519-EP2272537A2; 2519-EP2272813A2; 2519-EP2272817A1; 2519-EP2272825A2; 2519-EP2272827A1; 2519-EP2272828A1; 2519-EP2272832A1; 2519-EP2272838A1; 2519-EP2272839A1; 2519-EP2272840A1; 2519-EP2272841A1; 2519-EP2272848A1; 2519-EP2272849A1; 2519-EP2272935A1; 2519-EP2272972A1; 2519-EP2272973A1; 2519-EP2274983A1; 2519-EP2275102A1; 2519-EP2275395A2; 2519-EP2275401A1; 2519-EP2275404A1; 2519-EP2275409A1; 2519-EP2275411A2; 2519-EP2275412A1; 2519-EP2275413A1; 2519-EP2275414A1; 2519-EP2276085A1; 2519-EP2277848A1; 2519-EP2277858A1; 2519-EP2277872A1; 2519-EP2277880A1; 2519-EP2280000A1; 2519-EP2280005A1; 2519-EP2280009A1; 2519-EP2281563A1; 2519-EP2281813A1; 2519-EP2281815A1; 2519-EP2281818A1; 2519-EP2281819A1; 2519-EP2281824A1; 2519-EP2284149A1; 2519-EP2284150A2; 2519-EP2284151A2; 2519-EP2284152A2; 2519-EP2284153A2; 2519-EP2284155A2; 2519-EP2284156A2; 2519-EP2284157A1; 2519-EP2284164A2; 2519-EP2284169A1; 2519-EP2284920A1; 2519-EP2286812A1; 2519-EP2286915A2; 2519-EP2287140A2; 2519-EP2287148A2; 2519-EP2287150A2; 2519-EP2287161A1; 2519-EP2287162A1; 2519-EP2287165A2; 2519-EP2287166A2; 2519-EP2287167A1; 2519-EP2289868A1; 2519-EP2289871A1; 2519-EP2289884A1; 2519-EP2289890A1; 2519-EP2289894A2; 2519-EP2292586A2; 2519-EP2292590A2; 2519-EP2292592A1; 2519-EP2292593A2; 2519-EP2292596A2; 2519-EP2292597A1; 2519-EP2292604A2; 2519-EP2292606A1; 2519-EP2292610A1; 2519-EP2292611A1; 2519-EP2292612A2; 2519-EP2292613A1; 2519-EP2292617A1; 2519-EP2292619A1; 2519-EP2292620A2; 2519-EP2292621A1; 2519-EP2292630A1; 2519-EP2295401A2; 2519-EP2295402A2; 2519-EP2295406A1; 2519-EP2295414A1; 2519-EP2295415A1; 2519-EP2295419A2; 2519-EP2295421A1; 2519-EP2295426A1; 2519-EP2295427A1; 2519-EP2295429A1; 2519-EP2295432A1; 2519-EP2295433A2; 2519-EP2295434A2; 2519-EP2295550A2; 2519-EP2298731A1; 2519-EP2298732A1; 2519-EP2298742A1; 2519-EP2298743A1; 2519-EP2298744A2; 2519-EP2298755A1; 2519-EP2298763A1; 2519-EP2298766A1; 2519-EP2298767A1; 2519-EP2298770A1; 2519-EP2298772A1; 2519-EP2298774A1; 2519-EP2298776A1; 2519-EP2298778A1; 2519-EP2298783A1; 2519-EP2298828A1; 2519-EP2299509A1; 2519-EP2300438A1; 2519-EP2301534A1; 2519-EP2301536A1; 2519-EP2301538A1; 2519-EP2301912A2; 2519-EP2301913A1; 2519-EP2301914A1; 2519-EP2301916A2; 2519-EP2301918A1; 2519-EP2301921A1; 2519-EP2301926A1; 2519-EP2301929A1; 2519-EP2301930A1; 2519-EP2301931A1; 2519-EP2301932A1; 2519-EP2301933A1; 2519-EP2301934A1; 2519-EP2301935A1; 2519-EP2301937A1; 2519-EP2301940A1; 2519-EP2301983A1; 2519-EP2302003A1; 2519-EP2302015A1; 2519-EP2305219A1; 2519-EP2305250A1; 2519-EP2305637A2; 2519-EP2305640A2; 2519-EP2305643A1; 2519-EP2305648A1; 2519-EP2305651A1; 2519-EP2305652A2; 2519-EP2305657A2; 2519-EP2305658A1; 2519-EP2305659A1; 2519-EP2305668A1; 2519-EP2305674A1; 2519-EP2305676A1; 2519-EP2305682A1; 2519-EP2305689A1; 2519-EP2305695A2; 2519-EP2305696A2; 2519-EP2305697A2; 2519-EP2305698A2; 2519-EP2305769A2; 2519-EP2305808A1; 2519-EP2308510A1; 2519-EP2308562A2; 2519-EP2308812A2; 2519-EP2308832A1; 2519-EP2308833A2; 2519-EP2308839A1; 2519-EP2308840A1; 2519-EP2308848A1; 2519-EP2308852A1; 2519-EP2308854A1; 2519-EP2308855A1; 2519-EP2308861A1; 2519-EP2308863A1; 2519-EP2308867A2; 2519-EP2308868A1; 2519-EP2308869A1; 2519-EP2308870A2; 2519-EP2308872A1; 2519-EP2308873A1; 2519-EP2308874A1; 2519-EP2308877A1; 2519-EP2308879A1; 2519-EP2308880A1; 2519-EP2308883A1; 2519-EP2309584A1; 2519-EP2311451A1; 2519-EP2311455A1; 2519-EP2311464A1; 2519-EP2311796A1; 2519-EP2311797A1; 2519-EP2311798A1; 2519-EP2311799A1; 2519-EP2311802A1; 2519-EP2311803A1; 2519-EP2311815A1; 2519-EP2311818A1; 2519-EP2311820A1; 2519-EP2311823A1; 2519-EP2311825A1; 2519-EP2311826A2; 2519-EP2311827A1; 2519-EP2311830A1; 2519-EP2311841A1; 2519-EP2311842A2; 2519-EP2314295A1; 2519-EP2314558A1; 2519-EP2314574A1; 2519-EP2314575A1; 2519-EP2314582A1; 2519-EP2314583A1; 2519-EP2314587A1; 2519-EP2315303A1; 2519-EP2315502A1; 2519-EP2316450A1; 2519-EP2316452A1; 2519-EP2316459A1; 2519-EP2316470A2; 2519-EP2316829A1; 2519-EP2316831A1; 2519-EP2316832A1; 2519-EP2316833A1; 2519-EP2316836A1; 2519-EP2316905A1; 2519-EP2316906A2; 2519-EP2371810A1; 2519-EP2371811A2; 2519-EP2371812A1; 2519-EP2371831A1; 2519-EP2372017A1; 2519-EP2372804A1; 2519-EP2377847A1; 2519-EP2377848A1; 2519-EP2378585A1; 2519-EP2380874A2; C01589; M-6056; 59390-EP2270011A1; 59390-EP2272846A1; 59390-EP2305808A1; 59390-EP2308852A1; 59390-EP2371806A1; 59390-EP2371812A1; 142240-EP2270010A1; 142240-EP2292593A2; Imidazole buffer Solution, BioUltra, 1 M in H2O; Q328692; J-200340; F2190-0638; Z1245636370; 4286D518-643C-4C69-BCE7-519D073F4992
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| Activity |
IC50 = 670000 nM
|
[1] | |||
| Compound Name |
(Z)-7-[(2S,3S)-3-[(E,3R)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL37218; BDBM50405186
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| Activity |
IC50 = 770000 nM
|
[10] | |||
| Compound Name |
2-[[5-[3-Oxo-3-(2-phenyl-2-pyridin-3-ylhydrazinyl)propyl]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11407; SCHEMBL9047479; BDBM50284383
Click to Show/Hide
|
||||
| Activity |
IC50 = 940000 nM
|
[6] | |||
| Compound Name |
(Z)-7-[(2R,3R)-3-[(E,3S)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36493; BDBM50405187
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[10] | |||
| Compound Name |
(Z)-7-[(2R,3S)-3-[(E,3S)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41435; BDBM50405182
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[10] | |||
| Compound Name |
(Z)-7-[(2S,3R)-3-[(E,3S)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288452; BDBM50405180
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[10] | |||
| Compound Name |
(Z)-7-[(2S,3R)-3-[(E,3R)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290245; BDBM50405185
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[10] | |||
| Compound Name |
(6-{2-[(E)-Phenyl-pyridin-2-yl-methoxyimino]-propyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11563; BDBM50284379
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[6] | |||
| Compound Name |
(Z)-7-[(2S,3S)-3-[(E,3S)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290391; BDBM50405183
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. J Med Chem. 1985 Oct;28(10):1427-32. | ||||
| REF 2 | Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of omega-pyridylalkenoic acids. J Med Chem. 1985 Mar;28(3):287-94. | ||||
| REF 3 | Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule. J Med Chem. 1993 May 28;36(11):1613-8. | ||||
| REF 4 | Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9. | ||||
| REF 5 | [(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors. J Med Chem. 1989 Apr;32(4):890-7. | ||||
| REF 6 | Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. I. Bioorg Med Chem Lett. 1995 May 18;5(10):1087-90. | ||||
| REF 7 | On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel. J Med Chem. 1996 Sep 27;39(20):4058-64. | ||||
| REF 8 | Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1604-9. | ||||
| REF 9 | Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids. J Med Chem. 1995 Feb 17;38(4):686-94. | ||||
| REF 10 | Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2. J Med Chem. 1985 Nov;28(11):1580-90. | ||||
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