Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80942 | Target Info | |||
| Target Name | Matrix metalloproteinase (MMP) | ||||
| Synonyms |
Matrix metalloproteinase
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 785 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Zoledronate
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|
Approved | Compound Info | ||
| Synonyms |
Aclasta; Reclast; ZOL; Zometa; Novartis brand of zoledronic acid; Zoledronic acid; Zometa Concentrate; Bisphosphonate 3; CGP 42446; CGP 42446A; Aclasta (TN); CGP 42'446; CGP-42446; KS-1132; Reclast (TN); Zoledronic acid (INN); Zoledronic acid [USAN:INN]; Zomera (TN); Zometa (Novartis); Zometa (TN); CGP-42'446; Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid); (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid; (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid; (1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate; 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid; 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
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| Activity | Matrix metalloproteinase 9 |
IC50 = 52000 nM
|
[1] | ||
| Compound Name |
Tiludronic acid
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Approved | Compound Info | ||
| Synonyms |
Skelid; Tiludronate disodium; ME-3737; SR-41319
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| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
Clodronate
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Approved | Compound Info | ||
| Synonyms |
Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)
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| Activity | Matrix metalloproteinase 12 |
IC50 = 121000 nM
|
[2] | ||
| Matrix metalloproteinase 2 |
IC50 = 145000 nM
|
[2] | |||
| Compound Name |
1607004-34-1
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Patented | Compound Info | ||
| Synonyms |
ADAMTS Inhibitor C7; SCHEMBL15692551; CHEMBL3980860; BDBM194644; 1607004-34-1; US9206139, 3
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| Activity | Matrix metalloproteinase 14 |
IC50 = 50000 nM
|
[3] | ||
| Matrix metalloproteinase 3 |
IC50 = 99710 nM
|
[4] | |||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[4] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
US9206139, 4
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|
Patented | Compound Info | ||
| Synonyms |
CHEMBL3955404; SCHEMBL15692527; BDBM194645; US9206139, 4
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| Activity | Matrix metalloproteinase 1 |
IC50 = 56800 nM
|
[4] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[4] | |||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[4] | |||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[4] | |||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[4] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[4] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
US9206139, 5
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|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL15692518; CHEMBL3972836; BDBM194646; US9206139, 5
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
N-hydroxy-1-naphthamide
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Investigative | Compound Info | ||
| Synonyms |
1-Naphthohydroxamic acid; 6953-61-3; N-Hydroxy-1-naphthamide; 1-NAPHTHALENECARBOXAMIDE, N-HYDROXY-; NSC 57457; N-Hydroxynaphthalene-1-carboxamide; alpha-Naphthohydroxamic acid; a-Naphthohydroxamic acid; BRN 2094470; CHEMBL115468; Naphthalene-1-carboxylic acid hydroxyamide; 8GK; naphthylhydroxamic acid; AC1L2M8D; N-Hydroxy-1-naphthamide #; 4-09-00-02407 (Beilstein Handbook Reference); .alpha.-Naphthohydroxamic acid; ACMC-209o98; SCHEMBL2230679; CTK5D0341; DTXSID30219789; JRZGPWOEHDOVMC-UHFFFAOYSA-N
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| Activity | Matrix metalloproteinase 3 |
IC50 = 50000 nM
|
[5] | ||
| Compound Name |
5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176517; 219311-20-3; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(4-phenoxyphenyl)-; SCHEMBL6380971; CTK0J6997; DTXSID60470422; NNRYJLARUIVRRO-UHFFFAOYSA-N; 5-(4'-phenoxyphenyl)barbituric acid; 5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
5-Methyl-5-phenyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
Heptobarbital; Mephebarbital; Eudan; Phenylmethylbarbituric acid; Rutonal; Methylphenylbarbital; 5-Methyl-5-phenylbarbituric acid; 5-Methyl-5-phenylbarbityric acid; 76-94-8; 5-Phenyl-5-methylbarbituric acid; NSC 80543; Barbituric acid, 5-methyl-5-phenyl-; UNII-GFR227X6YY; 5-Methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; EINECS 200-994-8; BRN 0201825; GFR227X6YY; CHEMBL329617; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-methyl-5-phenyl-; 5-methyl-5-phenyl-barbituric acid; C11H10N2O3; 5-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
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| Activity | Matrix metalloproteinase 2 |
IC50 = 50000 nM
|
[6] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL575895; N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 50000 nM
|
[7] | ||
| Matrix metalloproteinase 8 |
IC50 = 72000 nM
|
[7] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
5-Hexyl-5-phenylbarbituric acid; BRN 0297956; BARBITURIC ACID, 5-HEXYL-5-PHENYL-; 67051-21-2; CHEMBL173075; AC1L2LKK; 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione; 4-24-00-02103 (Beilstein Handbook Reference); CTK8J9653; DTXSID20217355; 5-hexyl-5-phenyl barbituric acid; BDBM50099125; LS-24512
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
ARP100
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Investigative | Compound Info | ||
| Synonyms |
ARP 100; ARP-100
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[8] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175282; 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione; BDBM50099116
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL367524; 94209-48-0; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[1,1'-biphenyl]-4-yl-5-ethyl-; ACMC-20lyhc; AC1M3WRE; Oprea1_691960; MLS001000776; 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione; NIOSH/CQ0532020; CTK3G9325; DTXSID20367041; MolPort-002-095-507; HMS2827O03; BDBM50099119; ZINC96299878; STK760260; AKOS005616072; MCULE-2406616532; Acido 5-etil 5-(p-difenilil)barbiturici; NCGC00245692-01; 5-(4-Biphenylyl)-5-ethylbarbituric acid; SMR000498104; LS-23825; M.G. 3419; CQ05320200; Barbituric acid, 5-(4-biphenylyl)-5-ethyl-
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
UK-356618
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Investigative | Compound Info | ||
| Synonyms |
UK 356618; 230961-08-7; CHEMBL117225; UK-356,618; SCHEMBL6437730; GTPL6528; CHEBI:94305; DTXSID50438778; MolPort-023-277-089; ZINC3924338; BDBM50097263; AKOS024458021; FT-0675728; PF 03890101; PF-03890101; UK-356618, > J-014983; BRD-K57011718-001-01-5; (R)-N*1*-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methyl-biphenyl-4-yl)-propyl]-succinamide
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| Activity | Matrix metalloproteinase 1 |
IC50 = 51000 nM
|
[8] | ||
| Compound Name |
5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL574666; SCHEMBL5613445; BDBM50300481; 5-(3''-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
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| Activity | Matrix metalloproteinase 13 |
IC50 = 52000 nM
|
[9] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
(biphenyl-3-ylamino)methylenediphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55371; AC1NQQUY; (biphenyl-3-ylamino)methylenediphosphonic acid; BPH-218; NSC725581; BDBM50138040; ZINC13532369; NSC-725581; [(3-phenylanilino)-phosphonomethyl]phosphonic acid; [(3-phenylanilino)-phosphono-methyl]phosphonic acid; [(Biphenyl-3-ylamino)-phosphono-methyl]-phosphonic acid; (Biphenyl-3-yl)- aminomethylene-1,1-bisphosphonate (dihydrate); Phosphonic acid, [([1,1'-biphenyl]-3-ylamino)methylene]bis-
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| Activity | Matrix metalloproteinase 8 |
IC50 = 52000 nM
|
[1] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
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[1] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Methotrexate gamma-L-phenylalaninehydroxamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396296; methotrexate gamma-L-phenylalaninehydroxamic acid
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| Activity | Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[10] | ||
| Matrix metalloproteinase 14 |
IC50 = 70000 nM
|
[10] | |||
| Compound Name |
UK-383367
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Investigative | Compound Info | ||
| Synonyms |
UK 383367; 348622-88-8; UK-383367; CHEMBL226630; 5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide; (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide; ARJCBSRIPGJMAD-LLVKDONJSA-N; UK383367; 5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide; MLS006011234; SCHEMBL6430715; CTK8F1316; SYN3014; DTXSID30431303; MolPort-016-633-322; ZINC3818556; s2224; BDBM50216795; AKOS024458022; SB19579; RL03300; CS-0414
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| Activity | Matrix metalloproteinase 2 |
IC50 ~ 60000 nM
|
[11] | ||
| Compound Name |
Folate gamma-L-phenylalaninehydroxamic acid
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Investigative | Compound Info | ||
| Activity | Matrix metalloproteinase 2 |
IC50 = 65000 nM
|
[10] | ||
| Matrix metalloproteinase 14 |
IC50 = 80000 nM
|
[10] | |||
| Compound Name |
RXP470.1
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Investigative | Compound Info | ||
| Synonyms |
RXP470.1; CHEMBL507420; N-[(2s)-3-[(S)-(4-Bromophenyl)(Hydroxy)phosphoryl]-2-{[3-(3'-Chlorobiphenyl-4-Yl)-1,2-Oxazol-5-Yl]methyl}propanoyl]-L-Alpha-Glutamyl-L-Alpha-Glutamine; R47; GTPL7812; BDBM50265078; (4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hydroxy)phosphoryl)-2-((3-(3''-chlorobiphenyl-4-yl)isoxazol-5-yl)methyl)propanamido)-4-carboxybutanamido)-5-oxopentanoic acid
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| Activity | Matrix metalloproteinase 1 |
Ki = 67000 nM
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[8] | ||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228229; 2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 68000 nM
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[12] | ||
| Matrix metalloproteinase 9 |
IC50 = 141000 nM
|
[12] | |||
| Compound Name |
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL574589; 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide
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| Activity | Matrix metalloproteinase 1 |
IC50 = 73000 nM
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[7] | ||
| Compound Name |
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL573935; [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid
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| Activity | Matrix metalloproteinase 3 |
IC50 = 74000 nM
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[7] | ||
| Compound Name |
2-(benzyloxyamino)-N-hydroxyhexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228230; 2-(benzyloxyamino)-N-hydroxyhexanamide
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| Activity | Matrix metalloproteinase 9 |
IC50 = 81000 nM
|
[13] | ||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388309; 2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 81800 nM
|
[12] | ||
| Matrix metalloproteinase 9 |
IC50 = 125000 nM
|
[12] | |||
| Compound Name |
2-(benzyloxyamino)-N-hydroxyacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL226149; 2-(benzyloxyamino)-N-hydroxyacetamide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 94000 nM
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[12] | ||
| Compound Name |
2-(2-(biphenyl-4-yl)ethylthio)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572980; 2-(2-(biphenyl-4-yl)ethylthio)acetic acid
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| Activity | Matrix metalloproteinase 13 |
IC50 = 95200 nM
|
[9] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572947; 2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid
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| Activity | Matrix metalloproteinase 13 |
IC50 = 95900 nM
|
[9] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
(+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572982; (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid; SCHEMBL5613354; ILGSIIFHQGOKKV-UHFFFAOYSA-N; BDBM50300465; 5-biphenyl-4-yl-3-hydroxy-pentanoic acid; 5-(biphenyl-4-yl)-3-hydroxypentanoic acid
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 98000 nM
|
[9] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 98000 nM
|
[9] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL583588; SCHEMBL5613483; BDBM50300472; 5-(4''-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
5-(biphenyl-4-yl)-3-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572979; 5-(biphenyl-4-yl)-3-oxopentanoic acid
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| Activity | Matrix metalloproteinase 13 |
IC50 ~ 98000 nM
|
[9] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL566511; 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
5-(biphenyl-4-yl)-3-methoxypentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL583771; 5-(biphenyl-4-yl)-3-methoxypentanoic acid
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| Activity | Matrix metalloproteinase 13 |
IC50 ~ 98000 nM
|
[9] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
PF-00356231
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Investigative | Compound Info | ||
| Synonyms |
PF-00356231; CHEMBL508461; (2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID; 3-PHENYL-3-({[4-(4-PYRIDIN-4-YLPHENYL)THIEN-2-YL]CARBONYL}AMINO)PROPANOIC ACID; 1utz; AC1L9MIX; SCHEMBL8298104; MolPort-042-665-664; ZINC6744035; BDBM50264813; DB03367; NCGC00386512-01; (3R)-3-phenyl-3-({4-[4-(pyridin-4-yl)phenyl]thiophen-2-yl}formamido)propanoic acid; (3R)-3-phenyl-3-({[4-(4-pyridin-4-ylphenyl)thiophen-2-yl]carbonyl}amino)propanoic acid
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| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[8] | ||
| Compound Name |
N,N'-Bis(4-Amino-2-Methylquinolin-6-Yl)Urea
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Investigative | Compound Info | ||
| Synonyms |
Aminoquinuride; Surfen; aminokinuride; UNII-08T7936572; 3811-56-1; N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA; 1,3-bis(4-amino-2-methylquinolin-6-yl)urea; N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea; Aminochinurid; 08T7936572; Aminochinuridum; Aminoquinuridum; Aminoquinurida; Aminokinuridum; Aminochincarbamidum; Aminoquin carbamide; NSC12155; Aminoquinuride [INN]; NCGC00013130-04; NCGC00013130-03; 5424-37-3; Aminoquinuridum [INN-Latin]; Aminoquinurida [INN-Spanish]; 1pwp; N,N-Bis(4-aminochinaldyl-6)harnstoff
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| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[14] | ||
| Compound Name |
N1,N3-bis(3-methoxybenzyl)isophthalamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605201; N1,N3-bis(3-methoxybenzyl)isophthalamide; SCHEMBL5332068
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| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[15] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[15] | |||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[15] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[15] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[15] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Methotrexate gamma-hydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
methotrexate gamma-hydroxamic acid; CHEMBL244883
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 100000 nM
|
[10] | ||
| Compound Name |
Bb-3497
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BB-3497; CHEMBL431210; BB 3497; 235784-88-0; 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC ACID (1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE; (2r)-n-[(2s)-1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-{[formyl(hydroxy)amino]methyl}hexanamide; BB1; 1g27; (2R)-N-[(2S)-1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide; AC1L4M3L; AC1Q5HZ8; SCHEMBL13754309; DTXSID80178216; BDBM50104501; BB3497; DB04368; (R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[16] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Cis-2-aminocyclohexylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
cis-ACCP; cis-2-aminocyclohexylcarbamoylphosphonic acid; 777075-44-2; CHEMBL270083; SCHEMBL569075; C7H15N2O4P; CTK8E9417; MolPort-039-139-066; BDBM50234465; 1683AH; ZINC29134634
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[8] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
OXYQUINOLINE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-HYDROXYQUINOLINE; quinolin-8-ol; 8-quinolinol; 148-24-3; Oxyquinoline; Oxine; Quinophenol; 8-Quinol; 8-Oxyquinoline; Phenopyridine; Oxychinolin; Bioquin; Oxybenzopyridine; Oxin; Hydroxybenzopyridine; 1-Azanaphthalene-8-ol; Tumex; 8-Chinolinol; 8-Hydroxychinolin; 8-OQ; 8-Hydroxy-chinolin; Fennosan H 30; Fennosan; o-Oxychinolin; 8-Oxychinolin; Usaf ek-794; Fennosan HF-15; NCI-C55298; NSC 2039; Oxyquinoline [USAN]; Caswell No. 719; Oxoquinoline; 8-Chinolinol [Czech]; o-Oxychinolin [German]; Quinoline, 8-hydroxy-; NSC 615011; UNII-5UTX5635HP
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 130000 nM
|
[17] | ||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227566; 2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 137000 nM
|
[12] | ||
| Compound Name |
TROPOLONE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tropolone; 533-75-5; 2-Hydroxycyclohepta-2,4,6-trienone; Purpurocatechol; 2-Hydroxy-2,4,6-cycloheptatrien-1-one; 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-; 2-hydroxycyclohepta-2,4,6-trien-1-one; 2-Hydroxytropone; 2-Hydroxy-2,4,6-cycloheptatrienone; UNII-7L6DL16P1T; Tropolone, 98%; CCRIS 6609; NSC89303; EINECS 208-577-2; NSC 89303; BRN 1904978; CHEMBL121188; 7L6DL16P1T; CHEBI:79966; MDYOLVRUBBJPFM-UHFFFAOYSA-N; MFCD00004158; Tropomyosins; 0TR; PubChem6330; NCIMech_000829; AC1L1VY5; DSSTox_RID_83491; DSSTox_CID_29376; DSSTox_GSID_49416
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 146000 nM
|
[17] | ||
| Compound Name |
2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228231; 2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 151000 nM
|
[12] | ||
| Compound Name |
2-Cinnamamido-N4-hexyl-N1-hydroxysuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595209; 2-Cinnamamido-N4-hexyl-N1-hydroxysuccinamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 178600 nM
|
[18] | ||
| Compound Name |
2-Cinnamamido-N1-hydroxy-N4-pentylsuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596560; 2-Cinnamamido-N1-hydroxy-N4-pentylsuccinamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 196500 nM
|
[18] | ||
| Compound Name |
N-Hydroxy-N-[2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-1-(2,2,5-trimethyl-[1,3]dioxolan-4-yl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306050; BDBM50108165
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
Benzyl N-[(4R)-4-[[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770688
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 50000 nM
|
[20] | ||
| Compound Name |
(2R)-2-[(4-But-2-ynoxyphenyl)sulfonylamino]-3-[1-[(4-methoxyphenyl)methyl]indol-3-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499905; SCHEMBL3847951; BDBM50278942; D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-methoxybenzyl)-1H-indol-3-yl)propanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[21] | ||
| Compound Name |
2-Benzo[1,3]dioxol-5-ylmethyl-N*4*-hydroxy-N*1*-(2-hydroxy-indan-1-yl)-succinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115082; SCHEMBL6046197; BDBM50104972
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 50000 nM
|
[22] | ||
| Compound Name |
2-(4-Chlorophenoxy)-N-{[(4r)-4-Methyl-2,5-Dioxoimidazolidin-4-Yl]methyl}acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358151; 4wk7; BDBM50033809; Q27454023; 3PQ
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 50000 nM
|
[23] | ||
| Matrix metalloproteinase 14 |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-isoquinolin-4-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098997; BDBM50444721
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[14] | ||
| Compound Name |
(2R)-N-Hydroxy-2-[(biphenyl-4-ylcarbonyl)amino]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157592; BDBM50063149; Biphenyl-4-carboxylic acid ((R)-1-hydroxycarbamoyl-2-phenyl-ethyl)-amide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 50000 nM
|
[24] | ||
| Compound Name |
2-Thioxo-5-hexyl-5-(4-biphenylyl)hexahydropyrimidine-4,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL176876; BDBM50099122; 5-Biphenyl-4-yl-5-hexyl-2-thioxo-dihydro-pyrimidine-4,6-dione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
4-[2-[Formyl(hydroxy)amino]-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpropyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221177
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
1-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-1-hydroxyurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43026; BDBM50100910; N-{2-[(4''-cyano-1,1''-biphenyl-4-yl)oxy]ethyl}-N-hydroxyurea
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[26] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Cyclohexanamine;3-methylbutylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160686
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 50000 nM
|
[27] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-{3-(Formyl-hydroxy-amino)-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78213; SCHEMBL7990364; BDBM50108136; methyl 4-[3-[formyl(hydroxy)amino]-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylbutyl]benzoate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-5-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098998; BDBM50444720
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 = 65000 nM
|
[14] | |||
| Compound Name |
(3R)-6-Cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226852; SCHEMBL6599390; BDBM50216790
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[28] | ||
| Matrix metalloproteinase 3 |
IC50 = 78000 nM
|
[28] | |||
| Matrix metalloproteinase 2 |
IC50 = 79600 nM
|
[28] | |||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309794; BDBM50290159
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[29] | ||
| Compound Name |
5-Benzyloxymethyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177740; SCHEMBL6814140; BDBM50099121; 5-(4-phenoxyphenyl)-5-(phenylmethoxymethyl)-1,3-diazinane-2,4,6-trione; 5-(Benzyloxymethyl)-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
5-Hexyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL176832; SCHEMBL6813840; 5-hexyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione; BDBM50099123; 5-Hexyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione; 5-n-hexyl-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
(Propylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94346; BDBM50146797
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 50000 nM
|
[27] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75189; SCHEMBL8000486; BDBM50108149; N-[2-[4-[4-(Trifluoromethoxy)phenoxy]phenylsulfonyl]-1-(2-morpholinoethyl)ethyl]-N-hydroxyformamide; N-hydroxy-N-[4-morpholin-4-yl-1-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylbutan-2-yl]formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
N-(1,1':4',1''-Terbenzene-4-ylmethyl)-3-hydroxy-4-oxo-6-methyl-4H-pyran-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489603; AM-6; SCHEMBL13208686; BDBM50264772; 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid ([1,1'';4'',1'''']terphenyl-4-ylmethyl)-amide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[8] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306276; SCHEMBL7998643; BDBM50108153
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
N-Hydroxy-N-{1-methoxymethyl-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73866; SCHEMBL7677334; BDBM50108156; N-[2-[4-[4-(Trifluoromethoxy)phenoxy]phenylsulfonyl]-1-(methoxymethyl)ethyl]-N-hydroxyformamide; N-hydroxy-N-[1-methoxy-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpropan-2-yl]formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
5-(2-Hydroxyethyl)-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174641; SCHEMBL6810540; 5-(2-hydroxyethyl)-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione; BDBM50099120; 5-(2-Hydroxy-ethyl)-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid (biphenyl-4-ylmethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255374; SCHEMBL8268658; BDBM50241504; N-(Biphenyl-4-ylmethyl)-3-hydroxy-4-oxo-6-methyl-4H-pyran-2-carboxamide; N-(biphenyl-4-ylmethyl)-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[30] | ||
| Compound Name |
N-(1-Benzylcarbamoyl-ethyl)-N''-hydroxy-2-isobutyl-malonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334065; BDBM50062460
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 50000 nM
|
[31] | ||
| Compound Name |
N-{[4-(But-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL527018; BDBM50279256; DB07233; Q27096457; D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methyl-1H-indol-3-yl)propanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[21] | ||
| Compound Name |
(3S,4S)-3-(4-Phenoxybenzenesulfonamido)-4-mercaptopyrrolidine Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380399; SCHEMBL1973277
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 50000 nM
|
[32] | ||
| Compound Name |
3-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398892; BDBM50227585
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 70000 nM
|
[33] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenylamino)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269994; SCHEMBL4738506; BDBM50329265; (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
(S)-2-(4-Fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760324; SCHEMBL3436885; BDBM50340754; (2S)-2-[(4-fluoro-3,5-dimethylphenyl)methyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
(2R,3R)-4-(2-(3-Chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxo-N-(2-(thiophen-2-yl)ethyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590343; SCHEMBL8217068; BDBM50309147
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[35] | ||
| Matrix metalloproteinase 7 |
Ki ~ 50000 nM
|
[35] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[35] | |||
| Compound Name |
Furan-2-carboxamide deriv., 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568644; BDBM32409
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 50000 nM
|
[36] | ||
| Compound Name |
(1R,2S,5R)-2-[2-[4-(4-Chlorophenyl)phenyl]ethylsulfanyl]-5-[(1,3-dioxoisoindol-2-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340455; BDBM50131940
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[37] | ||
| Compound Name |
(R)-3-((S)-1-Methylcarbamoyl-2-phenyl-ethylcarbamoyl)-nonadecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61538; SCHEMBL8053894; BDBM50290443; (R)-3-(((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)nonadecanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 50000 nM
|
[38] | ||
| Compound Name |
(Dibutylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96438; BDBM50146804
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 50000 nM
|
[27] | ||
| Matrix metalloproteinase 1 |
IC50 = 70000 nM
|
[27] | |||
| Matrix metalloproteinase 8 |
IC50 = 90000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589199; BDBM50270510
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[39] | ||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012837; BDBM50379534
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
Dipotassium;6-amino-2-[[2-[4-[3-(carboxylatomethylamino)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]-3-oxopropyl]phenoxy]acetyl]amino]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1744412
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
Ki = 50000 nM
|
[40] | ||
| Compound Name |
But-2-ynyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254837; BDBM50227600
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 68000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 70000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 71000 nM
|
[33] | |||
| Compound Name |
N-Hydroxy-N-{1-(1-methyl-1H-indol-2-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74812; BDBM50108133
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2010824; BDBM50379535
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(4-oxo-cyclohexylidenemethyl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98852; SCHEMBL3996441; BDBM50146468
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[41] | ||
| Compound Name |
2-[(4-But-2-ynoxyphenyl)sulfonylamino]-3-(5-methoxy-1H-indol-3-yl)propanoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497908; SCHEMBL3848351; BDBM50279257; 2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methoxy-1H-indol-3-yl)propanoic acid; rac-2-(4-But-2-ynyloxy-benzenesulfonyl-amino)-3-(5-methoxy-1H-indol-3-yl)-propionic acid; 2-(4-BUT-2-YNYLOXY-BENZENESULFONYLAMINO)-3-(5-METHOXY-1H-INDOL-3-YL)-PROPIONIC ACID
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[21] | ||
| Compound Name |
N-{1-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306301; BDBM50108167
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
N-Hydroxy-N-[2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-1-(4-trifluoromethyl-phenyl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74365; SCHEMBL7670979; BDBM50108139
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
CID 66559934
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164120; SCHEMBL17814861; BDBM50395680
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 50000 nM
|
[42] | ||
| Compound Name |
N-Hydroxy-N-{1-(2-hydroxy-ethoxymethyl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309329; SCHEMBL7990013; BDBM50108163
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
(S)-2-{4'-[(5-Chloro-4-isopropoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL194430; SCHEMBL3609695; BDBM50173231
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 50000 nM
|
[43] | ||
| Compound Name |
N-[2-[4-[4-(Trifluoromethoxy)phenoxy]phenylsulfonyl]-1-[(R)-tetrahydrofuran-2-yl]ethyl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221178
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
N-Hydroxy-N-{4-morpholin-4-yl-4-oxo-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-butyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306585; SCHEMBL8002034; BDBM50108134
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[19] | ||
| Compound Name |
1-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-3-hydroxyurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41928; BDBM50100898; N-{2-[(4''-cyano-1,1''-biphenyl-4-yl)oxy]ethyl}-N''-hydroxyurea
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[26] | ||
| Matrix metalloproteinase 3 |
IC50 = 80000 nM
|
[90] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[26] | |||
| Matrix metalloproteinase 8 |
IC50 ~ 120000 nM
|
[90] | |||
| Compound Name |
Chembl4278980
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50466704
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 ~ 50000 nM
|
[44] | ||
| Compound Name |
(4R)-N-Hydroxy-3-naphthalen-2-ylsulfonyl-1,3-thiazolidine-4-carboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957599; BDBM50366201
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 50000 nM
|
[45] | ||
| Compound Name |
2-Benzyl-N-hydroxy-3-morpholino-3-oxopropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL117932; BDBM50062459; 2-Benzyl-N-hydroxy-3-morpholin-4-yl-3-oxo-propionamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 8 |
Ki = 50000 nM
|
[31] | ||
| Compound Name |
(4S)-5-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-[3-(4-phenylphenyl)propanoylamino]pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6867825; CHEMBL3675552; BDBM120201; US8691753, 50
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[46] | ||
| Compound Name |
Pentyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL252326; BDBM50227593
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 66000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 68000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 103000 nM
|
[33] | |||
| Compound Name |
(R)-2-Dodecyl-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL59722; BDBM50290450; (R)-2-Dodecyl-N*4*-hydroxy-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[38] | ||
| Compound Name |
N-Benzhydryl-2-[1-benzhydryl-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97454; BDBM50081801
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 50000 nM
|
[47] | ||
| Compound Name |
2-[(4-But-2-ynoxyphenyl)sulfonylamino]-3-(5-phenylmethoxy-1H-indol-3-yl)propanoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL463395; SCHEMBL3850968; BDBM50279287; 3-(5-(benzyloxy)-1H-indol-3-yl)-2-(4-(but-2-ynyloxy)phenylsulfonamido)propanoic acid; rac-2-(4-But-2-ynyloxy-benzenesulfonyl-amino)-3-(5-benzyloxy-1H-indol-3-yl)-propionic acid; 2-(4-BUT-2-YNYLOXY-BENZENESULFONYLAMINO)-3-(5-BENZYLOXY-1H-INDOL-3-YL)-PROPIONIC ACID
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[21] | ||
| Compound Name |
N-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-N-hydroxyformamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL36615; SCHEMBL6261290; BDBM50100904; N-[2-(4''-Cyano-biphenyl-4-yloxy)-ethyl]-N-hydroxy-formamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[26] | ||
| Compound Name |
4-{3-(Formyl-hydroxy-amino)-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78145; SCHEMBL8000432; BDBM50108143; 4-[3-[formyl(hydroxy)amino]-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylbutyl]benzoic acid
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
N-[1-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpropan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221179
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
1,5-Dimethyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL366956; SCHEMBL6810545; BDBM50099124; 1,5-Dimethyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione; 1,5-dimethyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
Click to Show/Hide
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 50000 nM
|
[6] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
trans-2-Aminocyclohexylcarbamoylphosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL270296; SCHEMBL4854279; BDBM50372742; ZINC29134636; [(1R,2R)-2-aminocyclohexyl]carbamoylphosphonic acid
Click to Show/Hide
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| Activity | Matrix metalloproteinase 8 |
IC50 = 50000 nM
|
[48] | ||
| Matrix metalloproteinase 13 |
IC50 = 55000 nM
|
[48] | |||
| Matrix metalloproteinase 1 |
IC50 = 90000 nM
|
[48] | |||
| Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[48] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[48] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2R,3R)-N-(2-(4-Benzylthiophen-2-yl)ethyl)-2,3-dihydroxy-4-oxo-4-(2-phenylpyrrolidin-1-yl)butanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602949; SCHEMBL8217850; BDBM50309154
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[35] | ||
| Matrix metalloproteinase 2 |
Ki ~ 50000 nM
|
[35] | |||
| Compound Name |
N-Hydroxy-N-[2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-1-[(4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethyl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2043424; BDBM50385607
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
N-Hydroxy-N-{3-hydroxy-2-hydroxymethyl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77874; SCHEMBL7673637; BDBM50108171
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
N-Hydroxy-N-{1-(tetrahydro-furan-2-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75114; BDBM50108147
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[19] | ||
| Compound Name |
Antibiotic A 26771B
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
A-26771B; UNII-QH19TJ89BL; QH19TJ89BL; A 26771B; CHEMBL1809124; A26771B; BRN 5309307; A-26771-B; SCHEMBL20510247; BDBM50468230; Q27287257; BUTANEDIOIC ACID, MONO(16-METHYL-2,5-DIOXOOXACYCLOHEXADEC-3-EN-6-YL) ESTER
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 = 50000 nM
|
[49] | ||
| Compound Name |
N-Hydroxy-N-{3-(4-methanesulfonyl-piperazin-1-yl)-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78052; SCHEMBL7990283; BDBM50108138
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[19] | ||
| Compound Name |
(2s)-6-[(4-Fluorobenzyl)amino]-2-[(2r)-2-(4-Fluorophenyl)-2-Methoxyethyl]-N-Hydroxyhexanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760318; SCHEMBL639348; BDBM50340758; Q27451207; (s)-6-(4-fluorobenzylamino)-2-((r)-2-(4-fluorophenyl)-2-methoxyethyl)-n-hydroxyhexanamide; (2S)-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
(2R)-2-[(Biphenyl-4-ylcarbonyl)amino]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49671; BDBM50063131; (R)-2-[(Biphenyl-4-carbonyl)-amino]-3-phenyl-propionic acid
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 50000 nM
|
[24] | ||
| Compound Name |
N-{2,3-Dihydroxy-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-N-hydroxy-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75164; BDBM50108151
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[25] | ||
| Compound Name |
5-Methyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-methyl-5-(4-phenoxyphenyl)barbituric acid; CHEMBL176467; 5-methyl-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-methyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione; SCHEMBL4321603; CTK0J1794; DTXSID10274336; BDBM50099118; DB03368; Q27094311; 5-Methyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-methyl-5-(4-phenoxyphenyl)-
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
Chembl4212208
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8229791; BDBM50455848
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[50] | ||
| Compound Name |
N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380397; BDBM50433870
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
Ki = 50000 nM
|
[32] | ||
| Matrix metalloproteinase 13 |
Ki = 100000 nM
|
[32] | |||
| Matrix metalloproteinase 9 |
Ki = 200000 nM
|
[32] | |||
| Compound Name |
(2r,3r)-4-[4-(2-Chlorophenyl)piperazin-1-Yl]-2,3-Dihydroxy-4-Oxo-N-(2-Thiophen-2-Ylethyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605764; SCHEMBL8216976; BDBM50309132; Q27454292
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[35] | ||
| Matrix metalloproteinase 7 |
Ki ~ 60000 nM
|
[35] | |||
| Matrix metalloproteinase 1 |
Ki ~ 90000 nM
|
[35] | |||
| Compound Name |
CID 10874819
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114138; SCHEMBL7429119; BDBM50024168
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[19] | ||
| Compound Name |
N-[(1S,2S)-2-Sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380393; BDBM50433874
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki ~ 50000 nM
|
[32] | ||
| Compound Name |
N-Hydroxy-N-{1-phenyl-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307915; SCHEMBL7673120; BDBM50108170; N-hydroxy-N-[1-phenyl-2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylethyl]formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
N-Hydroxy-N-[2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-1-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77907; SCHEMBL7676418; BDBM50108145
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
[(R)-2-Methyl-1-(4-phenethyl-benzenesulfonylamino)-propyl]-phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227553; BDBM50198032; ZINC28640034
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 50000 nM
|
[51] | ||
| Compound Name |
Morpholin-4-ylcarbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97838; BDBM50146803
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-Hydroxy-N-{1-pyridin-2-yl-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73928; BDBM50108155; N-[2-[4-[4-(Trifluoromethoxy)phenoxy]phenylsulfonyl]-1-(2-pyridyl)ethyl]-N-hydroxyformamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[19] | ||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251426; BDBM50227601
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 50000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 52000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 75000 nM
|
[33] | |||
| Compound Name |
(2S)-2-[(2R)-2-(4-Fluorophenyl)-2-methoxyethyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012838; BDBM50379533
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | ||
| Compound Name |
N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380404
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[32] | ||
| Matrix metalloproteinase 14 |
Ki = 85000 nM
|
[32] | |||
| Matrix metalloproteinase 3 |
Ki ~ 100000 nM
|
[32] | |||
| Matrix metalloproteinase 7 |
Ki ~ 100000 nM
|
[32] | |||
| Compound Name |
(2R,3R)-N-(Benzofuran-2-ylmethyl)-2,3-dihydroxy-4-oxo-4-(2-phenylpyrrolidin-1-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591774; SCHEMBL8219481; BDBM50309153
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki ~ 50000 nM
|
[35] | ||
| Compound Name |
5-Methyl-5-(4-octyloxy-benzyl)-pyrimidine-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177077; BDBM50099117; 5-Methyl-5-[4-(octyloxy)benzyl]hexahydropyrimidine-2,4,6-trione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
(Isopropylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97034; Isopropylcarbamoylphosphonic Acid; BDBM50146799
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 50000 nM
|
[27] | ||
| Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[27] | |||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(Ethylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94348; Ethylcarbamoylphosphonic Acid; SCHEMBL11569435; BDBM50146811
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[27] | ||
| Matrix metalloproteinase 3 |
IC50 = 100000 nM
|
[27] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012836; BDBM50379536
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
(2S)-2-[[5-(Dimethylamino)naphthalen-1-yl]sulfonylamino]-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142608
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 50000 nM
|
[52] | ||
| Matrix metalloproteinase 1 |
Ki = 87000 nM
|
[52] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760322; BDBM50340768
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki ~ 50000 nM
|
[34] | ||
| Matrix metalloproteinase 14 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 3 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[34] | |||
| Matrix metalloproteinase 1 |
Ki ~ 50000 nM
|
[34] | |||
| Compound Name |
(4R)-3-[4-(4-Fluorophenoxy)phenyl]sulfonyl-N-hydroxy-1,3-thiazolidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957603; BDBM50366205
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 50000 nM
|
[45] | ||
| Compound Name |
(4S)-5-Amino-4-[[(2S)-3-(1H-imidazol-5-yl)-2-[3-[4-(4-phenylphenyl)phenyl]propanoylamino]propanoyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6869254; CHEMBL3675578; BDBM120228; US8691753, 77
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 50000 nM
|
[46] | ||
| Compound Name |
2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44898; SCHEMBL7870635; BDBM50084304; ZINC13803841; (4''-Bromo-biphenyl-4-sulfonylamino)-acetic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50000 nM
|
[53] | ||
| Matrix metalloproteinase 7 |
IC50 = 77000 nM
|
[53] | |||
| Compound Name |
N-Methyl-4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796282; BDBM50418815
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 50118.72 nM
|
[54] | ||
| Compound Name |
N-(Cyclohexylmethyl)-4-(4-methylphenoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796284; BDBM50418814
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 50118.72 nM
|
[54] | ||
| Compound Name |
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000755676; SMR000337350; 4-(4-methylphenoxy)-N-[(pyridin-4-yl)methyl]benzamide; 4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide; CHEMBL1427458; BDBM46421; cid_4358655; HMS2618P15; KS-00003O5G; ZINC4054502; AKOS005107358; MCULE-5269053313; MS-1279; 4-(4-methylphenoxy)-N-(4-pyridylmethyl)benzamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 50118.72 nM
|
[54] | ||
| Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[54] | |||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[54] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
Secoisolariciresinol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(-)-Secoisolariciresinol; UNII-M8QRJ7JEJH; CCRIS 7790; M8QRJ7JEJH; EINECS 249-599-2; (2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol; CHEMBL368347; (2R,3R)-2,3-bis(4-hydroxy-3-methoxybenzyl)butane-1,4-diol; (R-(R*,R*))-2,3-Bis((4-hydroxy-3-methoxyphenyl)methyl)butane-1,4-diol; RR-secoisolariciresinol; (-) secoisolariciresinol; (+/-)-Secoisolariciresinol; 8R,8'R-secoisolariciresinol; MLS001424213; SCHEMBL12427083; CTK4C5737; DTXSID50183615; HMS2052G03; HMS2232J05; (2R*,3R*)-2,3-Bis(4-hydroxy-3-methoxybenzyl)-1,4-butanediol; HY-N6071; ZINC2020114; BDBM50240914; MFCD01075136; AKOS032948353; CCG-101074; DB12179; NC00324; NCGC00346838-01; Secoisolariciresinol, >=95.0% (HPLC); SMR000469212; LS-185231; CS-0032316; C18167; Q-100372; Q4413253; 2,3-Bis(4-hydroxy-3-methoxybenzyl)-1,4-butanediol, (-); (2R,3R)-2,3-bis[(4-hydroxy-3-methoxy-phenyl)methyl]butane-1,4-diol
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 50120 nM
|
[55] | ||
| Compound Name |
5-(4-(Benzofuran-2-yl)phenyl)-3-hydroxypentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574444; BDBM50300480
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 50200 nM
|
[9] | ||
| Compound Name |
(R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-methyl-N-(pyridin-2-ylmethyl)-1,2,4-oxadiazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482341; SCHEMBL6429969; BDBM50256096
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 50500 nM
|
[11] | ||
| Compound Name |
N6-[(Benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483320; BDBM50271856
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 50500 nM
|
[56] | ||
| Compound Name |
N-Butyl-2-[1-[2-(4-fluoro-phenyl)-ethyl]-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95560; BDBM50081788
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 51000 nM
|
[47] | ||
| Compound Name |
3-(4-(2-Oxo-2H-chromen-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927183; ZINC2957866; BDBM50359721; AKOS024602290; MCULE-4659831116; F0920-6501
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 51000 nM
|
[57] | ||
| Matrix metalloproteinase 2 |
IC50 = 67000 nM
|
[57] | |||
| Matrix metalloproteinase 3 |
IC50 = 110000 nM
|
[57] | |||
| Compound Name |
2-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399685; BDBM50227554
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 51000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 68000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 69000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 81000 nM
|
[33] | |||
| Compound Name |
Cyclobutyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251937; BDBM50227567
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 51000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 62000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 66000 nM
|
[33] | |||
| Compound Name |
N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576762; BDBM50299066
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 51000 nM
|
[7] | ||
| Matrix metalloproteinase 3 |
IC50 = 60000 nM
|
[7] | |||
| Matrix metalloproteinase 16 |
IC50 = 110000 nM
|
[7] | |||
| Matrix metalloproteinase 14 |
IC50 = 120000 nM
|
[7] | |||
| Compound Name |
5-Pyridin-3-yl-1H-indole-2-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939869; SCHEMBL15642502; BDBM50361627; DB-124065; ethyl 5-pyridin-3-yl-1H-indole-2-carboxylate; 5-(pyridin-3-yl)-1H-indole-2-carboxylic acid ethyl ester
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 51000 nM
|
[58] | ||
| Compound Name |
N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431021; BDBM50441215
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 51000 nM
|
[59] | ||
| Matrix metalloproteinase 14 |
IC50 = 113000 nM
|
[59] | |||
| Compound Name |
(+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]propionic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL579068; BDBM50299067
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 51000 nM
|
[7] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4215930
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456795
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 51600 nM
|
[60] | ||
| Compound Name |
Chembl4218730
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456797
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 51900 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 = 55100 nM
|
[60] | |||
| Compound Name |
N-[3,3-Dimethyl-1-oxo-1-(1-phenylethylamino)butan-2-yl]-N'-hydroxy-2-[3-[4-phenyl-3-(trifluoromethyl)phenyl]propyl]butanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828582; BDBM50187412
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 51999.6 nM
|
[61] | ||
| Compound Name |
4-Phenylbutyl[1-(4-phenylbutyl)-3-(4-phenoxyphenyl)ureidoacetyl]aminoacetohydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316884; BDBM50081780
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 52000 nM
|
[47] | ||
| Compound Name |
[(4-Bromophenyl)sulfonyl-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3291004; BDBM50018629; ZINC169351253
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 52000 nM
|
[62] | ||
| Compound Name |
(S)-3-Benzyloxy-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403340; SCHEMBL6954663; BDBM50241378
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 52000 nM
|
[63] | ||
| Compound Name |
[4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl] N-propylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2442879; BDBM50442358
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 52000 nM
|
[64] | ||
| Compound Name |
(S)-2-Tert-Butoxycarbonylamino-3-[1-(2,4,6-trimethyl-benzenesulfonyl)-1H-indol-3-yl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65017; Boc-Trp(Mts)-OH; ZINC2539210; BDBM50043806; N-alpha-(t-Butoxycarbonyl)-1-(2-mesitylenesulfonyl)-L-tryptophan
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 52000 nM
|
[65] | ||
| Compound Name |
(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4-dihydroxy-5-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556277; BDBM50296240
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 52000 nM
|
[66] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
(2R)-N-[(2S)-3,3-Dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-[3-[4-phenyl-3-(trifluoromethyl)phenyl]propyl]butanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345305; BDBM50097269
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 52000 nM
|
[67] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2R)-2-Aminopropanoyl]amino]-3-phenylpropanoyl]amino]-4-methyl-N-phenylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434624; BDBM50043595
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 52100 nM
|
[68] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
Chembl4210975
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456781
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 52100 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 54600 nM
|
[60] | |||
| Compound Name |
(R)-5-(4-Chlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489826; BDBM50267918
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 52300 nM
|
[69] | ||
| Compound Name |
Ethyl 2-benzyl-3-(hydroxyamino)-3-oxopropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418619; BDBM50062473; 2-Benzyl-N-hydroxy-malonamic acid ethyl ester
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 52480.75 nM
|
[70] | ||
| Compound Name |
Chembl4211708
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456798
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 52500 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 56200 nM
|
[60] | |||
| Compound Name |
Chembl4206886
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456777
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 52500 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 53600 nM
|
[60] | |||
| Compound Name |
(2S)-N-[(2S,3S)-2-Amino-3-hydroxy-3-(4-iodophenyl)propyl]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819450; BDBM50351046
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 52700 nM
|
[71] | ||
| Compound Name |
(R)-5-(4-Chloro-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL514379; BDBM50267320
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 52800 nM
|
[69] | ||
| Compound Name |
Chembl4211700
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456782
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 52800 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 = 90200 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(tetrahydro-pyran-4-ylidenemethyl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99045; SCHEMBL3881836; BDBM50146477
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 53000 nM
|
[41] | ||
| Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[41] | |||
| Compound Name |
(2S)-2-(Naphthalen-2-ylsulfonylamino)-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142591
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 53000 nM
|
[52] | ||
| Matrix metalloproteinase 1 |
Ki = 72000 nM
|
[52] | |||
| Compound Name |
2-(2,5-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104863; BDBM50037061; 2-(2,5-Dimethoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 10 |
IC50 = 53000 nM
|
[72] | ||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(4-oxo-cyclohexylmethyl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99365; SCHEMBL3883225; BDBM50146467
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 53000 nM
|
[41] | ||
| Compound Name |
(2E)-3-(N-Hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401445; BDBM50213419
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 53100 nM
|
[73] | ||
| Compound Name |
Procyanidin C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Procyanidol C1; Proanthocyanidin C1; Cinnamtannin A1; Procyanidin C-1; UNII-33516LCW4F; Procyanidin trimer C1; CHEMBL290632; 33516LCW4F; [Epicatechin(4b->8)]2-epicatechin; [Epicatechin-(4beta->8)]2-epicatechin; EC-(4b,8)-EC-(4b,8)-EC; Epicatechin-(4beta->8)-epicatechin-(4beta->8)-epicatechin; Proanthocyanidin C1;; SCHEMBL678609; CTK4H7642; DTXSID10190562; HY-N2342; BDBM50240460; ZINC96095372; ACN-053267; CS-0021304; C17624; Q7247556; epicatechin-(4beta-8)-epicatechin-(4beta-8)-epicatechin; Epicatechin-(4.beta.-->8)epicatechin-(4.beta.-->8)epicatechin
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 53200 nM
|
[74] | ||
| Compound Name |
3-[({2-[4-({[(4s)-4-Methyl-2,5-Dioxoimidazolidin-4-Yl]methyl}sulfonyl)piperazin-1-Yl]pyrimidin-5-Yl}oxy)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409696; 4jpa; AZ6; BDBM50437765; Q27458135
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 53584 nM
|
[75] | ||
| Compound Name |
Chembl4206592
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457771
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 53670 nM
|
[76] | ||
| Matrix metalloproteinase 3 |
IC50 = 87770 nM
|
[76] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-2-[(E)-3-phenylprop-2-enoyl]oxypropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333261; BDBM50429259
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 53700 nM
|
[77] | ||
| Compound Name |
(R)-2-(N-Isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575881; BDBM50299057; ZINC45289527
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 54000 nM
|
[7] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-Sec-Butyl-2-[1-butyl-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420447; BDBM50081783
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 54000 nM
|
[47] | ||
| Compound Name |
Chembl4208066
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457773
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 54180 nM
|
[76] | ||
| Matrix metalloproteinase 3 |
IC50 = 66120 nM
|
[76] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[76] | |||
| Compound Name |
3-Acetoxy-5-(biphenyl-4-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574445; SCHEMBL5694346; BDBM50300477; 3-acetyloxy-5-(4-phenylphenyl)pentanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 54400 nM
|
[9] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 98000 nM
|
[9] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
(R)-5-(4-Bromophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523279; BDBM50267919
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 54400 nM
|
[69] | ||
| Compound Name |
6-(4-Chloro-phenyl)-3-{2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420376; BDBM50101525
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 54954.09 nM
|
[70] | ||
| Compound Name |
N-[(2S,4S)-1-[4-[2-(2,5-Dimethylpyridin-3-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683459; BDBM50337737
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 55000 nM
|
[78] | ||
| Compound Name |
N*1*-Benzyl-2-(2-hydroxycarbamoyl-4-methyl-pentanoylamino)-succinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324522; BDBM50062472
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 55000 nM
|
[31] | ||
| Compound Name |
3-[2-Cyclohexyl-1-(4-morpholin-4-yl-butylcarbamoyl)-ethylcarbamoyl]-6-p-tolyl-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307027; BDBM50101500; (R)-3-[(S)-2-Cyclohexyl-1-(4-morpholin-4-yl-butylcarbamoyl)-ethylcarbamoyl]-6-p-tolyl-hexanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 55000 nM
|
[79] | ||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(tetrahydro-thiopyran-4-ylidenemethyl)-ethyl]-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98202; SCHEMBL3881504; BDBM50146475
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 55000 nM
|
[41] | ||
| Compound Name |
2-[2-[(E)-(5-Oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927185; BDBM50359723
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 55000 nM
|
[57] | ||
| Matrix metalloproteinase 2 |
IC50 = 61000 nM
|
[57] | |||
| Matrix metalloproteinase 13 |
IC50 = 67000 nM
|
[57] | |||
| Matrix metalloproteinase 3 |
IC50 = 77000 nM
|
[57] | |||
| Matrix metalloproteinase 1 |
IC50 = 114000 nM
|
[57] | |||
| Compound Name |
2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585376; BDBM50299069
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 55000 nM
|
[7] | ||
| Matrix metalloproteinase 2 |
IC50 = 58000 nM
|
[7] | |||
| Matrix metalloproteinase 8 |
IC50 = 74000 nM
|
[7] | |||
| Matrix metalloproteinase 14 |
IC50 = 77000 nM
|
[7] | |||
| Matrix metalloproteinase 12 |
IC50 = 89000 nM
|
[7] | |||
| Matrix metalloproteinase 16 |
IC50 = 93000 nM
|
[7] | |||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[7] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[7] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S,4R)-4-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-2-methyl-6-phenyl-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL51407; BDBM50289669
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 55000 nM
|
[80] | ||
| Compound Name |
4-Cyano-N-(2-piperidin-1-yl-phenyl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97612; BDBM50283774; AKOS008412051
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 55000 nM
|
[81] | ||
| Compound Name |
[[4-(4-Chlorophenoxy)anilino]-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440431; BDBM50442509
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 55000 nM
|
[1] | ||
| Matrix metalloproteinase 14 |
IC50 = 76000 nM
|
[1] | |||
| Compound Name |
(5Z)-5-(3-Phenoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL161669; SCHEMBL8308267; ZINC2779401; STK899182; AKOS001112966; 2-Thioxo-5-(3-phenoxybenzylidene)thiazolidine-4-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 55270 nM
|
[82] | ||
| Compound Name |
(4R)-5-Oxo-5-[4-(1,3-thiazol-2-ylsulfamoyl)anilino]-4-[(3,4,5-trimethoxybenzoyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486063; BDBM50267841
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 55300 nM
|
[69] | ||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(4-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL410649; BDBM50359896
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 55880 nM
|
[83] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[83] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(3-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261267; BDBM50359895
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 55880 nM
|
[83] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[83] | |||
| Compound Name |
5-[5-[(4-Carboxyphenyl)methylcarbamoyl]-2-methylpyrazol-3-yl]-1H-indole-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939879; SCHEMBL1313634; BDBM50361636
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 56000 nM
|
[58] | ||
| Compound Name |
(2R)-3-(1-Benzothiophen-3-yl)-2-[[5-[2-(4-butylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795860; BDBM50346801
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 56000 nM
|
[84] | ||
| Compound Name |
2,4,5-Trifluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398450; BDBM50227548
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 56000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 67000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 86000 nM
|
[33] | |||
| Compound Name |
Thiophen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254039; BDBM50227537
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 56000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 65000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 70000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 73000 nM
|
[33] | |||
| Compound Name |
(2S)-2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43276; SCHEMBL4422490; BDBM50084284; 2-(4''-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-propionic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 56000 nM
|
[53] | ||
| Matrix metalloproteinase 7 |
IC50 = 100000 nM
|
[53] | |||
| Compound Name |
4-Benzylsulfanyl-2-(4''-bromo-biphenyl-4-sulfonylamino)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295871; BDBM50084298
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 56000 nM
|
[53] | ||
| Compound Name |
Chembl4203717
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456771
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 56100 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 57800 nM
|
[60] | |||
| Compound Name |
(2S)-2-[[2-(3-Methyl-2-oxoquinoxalin-1-yl)acetyl]amino]-3-phenyl-N-propylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603452; BDBM50306923; (S)-2-(2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)acetamido)-3-phenyl-N-propylpropan-amide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 56600 nM
|
[85] | ||
| Compound Name |
4-(4,5-Dibromo-1H-pyrrol-2-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394362; BDBM50215934
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 56900 nM
|
[86] | ||
| Compound Name |
2-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254239; BDBM50227569
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 57000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 59000 nM
|
[33] | |||
| Compound Name |
3-[2-Cyclohexyl-1-(2-methoxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-6-phenyl-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78047; BDBM50101507; (R)-3-[(S)-2-Cyclohexyl-1-(2-methoxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-6-phenyl-hexanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 57543.99 nM
|
[70] | ||
| Compound Name |
(S)-3-Methyl-2-(8-(thiazol-2-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1935291; SCHEMBL3081114; BDBM50360969; (2S)-3-methyl-2-[[8-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 57700 nM
|
[87] | ||
| Compound Name |
Hydroxamate deriv., 78
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BMCL1954 Compound 3; CHEMBL269834; SCHEMBL8357412; BDBM23487
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 58000 nM
|
[88] | ||
| Matrix metalloproteinase 7 |
Ki = 110000 nM
|
[88] | |||
| Compound Name |
(2R,3Ar,7aR)-1-[2-[[4-[[4-chloro-3-[[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylacetyl]sulfamoyl]benzoyl]sulfamoyl]benzoyl]amino]-3-methylbutanoyl]-N-(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265769; BDBM50058473
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 58000 nM
|
[89] | ||
| Compound Name |
N-[1-(4'-Cyano-4-biphenylyloxymethyl)-2-(2,5-dioxo-3,4,4-trimethylimidazolidine-1-yl)ethyl]formhydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288067; SCHEMBL7505333; BDBM50100902
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 58000 nM
|
[26] | ||
| Compound Name |
N-{2-[(4'-Cyano-1,1'-biphenyl-4-YL)oxy]ethyl}-N'-hydroxy-N-methylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200435; BDBM50175780; DB06971; Q27095882; 1-{2-[(4'-cyanobiphenyl-4-yl)oxy]ethyl}-3-hydroxy-1-methylurea; N-{2-[(4''-cyano-1,1''-biphenyl-4-yl)oxy]ethyl}-N''-hydroxy-N-methylurea
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 58000 nM
|
[90] | ||
| Matrix metalloproteinase 3 |
IC50 = 200000 nM
|
[90] | |||
| Compound Name |
(S)-2-(2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)acetamido)-N,3-diphenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604328; BDBM50306912
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 58140 nM
|
[85] | ||
| Compound Name |
2,6-Dichloro-N'-[2-(3-methyl-2-oxo-quinoxalin-1-yl)acetyl]benzohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775574; BDBM50155279
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 58220 nM
|
[91] | ||
| Compound Name |
Chembl4202989
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456792
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 58300 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 82600 nM
|
[60] | |||
| Matrix metalloproteinase 8 |
IC50 = 84000 nM
|
[60] | |||
| Compound Name |
2-(5-(4-(Benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185623; (Z)-2-(5-(4-(benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid; ClpP inhibitor M21; SCHEMBL1060503; SCHEMBL19736228; ZINC1238457; BDBM50149769; SBB043566; AKOS000274250; ACN-052899; ST50197389; J3.517.004I; 2-Thioxo-4-oxo-5-(4-(benzyloxy)benzylidene)thiazolidine-3-acetic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 58500 nM
|
[82] | ||
| Compound Name |
Schembl22225166
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048503
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 58810 nM
|
[55] | ||
| Matrix metalloproteinase 2 |
IC50 = 64190 nM
|
[55] | |||
| Compound Name |
N-(4'-Cyano-1,1'-biphenyl-4-ylsulfonyl)valine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45040; 2-(4''-Cyano-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; SCHEMBL7403535; BDBM50084287; (S)-2-(4''-cyano-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(4-cyanophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 58884.37 nM
|
[70] | ||
| Compound Name |
2-Phenoxyethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438519; BDBM50227595
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 59000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 79000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 127000 nM
|
[33] | |||
| Compound Name |
N-Hydroxy-2-nitrobenzene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Hydroxy-2-nitrobenzenesulfonamide; Hydroxysulfonamide 61; CHEMBL121501; SCHEMBL8224048; BDBM11380; CTK0J7177; DTXSID60635312; MFCD18072514; ZINC13813802; Benzenesulfonamide, N-hydroxy-2-nitro-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 59000 nM
|
[92] | ||
| Compound Name |
N-Hydroxy-2-(N-isopropoxy-4-phenoxyphenylsulfonamido)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561038; BDBM50294126
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 59000 nM
|
[93] | ||
| Compound Name |
Chembl4203061
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456794
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 59700 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 = 92100 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
(S,E)-5-(4-Chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516281; BDBM50267340
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 59900 nM
|
[94] | ||
| Compound Name |
5-[2-[4-(3-Chlorophenyl)phenyl]-2-oxoethyl]-5-hydroxy-1,3-diazinane-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2151353; BDBM50392684
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[95] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-Aminopropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265583; BDBM50043599
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 60000 nM
|
[68] | ||
| Compound Name |
2,6-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253375; BDBM50227604
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 60000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 60000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 66000 nM
|
[33] | |||
| Compound Name |
(2S)-N-[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135857; BDBM50043579
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 60000 nM
|
[68] | ||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2R)-2-Aminopropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methyl-N-[(1R)-1-phenylethyl]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132816; BDBM50043602
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 60000 nM
|
[68] | ||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-L-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501715; BDBM50272134
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[96] | ||
| Matrix metalloproteinase 8 |
IC50 = 70000 nM
|
[96] | |||
| Compound Name |
N-Heptyl-N-hydroxycarbamoylmethyl-2-[1-pentyl-3-(4-phenoxy-phenyl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94873; BDBM50081797
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[47] | ||
| Compound Name |
(2S)-2-(Dibenzothiophen-2-ylsulfonylamino)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551190; BDBM50295481; (S)-2-(Dibenzo[b,d]thiophene-2-sulfonamido)-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 60000 nM
|
[97] | ||
| Compound Name |
N-Hydroxy-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzenesulfonamide, N-hydroxy-4-methyl-; N-hydroxy-4-methylbenzene-1-sulfonamide; tosylhydroxylamine; N-Tosylhydroxylamine; N-hydroxy-4-methyl-benzenesulfonamide; Hydroxysulfonamide 58; ACMC-209djs; p-tolyl-N-hydroxysulfonamide; N-hydroxy-4-toluenesulfonamide; CHEMBL121559; SCHEMBL1832454; BDBM11377; CTK8B0907; DTXSID10435263; ANW-21830; MFCD11850835; ZINC13813791; AKOS015888649; MCULE-3823003338; SC-50302; DB-064280; CS-0068832; FT-0760726; V3581; A-3307
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 60000 nM
|
[92] | ||
| Matrix metalloproteinase 8 |
Ki = 64000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki = 65000 nM
|
[92] | |||
| Matrix metalloproteinase 2 |
Ki = 77000 nM
|
[92] | |||
| Compound Name |
(S)-2-{4'-[(5-Iodo-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199241; SCHEMBL3606939; BDBM50173218
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 60000 nM
|
[43] | ||
| Compound Name |
N-Hydroxycarbamoylmethyl-2-[3-(4-phenoxy-phenyl)-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-ureido]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97408; BDBM50081796
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[47] | ||
| Compound Name |
(2R)-2-Amino-N-[(2S)-1-[[(2S)-1-(benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339191; BDBM50043597
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 60000 nM
|
[68] | ||
| Compound Name |
Ethyl 5-carbamoyl-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ethyl 5-carbamoylindole-2-carboxylate; CHEMBL1939862; SCHEMBL6517054; BDBM50361620; ZINC45287075; AKOS032960944; 5-Cabamoyl-2-indole carboxylic acid ethyl ester; Q27455014
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 60000 nM
|
[58] | ||
| Compound Name |
5-(Benzothiazol-2-ylazamethylene)-1-(4-sulfophenyl)-2-pyrazoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438832; AKOS024277864; ST019413
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 60100 nM
|
[98] | ||
| Compound Name |
(2S)-2-Amino-N-[(3S)-1-[2-(3-chloroanilino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214543; BDBM50323938; (2S)-2-Amino-N-(1-(2-(3-chlorophenylamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 60400 nM
|
[99] | ||
| Compound Name |
1-Cinnamyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249249; BDBM50227597
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 61000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 149000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]carbonyl}-1,2,4-oxadiazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439012; SCHEMBL6178395; BDBM50216817
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 61000 nM
|
[28] | ||
| Matrix metalloproteinase 3 |
IC50 = 76000 nM
|
[28] | |||
| Matrix metalloproteinase 2 |
IC50 = 92000 nM
|
[28] | |||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[28] | |||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[28] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-Hydroxy-2-[4-(3-fluorobenzyloxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431016; BDBM50441223
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 61000 nM
|
[59] | ||
| Compound Name |
N-[4-[[4-[2-(2,5-Dimethylpyridin-4-yl)ethyl]piperidin-1-yl]sulfonylmethyl]oxan-4-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784338; BDBM50345513
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 61000 nM
|
[100] | ||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[100] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
[(Naphthalen-1-ylamino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440429; SCHEMBL8333842; BDBM50442507
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 61000 nM
|
[1] | ||
| Matrix metalloproteinase 14 |
IC50 = 69000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-3-(4-hydroxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819325; BDBM50351026
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 61300 nM
|
[71] | ||
| Compound Name |
2-(2,4-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104611; BDBM50037075; 2-(2,4-Dimethoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 10 |
IC50 = 62000 nM
|
[72] | ||
| Compound Name |
Thiophen-3-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398838; BDBM50227596
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 62000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 65000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 67000 nM
|
[33] | |||
| Compound Name |
(2S)-2-Amino-N-[(3S)-1-[2-(2-fluoroanilino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214544; BDBM50323939; (2S)-2-Amino-N-(1-(2-(2-fluorophenylamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 62700 nM
|
[99] | ||
| Compound Name |
5-Hydroxy-5-[2-(4-nitrophenyl)-2-oxoethyl]-1,3-diazinane-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2151351; BDBM50392698
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 63000 nM
|
[95] | ||
| Compound Name |
(1R,2R,5S)-2-[(2,4-Dioxopyrido[1,2-a][1,3,5]triazin-3-yl)methyl]-5-[4-(4-methylsulfanylphenyl)phenyl]sulfanylcyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339610; BDBM50131955
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 63000 nM
|
[37] | ||
| Compound Name |
4-Phenoxybutyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254610; BDBM50227602
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 63000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 78000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 83000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 138000 nM
|
[33] | |||
| Compound Name |
Perfluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253820; BDBM50227562
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 63000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 64000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 69000 nM
|
[33] | |||
| Compound Name |
(4S,5S)-4-Phenylsulfanyl-2-p-tolyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184472; BDBM50152630
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 64000 nM
|
[101] | ||
| Compound Name |
5-Chloro-N-[[(4S)-4-(2-methylpyrazol-3-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358157; BDBM50033807
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 64000 nM
|
[23] | ||
| Compound Name |
[4-(Trifluoromethyl)phenyl]methyl 6-oxo-1H-pyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162966; BDBM50371234
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 64000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 101000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 112000 nM
|
[33] | |||
| Compound Name |
N-(4'-Fluoro-1,1'-biphenyl-4-ylsulfonyl)valine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418442; SCHEMBL7406959; BDBM50084301; 2-(4''-Fluoro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (S)-2-(4''-fluoro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(4-fluorophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 64000 nM
|
[51] | ||
| Compound Name |
2-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253373; BDBM50227552
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 64000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 68000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 71000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 76000 nM
|
[33] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(2-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407151; BDBM50359894
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 64000 nM
|
[83] | ||
| Compound Name |
N-[(E)-(4-Dimethylaminophenyl)methyleneamino]-2-(3-methyl-2-oxo-quinoxalin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775617; BDBM50155289
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 64300 nM
|
[91] | ||
| Compound Name |
(S,E)-5-(2-Chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476639; BDBM50267465
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 64300 nM
|
[94] | ||
| Compound Name |
Chembl4212449
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456788
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 64500 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 66600 nM
|
[60] | |||
| Compound Name |
4-Bromo-N-hydroxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
p-Bromo-N-hydroxybenzenesulfonamide; Benzenesulfonamide, p-bromo-N-hydroxy-; 4-bromo-N-hydroxybenzene-1-sulfonamide; N-(p-bromobenzenesulfonyl)hydroxylamine; BRN 2645335; Hydroxysulfonamide 56; p-Bromobenzenesulfonhydroxamide; CHEMBL123404; SCHEMBL8229526; BDBM11375; CTK8H4740; DTXSID90941675; N-Hydroxy-p-bromobenzenesulfonamide; ZINC6093148; 4-Bromo-N-hydroxybenzenesulfonamide #
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
Ki = 65000 nM
|
[92] | ||
| Matrix metalloproteinase 9 |
Ki = 66000 nM
|
[92] | |||
| Matrix metalloproteinase 8 |
Ki = 69000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki = 71000 nM
|
[92] | |||
| Compound Name |
4-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253374; BDBM50227557
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 65000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 71000 nM
|
[33] | |||
| Compound Name |
4-[[6-(3-Morpholin-4-ylprop-1-ynyl)-4-oxoquinazolin-3-yl]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL273114; SCHEMBL6833710; BDBM50372634
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 65000 nM
|
[102] | ||
| Compound Name |
((4S,5S)-2-Phenylethynyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364783; BDBM50152644
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 65000 nM
|
[101] | ||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(4-chlorophenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263909; BDBM50359899
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 65000 nM
|
[83] | ||
| Compound Name |
(2S)-2-[[4-(3-Fluorophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539683; SCHEMBL7404221; BDBM50084292; 2-(3''-Fluoro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 65000 nM
|
[53] | ||
| Compound Name |
Benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399070; SCHEMBL20083642; BDBM50227551; benzyl 6-oxo-1H-pyridine-2-carboxylate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 65000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 69000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 69000 nM
|
[33] | |||
| Compound Name |
6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid 4-methyl-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253801; BDBM50227586
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 65000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 68000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 69000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 73000 nM
|
[33] | |||
| Compound Name |
2,6-Difluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250058; BDBM50227531
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 66000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 92000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 101000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 127000 nM
|
[33] | |||
| Compound Name |
(Hydroxyamino)(4-iodophenyl)sulfone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 57; CHEMBL120934; SCHEMBL8229583; BDBM11376; ZINC5570003; AKOS024355469; N-hydroxy-4-iodobenzene-1-sulfonamide; MCULE-2099459518; ST50982751
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 66000 nM
|
[92] | ||
| Matrix metalloproteinase 9 |
Ki = 69000 nM
|
[92] | |||
| Matrix metalloproteinase 8 |
Ki = 71000 nM
|
[92] | |||
| Matrix metalloproteinase 2 |
Ki = 72000 nM
|
[92] | |||
| Compound Name |
(R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-YL)hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UK 370106; UK-370106; CHEMBL250266; SCHEMBL6449140; C35H44N2O5; ZINC3916209; 1503AB; BDBM50227718; AKOS016004936; HY-107639; CS-0029038; J-014984
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 66900 nM
|
[8] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[123] | |||
| Compound Name |
3-{1-[(Methoxy-phenyl-methyl)-carbamoyl]-2,2-dimethyl-propylcarbamoyl}-6-(2-methyl-biphenyl-4-yl)-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115460; BDBM50131663
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 66900 nM
|
[103] | ||
| Compound Name |
(S)-3-Cyclohexyl-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398703; SCHEMBL6958038; BDBM50241374; (2S)-3-cyclohexyl-N-methyl-2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)carbamoylamino]propanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 67000 nM
|
[63] | ||
| Compound Name |
3-Methylbut-2-enyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254627; BDBM50227565
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 67000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 69000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 72000 nM
|
[33] | |||
| Compound Name |
4-Phenoxybutyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253372; BDBM50227559
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 67000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 82000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 90000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 94000 nM
|
[33] | |||
| Compound Name |
(1S,2R,5S)-2-[4-(4-Chlorophenyl)phenyl]sulfanyl-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339588; SCHEMBL7223120; BDBM50131953
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 67000 nM
|
[37] | ||
| Compound Name |
3-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253823; BDBM50227589
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 67000 nM
|
[33] | ||
| Compound Name |
Isopropyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445939; BDBM50227603
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 67000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 67000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 67000 nM
|
[33] | |||
| Compound Name |
3-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254240; BDBM50227564
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 67000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 68000 nM
|
[33] | |||
| Compound Name |
2-[(4'-Fluorobiphenyl-4-yl)sulfonyl]benzeneacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326364; BDBM50427870
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 67000 nM
|
[104] | ||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(2-chlorophenyl)methyl]-2-phenoxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL481894; Oprea1_120906; SCHEMBL1813190; BDBM50256157; N-((5-chloro-8-hydroxyquinolin-7-yl)(2-chlorophenyl)methyl)-2-phenoxyacetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 67000 nM
|
[105] | ||
| Compound Name |
N-[(E)-Benzylideneamino]-2-(3-methyl-2-oxo-quinoxalin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775452; BDBM50155286
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 67010 nM
|
[91] | ||
| Compound Name |
(2R)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819324; BDBM50351025
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 67400 nM
|
[71] | ||
| Compound Name |
Methyl (2S)-2-benzamido-3-(4-phenylmethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147932; BDBM50391633
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 67500 nM
|
[106] | ||
| Compound Name |
((4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184058; BDBM50152657
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 68000 nM
|
[101] | ||
| Compound Name |
Phenethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255051; BDBM50227541
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 68000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 69000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 81000 nM
|
[33] | |||
| Compound Name |
3-Phenoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254038; BDBM50227574
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 68000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 118000 nM
|
[33] | |||
| Compound Name |
4-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254238; BDBM50227571
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 68000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 69000 nM
|
[33] | |||
| Compound Name |
Benzyl N-[(4R)-4-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431027; BDBM50441213
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 68000 nM
|
[20] | ||
| Matrix metalloproteinase 1 |
IC50 = 370000 nM
|
[20] | |||
| Compound Name |
(2S)-2-[(7,7-Dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methylsulfonylamino]-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142612
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 69000 nM
|
[52] | ||
| Compound Name |
1-(4-Methoxy-phenyl)-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40041; BDBM50076340; N-[(5-Thioxo-4,5-dihydro-1,3,4-thiadiazole)-2-yl]-N'-(4-methoxyphenyl)urea
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 69000 nM
|
[63] | ||
| Compound Name |
N-[[(4S)-4-(1-Methylimidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-5-(trifluoromethyl)-1-benzofuran-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358158; BDBM50033808
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 69000 nM
|
[23] | ||
| Matrix metalloproteinase 14 |
IC50 = 86000 nM
|
[23] | |||
| Compound Name |
3-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252965; BDBM50227578
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 69000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 69000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 70000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 88000 nM
|
[33] | |||
| Compound Name |
3,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399684; BDBM50227534
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 69000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 71000 nM
|
[33] | |||
| Compound Name |
N-[(2S,4S)-1-[4-[2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683462; BDBM50337741
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 70000 nM
|
[78] | ||
| Compound Name |
N-Hydroxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzenesulfohydroxamic acid; Piloty's acid; Benzenesulfonamide, N-hydroxy-; Benzenesulphonohydroxamic acid; Benzsulfohydroxamic acid; Hydroxamic acid, benzsulfo-; N-(Phenylsulfonyl)hydroxylamine; Hydroxylamine, N-(phenylsulfonyl)-; UNII-C64L4UMH19; CHEMBL55310; C64L4UMH19; MFCD00025013; EINECS 209-973-8; N-Hydroxy-benzenesulfonamide; BRN 2257368; Benzenesulfohyd; piloty acid; BENZENESULFOHYDROXAMICACID; Hydroxysulfonamide 53; Hydroxyphenylsulfonamide; Benzenesulfhydroxamic acid; (hydroxyamino)phenylsulfone; C6H7NSO3; Benzenesulfonamide,N-hydroxy-; 4-11-00-00093 (Beilstein Handbook Reference); SCHEMBL184252; DTXSID4060521; BDBM11372; CTK5B0780; HMS3650A13; NSC45357; ZINC4284435; 1634AH; 7672AF; ANW-43953; NSC-45357; AKOS001139035; MCULE-1579584179; NE34189; VZ36592; AS-59127; ST50825041; SR-01000946758; SR-01000946758-1; Q27275238
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
Ki = 70000 nM
|
[92] | ||
| Matrix metalloproteinase 8 |
Ki = 74000 nM
|
[92] | |||
| Matrix metalloproteinase 9 |
Ki = 78000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki = 79000 nM
|
[92] | |||
| Compound Name |
4-Chloro-N-hydroxybenzene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(p-chlorobenzenesulfonyl)hydroxylamine; 4-chloro-N-hydroxybenzenesulfonamide; NSC528513; Hydroxysulfonamide 55; CHEMBL301469; SCHEMBL5194625; BDBM11374; DTXSID10326460; ZINC1607221; 4-Chloro-N-hydroxy-benzenesulfonamide; NSC-528513; DS-014970
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 70000 nM
|
[92] | ||
| Matrix metalloproteinase 2 |
Ki = 70000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki = 71000 nM
|
[92] | |||
| Matrix metalloproteinase 9 |
Ki = 76000 nM
|
[92] | |||
| Compound Name |
(Diethylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97057; diethylcarbamoylphosphonic acid; Phosphonic acid, [(diethylamino)carbonyl]- (9CI); N-diethyl carbamyl phosphonate; SCHEMBL11592091; BDBM50146813
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 70000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1,10-Phenanthroline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
o-phenanthroline; Phenanthroline; orthophenanthroline; 4,5-diazaphenanthrene; 1,10-o-phenanthroline; 2-phenanthroline; 1,10-Phenanthroline anhydrous; [1,10]phenanthroline; beta-phenanthroline; 1,10-Fenanthrolin; .beta.-Phenanthroline; 1,10-Phenanthroline, Anhydrous; MFCD00011678; UNII-W4X6ZO7939; MLS000069797; CHEMBL415879; NSC 4265; W4X6ZO7939; NSC203545; NSC4265; SMR000058190; DSSTox_CID_5857; pyridino[3,2-h]quinoline; DSSTox_RID_77950; DSSTox_GSID_25857; 1,10-Phenanthroline, 99+%; MLS002701886; 1,10-Fenanthrolin [Czech]; Activ-8; NSC-4265; CCRIS 4855; EINECS 200-629-2; NSC 203545; phenantroline; o-Phenanthrolin; Cyto5A5; 1,10-phenanthrolin; 1,10-phenantroline; 1,10-phenathroline; 1,10 phenanthroline; 1,10-Fenanthroline; 1.10-phenanthroline; 1,1 0-phenanthroline; ACMC-209nwd; Opera_ID_711; [1,10]-Phenanthroline; Lopac-P-9375; Activ-8 in hexylene glycol; cid_1318; SCHEMBL8312; NCIStruc1_000192; NCIStruc2_000199; Lopac0_000985; KSC241K8T; ARONIS014409; DTXSID1025857; WLN: T B666 CN NNJ; 1,10 CPhenanthroline anhydrous; NCI4265; 1,10-Phenanthroline (anhydrous); 1,10-Phenanthroline, >=99%; 1,10-Phenanthroline,hydrochloride; HMS2234D03; HMS3263E11; HMS3371F11; ZINC164363; KS-000044UM; Tox21_201998; Tox21_303111; Tox21_500985; ANW-35243; BDBM50092158; CCG-38059; NCGC00013043; s6830; SBB089685; STL069281; AKOS000281773; CS-W004544; DB02365; HY-W004544; LP00985; MCULE-2911225521; NSC-203545; SDCCGSBI-0050958.P003; NCGC00013043-02; NCGC00013043-03; NCGC00013043-04; NCGC00013043-05; NCGC00013043-06; NCGC00013043-07; NCGC00013043-08; NCGC00013043-09; NCGC00013043-10; NCGC00013043-13; NCGC00091201-01; NCGC00091201-02; NCGC00091201-03; NCGC00091201-04; NCGC00257123-01; NCGC00259547-01; NCGC00261670-01; AC-18353; AK-27000; AS-14043; BR-27000; NCI60_003976; SC-23392; DB-013750; EU-0100985; FT-0606035; FT-0660636; P0221; P0879; P1826; ST45051101; Solution forms containing 1,10-phenanthroline; C-1044; C00604; M-5271; P 9375; 011P678; A835532; AA-860/25004133; Q416005; SR-01000076093; CU-00000000156-1; J-610043; SR-01000076093-1; W-104740; F3377-1129
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 70000 nM
|
[107] | ||
| Compound Name |
Hydroxysulfonamide 50
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122109; BDBM11369; 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-hydroxyoctane-1-sulfonamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 70000 nM
|
[92] | ||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid 3-methyl-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254403; BDBM50227572
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 70000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
(1R,2S,5R)-2-[2-[4-(4-Chlorophenyl)phenyl]ethylsulfanyl]-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339137; BDBM50131954
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 70000 nM
|
[37] | ||
| Compound Name |
2,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399304; BDBM50227547
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 70000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 70000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 85000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 100000 nM
|
[33] | |||
| Compound Name |
Cinnamyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254657; BDBM50227587
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 70000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 73000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 86000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 90000 nM
|
[33] | |||
| Compound Name |
Methyl (E)-5-(4-hydroxyphenyl)-2-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-3-oxopent-4-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2124084; CHEMBL3922961; US9187406, Compound 3; BDBM191767
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 70000 nM
|
[107] | ||
| Compound Name |
N-[(2S,4S)-1-[4-[2-(2-Chloro-4-methylsulfonylphenyl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683464; BDBM50337734
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 70000 nM
|
[78] | ||
| Compound Name |
Piperidin-1-ylcarbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95068; SCHEMBL11749901; BDBM50146802
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 70000 nM
|
[27] | ||
| Matrix metalloproteinase 3 |
IC50 = 90000 nM
|
[27] | |||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(1R,2S,5R)-2-[4-(4-Chlorophenyl)phenyl]sulfanyl-5-[(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126712; BDBM50131949
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 70000 nM
|
[37] | ||
| Compound Name |
3-Phenoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250069; BDBM50227575
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 71000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 75000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 78000 nM
|
[33] | |||
| Compound Name |
Biphenylsulfonamide carboxylate, 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43147; BDBM24032; N-(biphenyl-4-ylsulfonyl)-l-valine; ZINC13803822; N-(1,1'-Biphenyl-4-ylsulfonyl)valine; (2S)-3-methyl-2-[(4-phenylbenzene)sulfonamido]butanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 71000 nM
|
[53] | ||
| Compound Name |
Cyclohexyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254838; BDBM50227583
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 71000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 94000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 101000 nM
|
[33] | |||
| Compound Name |
{(R)-3-[(S)-2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbamoyl]-5-methyl-hexanoylaminooxy}-acetic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308032; BDBM50062320
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
Ki = 71000 nM
|
[108] | ||
| Compound Name |
Z-D-Trp-OH
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
N-Cbz-D-Tryptophan; Z-D-TRYPTOPHAN; Cbz-D-Trp-OH; (R)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; N(a)-Benzyloxycarbonyl-D-tryptophan; MFCD00037945; CHEMBL65134; D-Tryptophan, N-[(phenylmethoxy)carbonyl]-; (2R)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoic acid; Nalpha-Cbz-D-tryptophan; Cbz-D-Trp; PubChem9720; Z-DTrp-OH; Nalpha-Z-D-tryptophan; CBZ-D-TRYPTOPHAN; Z-(D)-Trp-OH; N(alpha)-Cbz-D-tryptophan; SCHEMBL3808330; Nalpha-Carbobenzoxy-D-tryptophan; CTK1A1830; KS-00000EYG; ZINC80835; N-alpha-Carbobenzoxy-D-tryptophan; N-benzyloxycarbonyl-(D)-tryptophan; ((Benzyloxy)carbonyl)-D-tryptophan; ACT07626; ANW-43294; BDBM50043809; Nalpha-Benzyloxycarbonyl-D-tryptophan; AKOS015924251; Nalpha -benzyloxycarbonyl-D-tryptophan; AB01681; CS-W009837; N-alpha-Benzyloxycarbonyl-D-tryptophane; AC-17152; AK-77035; AS-12753; AB0005805; A6936; K-6338; 279Z154; A816352; (R)-2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionic acid; (R)-2-(benzyloxycarbonylamino)-3-(1H-indol-3-yl)propanoic acid
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 3 |
Ki = 71000 nM
|
[65] | ||
| Compound Name |
(R)-2-(4-Fluorophenylsulphonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393793; BDBM50225398
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 71000 nM
|
[109] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[109] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[109] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[109] | |||
| Compound Name |
(S,E)-5-(4-Bromophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL514357; BDBM50267370
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 71200 nM
|
[94] | ||
| Compound Name |
(R)-4-(4-Carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489026; BDBM50267958
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 71200 nM
|
[69] | ||
| Compound Name |
(S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(2-fluorophenylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476638; BDBM50267464
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 71400 nM
|
[94] | ||
| Compound Name |
(2S)-2-Amino-N-[(3S)-1-[2-(4-bromoanilino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214590; BDBM50323940; (2S)-2-Amino-N-(1-(2-(4-bromophenylamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 71600 nM
|
[99] | ||
| Compound Name |
2-[1-Sec-Butyl-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-N-isopropyl-acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95004; BDBM50081786
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 72000 nM
|
[47] | ||
| Compound Name |
N-(p-Fluorobenzenesulfonyl)hydroxylamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
4-fluoro-N-hydroxybenzene-1-sulfonamide; Hydroxysulfonamide 54; CHEMBL332145; SCHEMBL2492594; BDBM11373; 4-fluoro-n-hydroxybenzenesulfonamide; N-Hydroxy-4-fluorobenzenesulfonamide
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
Ki = 72000 nM
|
[92] | ||
| Matrix metalloproteinase 9 |
Ki = 73000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki = 74000 nM
|
[92] | |||
| Matrix metalloproteinase 8 |
Ki = 75000 nM
|
[92] | |||
| Compound Name |
4''-Methylepigallocatechin gallate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
UNII-CUX41G3911; CHEMBL559294; (-)-Epigallocatechin 3-(4-methyl-gallate); CUX41G3911; Egcg4''me; NSC714028; Epigallocatechin-3-O-(4-O-methyl)gallate; 4''-O-methyl-EGCG; (-)-Epigallocatechin 3-(4''-O-methyl) gallate; 4''-O-Methyl-(-)-epigallocatechin-3-o-gallate; (-)-EPIGALLOCATECHIN 3-(4''-O-METHYL)GALLATE; SCHEMBL16887923; CTK6J4412; 4-O-Methylgalloyl epigallocatechin; BDBM50296235; Epigallocatechin 3-(4-methylgallate); NSC-714028; Epigallocatechin 3-O-(4-methylgallate); 3-O-(4-O-Methylgalloyl)epigallocatechin; NCI60_039612; 4'-Methyl-(-)-epigallocatechin 3-gallate; 4''-O-Methylepigallocatechin 3-O-gallate; (-)-Epigallocatechin-3-(4''''-O-methyl)gallate; Q27275816
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 72000 nM
|
[66] | ||
| Compound Name |
N-Hydroxy-2-[[4-[(4-phenylphenyl)methoxy]phenyl]sulfonylamino]acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431032; BDBM50441225
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 72000 nM
|
[59] | ||
| Compound Name |
Cruzain-IN-1
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Investigative | Compound Info | ||
| Synonyms |
ML092; CHEMBL567341; MMV676881; 6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile; 6-(3,5-difluoroanilino)-9-ethylpurine-2-carbonitrile; 6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile; 6-[(3,5-difluorophenyl)amino]-9-ethyl-9H-purine-2-carbonitrile; Cruzain-IN-1ML092; Cruzain-IN-1;ML-092; ML092 Cruzain-IN-1; MLS002471782; HMS2203P24; HMS3332L09; BCP29960; BDBM50303420; NCGC00181918-01; NCGC00181918-02; BS-14613; HY-10836; ML092;ML 092;ML-092; SMR001395197; CS-0002855; S0722; Q27164166
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
IC50 = 72443.6 nM
|
[110] | ||
| Compound Name |
Chembl4211189
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456774
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||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 72600 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 = 77400 nM
|
[60] | |||
| Compound Name |
Benzenemethanesulfonamide, N-hydroxy-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 52; N-Benzylsulfonylhydroxylamin; CHEMBL333122; N-hydroxyphenylmethanesulfonamide; SCHEMBL10656290; BDBM11371; N-hydroxy-1-phenylmethanesulfonamide
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
Ki = 73000 nM
|
[92] | ||
| Matrix metalloproteinase 8 |
Ki = 76000 nM
|
[92] | |||
| Matrix metalloproteinase 9 |
Ki = 83000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki = 95000 nM
|
[92] | |||
| Compound Name |
Cyclohexyl 6-mercaptopicolinate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL442286; BDBM50227588
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 73000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 87000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 91000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 102000 nM
|
[33] | |||
| Compound Name |
Hydroxysulfonamide 49
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332439; BDBM11368; 1,1,2,2,3,3,4,4,4-nonafluoro-N-hydroxybutane-1-sulfonamide
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
Ki = 74000 nM
|
[92] | ||
| Compound Name |
N-Hydroxy-2-[4-[4-(trifluoromethoxy)benzyloxy]phenylsulfonylamino]acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431031; BDBM50441226
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 74000 nM
|
[59] | ||
| Compound Name |
(2S)-N-[(2S)-1-Oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenyl-2-(quinolin-8-ylsulfonylamino)propanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142613
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 1 |
Ki = 74000 nM
|
[52] | ||
| Compound Name |
Chembl4208646
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457776
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 74340 nM
|
[76] | ||
| Compound Name |
Methyl (2S)-2-benzamido-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147937; BDBM50391639
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 74600 nM
|
[106] | ||
| Compound Name |
(R)-6-Cyclohexyl-N-hydroxy-3-(3-(piperidine-1-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL480351; BDBM50256305
Click to Show/Hide
|
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| Activity | Matrix metalloproteinase 2 |
IC50 = 74900 nM
|
[11] | ||
| Compound Name |
N-[(E)-(2,4-Dimethoxyphenyl)methylideneamino]-2-(3-methyl-2-oxoquinoxalin-1-yl)acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774826; BDBM50155293; N-[(E)-(2,4-dimethoxyphenyl)methyleneamino]-2-(3-methyl-2-oxo-quinoxalin-1-yl)acetamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 74910 nM
|
[91] | ||
| Compound Name |
N-((S)-2-Benzyloxy-1-dimethylcarbamoyl-propyl)-N''-hydroxy-oxalamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL367331; BDBM50111985
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 8 |
Ki = 75000 nM
|
[111] | ||
| Compound Name |
Naphthalen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253188; BDBM50227545
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 75000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 97000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 103000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 125000 nM
|
[33] | |||
| Compound Name |
N*4*-Hydroxy-2-(4-hydroxy-benzyl)-N*1*-indan-1-yl-succinamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL323874; BDBM50104964
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 75000 nM
|
[22] | ||
| Compound Name |
4-[[4-Oxo-6-(3-piperidin-1-ylprop-1-ynyl)quinazolin-3-yl]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL271616; SCHEMBL6834151; BDBM50372650
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 75000 nM
|
[102] | ||
| Compound Name |
(2S)-N-Hydroxy-1-(4-phenylphenyl)sulfonylpyrrolidine-2-carboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957597; BDBM50366199
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 76000 nM
|
[45] | ||
| Compound Name |
Furan-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254821; BDBM50227529
Click to Show/Hide
|
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| Activity | Matrix metalloproteinase 12 |
IC50 = 76000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 90000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 111000 nM
|
[33] | |||
| Compound Name |
3-Hydroxy-4H-pyran-4-thione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1649594; 4H-Pyran-4-thione, 3-hydroxy-; 3-hydroxypyran-4-thione; Thiomeconic acid; ACMC-20lkcd; SCHEMBL1298196; CTK2J8099; DTXSID10463243; BDBM50335806
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 76000 nM
|
[17] | ||
| Compound Name |
N-[1-[4-(4-Cyanophenyl)phenoxy]propan-2-yl]-N-hydroxyformamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41067; SCHEMBL7453489; BDBM50100919; N-[1-Methyl-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid; N-[2-(4''-Cyano-biphenyl-4-yloxy)-1-methyl-ethyl]-N-hydroxy-formamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 76000 nM
|
[26] | ||
| Compound Name |
(R)-5-(4-Bromo-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476657; BDBM50267360
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 76100 nM
|
[69] | ||
| Compound Name |
Chembl4160618
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278364
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
IC50 = 76300 nM
|
[112] | ||
| Matrix metalloproteinase 12 |
IC50 = 100100 nM
|
[112] | |||
| Matrix metalloproteinase 8 |
IC50 = 198900 nM
|
[112] | |||
| Compound Name |
Chembl4211258
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456773
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 76500 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 83400 nM
|
[60] | |||
| Compound Name |
(4S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(3-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523446; BDBM50267608
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 76500 nM
|
[94] | ||
| Compound Name |
(R)-5-(3-Iodobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477449; BDBM50267319
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 76800 nM
|
[69] | ||
| Compound Name |
(4S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(1-methoxy-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL491656; BDBM50267568
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 76800 nM
|
[94] | ||
| Compound Name |
Thiophen-3-yl 6-mercaptopicolinate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399999; BDBM50227561
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 77000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 90000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 93000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 108000 nM
|
[33] | |||
| Compound Name |
(5Z)-5-[4-(Benzyloxy)benzylidene]-2-thioxo-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1248973; CHEMBL1645391; ZINC973836; STK796782; AKOS001297998; (5Z)-5-[(4-phenylmethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 = 77430 nM
|
[82] | ||
| Compound Name |
Methyl (8S)-7-(4-nitrophenyl)sulfonyl-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092085; BDBM50494836
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 77930 nM
|
[113] | ||
| Compound Name |
(R)-2-(N-((2-Fluoropyridin-3-yl)methyl)-4-methoxyphenylsulphonamido)-3-methylbutanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL428554; BDBM50225403
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 78000 nM
|
[109] | ||
| Compound Name |
3-Methoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254406; BDBM50227568
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 78000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 86000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 90000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 93000 nM
|
[33] | |||
| Compound Name |
alpha-Arylsulfonylamino hydroxamate 3S
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43644; BDBM12077; (2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-hydroxy-3-methylbutanamide; (S)-N-Hydroxy-3-methyl-2-[[(4'-bromo-1,1'-biphenyl-4-yl)sulfonyl]amino]butanamide
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 78000 nM
|
[53] | ||
| Matrix metalloproteinase 9 |
IC50 = 84000 nM
|
[53] | |||
| Compound Name |
2-Amino-5-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834423; SCHEMBL2369869; BDBM50354625; 2-amino-5-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenol
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
Ki = 78000 nM
|
[114] | ||
| Matrix metalloproteinase 7 |
Ki = 116000 nM
|
[114] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-quinolin-3-ylbenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098991; BDBM50444727
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 78000 nM
|
[14] | ||
| Compound Name |
(2S)-2-Amino-3-thiol-N-[(2R)-2-amino-3-phenylpropyl]propionamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL457867; BDBM50273669
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 78800 nM
|
[115] | ||
| Compound Name |
2,5-Difluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400449; BDBM50227576
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 79000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 114000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 140000 nM
|
[33] | |||
| Compound Name |
N-[(2S,4S)-4-(5-Fluoropyrimidin-2-yl)-2-methyl-1-[4-[2-[3-methyl-5-(trifluoromethyl)pyridin-2-yl]ethyl]piperidin-1-yl]sulfonylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683463; BDBM50337740
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 79000 nM
|
[78] | ||
| Compound Name |
(S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(2-methoxy-2-oxoethylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489414; BDBM50267566
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 79600 nM
|
[94] | ||
| Compound Name |
(2S)-2-(Naphthalen-1-ylsulfonylamino)-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142599
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 80000 nM
|
[52] | ||
| Compound Name |
Cyclohexylmethylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97951; SCHEMBL4859789; BDBM50146805; [(cyclohexylmethyl)amino]carbonylphosphonic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 80000 nM
|
[27] | ||
| Compound Name |
(Sec-butylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97510; Phosphonic acid, [[(1-methylpropyl)amino]carbonyl]- (9CI); BDBM50146817
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 80000 nM
|
[27] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Phenethylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24447; [(2-phenylethyl)amino]carbonylphosphonic acid; SCHEMBL13986851; BDBM50112446
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 80000 nM
|
[27] | ||
| Matrix metalloproteinase 3 |
IC50 = 90000 nM
|
[27] | |||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Pentan-3-ylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318664; [(1-ethylpropyl)amino]carbonylphosphonic acid; BDBM50146808
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 80000 nM
|
[27] | ||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(R)-Ethyl 5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374840; SCHEMBL6430169; BDBM50216798; ethyl 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxylate; Ethyl 5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxylate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 80000 nM
|
[11] | ||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid 4-methyl-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254404; BDBM50227582
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 81000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 98000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 119000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
4-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254448; BDBM50227563
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 81000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 105000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 107000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 114000 nM
|
[33] | |||
| Compound Name |
Thioacetic acid S-((4S,5S)-2-biphenyl-4-yl-5-vinyl-4,5-dihydro-oxazol-4-yl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363953; BDBM50152633
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 81000 nM
|
[101] | ||
| Compound Name |
N-[(E)-(4-Chlorophenyl)methyleneamino]-2-(3-methyl-2-oxo-quinoxalin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774656; BDBM50155290
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 81010 nM
|
[91] | ||
| Compound Name |
Chembl4211480
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457772
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 81210 nM
|
[76] | ||
| Compound Name |
(R)-N-Benzyl-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-methyl-1,2,4-oxadiazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482319; BDBM50256366
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 81800 nM
|
[11] | ||
| Compound Name |
Benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402720; BDBM50227533
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 82000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 85000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 88000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 101000 nM
|
[33] | |||
| Compound Name |
3-(Trifluoromethyl)benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254006; BDBM50227549
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 82000 nM
|
[33] | ||
| Compound Name |
5-Pyridin-4-yl-1H-indole-2-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939870; SCHEMBL15642864; BDBM50361628; DB-124067; ethyl 5-pyridin-4-yl-1H-indole-2-carboxylate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 82000 nM
|
[58] | ||
| Compound Name |
3-(Hydroxymethyl)-6-(4-hydroxyphenyl)-2-[2-(4-hydroxyphenyl)ethynyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585679; BDBM50093523
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 82560 nM
|
[76] | ||
| Matrix metalloproteinase 2 |
IC50 = 85350 nM
|
[76] | |||
| Compound Name |
Carbobenzoxyphenylalanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Z-Phe-OH; N-CBZ-L-PHENYLALANINE; Z-L-Phenylalanine; N-Carbobenzoxy-L-phenylalanine; Carbobenzoxy-L-phenylalanine; CBZ-L-Phenylalanine; N-(Carbobenzyloxy)-L-phenylalanine; (Benzyloxycarbonyl)phenylalanine; N-Carbobenzyloxy-L-phenylalanine; Cbz-Phe; Cbz-Phe-OH; L-N-Carboxy-3-phenylalanine N-benzyl ester; MFCD00020418; Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-; (S)-2-(Benzyloxycarbonylamino)-3-phenylpropanoicacid; (S)-2-(benzyloxycarbonylamino)-3-phenylpropanoic acid; CHEMBL66143; Phenylalanine, N-[(phenylmethoxy)carbonyl]-; n-benzyloxycarbonyl-l-phenylalanine; ((benzyloxy)carbonyl)-L-phenylalanine; (2S)-2-{[(Benzyloxy)carbonyl]amino}-3-phenylpropanoic acid; L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-; N-Carbobenzyloxy-L-phenylalanine, 99+%; CBZ-L-phenylalaine; CBZ-L-PHE; EINECS 214-599-3; N-Benzyloxycarbonyl-L-3-phenylalanine; NSC 402059; (2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoic acid; N-((Phenylmethoxy)carbonyl)-L-phenylalanine; N-[(Benzyloxy)carbonyl]phenylalanine #; ZPheOH; N-Cbz-phenylalanine; N-CBz phenylalanine; Z-Phe; Z-PheOH; N-(benzyloxycarbonyl)-L-phenylalanine; PubChem10514; Z-L-Phe-OH; Z-(L)-Phe-OH; N-carbobenzoxy-phenylalanine; benzyloxycarbonylphenylalanine; Z-Phe-OH, 99%; KSC175A9P; SCHEMBL220648; N-benzyloxycarbonylphenylalanine; benzyloxycarbonyl-L-phenylalanine; CTK0H5097; ZINC38519; DTXSID30151276; n-benzyloxycarbonyl-s-phenylalanine; ACT06651; ALBB-028189; KS-00000AA8; n-benzyloxycarbonyl-l-phenyl alanine; N-alpha-Carbobenzoxy-L-phenylalanine; ANW-16940; BDBM50043796; SBB028600; AKOS010373384; AKOS015839335; N-Benzyloxycarbonyl-(L)-Phenylalanine; AC-7045; AM82160; CS-W012139; MCULE-6887552669; nalpha-benzyloxycarbonyl-l-phenylalanine; N-alpha-Benzyloxycarbonyl-L-phenylalanine; Nalpha -Benzyloxycarbonyl-L-phenylalanine; AS-12743; BP-13289; AB0004792; DB-030165; C0660; M-5831; M03068; Nalpha -[(phenylmethoxy)carbonyl]-L-phenylalanine; J-300211; (S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid; L-Phenylalanine, N-((phenylmethoxy)carbonyl)- (9CI); (S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoic acid; (2S)-3-phenyl-2-[(phenylmethoxy)carbonylamino]propanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 83000 nM
|
[65] | ||
| Compound Name |
Ethyl 5-(5-methoxycarbonyl-2-methylpyrazol-3-yl)-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939873; BDBM50361631
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 83000 nM
|
[58] | ||
| Compound Name |
N-Phenyl-4-[(4h-1,2,4-Triazol-3-Ylsulfanyl)methyl]-1,3-Thiazol-2-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1511860; MLS001003711; HMS2683M19; BDBM50233887; ZINC13683603; AKOS033640205; MCULE-7057035395; SMR000347505; SR-01000034919; SR-01000034919-1; Z18740505
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 10 |
IC50 = 83000 nM
|
[116] | ||
| Compound Name |
(4S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489415; BDBM50267567
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 83200 nM
|
[94] | ||
| Compound Name |
Methyl (2S)-2-[(4-methylbenzoyl)amino]-3-(4-phenylmethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147933; BDBM50391616
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 83700 nM
|
[106] | ||
| Compound Name |
(2S)-N-[(2S,3S)-2-Amino-3-hydroxy-3-(4-nitrophenyl)propyl]-2-[[(2S)-3-amino-2-hydroxypropanoyl]amino]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819327; BDBM50351028
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 83900 nM
|
[71] | ||
| Compound Name |
Boc-Trp-OSu
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65234; Nalpha-(tert-Butoxycarbonyl)-L-tryptophan N-Succinimidyl Ester; 2,5-dioxopyrrolidin-1-yl n-(tert-butoxycarbonyl)-l-tryptophanate; SCHEMBL902110; DTXSID00187542; ZINC2571371; EINECS 222-234-4; BDBM50043812; MFCD00022756; AKOS015901949; NSC 164059; KS-000017B7; AS-56324; B3435; Nalpha-Boc-L-tryptophan N-Succinimidyl Ester; V5286; K-0047; Nalpha-Boc-L-tryptophan N-hydroxysuccinimide ester; J-019383; N-alpha-t-Butyloxycarbonyl-L-tryptophane succinimidyl ester; Nalpha-(tert-Butoxycarbonyl)-L-tryptophanN-SuccinimidylEster; N(ALPHA)-(TERT-BUTOXYCARBONYL)-L-TRYPTOPHAN N-HYDROXYSUCCINIMIDE ESTER
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 84000 nM
|
[65] | ||
| Compound Name |
(2S)-2,6-Diamino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819323; BDBM50351024
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 84300 nM
|
[71] | ||
| Compound Name |
Hexyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249859; BDBM50227581
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 85000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 105000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 109000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 115000 nM
|
[33] | |||
| Compound Name |
US9187406, Curcumin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892642; SCHEMBL10077702; BDBM191763
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 85000 nM
|
[107] | ||
| Matrix metalloproteinase 13 |
IC50 = 110000 nM
|
[107] | |||
| Compound Name |
(E)-5-(4-Hydroxy-3-methoxyphenyl)-2-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]-3-oxo-N-phenylpent-4-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2124629; CHEMBL3962579; US9187406, Compound 6; BDBM191769
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 85000 nM
|
[107] | ||
| Compound Name |
[3-(5-Thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-acetic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36682; BDBM50076349; 2-[3-[(5-Thioxo-4,5-dihydro-1,3,4-thiadiazole)-2-yl]ureido]acetic acid ethyl ester
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 85000 nM
|
[63] | ||
| Compound Name |
3-Phenylpropyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252523; BDBM50227542
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 85000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 95000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 100000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 112000 nM
|
[33] | |||
| Compound Name |
Methyl (2S)-2-[(4-methylbenzoyl)amino]-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147938; BDBM50391638
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 85500 nM
|
[106] | ||
| Compound Name |
(R)-4-(4-Carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489231; BDBM50267959
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 86300 nM
|
[69] | ||
| Compound Name |
(2S)-2-Amino-N-[(2R)-1-[[(2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819448; BDBM50351044
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 86600 nM
|
[71] | ||
| Compound Name |
[[4-(4-Bromophenoxy)anilino]-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440432; BDBM50442508
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 87000 nM
|
[1] | ||
| Compound Name |
Chembl4164016
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278389
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 87100 nM
|
[112] | ||
| Matrix metalloproteinase 12 |
IC50 = 109100 nM
|
[112] | |||
| Compound Name |
Chembl4211771
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456785
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 87500 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 93100 nM
|
[60] | |||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-(4-bromo-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363675; BDBM50152647
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 88000 nM
|
[101] | ||
| Compound Name |
(4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362099; BDBM50152637
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
Ki = 88000 nM
|
[101] | ||
| Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | |||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[101] | |||
| Compound Name |
Epicatechin 3-O-(3-O-methylgallate)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158521; (-)-ECG-3''-O-ME; (-)-Epicatechin-3-(3''-O-methyl) gallate; CTK6J6178; 3-O-(3-Methylgalloyl)epicatechin; Epicatechin 3-(3-O-methylgallate); BDBM50296236; epicatechin 3-(3'-O-methylgallate); LMPK12020093; ZINC14642643; epicatechin 3-O-(3'-O-methylgallate); (-)-epicatechin 3-(3'-O-methylgallate); (-)-epicatechin 3-O-(3'-O-methylgallate)
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 88000 nM
|
[66] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
N-Benzyl-3-(2-hydroxycarbamoyl-4-methyl-pentanoylamino)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326760; BDBM50062464
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 88000 nM
|
[31] | ||
| Compound Name |
(2R,3R)-4-[(2R)-2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770629; SCHEMBL8224023; BDBM50342963
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 88400 nM
|
[117] | ||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[138] | |||
| Compound Name |
Chembl4206821
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456784
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 89300 nM
|
[60] | ||
| Matrix metalloproteinase 9 |
IC50 = 95900 nM
|
[60] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(2-chlorophenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264164; BDBM50359897
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 89430 nM
|
[83] | ||
| Compound Name |
(Methylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97388; SCHEMBL12758377; BDBM50146809; AKOS006379972
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 90000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(S)-2-(Acetyl-methyl-amino)-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL92847; BDBM50105442
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 90000 nM
|
[118] | ||
| Compound Name |
N-(3-(1-Tert-butylpiperidin-4-yl)-1-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)propan-2-yl)-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400206; BDBM50197217
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 90000 nM
|
[119] | ||
| Compound Name |
N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylmethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98390; BDBM50146478
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 90000 nM
|
[41] | ||
| Compound Name |
2-[1-[2-(4-Fluoro-phenyl)-ethyl]-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-N-isopropyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95143; BDBM50081793
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 90000 nM
|
[47] | ||
| Compound Name |
2,4,5-Trifluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250059; BDBM50227592
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 90000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 105000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 106000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 124000 nM
|
[33] | |||
| Compound Name |
2-(3-Methyl-2-oxoquinoxalin-1-yl)-N-[(E)-1-(4-nitrophenyl)ethylideneamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775356; BDBM50155282; 2-(3-methyl-2-oxo-quinoxalin-1-yl)-N-[(E)-1-(4-nitrophenyl)ethylideneamino]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 90810 nM
|
[91] | ||
| Compound Name |
4-Methoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399908; BDBM50227579
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 91000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 95000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 96000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 108000 nM
|
[33] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389020; SCHEMBL5411951; BDBM50216802; (R)-6-cyclohexyl-N-hydroxy-3-(3-(methylsulfonamidomethyl)-1,2,4-oxadiazol-5-yl)hexanamide; (3R)-6-cyclohexyl-N-hydroxy-3-[3-(methanesulfonamidomethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
Ki = 91000 nM
|
[8] | ||
| Matrix metalloproteinase 3 |
IC50 = 91000 nM
|
[28] | |||
| Matrix metalloproteinase 14 |
Ki ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[28] | |||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
Isoacteoside
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoverbascoside; UNII-588LJK42AP; 588LJK42AP; Isoacetoside; iso-acteoside; Acteoside isomer; Verbascoside,(S); CHEMBL504873; EBD36820; HY-N0022; BDBM50386896; MFCD06798947; NSC729649; s9128; ZINC49898792; AKOS037514697; CCG-270268; NSC-729649; AB0123609; W2067; 303I137; Q-100709; Q27261572
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 91410 nM
|
[55] | ||
| Compound Name |
(4S,5S)-2-Styryl-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186559; BDBM50152635
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 92000 nM
|
[101] | ||
| Matrix metalloproteinase 9 |
Ki = 94000 nM
|
[101] | |||
| Compound Name |
4-Phenoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250070; BDBM50227532
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 93000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 109000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 110000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 114000 nM
|
[33] | |||
| Compound Name |
4-{(5Z)-2,4-Dioxo-5-[(2E)-3-phenylprop-2-enylidene]-1,3-thiazolidin-3-yl}butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927184; HMS1425E10; BDBM50359722; ZINC15906851; AKOS001490556; IDI1_010429; ST50054937; 4-[5-((2E)-3-phenylprop-2-enylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]butanoic a cid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 93000 nM
|
[57] | ||
| Matrix metalloproteinase 3 |
IC50 = 110000 nM
|
[57] | |||
| Compound Name |
(4S,5S)-2-(4-Bromo-phenyl)-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187808; BDBM50152642
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 94000 nM
|
[101] | ||
| Compound Name |
4-(Trifluoromethyl)benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398662; BDBM50227544
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 94000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 125000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 141000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
(2S)-N-[(2S,3S)-2-Amino-3-(4-aminophenyl)-3-hydroxypropyl]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819445; BDBM50351041
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 94000 nM
|
[71] | ||
| Compound Name |
Chembl4163839
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278363
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 95200 nM
|
[112] | ||
| Matrix metalloproteinase 14 |
IC50 = 109000 nM
|
[112] | |||
| Matrix metalloproteinase 8 |
IC50 = 172800 nM
|
[112] | |||
| Compound Name |
N*4*-Hydroxy-N*1*-(2-hydroxy-indan-1-yl)-2-(3-methoxy-benzyl)-succinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114357; SCHEMBL6045948; BDBM50104970
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 95500 nM
|
[22] | ||
| Compound Name |
2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SB-3CT; 2-((4-phenoxyphenylsulfonyl)methyl)thiirane; SB3CT; SB 3CT; CHEMBL483857; 2-(((4-Phenoxyphenyl)sulfonyl)methyl)thiirane; Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-; 2-[(4-PHENOXYBENZENESULFONYL)METHYL]THIIRANE; MMP-2/MMP-9 Inhibitor IV; 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane; 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-Thiirane; Thiirane, 1; (4-phenoxyphenylsulfonyl)methylthiirane; MLS006010722; Thiirane (deuterium), 1-d2; GTPL9509; SCHEMBL2684163; CTK8F0499; KS-00001CWI; AOB6468; DTXSID70432359; EX-A687; C15H14O3S2; HMS3653B03; BCP10428; 2705AH; BDBM50264809; MFCD09836266; s7430; AKOS026750307; CCG-267539; CS-3445; inhibitor 1 (Brown et al., 2000); SB-3CT, >=98% (HPLC), powder; NCGC00346932-01; 2-(4-phenoxyphenylsulfonylmethyl)thiirane; AC-32656; AK270339; AS-67674; HY-12354; SMR004701685; DS-015900; FT-0700278; SW219838-1; 2-[[4-(phenoxy)phenyl]sulfonylmethyl]thiirane; J-017452; Q27165480
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki = 96000 nM
|
[120] | ||
| Matrix metalloproteinase 1 |
Ki = 206000 nM
|
[120] | |||
| Compound Name |
4-Chlorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251081; BDBM50227556
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 96000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 112000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 115000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 126000 nM
|
[33] | |||
| Compound Name |
Ethyl 5-(methanesulfonamido)-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939861; SCHEMBL8408444; BDBM50361619
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 97000 nM
|
[58] | ||
| Compound Name |
5-Dodecylamino-3H-[1,3,4]thiadiazole-2-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441781; BDBM50076359
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 97000 nM
|
[63] | ||
| Compound Name |
5-(Benzylamino)-1,3,4-thiadiazole-2-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288599; 5-Benzylamino-3H-[1,3,4]thiadiazole-2-thione; 5-(benzylamino)-1,3,4-thiadiazole-2(3H)-thione; 1,3,4-Thiadiazole-2(3H)-thione,5-[(phenylmethyl)amino]-; 5-[benzylamino]-1,3,4-thiadiazole-2-thiol; 5-(benzylamino)-3H-1,3,4-thiadiazole-2-thione; Oprea1_342333; CTK4C5357; KS-00001PEY; DTXSID90356725; ZINC1443672; BDBM50076375; MFCD03152454; STK780190; STK946149; AKOS000115784; MCULE-4110834955; NE35005; ST50072213; EN300-03106; SR-01000270042; SR-01000270042-1; 1,3,4-Thiadiazole-2(3H)-thione, 5-[(phenylmethyl)amino]-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 97000 nM
|
[63] | ||
| Compound Name |
(5E)-2-(1,2-Benzothiazol-3-ylimino)-5-[(2-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398610; BDBM50063579
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 97350 nM
|
[83] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[83] | |||
| Compound Name |
Ethyl 3-(hydroxyamino)-3-oxo-2-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117316; BDBM50062454; N-Hydroxy-2-phenyl-malonamic acid ethyl ester
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 97723.72 nM
|
[70] | ||
| Compound Name |
5-[4-(4-Acetylphenyl)phenyl]-3-hydroxypentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL584559; SCHEMBL5613397; BDBM50300471; 5-(4''-acetylbiphenyl-4-yl)-3-hydroxypentanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
Naphthalen-1-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251423; BDBM50227543
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 98000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
5-(4-(Dibenzo[b,d]furan-3-yl)phenyl)-3-hydroxypentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575946; BDBM50300468
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
5-(4-(9H-Fluoren-2-yl)phenyl)-3-hydroxypentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566512; BDBM50300469
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
5-(4''-(Benzyloxy)biphenyl-4-yl)-3-hydroxypentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572926; BDBM50300466
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 98000 nM
|
[9] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | |||
| Compound Name |
3-Hydroxy-5-[4-(4-methylsulfanylphenyl)phenyl]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575320; SCHEMBL5613380; BDBM50300470; 3-hydroxy-5-(4''-(methylthio)biphenyl-4-yl)pentanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
3-Hydroxy-5-[4-(4-phenoxyphenyl)phenyl]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575947; SCHEMBL5613747; BDBM50300467; 3-hydroxy-5-(4''-phenoxybiphenyl-4-yl)pentanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 98000 nM
|
[9] | ||
| Compound Name |
3-Methyl-2-oxo-quinoxaline-1(2h)-acetohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775799; BDBM50155274; AKOS012886366; 2-(3-methyl-2-oxo-quinoxalin-1-yl)acetohydrazide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 98020 nM
|
[91] | ||
| Compound Name |
(5S)-5-[[4-[5-[(3-Ethyl-1,2-oxazol-5-yl)methoxy]pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409675; BDBM50437761
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 98907 nM
|
[75] | ||
| Compound Name |
4-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253172; BDBM50227538
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 99000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 105000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 110000 nM
|
[33] | |||
| Compound Name |
Naphthalen-2-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251424; BDBM50227584
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 99000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 100000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 101000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 119000 nM
|
[33] | |||
| Compound Name |
6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253835; BDBM50227553
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 99000 nM
|
[33] | ||
| Compound Name |
1-Phenyl-3-(5-sulfanyl-1,3,4-thiadiazol-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417885; 1-Phenyl-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea; 1-(5-mercapto-[1,3,4]thiadiazol-2-yl)-3-phenylurea; CTK7G8311; KS-00001PI5; BDBM50076361; MFCD11226438; ZINC13796897; AKOS005256500; MCULE-3383586899; 1-(5-Mercapto-1,3,4-thiadiazol-2-yl)-3-phenylurea; 1-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-3-PHENYL-UREA; N-[(5-Thioxo-4,5-dihydro-1,3,4-thiadiazole)-2-yl]-N'-phenylurea
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 99000 nM
|
[63] | ||
| Compound Name |
6-Amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448755; BDBM50273671
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 99700 nM
|
[115] | ||
| Compound Name |
(2S)-2,6-Amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457648; BDBM50273633
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 99700 nM
|
[115] | ||
| Compound Name |
(5S)-5-[[4-[5-[(4-Fluorophenyl)methoxy]pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409695; BDBM50437766
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 99999 nM
|
[75] | ||
| Compound Name |
(5S)-5-Methyl-5-[[4-[5-[(3-methyl-1,2-oxazol-5-yl)methoxy]pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409674; BDBM50437763
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[75] | ||
| Compound Name |
(4S)-5-[3-(Carboxymethyl)piperidin-1-yl]-5-oxo-4-[3-(4-thiophen-2-ylphenyl)propanoylamino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3675590; SCHEMBL14210000; BDBM120240; US8691753, 89
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki ~ 100000 nM
|
[46] | ||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-(4-chloro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184148; BDBM50152652
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[101] | ||
| Compound Name |
(2S)-4-Fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585764; SCHEMBL13570539; BDBM50093570; (S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluorobutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[121] | ||
| Compound Name |
2-[(4-Methoxyphenyl)methylthio]-6-methyl-1H-pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ML032; MLS000109390; CHEMBL500351; 2-[(4-methoxyphenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-4-one; SMR000105333; SR-01000474780; CDS1_004684; CBMicro_030348; 6-methyl-2-(p-anisylthio)-1H-pyrimidin-4-one; Oprea1_680293; DivK1c_005724; cid_716696; SCHEMBL16743643; BDBM40478; CTK8J7376; HMS2282I24; ZINC8670459; AKOS000530959; MCULE-9257305475; BIM-0030343.P001; ST50101336; EC-000.1648; SR-01000474780-1; SR-01000474780-3; Q27164593; 2-[(4-methoxyphenyl)methylthio]-6-methylpyrimidin-4-ol; 2-(4-Methoxy-benzylsulfanyl)-6-methyl-3H-pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[122] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[122] | |||
| Compound Name |
[Phosphono-[4-(trifluoromethyl)anilino]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440440; BDBM50442517
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-[5-(5,7-Dihydroxy-4-oxo-chromen-2-yl)-2-methoxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451902; robustaflavone-4'-methyl ether; Robustaflavone-4''''-Methyl Ether; BDBM50457775; 4''',5,5'',7,7''-Pentahydroxy-4'-methoxy-3',6''-biflavone
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[76] | ||
| Compound Name |
N-[(2S)-1-(Dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL84969; BB-3554; SCHEMBL4956500; BDBM50104500; 2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[16] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[16] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[16] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)aminobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585760; SCHEMBL13570529; BDBM50093566; (2S)-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acid; (S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-aminobutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[121] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[121] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-isoquinolin-4-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098992; BDBM50444726
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
4-(5-Bromo-4-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571149; BDBM50301408; 4-(4-Methyl-5-bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
(R)-2-(5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480191; SCHEMBL6430699; BDBM50256303
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[11] | ||
| Compound Name |
Chembl4213048
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457778
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[76] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-[4-(dimethylamino)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098985; BDBM50444734
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
5-((5-Methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-methylimidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078396; SCHEMBL7899982; BDBM50313818
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 100000 nM
|
[125] | ||
| Compound Name |
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072836; SCHEMBL15692522; BDBM194639; US9206139, 2
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
Thioacetic acid S-((4S,5S)-2-p-tolyl-5-vinyl-4,5-dihydro-oxazol-4-yl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360868; BDBM50152654
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | ||
| Compound Name |
(P-Tolylamino)methylenediphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440439; SCHEMBL11570312; BDBM50442518; ZINC96286211; p-tolylaminomethylenedi-phosphonic acid; (4-Methylphenyl)aminomethylenebisphosphonic acid; [(4-methylanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-{3-[1-(methylsulfonyl)-4-piperidinyl]-1,2,4-oxadiazol-5-yl}hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226840; BDBM50216838
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[28] | ||
| Compound Name |
5-Chloro-N-{[(4s)-4-(1-Methyl-1h-Imidazol-2-Yl)-2,5-Dioxoimidazolidin-4-Yl]methyl}-1-Benzofuran-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358156; 4wki; BDBM50033806; Q27454018; 3PW
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
(2R)-4-Fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585763; SCHEMBL13570653; BDBM50093569; (R)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluorobutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[121] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[121] | |||
| Compound Name |
N-Hydroxy-2-[[4-[(3-phenylphenyl)methoxy]phenyl]sulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431018; BDBM50441221
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 100000 nM
|
[59] | ||
| Compound Name |
(E)-N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methoxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099009; BDBM50444709
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-[(2S)-3-(4-Methoxyphenyl)-1-(methylamino)-1-oxopropan-2-yl]-4-methyl-2-[(2-sulfanylidene-1H-pyridin-3-yl)methyl]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323285; BDBM50286125
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[126] | ||
| Compound Name |
(1R,2S,5R)-2-[4-(4-Chlorophenyl)phenyl]sulfonyl-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341249; BDBM50131962
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[37] | ||
| Compound Name |
4-(4,5-Dibromo-1H-pyrrol-2-yl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230084; BDBM50215929
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[86] | ||
| Compound Name |
N-[(2S,4S)-1-[4-[2-(2,5-Dimethylpyridin-4-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683458; BDBM50337724
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[78] | ||
| Compound Name |
2-(2-Mercapto-benzyl)-4-methyl-pentanoic acid (2-oxo-azacyclotridec-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103665; BDBM50286127
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[126] | ||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(2-hydroxy-1,1-dimethylethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229866; SCHEMBL5412113; BDBM50216829
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[28] | ||
| Compound Name |
[(3-Fluoroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440436; BDBM50442513
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R)-4-Fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]pent-4-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585771; SCHEMBL13570943; BDBM50093577
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[121] | ||
| Compound Name |
[(4-Phenylanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293479; BDBM50138035; NSC725580; ZINC13673810; NSC-725580; (biphenyl-4-ylamino)methylenediphosphonic acid; (biphenyl-4-yl)-aminomethylene-1,1-bisphosphonate; (Biphenyl-4-yl)- aminomethylene-1,1-bisphosphonate; [(Biphenyl-4-ylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [([1,1'-biphenyl]-4-ylamino)methylene]bis-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[3,5-Dibromo-4-[2-(trifluoromethyl)phenethyl]-1H-pyrrole-2-yl]-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572244; BDBM50301415; 4-(3,5-dibromo-4-(2-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
Chembl4215193
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456799
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
[(2,4-Dichloroanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191613; BDBM50165966; 2,4-Dichloroanilinomethylenebisphosphonic acid; 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID; [(2,4-dichloro-phenyl)aminomethylene]-1,1-bisphosphonate; [(2,4-Dichloro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(2,4-dichlorophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[3-(4-Biphenylyloxymethyl)-4-oxo-4-(hydroxyamino)butyl]-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103442; SCHEMBL7224224; BDBM50096643; N-hydroxy-2-[(4-phenylphenoxy)methyl]-4-(1,1,3-trioxo-1,2-benzothiazol-2-yl)butanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[127] | ||
| Compound Name |
5-Chloro-2-oxo-1,2,3,4-tetrahydroquinazoline-3-acetohydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL298647; BDBM50100095; 2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-N-hydroxy-acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[128] | ||
| Compound Name |
4-Phenoxy-N-[(1R,2S)-2-sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380391; BDBM50433876
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
Ki ~ 100000 nM
|
[32] | ||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[32] | |||
| Compound Name |
4-(5-Bromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL583670; BDBM50301418; 4-[4-(3-Phenylpropyl)-5-bromo-1H-pyrrole-2-yl]-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
2-(N-Methyl-N-phenylamino)-N-((5-chloro-8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL473841; SCHEMBL1817784; BDBM50256700; N-[(5-chloro-8-hydroxyquinolin-7-yl)-(3-nitrophenyl)methyl]-2-(N-methylanilino)acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[105] | ||
| Compound Name |
[(1S)-6-Fluoro-1-[[4-(4-methoxyphenyl)phenyl]sulfonylamino]hexyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752419; BDBM50500716
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[129] | ||
| Compound Name |
Epicatechin 3-O-(4-O-methylgallate)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159433; (-)-ECG-4''-O-ME; CTK6J4413; 3-O-(4-Methylgalloyl)epicatechin; Epicatechin 3-O-(4-methylgallate); BDBM50296237; LMPK12020094
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[66] | ||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(4-cyclohexylbutyl)thiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437163; BDBM50441574
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[130] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[130] | |||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[130] | |||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-butyl-1-[(2S)-1-(4-hydroxyphenyl)-3-[(2S)-2-[[(6R)-6-(naphthalen-2-ylmethyl)-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593549; BDBM50104623
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[131] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[131] | |||
| Compound Name |
4-(4-Benzyl-5-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL579026; BDBM50301411; 4-(4-Benzyl-5-bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
Prop-2-enyl 2-[(E)-3-(4-bromophenyl)prop-2-enoyl]oxy-3-(3,4-dimethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333284; BDBM50429236
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
Thiadiazole derivative, 34
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401435; SCHEMBL4354162; BDBM24008; 1'-benzyl-5-(4-methoxyphenyl)-5'-methylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[8] | ||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-2-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]oxypropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333272; BDBM50429247
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
Prop-2-enyl 3-(3,4-dimethoxyphenyl)-2-[(E)-3-(4-nitrophenyl)prop-2-enoyl]oxypropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333285; BDBM50429235
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
CID 50943150
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933882; BDBM50360393; (E)-2-(1H-benzimidazol-2-yl)-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[132] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[132] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[132] | |||
| Compound Name |
N-(2-Methyl-4-amino-6-quinolyl)-4-(6-quinolyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099031; BDBM50444735
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
2-(Biphenyl-4-ylmethylsulfanyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclopentanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL125104; BDBM50131952
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[37] | ||
| Compound Name |
[(4-Cyanoanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440437; BDBM50442516
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-2-(4''-((4-(4-Fluorobenzoyl)phenoxy)methyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468722; SCHEMBL13978744; BDBM50258875
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[133] | ||
| Compound Name |
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066965; SCHEMBL15692521; BDBM194638; US9206139, 1
Click to Show/Hide
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| Activity | Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1940296; BDBM50419619
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[134] | ||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[134] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[134] | |||
| Compound Name |
2-(Benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL234737; BDBM50241254; N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[135] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[135] | |||
| Compound Name |
(4S,5S)-2-(4-Chloro-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361034; BDBM50152648
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | ||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[101] | |||
| Compound Name |
(S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-aminopent-4-enoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585768; SCHEMBL13570710; BDBM50093574; (2S)-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]pent-4-enoic acid
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[121] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[121] | |||
| Compound Name |
3-[1-(2-Carboxy-ethylcarbamoyl)-2-cyclohexyl-ethylcarbamoyl]-6-p-tolyl-hexanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306177; BDBM50101524; (R)-3-(((S)-1-(2-carboxyethylamino)-3-cyclohexyl-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid; (R)-3-[(S)-1-(2-Carboxy-ethylcarbamoyl)-2-cyclohexyl-ethylcarbamoyl]-6-p-tolyl-hexanoic acid
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
Ki = 100000 nM
|
[79] | ||
| Compound Name |
Sodium hydrogen (butylamino)carbonylphosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97389
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Berkeleylactone A
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4294879; SCHEMBL20510249; BDBM50468228; J3.652.282H
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 = 100000 nM
|
[49] | ||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[136] | ||
| Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 10 |
IC50 ~ 100000 nM
|
[136] | |||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[136] | |||
| Compound Name |
Chembl4214716
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456783
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-2-(4-phenylmethoxyphenoxy)acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098987; BDBM50444732
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-Phenoxy-N-[(1S,2R)-2-sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380392; BDBM50433875
Click to Show/Hide
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| Activity | Matrix metalloproteinase 7 |
Ki ~ 100000 nM
|
[32] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-phenylbenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099029; BDBM50444737
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
(1R,2S,5R)-2-[2-[4-(4-Chlorophenyl)phenyl]ethylsulfonyl]-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL127787; BDBM50131958
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[37] | ||
| Compound Name |
Schembl21751149
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235912; BDBM50104619
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[131] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[131] | |||
| Compound Name |
{2-[2-Cyclohexyl-1-(2-morpholin-4-yl-ethylcarbamoyl)-ethylcarbamoyl]-5-phenyl-pentyl}-phosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306779; BDBM50101493
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
Ki = 100000 nM
|
[79] | ||
| Compound Name |
2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-(4-thiazol-2-yl-phenylsulfanyl)-cyclopentanecarboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL125302; BDBM50131951
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[37] | ||
| Compound Name |
(2R,3R)-4-[2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(4-pyrazol-1-ylphenyl)methyl]butanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779630; SCHEMBL8221083; BDBM50343959
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[117] | ||
| Compound Name |
Cyclooctylcarbamoylphosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97709; (cyclooctylamino)carbonylphosphonic acid; BDBM50146798
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Thiadiazole derivative, 35
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL237366; SCHEMBL4983250; BDBM24009; 5-(4-methoxyphenyl)-5'-methyl-1'-(2-methylphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
Click to Show/Hide
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| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[137] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-3-ylbenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098996; BDBM50444722
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
[(4-Phenoxyanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440430; BDBM50442510
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
[(4S,5S)-2-(4-Nitro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364775; BDBM50152643
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
Ki ~ 100000 nM
|
[101] | ||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[101] | |||
| Compound Name |
3-{2-Cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-6-(4-methoxy-phenyl)-hexanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL309067; BDBM50101521
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
Ki = 100000 nM
|
[70] | ||
| Compound Name |
Prop-2-enyl 3-(3,4-dimethoxyphenyl)-2-[(E)-3-(4-phenylmethoxyphenyl)prop-2-enoyl]oxypropanoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333286; BDBM50429234
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
(2R)-2-[[4-[4-[(3-Methyl-1-benzofuran-2-yl)methoxy]phenyl]phenyl]sulfonylamino]-3-phenylpropanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL372405
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[139] | ||
| Compound Name |
[Pentyl[1-(3-phenylpropyl)-3-(4-phenoxyphenyl)ureidoacetyl]amino]acetohydroximic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL328477; BDBM50081775; N-Hydroxycarbamoylmethyl-N-pentyl-2-[3-(4-phenoxy-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 = 100000 nM
|
[47] | ||
| Compound Name |
(Cycloheptylamino)carbonylphosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97614; SCHEMBL5886552; BDBM50146807
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-isopropyl-1,2,4-oxadiazole-3-carboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL480757; SCHEMBL6429362; BDBM50256203; 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N-propan-2-yl-1,2,4-oxadiazole-3-carboxamide
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[11] | ||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-[(4-hydroxyphenyl)methyl]-1-[(2R)-1-[(2S)-2-[[(6R)-6-[(4-hydroxyphenyl)methyl]-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-naphthalen-2-ylpropan-2-yl]piperazine-2,3-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593550; BDBM50104622
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[131] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[131] | |||
| Compound Name |
4-(3,5-Dibromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL583673; BDBM50301419
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-8-ylbenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098999; BDBM50444719
Click to Show/Hide
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| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(4S)-5-Amino-5-oxo-4-[[(2S)-2-[3-(4-phenylphenyl)propanoylamino]butanoyl]amino]pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3675544; SCHEMBL14233120; BDBM120192; US8691753, 40
Click to Show/Hide
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| Activity | Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[46] | ||
| Compound Name |
4-(3,5-Dibromo-4-(3-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571601; BDBM50301416
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
4-(4-Bromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL576790; BDBM50301403
Click to Show/Hide
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| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
(Cyclopropylamino)carbonylphosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540952; BDBM50146815
Click to Show/Hide
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| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3-Bromophenylamino)Methylenediphosphonic Acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370662; BDBM50173799; [(3-Bromophenyl)amino]methylenebisphosphonic acid; [(3-bromoanilino)-phosphono-methyl]phosphonic acid; (3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate; [(3-Bromo-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-bromophenyl)amino]methylene]bis-
Click to Show/Hide
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| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R)-4-(4,5-Dihydroxy-3-methoxy-6-methyloxan-2-yl)oxy-8,10-bis(dimethylamino)-2,5,7-trihydroxy-3-methoxy-2-methyl-3,4-dihydrotetracene-1,6,11-trione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL328472; BDBM50001008
Click to Show/Hide
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| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[140] | ||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL260886; BDBM50359901
Click to Show/Hide
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| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[83] | ||
| Compound Name |
(4S)-5-[[(2S)-1-Amino-3-carboxy-1-oxopropan-2-yl]amino]-5-oxo-4-[3-[4-(4-phenylthiophen-2-yl)phenyl]propanoylamino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6868749; CHEMBL3675599; BDBM120252; US8691753, 101
Click to Show/Hide
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| Activity | Matrix metalloproteinase 7 |
Ki ~ 100000 nM
|
[46] | ||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[46] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-[(2S)-2-[[(6R)-6-benzyl-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-cyclohexylpropan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593552; BDBM50104618
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[131] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[131] | |||
| Compound Name |
(Hydroxysulfamoyl)dimethylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 51; CHEMBL330950; SCHEMBL6791061; BDBM11370; N-(Dimethylsulfamoyl)hydroxylamine
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 8 |
Ki ~ 100000 nM
|
[92] | ||
| Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[92] | |||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[92] | |||
| Compound Name |
N-[(2S,4S)-1-[4-[2-(4,6-Dimethylpyridin-3-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683461; BDBM50337739
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[78] | ||
| Compound Name |
(R)-2-(4''-((4-(Cyclohexanecarbonyl)phenoxy)methyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467891; SCHEMBL13978743; BDBM50258917
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[133] | ||
| Compound Name |
2-[(E)-3-(2,3-Dihydro-1-benzofuran-6-yl)prop-2-enoyl]oxy-3-(3,4-dimethoxyphenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333275; BDBM50429245
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-5-methoxy-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099028; BDBM50444738
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235416; SCHEMBL12198648; BDBM50005641; Q27463133
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[141] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[141] | |||
| Compound Name |
4-[[4-Oxo-6-(3-phenylpropa-1,2-dienyl)quinazolin-3-yl]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272188; SCHEMBL6297946; BDBM50372651; 4-[4-oxo-6-(3-phenyl-propa-1,2-dienyl)-4h-quinazolin-3-ylmethyl]-benzoic acid
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 100000 nM
|
[102] | ||
| Compound Name |
4-(Benzyloxy)-N-(4-pyridinylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1703805; MLS001001031; ZINC4841066; BDBM50418817; AKOS003370326; MCULE-7657311868; SMR000498738
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[54] | ||
| Compound Name |
(4S,5S)-4-Phenylsulfanyl-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184020; BDBM50152649
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | ||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[101] | |||
| Compound Name |
(2R)-N-Hydroxy-4-methyl-2-[[methyl(phenyl)phosphoryl]amino]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355754; (2R)-N-hydroxy-4-methyl-2-{[methyl(phenyl)phosphoryl]amino}pentanamide; SCHEMBL7403306; BDBM50291978; ZINC13782650; N-hydroxy-2(R)-[[(S)-methylphenylphosphinyl]amino]-4-methylpentanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[142] | ||
| Matrix metalloproteinase 3 |
IC50 = 130500 nM
|
[142] | |||
| Compound Name |
[Anilino(phosphono)methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440580; SCHEMBL7796889; N-phenylaminomethanediphosphonic acid; BDBM50442523; Phenylaminomethylenebisphosphonic acid; (PHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-{(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226686; SCHEMBL6428452; BDBM50241177; (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide; 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide; 5-{(1R)-4-cyclohexyl-1-[2-(hydroxylamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[11] | ||
| Compound Name |
[2-Methyl-1-[[4-(5-methylthiophen-2-yl)phenyl]sulfonylamino]propyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752826; BDBM50500715
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[129] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[129] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[129] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[129] | |||
| Compound Name |
4-(5-(Biphenyl-4-yl)-4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL569118; BDBM50301407
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
4-(3,4-Dibromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL578412; BDBM50301404
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
Acetic acid 3-acetoxy-5-methoxy-2-methyl-6-(3,10,12-trihydroxy-2-methoxy-3-methyl-4,6,11-trioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-tetrahydro-pyran-4-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91905; BDBM50001016
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[140] | ||
| Compound Name |
(S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585772; SCHEMBL13570522; BDBM50093578; (2S)-4-fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]pent-4-enoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[121] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[121] | |||
| Compound Name |
Cyclohexanamine;2-methylpropylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160685
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[[1-[2-[2-[2-[2-[4-[[[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-(4-methoxyphenyl)sulfonylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064553; BDBM50389105
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[143] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[143] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[143] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[143] | |||
| Compound Name |
[(4-Hydroxyanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440438; SCHEMBL4088119; BDBM50442515
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(3,5-Dibromo-4-(4-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571388; BDBM50301417
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
(2R)-2-Amino-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133199; BDBM50043598
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[68] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,5-dihydroxy-4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556692; BDBM50296241
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[66] | ||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
N-({4'-[(4-Isobutyrylphenoxy)methyl]biphenyl-4-Yl}sulfonyl)-D-Valine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511203; SCHEMBL13978734; BDBM50259007; Q27456853; N-({4''-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}sulfonyl)-D-valine; (R)-2-(4''-((4-isobutyrylphenoxy)methyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid; N-[(4'-{[4-(2-methylpropanoyl)phenoxy]methyl}biphenyl-4-yl)sulfonyl]-D-valine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[133] | ||
| Compound Name |
2-(3''-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43206; SCHEMBL7409278; BDBM50084299; (S)-2-(3''-bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(3-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 100000 nM
|
[53] | ||
| Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[70] | |||
| Matrix metalloproteinase 1 |
IC50 = 100000 nM
|
[53] | |||
| Compound Name |
1,1,1-Trifluoro-N-hydroxymethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 47; CHEMBL331308; SCHEMBL8231627; BDBM11366; CTK1H6610; DTXSID10635307; Methanesulfonamide, 1,1,1-trifluoro-N-hydroxy-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki ~ 100000 nM
|
[92] | ||
| Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[92] | |||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[92] | |||
| Compound Name |
Cyclohexylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329784; (cyclohexylamino)carbonylphosphonic acid; SCHEMBL13986865; BDBM50146801
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
CID 78426619
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235911; SCHEMBL20271444; BDBM50104621
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[131] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[131] | |||
| Compound Name |
(2R)-3-Methyl-2-[[4-[4-[(5-oxo-7,8-dihydro-6H-naphthalen-2-yl)oxymethyl]phenyl]phenyl]sulfonylamino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466118; SCHEMBL8284164; BDBM50259009
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[133] | ||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364212; BDBM50152631
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | ||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[101] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-cyclohexyl-3-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593551; BDBM50104620
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[131] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[131] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[131] | |||
| Compound Name |
[1-[[4-(6-Fluoropyridin-3-yl)phenyl]sulfonylamino]-2-methylpropyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752747; BDBM50500713
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[129] | ||
| Compound Name |
N-(2-Methyl-4-amino-6-quinolyl)-3-(2-methoxyphenyl)propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098990; BDBM50444728
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4202455
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456772
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
Chembl4202528
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456800
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
(2E)-2-(1H-Benzimidazol-2-yl)-3-(3-iodo-4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933865; BDBM50360392; STK288035; ZINC13943922; AKOS000417983; NCGC00330396-01; AB01325241-02
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[132] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[132] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[132] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-[2-(trifluoromethyl)phenyl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099007; BDBM50444711
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-Chloroanilinomethylenebisphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440579; BDBM50442521; ZINC59245747; N-(p-chlorphenyl)-aminomethanediphosphonic acid; (4-CHLOROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-2-(1,2-Benzothiazol-3-ylimino)-5-[(3-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398611; BDBM50063580
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[83] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methoxypyridin-3-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098973; BDBM50444760
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[(4-Fluoro-3-nitroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440434; BDBM50442511
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3,4-Dichloroanilinomethylenebisphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440433; BDBM50442512; ZINC96286205; 3,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-(4-benzoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098982; BDBM50444751
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[(4-Chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000062185; CHEMBL473326; SMR000070991; 2-[(4-chlorobenzyl)thio]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one; Oprea1_513869; Oprea1_558114; BDBM40467; cid_2047223; HMS2339I08; ML033; ZINC8602241; BDBM50031314; STL286652; AKOS001659025; CCG-317667; MCULE-1700867569; ST081503; SR-01000464438; SR-01000627583; SR-01000464438-1; SR-01000464438-2; SR-01000627583-2; SR-01000627583-3; Q27165053; 2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-cyclopentapyrimidine-4-ol; 2-[(4-chlorobenzyl)thio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one; 2-[(4-chlorobenzyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[122] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[122] | |||
| Compound Name |
(4S,5S)-2-(4-Bromo-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184492; BDBM50152651
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | ||
| Compound Name |
N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylidenemethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318252; SCHEMBL3882021; BDBM50146472
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[8] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[8] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4207344
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456779
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
Prop-2-enyl 3-(3,4-dimethoxyphenyl)-2-[(E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]oxypropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333282; BDBM50429238
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
4-(4,5-Dibromo-1H-pyrrol-2-yl)-N,N-dimethyl-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230085; BDBM50215925
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[86] | ||
| Compound Name |
2-(5-{(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226853; SCHEMBL6599569; BDBM50216823
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[28] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-pyridin-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099030; BDBM50444736
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
(4S,5S)-2-Biphenyl-4-yl-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186765; BDBM50152638
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[101] | ||
| Compound Name |
MMP Inhibitor, 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US8691753, 97; SCHEMBL6868870; CHEMBL3675606; BDBM92443; Thiophene derivative, compound 36
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[46] | ||
| Compound Name |
[1-[[4-[5-(Methoxymethyl)thiophen-2-yl]phenyl]sulfonylamino]-2-methylpropyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754314; BDBM50500719
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[129] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[129] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[129] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[129] | |||
| Compound Name |
Thiadiazole derivative, 33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237149; SCHEMBL4356155; BDBM24007; 1'-benzyl-5-(4-methoxyphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one; 1-benzyl-5''-(4-methoxyphenyl)-1,2-dihydro-3''H-spiro[indole-3,2''-[1,3,4]thiadiazole]-2-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[137] | ||
| Compound Name |
(2S)-2-[[(2R)-2-Amino-3-methylbutanoyl]amino]-N-[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132762; BDBM50043587
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[68] | ||
| Compound Name |
(4s)-3-{[4-(4-Cyano-2-Methylphenyl)piperazin-1-Yl]sulfonyl}-N-Hydroxy-1,3-Thiazolidine-4-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770935; Q27462716
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 100000 nM
|
[20] | ||
| Compound Name |
[(3-Nitroanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450938; SCHEMBL13458525; BDBM50173796; (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID; [(3-Nitro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-nitrophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(5-(Biphenyl-3-yl)-4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570917; BDBM50301406
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
N-Methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400314; BDBM50241371; 1-(2-(methylamino)-2-oxoethyl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea; N-Methyl-2-[3-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazole)-2-yl]ureido]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[63] | ||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[144] | |||
| Matrix metalloproteinase 3 |
Ki = 165958.69 nM
|
[70] | |||
| Compound Name |
4-(4,5-Dibromo-3-phenethyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL582812; BDBM50301420
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-2-[(E)-3-(4-methylphenyl)prop-2-enoyl]oxypropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333262; BDBM50429258
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
(S)-2-((R)-2-Acetylamino-3-mercapto-propionylamino)-3-phenyl-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55843; BDBM50287614
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[145] | ||
| Compound Name |
[2-(2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-p-tolyl-pentyl]-phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76869; BDBM50101522; [(S)-2-((S)-2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-p-tolyl-pentyl]-phosphonic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 100000 nM
|
[79] | ||
| Compound Name |
(Cyclobutylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95763; Phosphonic acid, [(cyclobutylamino)carbonyl]- (9CI); BDBM50146800
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-(4''-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-methyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42067; BDBM50084296; (S)-N-Hydroxy-3-methyl-2-[[(4'-cyano-1,1'-biphenyl-4-yl)sulfonyl]amino]butanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 100000 nM
|
[53] | ||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437488; SCHEMBL6429290; BDBM50216848; (3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-3-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[28] | ||
| Compound Name |
N-[(2S,4S)-1-[4-[2-[2-Chloro-4-(trifluoromethyl)phenyl]ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683449; BDBM50337725
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[78] | ||
| Compound Name |
(R)-2-(N-Benzyl-4-(2-fluoroethoxy)phenylsulphonamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237177; BDBM50225408
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[109] | ||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-benzylidene-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409502; BDBM50359903
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[83] | ||
| Compound Name |
Chembl4206956
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457774
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[76] | ||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[76] | |||
| Compound Name |
4-(4-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231012; BDBM50215928; 4-(4-Bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
Cyclopentylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316997; (cyclopentylamino)carbonylphosphonic acid; SCHEMBL4846602; CTK8I2608; BDBM50146816
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(4S)-5-Amino-4-[[(2S)-4-methyl-2-[3-[4-(4-phenylphenyl)phenyl]propanoylamino]pentanoyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6869217; CHEMBL3675580; BDBM120230; US8691753, 79
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[46] | ||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]oxypropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333270; BDBM50429249
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD-503; CHEMBL409536; SCHEMBL5957461; PD503; BDBM50234334; ZINC29133346; DB08561; Q27097766
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[102] | ||
| Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[102] | |||
| Matrix metalloproteinase 17 |
IC50 ~ 100000 nM
|
[146] | |||
| Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[102] | |||
| Matrix metalloproteinase 7 |
IC50 ~ 100000 nM
|
[102] | |||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[146] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[102] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[102] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[102] | |||
| Compound Name |
Lithium ethyl (cyclohexylamino)carbonylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1627009
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[27] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[27] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(5-Chloro-3,4-dihydro-1H-2,1,3-benzothiadiazine-3-acetohydroxamic acid)2,2-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299946; BDBM50100097; 2-(5-Chloro-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[128] | ||
| Compound Name |
4-(5-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395799; BDBM50215930; 4-(5-Bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496942; MMP Inhibitor, 5; SCHEMBL6244295; ZINC3815953; BDBM50265079; DB07827; DB-123234; SR-03000000793-1; Q27097037
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[146] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[146] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[146] | |||
| Compound Name |
(2E)-3-(N-Hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236446; BDBM50213418
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[73] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[73] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-quinolin-8-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098994; BDBM50444724
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-2-[(E)-3-naphthalen-2-ylprop-2-enoyl]oxypropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333274; BDBM50429246
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
(1R,2S,5R)-2-[4-(4-Chlorophenyl)phenyl]sulfanyl-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126380; BDBM50131937
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[37] | ||
| Compound Name |
3-(1-Carbamoyl-2-cyclohexyl-ethylcarbamoyl)-6-phenyl-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307207; BDBM50101527; (R)-3-(((S)-1-amino-3-cyclohexyl-1-oxopropan-2-yl)carbamoyl)-6-phenylhexanoic acid; (R)-3-((S)-1-Carbamoyl-2-cyclohexyl-ethylcarbamoyl)-6-phenyl-hexanoic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 100000 nM
|
[79] | ||
| Compound Name |
[Phosphono-[3-(trifluoromethyl)anilino]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440435; BDBM50442514
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Phenoxy-N-[(1R,2R)-2-sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380396; BDBM50433871
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 100000 nM
|
[32] | ||
| Compound Name |
Hydroxysulfonamide 48
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124237; BDBM11367; 1,1,1-trichloro-N-hydroxymethanesulfonamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki ~ 100000 nM
|
[92] | ||
| Matrix metalloproteinase 9 |
Ki ~ 100000 nM
|
[92] | |||
| Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[92] | |||
| Matrix metalloproteinase 2 |
Ki ~ 100000 nM
|
[92] | |||
| Compound Name |
Chembl4214656
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456793
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
4-(2-Phenylethoxy)-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796290; BDBM50418816
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[54] | ||
| Compound Name |
N-(2beta-Mercaptocyclopentane-1alpha-yl)-4-phenoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380395; BDBM50433872
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki ~ 100000 nM
|
[32] | ||
| Compound Name |
4-(4-Bromo-5-phenyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571814; BDBM50301405
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
N-Hydroxycarbamoylmethyl-N-(1-methyl-butyl)-2-[3-(4-phenoxy-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94887; BDBM50081771; N-Hydroxy-2-[(1-methylbutyl)[1-(3-phenylpropyl)-3-(4-phenoxyphenyl)ureidoacetyl]amino]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 100000 nM
|
[47] | ||
| Compound Name |
4-(1H-Pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230194; BDBM50215927; 4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine; 4-(1H-Pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[86] | ||
| Compound Name |
Prop-2-enyl 2-[(E)-3-(4-chlorophenyl)prop-2-enoyl]oxy-3-(3,4-dimethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333283; BDBM50429237
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[77] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-6-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098995; BDBM50444723
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4207416
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456780
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 100000 nM
|
[60] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[60] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
4-(4-Benzyl-3,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572027; BDBM50301412; 4-(4-Benzyl-3,5-dibromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[124] | ||
| Compound Name |
4-(1-Methyl-4,5-dibromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230196; BDBM50215932; 4-(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 100000 nM
|
[86] | ||
| Compound Name |
Ubenimex
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Bestatin; Ubenimex (Bestatin); UNII-I0J33N5627; MFCD00083262; NK-421; CHEMBL29292; 58970-76-6 (free base); I0J33N5627; Ubenimexum [Latin]; Ubenimexum; Ubenimex [INN:JAN]; Ubenimex(Bestatin); SMR000059165; EINECS 261-529-2; NK 421; NSC 265489; BRN 4704312; Ubestatin; Ubenimex, solid; NSC-265489; Ubenimex, Bestatin; Ubenimex,(S); SCHEMBL7944; (3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine; Lopac0_000214; BSPBio_001553; KBioGR_000273; KBioSS_000273; MLS000028649; MLS001424177; MLS006010137; BCBcMAP01_000178; BDBM23971; KBio2_000273; KBio2_002841; KBio2_005409; KBio3_000545; KBio3_000546; Bio2_000273; Bio2_000753; HMS1361N15; HMS1791N15; HMS1989N15; HMS2052A03; HMS2232H13; HMS3268O06; HMS3402N15; HMS3412N16; HMS3676N16; HMS3715B20; EX-A1292; HY-B0134; KS-00000JJ0; ZINC1542895; BDBM50367209; KM0266; s1591; AKOS016339610; CCG-101071; CS-1910; DB03424; KS-5207; NC00321; QC-8204; SDCCGSBI-0050202.P003; IDI1_034023; SMP1_000030; NCGC00025323-01; NCGC00025323-02; NCGC00025323-03; NCGC00025323-04; NCGC00025323-05; NCGC00025323-06; NCGC00025323-08; NCGC00025323-14; AT-11558; BCP0726000308; AB0010690; ST50405897; AB00698345_05; 970B766; SR-01000075724-3; W-105351; BRD-K59574735-001-02-7; BRD-K59574735-001-05-0; Q10909912
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 ~ 100000 nM
|
[147] | ||
| Compound Name |
(4S)-5-Amino-4-[[(2S)-4-carboxy-2-[3-(4-thiophen-2-ylphenyl)propanoylamino]butanoyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6868823; CHEMBL3675581; BDBM120231; US8691753, 80
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki ~ 100000 nM
|
[46] | ||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-phenoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099020; BDBM50444747
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[14] | ||
| Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-[4-(1H-[1,2,3]triazol-4-yl)-phenylsulfanyl]-cyclopentanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339315; BDBM50131961
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 ~ 100000 nM
|
[37] | ||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(3-chlorophenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412064; BDBM50359898
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 ~ 100000 nM
|
[83] | ||
| Compound Name |
N-Hydroxy-N-[1-(4-methylidenecyclohexyl)-2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]sulfonylethyl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328199; SCHEMBL3883897; BDBM50146470
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[41] | ||
| Compound Name |
[(4-Fluoroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440581; BDBM50442522
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 ~ 100000 nM
|
[1] | ||
| Matrix metalloproteinase 8 |
IC50 ~ 100000 nM
|
[1] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-3-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-2-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819321; BDBM50351022
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 100100 nM
|
[71] | ||
| Compound Name |
N-[(2R)-2-Amino-3-phenylpropyl]-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457448; BDBM50273774
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 100700 nM
|
[115] | ||
| Compound Name |
4-(4-Methoxyphenyl)-N-(2-morpholin-4-ylethyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181682; Peakdale1_000543; SCHEMBL6450822; HMS519I15; BDBM50170202; N-(2-Morpholinoethyl)-4-(4-methoxyphenyl)thiophene-2-carboxamide; 4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 ~ 101000 nM
|
[148] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 101000 nM
|
[148] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 101000 nM
|
[148] | |||
| Compound Name |
(4S,E)-5-(1,4-Dimethoxy-1,4-dioxobutan-2-ylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521626; BDBM50267569
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 101500 nM
|
[94] | ||
| Compound Name |
(2R)-N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]-4-(benzyloxycarbonylamino)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431026; BDBM50441214
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 104000 nM
|
[59] | ||
| Compound Name |
Benzo[d][1,3]dioxol-5-ylmethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253189; BDBM50227540
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 105000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 107000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 114000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 128000 nM
|
[33] | |||
| Compound Name |
(S)-N,N-Diethyl-2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamido)-3-phenyl-propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599733; BDBM50306925
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 105300 nM
|
[85] | ||
| Compound Name |
(2S)-N-[(2S,3S)-2-Amino-3-hydroxy-3-(4-nitrophenyl)propyl]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819332; BDBM50351033
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 105600 nM
|
[71] | ||
| Compound Name |
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378575; BDBM11980; BHT102866; chemical diversity library compound 5; AKOS027461626; ST003272; 2-Thioxo-5-[(Z)-2,4-dihydroxybenzylidene]imidazolidine-4-one; 5-[(2,4-dihydroxyphenyl)methylene]-2-thioxo-1,3-diazolidin-4-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 105900 nM
|
[98] | ||
| Compound Name |
(2S)-N-Butyl-2-[[2-(3-methyl-2-oxoquinoxalin-1-yl)acetyl]amino]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598119; BDBM50306924; (S)-N-Butyl-2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamido)-3-phenylpropan-amide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 106000 nM
|
[85] | ||
| Compound Name |
3-Fluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254611; BDBM50227528
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 107000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 119000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 124000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 151000 nM
|
[33] | |||
| Compound Name |
Phenethyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252522; BDBM50227599
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 107000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 117000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 = 119000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 120000 nM
|
[33] | |||
| Compound Name |
2-(2-(3-((S)-2-Amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl)acetamido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213732; BDBM50323950
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 107000 nM
|
[99] | ||
| Compound Name |
(2R)-2-Amino-N-[(2R)-1-[[(2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819449; BDBM50351045
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 107100 nM
|
[71] | ||
| Compound Name |
(R)-5-(3-Chloro-4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477656; BDBM50267317
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 107200 nM
|
[69] | ||
| Compound Name |
5-[4-[[3-Azido-5-(azidomethyl)benzoyl]amino]phenyl]-N-[7-(hydroxyamino)-7-oxoheptyl]-1,2-oxazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1914702; BDBM50356634
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 108000 nM
|
[149] | ||
| Compound Name |
2-Bromobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399997; BDBM50227598
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 108000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
4-Fluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250057; BDBM50227527
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 108000 nM
|
[33] | ||
| Matrix metalloproteinase 12 |
IC50 = 112000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 120000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 120000 nM
|
[33] | |||
| Compound Name |
(R)-5-(2,4-Difluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489232; BDBM50267960
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 108700 nM
|
[69] | ||
| Compound Name |
(2R)-2-Amino-N-[(2S)-3-[[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]amino]-2-hydroxy-3-oxopropyl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819330; BDBM50351031
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 108900 nM
|
[71] | ||
| Compound Name |
Naphthalen-1-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399504; BDBM50227555
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 109000 nM
|
[33] | ||
| Matrix metalloproteinase 2 |
IC50 = 109000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 111000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 115000 nM
|
[33] | |||
| Compound Name |
2-(1-Benzyl-3-naphthalen-1-yl-ureido)-N-sec-butyl-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95187; BDBM50081782
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 110000 nM
|
[47] | ||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid biphenyl-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251425; BDBM50227590
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 110000 nM
|
[33] | ||
| Matrix metalloproteinase 1 |
IC50 = 119000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 135000 nM
|
[33] | |||
| Matrix metalloproteinase 9 |
IC50 = 150000 nM
|
[33] | |||
| Compound Name |
N-[4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485492; N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)acetamide; SCHEMBL314064; BDBM50264811
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
Ki = 110000 nM
|
[114] | ||
| Compound Name |
2-{Isopropoxy[(4-methoxyphenyl)sulfonyl]amino}-N-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226439; BDBM50204371; N-hydroxy-2-(N-isopropoxy-4-methoxyphenylsulfonamido)acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 110000 nM
|
[150] | ||
| Compound Name |
3-(Trifluoromethyl)benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254405; BDBM50227535
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 110000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 126000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 134000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 = 134000 nM
|
[33] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S)-1-[[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]amino]-3-hydroxy-1-oxopropan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819329; BDBM50351030
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 110100 nM
|
[71] | ||
| Compound Name |
(2S)-2-Amino-N-[(2S,3S)-2-amino-3-(4-aminophenyl)-3-hydroxypropyl]-3-(4-hydroxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819442; BDBM50351038
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 111300 nM
|
[71] | ||
| Compound Name |
Chembl4162521
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278366
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 111350 nM
|
[112] | ||
| Matrix metalloproteinase 12 |
IC50 = 198300 nM
|
[112] | |||
| Compound Name |
(2S)-2-Amino-4-methylthio-N-[(2R)-2-amino-3-phenylpropyl]butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457649; BDBM50273634
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 112100 nM
|
[115] | ||
| Compound Name |
N-[(E)-1-(2-Chlorophenyl)ethylideneamino]-2-(3-methyl-2-oxoquinoxalin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775412; BDBM50155283; N-[(E)-1-(2-chlorophenyl)ethylideneamino]-2-(3-methyl-2-oxo-quinoxalin-1-yl)acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 112260 nM
|
[91] | ||
| Compound Name |
N-[2-(4-Fluoro-phenyl)-ethyl]-2-[1-heptyl-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320908; BDBM50081792
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 114000 nM
|
[47] | ||
| Compound Name |
(R)-5-(2-Nicotinoylhydrazinyl)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521950; BDBM50267881
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 114900 nM
|
[69] | ||
| Compound Name |
(S,E)-5-(3,5-Difluorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476637; BDBM50267463
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 116300 nM
|
[94] | ||
| Compound Name |
1-(4-Chloro-2-methyl-phenyl)-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290892; BDBM50076356
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 119000 nM
|
[63] | ||
| Compound Name |
(2S)-2-Amino-N-[(2S,3S)-2-amino-3-(4-aminophenyl)-3-hydroxypropyl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819334; BDBM50351035
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 119300 nM
|
[71] | ||
| Compound Name |
(2S)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819446; BDBM50351042
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 119500 nM
|
[71] | ||
| Compound Name |
N-Hydroxy-2-[4-(4-bromobenzyloxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431029; BDBM50441228
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 120000 nM
|
[59] | ||
| Compound Name |
N-Hydroxy-2-[4-(8-quinolylmethoxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431019; BDBM50441220
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 120000 nM
|
[59] | ||
| Compound Name |
4-(Thiiran-2-ylmethylsulfonyl)phenyl propane-2-sulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651849; BDBM50335502
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki = 120000 nM
|
[120] | ||
| Compound Name |
(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927186; ZINC2698193; BDBM50359724; STK711873; AKOS002386597; ST50326453; AB00674549-01; F1542-0089
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 120000 nM
|
[57] | ||
| Compound Name |
(S)-2-((E)-3-Furan-2-yl-acryloylamino)-3-(1H-indol-3-yl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63328; ZINC2522638; BDBM50043800; N-(3-(2-FURYL)ACRYLOYL)-L-TRYPTOPHAN
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 120000 nM
|
[65] | ||
| Compound Name |
N-[1-(4'-Cyano-4-biphenylyloxymethyl)-3-methylbutyl]formhydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42862; SCHEMBL7509014; BDBM50100914; N-[1-[4-(4-cyanophenyl)phenoxy]-4-methylpentan-2-yl]-N-hydroxyformamide; N-[1-(4''-Cyano-biphenyl-4-yloxymethyl)-3-methyl-butyl]-N-hydroxy-formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 120000 nM
|
[26] | ||
| Compound Name |
(2Z,NE)-N-benzylidene-4-(3,4-dimethoxyphenyl)-2-(phenylimino)thiazol-3(2H)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927187; BDBM50359725; STL264510; AKOS002238584; ST50113618; F0807-0342; (2Z)-4-(3,4-dimethoxyphenyl)-2-(phenylimino)-N-[(E)-phenylmethylidene]-1,3-thiazol-3(2H)-amine; 4-[3-((1E)-2-phenyl-1-azavinyl)-2-(phenylazamethylene)(1,3-thiazolin-4-yl)]-1, 2-dimethoxybenzene
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 120000 nM
|
[57] | ||
| Matrix metalloproteinase 13 |
IC50 = 140000 nM
|
[57] | |||
| Matrix metalloproteinase 14 |
IC50 = 150000 nM
|
[57] | |||
| Compound Name |
Dipotassium;2-[[2-[[(2S,3S)-2-[[ethoxy(oxido)phosphoryl]amino]-3-methylpentanoyl]amino]-3-(4-phenylmethoxyphenyl)propanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1744415
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 120000 nM
|
[40] | ||
| Compound Name |
N-Hydroxycarbamoylmethyl-N-(1-methyl-butyl)-2-[3-naphthalen-2-yl-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98186; BDBM50081776
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 120000 nM
|
[47] | ||
| Compound Name |
(S,E)-5-(3-Chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477652; BDBM50267466
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 120800 nM
|
[94] | ||
| Compound Name |
4-Thiouracil
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Hydroxy-4(1H)-pyrimidinethione; 4-sulfanylidene-1H-pyrimidin-2-one; 2-Hydroxy-4-mercaptopyrimidine; 4-mercaptopyrimidin-2-ol; Uracil, 4-thio-; 4-Thiouracil, 97%; 2(1H)-pyrimidinone, 3,4-dihydro-4-thioxo-; 4-sulfanylpyrimidin-2-ol; 2-Hydroxy-4-thiopyrimidine; CHEMBL1650608; KC 135; MFCD00090842; 4-Thiouracyl; 4-thiopyrimidin-2-one; ACMC-1AXFO; 2(1H)-Pyrimidinone, 4-mercapto- (9CI); SCHEMBL26167; 2-Pyrimidinol, 4-mercapto-; SCHEMBL10524664; CTK1A1769; CTK5A9480; CTK8H5107; DTXSID50207840; KS-000010TK; NSC43288; ZINC5117659; ANW-33167; BBL101106; BDBM50335810; GEO-02327; NSC-43288; STL554902; TD8160; 4(3H)-Pyrimidinethione, 2-hydroxy-; AKOS005256998; AKOS006229660; AKOS015916356; AKOS015995934; MCULE-8582608477; 6-sulfanyl-1,2-dihydropyrimidin-2-one; 4-sulfanylidene-1~{H}-pyrimidin-2-one; AS-54718; SC-76314; 3,4-Dihydro-4-thioxo-2(1H)-pyrimidinone; 4-thioxo-3,4-dihydro-2(1H)-pyrimidinone; AB0101133; DB-053326; DB-066140; 2(1H)-Pyrimidinone,3,4-dihydro-4-thioxo-; FT-0619526; FT-0721260; ST51038365; Z2909; A-8137; T-3812; 268H535; A832178; W-201773; Q20892040; Benzenepropanoic acid, 2,4,6-trimethyl-.beta.-oxo-, ethyl ester
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 121000 nM
|
[17] | ||
| Compound Name |
(S)-Benzyl-2-(2-((S)-3-((S)-2-amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl)acetamido)-4-methylpentanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213670; BDBM50323946
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 121000 nM
|
[99] | ||
| Compound Name |
Isopropyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404205; BDBM50227591
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 121000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 132000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 = 146000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
N-[(2r)-2-(Hydroxycarbamoyl)-4-Methylpentanoyl]-L-Alanylglycinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372437; SCHEMBL9287740; BDBM50035235; Q27447213; N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''''-hydroxy-2-isobutyl-malonamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 121000 nM
|
[31] | ||
| Compound Name |
(2S)-2-Amino-N-[(3S)-1-[2-(4-fluoroanilino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214487; BDBM50323935
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 122000 nM
|
[99] | ||
| Compound Name |
(R)-5-(2,5-Dichlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523936; BDBM50267961
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 122400 nM
|
[69] | ||
| Compound Name |
N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonyl(methyl)amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431022; BDBM50441218
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 123000 nM
|
[59] | ||
| Compound Name |
2,3-Bis(2,4-dimethoxyphenylsulfonamido)-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521689; BDBM50260884
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 124000 nM
|
[151] | ||
| Compound Name |
(2S)-N-(4-Fluorophenyl)-2-[[2-(3-methyl-2-oxoquinoxalin-1-yl)acetyl]amino]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604737; BDBM50306917; (S)-N-(4-Fluorophenyl)-2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamido)-3-phenyl-propanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 124320 nM
|
[85] | ||
| Compound Name |
(E)-5-(4-Hydroxyphenyl)-2-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-3-oxo-N-phenylpent-4-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2122254; CHEMBL3893144; US9187406, Compound 7; BDBM191770
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 125000 nM
|
[107] | ||
| Compound Name |
2-[[4-[(3,5-Dibromophenyl)methoxy]phenyl]sulfonylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431023; BDBM50441229
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 125000 nM
|
[59] | ||
| Compound Name |
N-Benzyl-2-[1-cyclohexylmethyl-3-(4-phenoxy-phenyl)-ureido]-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418779; BDBM50081798
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 125000 nM
|
[47] | ||
| Compound Name |
Benzyl-3-(2-((S)-3-((S)-2-amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl)acetamido)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213671; BDBM50323947
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 127000 nM
|
[99] | ||
| Compound Name |
(1R,2S)-1-({3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461220; SCHEMBL13648029; BDBM26524; hydroxamate-cyclopropyl compound, 1
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki = 128000 nM
|
[88] | ||
| Compound Name |
4-[4-(Thiirane-2-ylmethylsulfonyl)phenoxy]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063274; SCHEMBL10238452; BDBM50388914
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 128000 nM
|
[152] | ||
| Compound Name |
(S)-Benzyl-2-(2-(3-((S)-2-amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl)acetamido)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213668; BDBM50323944
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 129000 nM
|
[99] | ||
| Compound Name |
Berkchaetoazaphilone A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759333; BDBM50142040; J3.512.513B
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 130000 nM
|
[153] | ||
| Compound Name |
N-[1-(Phenoxymethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41485; SCHEMBL7504451; BDBM50100907; N-[1-[4-(4-cyanophenyl)phenoxy]-3-phenoxypropan-2-yl]-N-hydroxyformamide; N-[2-(4''-Cyano-biphenyl-4-yloxy)-1-phenoxymethyl-ethyl]-N-hydroxy-formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 130000 nM
|
[26] | ||
| Compound Name |
((R)-1-{4-[2-(4-Methoxy-phenyl)-ethyl]-benzenesulfonylamino}-2-methyl-propyl)-phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228141; BDBM50198036
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 = 130000 nM
|
[51] | ||
| Compound Name |
Dipotassium;2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(oxido)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369488; BDBM50367930
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 130000 nM
|
[40] | ||
| Compound Name |
2-Cinnamamido-N1-hydroxy-N4-propylsuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593542; BDBM50304546
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 131000 nM
|
[18] | ||
| Compound Name |
(2S)-2-Amino-N-[(3S)-1-[2-(3-chloro-4-fluoroanilino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214591; BDBM50323941
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 131000 nM
|
[99] | ||
| Compound Name |
(2S)-2-Amino-N-[(2R)-1-[[(2S,3S)-2-amino-3-(4-aminophenyl)-3-hydroxypropyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819443; BDBM50351039
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 133800 nM
|
[71] | ||
| Compound Name |
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567134; MLS002471787; SCHEMBL3353019; HMS2198O14; BDBM50303441; NCGC00182110-01; NCGC00182110-02; SMR001395200; Q27165373; 9-(3,5-difluorophenyl)-6-(ethylamino)purine-2-carbonitrile; 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 134896.29 nM
|
[110] | ||
| Compound Name |
Cyclobutyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252327; BDBM50227539
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 135000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 = 137000 nM
|
[33] | |||
| Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
4-(4-(Thiiran-2-ylmethylsulfonyl)phenoxy)phenyl methanesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651842; SCHEMBL10238468; BDBM50335495
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 140000 nM
|
[120] | ||
| Compound Name |
Dipotassium;2-[[(2S)-2-[[(2S)-2-[[ethoxy(oxido)phosphoryl]amino]-4-methylpentanoyl]amino]propanoyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369489; BDBM50367935
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 140000 nM
|
[40] | ||
| Compound Name |
(2R)-2-Amino-N-[(3S)-1-[2-[[2-(hydroxyamino)-2-oxoethyl]amino]-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213798; BDBM50323957
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 141000 nM
|
[99] | ||
| Compound Name |
(2S)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819322; BDBM50351048
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 142900 nM
|
[71] | ||
| Compound Name |
(2S)-N-Hydroxy-5-oxo-1-[(4-phenylphenyl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957584; BDBM50366185
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 144000 nM
|
[45] | ||
| Compound Name |
[(2S)-3-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-oxo-2-[2-(trifluoromethoxy)phenyl]sulfanylpropyl]-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153738; BDBM50393207
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 148000 nM
|
[154] | ||
| Compound Name |
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-trifluoromethoxy-phenylsulfanyl)-propyl]-phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323885; BDBM50138686
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 148000 nM
|
[155] | ||
| Matrix metalloproteinase 13 |
Ki = 200000 nM
|
[155] | |||
| Matrix metalloproteinase 8 |
Ki = 200000 nM
|
[155] | |||
| Matrix metalloproteinase 2 |
Ki = 200000 nM
|
[155] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S,3S)-2-amino-3-(4-aminophenyl)-3-hydroxypropyl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819336; BDBM50351037
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 149200 nM
|
[71] | ||
| Compound Name |
3-((2-Phenethyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251465; BDBM50227530
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-phenethyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400851; BDBM50227577
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
1-Cyclohexenyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249860; BDBM50227560
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452082; BDBM50245247
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 150000 nM
|
[96] | ||
| Matrix metalloproteinase 9 |
IC50 = 200000 nM
|
[96] | |||
| Compound Name |
2-[1-Tert-Butyl-3-(4-phenoxy-phenyl)-ureido]-N-cyclohexylmethyl-N-hydroxycarbamoylmethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329696; BDBM50081800
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 150000 nM
|
[47] | ||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249863; BDBM50227536
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
Chembl4282646
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Berkeleylactone F; SCHEMBL20510736; BDBM50468229; J3.652.287I
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 150000 nM
|
[49] | ||
| Compound Name |
2,3-Bis(1-(dimethylamino)naphthalene-5-sulfonamido)-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494644; BDBM50260885
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 150000 nM
|
[151] | ||
| Compound Name |
3-((2-Benzyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400357; BDBM50227573
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-hexyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249861; BDBM50227550
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
(E)-3-((2-Cinnamyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428762; BDBM50227546
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-heptyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400850; BDBM50227570
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
5-(3-Pyridylmethyl)-1H-tetrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399998; 3-(2H-tetrazol-5-ylmethyl)pyridine; BDBM50227558; AKOS000262059; 3-((2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
1-Benzyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249862; BDBM50227566; J3.517.457E; 1-Benzyl-4-(2-oxazoline-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
3-((2-(3-Phenylpropyl)-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400358; BDBM50227594
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 ~ 150000 nM
|
[33] | ||
| Matrix metalloproteinase 9 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 1 |
IC50 ~ 150000 nM
|
[33] | |||
| Matrix metalloproteinase 2 |
IC50 ~ 150000 nM
|
[33] | |||
| Compound Name |
N-Tert-Butyl-N-hydroxycarbamoylmethyl-2-[3-(2-methylsulfanyl-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97293; BDBM50081769
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 150000 nM
|
[47] | ||
| Compound Name |
[Heptyl[1-(3-phenylpropyl)-3-(4-phenoxyphenyl)ureidoacetyl]amino]acetohydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321088; BDBM50081794; N-Heptyl-N-hydroxycarbamoylmethyl-2-[3-(4-phenoxy-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 150000 nM
|
[47] | ||
| Compound Name |
(2S)-2-Amino-3-methyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457427; BDBM50273632
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 151400 nM
|
[115] | ||
| Compound Name |
(2R)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-3-sulfanylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819319; BDBM50351023
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 151600 nM
|
[71] | ||
| Compound Name |
[(4S,5S)-2-((Z)-4-Phenyl-buta-1,3-dienyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187079; BDBM50152645
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
Ki = 153000 nM
|
[101] | ||
| Compound Name |
N-Tert-Butyl-N-hydroxycarbamoylmethyl-2-[1-isopropyl-3-(4-phenoxy-phenyl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94796; BDBM50081772
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 155000 nM
|
[47] | ||
| Compound Name |
(S)-2-(2-(3-((S)-2-Amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl)acetamido)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213733; BDBM50323951
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 155000 nM
|
[99] | ||
| Compound Name |
(2S)-2,6-Diamino-N-[(2S,3S)-2-amino-3-(4-aminophenyl)-3-hydroxypropyl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819335; BDBM50351036
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 157400 nM
|
[71] | ||
| Compound Name |
(2S)-N-Hydroxy-1-[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830657
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 157420 nM
|
[156] | ||
| Compound Name |
(S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(methylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491451; BDBM50267525
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 159100 nM
|
[94] | ||
| Compound Name |
N'-[2-(3-Methyl-2-oxo-quinoxalin-1-yl)acetyl]-2-phenyl-acetohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775319; BDBM50155277
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 159390 nM
|
[91] | ||
| Compound Name |
N-[1-(Phenylthiomethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39358; SCHEMBL7498355; BDBM50100913; N-[1-(4''-Cyano-biphenyl-4-yloxymethyl)-2-phenylsulfanyl-ethyl]-N-hydroxy-formamide; N-[1-[4-(4-cyanophenyl)phenoxy]-3-phenylsulfanylpropan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 160000 nM
|
[26] | ||
| Compound Name |
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-methoxy-phenylsulfanyl)-propyl]-phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324891; BDBM50138685
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
Ki = 160000 nM
|
[155] | ||
| Compound Name |
N-Hydroxycarbamoylmethyl-2-[1-(1-methyl-butyl)-3-(4-phenoxy-phenyl)-ureido]-N-pentyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94268; BDBM50081773
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 160000 nM
|
[47] | ||
| Compound Name |
(2S)-2-Amino-5-(diaminomethylideneamino)-N-[4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834420; BDBM50354627
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki = 160000 nM
|
[114] | ||
| Compound Name |
(3S)-N-[(2S)-1-(Hydroxyamino)-4-methylsulfanyl-1-oxobutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830654
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 166110 nM
|
[156] | ||
| Compound Name |
2-Cinnamamido-N1-hydroxy-N4-isopropylsuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593795; BDBM50304539
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 166600 nM
|
[18] | ||
| Compound Name |
1-(2-Hydroxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440713; BDBM50062452
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 168000 nM
|
[31] | ||
| Compound Name |
(R)-5-Oxo-5-(2-(thiazole-2-carbonyl)hydrazinyl)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490844; BDBM50267880
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 169400 nM
|
[69] | ||
| Compound Name |
N6-[(Benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500911; BDBM50271955
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 170000 nM
|
[56] | ||
| Compound Name |
N-Hydroxy-2-[4-[3-bromo-5-(p-anisyl)benzyloxy]phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431024; BDBM50441217
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 170000 nM
|
[59] | ||
| Compound Name |
(2S)-2-Amino-4-methyl-N-[(2R)-2-amino-3-phenylpropyl]valeramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505762; BDBM50273631
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 170200 nM
|
[115] | ||
| Compound Name |
5-(2-Chloro-6-methyl-phenylamino)-3H-[1,3,4]thiadiazole-2-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39699; BDBM50076378; AKOS015597121; 5-[(2-Chloro-6-methylphenyl)amino]-1,3,4-thiadiazole-2(3H)-thione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 173000 nM
|
[63] | ||
| Compound Name |
(2S)-2-Amino-N-[(2R)-1-[[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819328; BDBM50351029
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 173100 nM
|
[71] | ||
| Compound Name |
2-Cinnamamido-4-(dodecylamino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594941; BDBM50304562
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 176500 nM
|
[18] | ||
| Compound Name |
3-(1-Phenyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-2H-chromen-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000583508; CHEMBL1352521; SMR000206694; Oprea1_153798; Oprea1_327986; BDBM63209; cid_3380837; 3-(3-phenyl-2-sulfanylidene-1H-imidazol-5-yl)chromen-2-one; HMS2546H23; ZINC5646879; AKOS002096713; MCULE-8333834154; 3-(1-phenyl-2-thioxo-4-imidazolin-4-yl)coumarin; SR-01000555381; SR-01000555381-1; 3-(3-phenyl-2-sulfanylidene-1H-imidazol-5-yl)-1-benzopyran-2-one
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 177000 nM
|
[57] | ||
| Compound Name |
N-[1-[4-(4-Cyanophenyl)phenoxy]-3-(4-fluorophenyl)propan-2-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289108; SCHEMBL7504912; BDBM50100901; N-[1-(4''-Cyano-biphenyl-4-yloxymethyl)-2-(4-fluoro-phenyl)-ethyl]-N-hydroxy-formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 180000 nM
|
[26] | ||
| Compound Name |
N-Hydroxy-N''-[(S)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355727; BDBM50112001
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
Ki = 180000 nM
|
[111] | ||
| Compound Name |
N-Hydroxy-2-[4-(3,5-difluorobenzyloxy)phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431020; BDBM50441219
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 181000 nM
|
[59] | ||
| Compound Name |
L-Phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457447; BDBM50273773; CHEMBL493555; BDBM50257208
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 182900 nM
|
[115] | ||
| Compound Name |
N'-[2-(3-Methyl-2-oxo-quinoxalin-1-yl)acetyl]benzohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775713; BDBM50155276
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 187410 nM
|
[91] | ||
| Compound Name |
Ethyl 2-(hydroxycarbamoyl)-4-phenylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116523; BDBM50062462; 2-Hydroxycarbamoyl-4-phenyl-butyric acid ethyl ester
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 189000 nM
|
[31] | ||
| Compound Name |
2-Hydroxycarbamoyl-4-methyl-pentanoic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406023; BDBM50062476
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 190000 nM
|
[31] | ||
| Compound Name |
5-(Phenylamino)-1,3,4-thiadiazole-2(3H)-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Anilino-1,3,4-thiadiazole-2-thiol; 5-anilino-3H-1,3,4-thiadiazole-2-thione; 5-(phenylamino)-1,3,4-thiadiazole-2-thiol; 5-Anilino-1,3,4-thiadiazole-2(3H)-thione; 1,3,4-Thiadiazole-2(3H)-thione, 5-anilino-; 1,3,4-Thiadiazole-2(3H)-thione, 5-(phenylamino)-; 2-Mercapto-5-anilino-1,3,4-thiadiazole; MLS000711623; CHEMBL289356; CL-17107; SMR000281390; Thiadiazole, 2-anilino-5-mercapto-1,3,4-; 5-Phenylamino-[1,3,4]thiadiazole-2-thiol; EINECS 233-592-6; BAS 00890534; Maybridge4_003659; Oprea1_019972; cid_707055; SCHEMBL8045369; BDBM44137; CTK4A1179; DTXSID80145261; HMS1531G07; HMS2636P15; HMS3361G19; MFCD00125876; STK727283; ZINC13114103; AKOS000117228; AKOS027381265; CCG-246653; MCULE-9602642601; NE39999; 2-FLUORO-5-NITROBENZYLALCOHOL96; NCGC00245202-01; ST4114018; 2-phenylamino-5-mercapto-1,3,4-thiadiazole; EN300-06433; 2-mercapto-5-phenyl-amino-1,3,4-thiadia-zole; 5-phenylazanyl-3H-1,3,4-thiadiazole-2-thione; 1,3,4-Thiadiazole-2(3H)-thione,5-(phenylamino)-; Z56926534
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 190000 nM
|
[63] | ||
| Compound Name |
Ethyl 2-(hydroxycarbamoyl)-3-methylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253470; BDBM50423425
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 190546.07 nM
|
[70] | ||
| Compound Name |
N-((R)-1-Benzylcarbamoyl-ethyl)-N''-hydroxy-2-isobutyl-malonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116588; BDBM50062465
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
Ki = 194000 nM
|
[31] | ||
| Compound Name |
N4-(4-Chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595881; BDBM50304535
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 196600 nM
|
[18] | ||
| Compound Name |
N-Benzhydryl-N-hydroxycarbamoylmethyl-2-[3-(4-phenoxy-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318122; BDBM50081779; N-Hydroxy-2-[benzhydryl[1-(3-phenylpropyl)-3-(4-phenoxyphenyl)ureidoacetyl]amino]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 200000 nM
|
[47] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 154 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Clodronate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 300000 nM
|
[2] | ||
| Matrix metalloproteinase 9 |
IC50 = 320000 nM
|
[2] | |||
| Compound Name |
N4-Butyl-2-cinnamamido-N1-hydroxysuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596553; N4-Butyl-2-cinnamamido-N1-hydroxysuccinamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 232500 nM
|
[18] | ||
| Compound Name |
2-(benzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226149; 2-(benzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 256000 nM
|
[12] | ||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227566; 2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 261000 nM
|
[12] | ||
| Compound Name |
2-Cinnamamido-N1-hydroxy-N4-octylsuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594848; 2-Cinnamamido-N1-hydroxy-N4-octylsuccinamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 285900 nM
|
[18] | ||
| Compound Name |
2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228231; 2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 352000 nM
|
[12] | ||
| Compound Name |
Benzyl N-[(4R)-4-[[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770688
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 > 200000 nM
|
[20] | ||
| Compound Name |
N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonyl(methyl)amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431022; BDBM50441218
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 > 200000 nM
|
[59] | ||
| Compound Name |
3-Hydroxy-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251901; BDBM50241377; (S)-3-Hydroxy-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[63] | ||
| Matrix metalloproteinase 2 |
Ki > 200000 nM
|
[144] | |||
| Compound Name |
6-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101230; 6-Methyl-8-mercaptochinolin; 8-Quinolinethiol, 6-methyl-; SCHEMBL18526845; BDBM50264491
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 > 200000 nM
|
[157] | ||
| Compound Name |
3-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100994; 8-Quinolinethiol, 3-methyl-; 3-methyl-8-quinolinethiol; SCHEMBL3067414; BDBM50264503
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 > 200000 nM
|
[157] | ||
| Compound Name |
4-Phenoxy-N-[(1R,2S)-2-sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380391; BDBM50433876
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki > 200000 nM
|
[32] | ||
| Matrix metalloproteinase 7 |
Ki > 200000 nM
|
[32] | |||
| Compound Name |
2-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Quinolinethiol, 2-methyl-; CHEMBL4083010; 2-methyl-8-mercaptochinolin; SCHEMBL1914441; CTK0G7734; DTXSID80461554; BDBM50264502; ZINC12462690
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 > 200000 nM
|
[157] | ||
| Compound Name |
(R)-N-Methyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398702; SCHEMBL6953380; BDBM50241373; (2R)-N-methyl-3-phenyl-2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)carbamoylamino]propanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[63] | ||
| Compound Name |
[(2S)-3-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-oxo-2-[2-(trifluoromethoxy)phenyl]sulfanylpropyl]-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153738; BDBM50393207
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
Ki > 200000 nM
|
[154] | ||
| Matrix metalloproteinase 8 |
Ki > 200000 nM
|
[154] | |||
| Matrix metalloproteinase 2 |
Ki > 200000 nM
|
[154] | |||
| Compound Name |
5-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Quinolinethiol, 5-methyl-; CHEMBL4084782; 5-methyl-8-quinolinethiol; SCHEMBL13977568; CTK1H9946; DTXSID70500764; BDBM50264484
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 > 200000 nM
|
[157] | ||
| Compound Name |
(3S,4S)-3-(4-Phenoxybenzenesulfonamido)-4-mercaptopyrrolidine Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380399; SCHEMBL1973277
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki > 200000 nM
|
[32] | ||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-(4-bromo-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363675; BDBM50152647
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[101] | ||
| Compound Name |
(S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39553; SCHEMBL6953038; BDBM50076343; ZINC13796963; (2S)-3-phenyl-2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)carbamoylamino]propanamide; (S)-alpha-[3-[(5-Thioxo-4,5-dihydro-1,3,4-thiadiazol)-2-yl]ureido]benzenepropanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[63] | ||
| Matrix metalloproteinase 2 |
Ki > 200000 nM
|
[144] | |||
| Compound Name |
N-((5-Chloro-8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl)-2-phenoxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480567; SCHEMBL1814553; BDBM50256102; N-[(3-nitrophenyl)(5-chloro-8-hydroxyquinolin-7-yl)methyl]-2-phenoxyacetamide; N-[(5-chloro-8-hydroxyquinolin-7-yl)-(3-nitrophenyl)methyl]-2-phenoxyacetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 200000 nM
|
[105] | ||
| Compound Name |
[(2S)-1-[[(2S)-1-(Benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]oxy-[4-(1,3-dioxoisoindol-2-yl)butyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL113500; BDBM50288689
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 200000 nM
|
[158] | ||
| Compound Name |
4-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Quinolinethiol, 4-methyl-; CHEMBL4063134; 4-methyl-8-quinolinethiol; SCHEMBL15703126; CTK0B7293; DTXSID80492580; BDBM50264490
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 > 200000 nM
|
[157] | ||
| Compound Name |
N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576762; BDBM50299066
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 > 200000 nM
|
[7] | ||
| Compound Name |
N-Hydroxy-2-[4-[3-bromo-5-(p-anisyl)benzyloxy]phenylsulfonylamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431024; BDBM50441217
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 > 200000 nM
|
[59] | ||
| Compound Name |
(4S,5S)-2-(4-Bromo-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184492; BDBM50152651
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[101] | ||
| Compound Name |
(S)-1-(4-Methyl-1-(methylamino)-1-oxopentan-2-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249848; BDBM50241375; (S)-4-Methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-pentanoic acid methylamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[63] | ||
| Compound Name |
8-Mercaptoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinoline-8-thiol; 8-Quinolinethiol; SQT-8; 8-thioquinoline; [S]c1cccc2cccnc12; 8-Mercaptoquinoline (8TQ); NCIOpen2_001790; SCHEMBL536578; CHEMBL4076575; DTXSID70197678; BDBM224013; HMS1788G22; ZINC389710; NSC48888; NSC-48888; AKOS022191814; AKOS024342879; MCULE-9204136169; DB-070965; FT-0735097; MLS-0472512.0001; 8-Quinolinethiol;Quinoline-8-thiol;8-Thioquinoline; F9994-0398
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 > 200000 nM
|
[157] | ||
| Compound Name |
N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380397; BDBM50433870
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
Ki > 200000 nM
|
[32] | ||
| Matrix metalloproteinase 3 |
Ki > 200000 nM
|
[32] | |||
| Matrix metalloproteinase 7 |
Ki > 200000 nM
|
[32] | |||
| Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[32] | |||
| Compound Name |
N-[(1S,2S)-2-Sulfanylcyclopentyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380393; BDBM50433874
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki > 200000 nM
|
[32] | ||
| Compound Name |
N-[[(4,5-Dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288866; SCHEMBL2679911; ZINC2583786; BDBM50076333; (S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[63] | ||
| Compound Name |
4-Phenoxy-N-[(1S,2S)-2-sulfanylcyclopentyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380398; BDBM50433869
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki > 200000 nM
|
[32] | ||
| Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[32] | |||
| Compound Name |
(S)-N-Cyclohexylmethyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL38263; mmp-3 inhibitor iv; SCHEMBL5443538; CTK8G1149; ZINC3874283; BDBM50076348
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 200000 nM
|
[63] | ||
| Compound Name |
N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380404
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
Ki > 200000 nM
|
[32] | ||
| Compound Name |
(R)-2-[(S)-3-(4-Cyclopentylmethyl-phenoxy)-1-((S)-6-methylcarbamoyl-tetrahydro-pyridazine-1-carbonyl)-propylamino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL52488; BDBM50289667
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 200000 nM
|
[80] | ||
| Compound Name |
N-(2beta-Mercaptocyclopentane-1alpha-yl)-4-phenoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380395; BDBM50433872
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki > 200000 nM
|
[32] | ||
| Compound Name |
2-(4-Methoxyphenoxy)-N-((5-chloro-8-hydroxyquinolin-7-yl)(4-methoxyphenyl)methyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472144; BDBM50256313; N-[(5-chloro-8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]-2-(4-methoxyphenoxy)acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 200000 nM
|
[105] | ||
| Compound Name |
(4S,5S)-2-(4-Chloro-phenyl)-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364322; BDBM50152632
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki > 200000 nM
|
[101] | ||
| Compound Name |
(R)-2-[(S)-3-(4-Isopropyl-phenoxy)-1-((S)-6-methylcarbamoyl-tetrahydro-pyridazine-1-carbonyl)-propylamino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300613; BDBM50289672
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 200000 nM
|
[80] | ||
| Compound Name |
Chembl1830656
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369772; BDBM50353917
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 200630 nM
|
[156] | ||
| Compound Name |
(2S)-2-Amino-3-hydroxyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458083; BDBM50273665
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 201900 nM
|
[115] | ||
| Compound Name |
Chembl4217681
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457483
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 203400 nM
|
[159] | ||
| Compound Name |
[4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063273; SCHEMBL10187460; BDBM50388912
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 205000 nM
|
[152] | ||
| Compound Name |
Ethyl 5-(methanesulfonamido)-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939861; SCHEMBL8408444; BDBM50361619
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 210000 nM
|
[58] | ||
| Compound Name |
(8S)-7-(4-Methylphenyl)sulfonyl-N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775720; BDBM50155525
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 210410 nM
|
[91] | ||
| Compound Name |
(2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-phenylacrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451473; BDBM50273693
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 211300 nM
|
[115] | ||
| Compound Name |
(S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(ethylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491650; BDBM50267526
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 211400 nM
|
[94] | ||
| Compound Name |
N-Hydroxy-2,3-bis(perfluorophenylsulfonamido)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494643; BDBM50260883
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 212000 nM
|
[151] | ||
| Compound Name |
(2S)-2,5-Amino-N-[(2R)-2-amino-3-phenylpropyl]-valeramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457656; BDBM50273666
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 219400 nM
|
[115] | ||
| Compound Name |
N-[2-(4,5-Dihydro-1,3-oxazol-2-yl)-1H-indol-5-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939866; BDBM50361624
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 220000 nM
|
[58] | ||
| Compound Name |
N-[(2R)-2-Amino-3-phenylpropyl]-4-phenylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459757; BDBM50273695
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 221000 nM
|
[115] | ||
| Compound Name |
(S)-N-Hydroxy-2,5-bis(4-iodophenylsulfonamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496093; BDBM50260940
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 221000 nM
|
[151] | ||
| Compound Name |
2-(3-Methyl-2-oxoquinoxalin-1-yl)-N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775970; BDBM50155519; 2-(3-methyl-2-oxo-quinoxalin-1-yl)-N-[(E)-(3,4,5-trimethoxyphenyl)methyleneamino]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 223370 nM
|
[91] | ||
| Compound Name |
5-Pyridin-4-yl-1H-indole-2-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939870; SCHEMBL15642864; BDBM50361628; DB-124067; ethyl 5-pyridin-4-yl-1H-indole-2-carboxylate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 225000 nM
|
[58] | ||
| Matrix metalloproteinase 2 |
IC50 = 310000 nM
|
[58] | |||
| Compound Name |
(S)-N,N-Dimethyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40034; SCHEMBL6951421; BDBM50076370; ZINC13796965; (2S)-N,N-dimethyl-3-phenyl-2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)carbamoylamino]propanamide; (S)-N,N-Dimethyl-alpha-[3-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol)-2-yl]ureido]benzenepropanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 226000 nM
|
[63] | ||
| Matrix metalloproteinase 2 |
Ki = 226000 nM
|
[144] | |||
| Compound Name |
(2Z,NE)-N-benzylidene-4-(3,4-dimethoxyphenyl)-2-(phenylimino)thiazol-3(2H)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927187; BDBM50359725; STL264510; AKOS002238584; ST50113618; F0807-0342; (2Z)-4-(3,4-dimethoxyphenyl)-2-(phenylimino)-N-[(E)-phenylmethylidene]-1,3-thiazol-3(2H)-amine; 4-[3-((1E)-2-phenyl-1-azavinyl)-2-(phenylazamethylene)(1,3-thiazolin-4-yl)]-1, 2-dimethoxybenzene
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 230000 nM
|
[57] | ||
| Matrix metalloproteinase 1 |
IC50 = 360000 nM
|
[57] | |||
| Compound Name |
Chembl4202548
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455850
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 230000 nM
|
[50] | ||
| Matrix metalloproteinase 2 |
IC50 = 230000 nM
|
[50] | |||
| Matrix metalloproteinase 9 |
IC50 = 332000 nM
|
[50] | |||
| Compound Name |
[Butyl[1-(3-phenylpropyl)-3-(4-phenoxyphenyl)ureidoacetyl]amino]acetohydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328607; BDBM50081774; N-Butyl-N-hydroxycarbamoylmethyl-2-[3-(4-phenoxy-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 230000 nM
|
[47] | ||
| Compound Name |
(S,E)-5-(Benzylamino)-4-(3-(3,4-dimethoxyphenyl)-acrylamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491450; BDBM50267524
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 235800 nM
|
[94] | ||
| Compound Name |
Dipotassium;(2S)-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(oxido)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369491; BDBM50367925
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 240000 nM
|
[40] | ||
| Compound Name |
2-(3-Methyl-2-oxo-quinoxalin-1-yl)-N-[(E)-(4-nitrophenyl)methyleneamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775708; BDBM50155291
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 246260 nM
|
[91] | ||
| Compound Name |
(3S)-N-[2-(Hydroxyamino)-2-oxoethyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830511
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 249240 nM
|
[156] | ||
| Compound Name |
Chembl4210206
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL315491; BDBM50455767; N-hydroxy-2-[2-[4-(4-methoxyphenyl)phenyl]sulfanylphenyl]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 250000 nM
|
[50] | ||
| Compound Name |
(1E,6E)-1-[4-[(Dimethylamino)methyl]phenyl]-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963341; US9187406, Compound 4; BDBM191768
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 = 250000 nM
|
[107] | ||
| Matrix metalloproteinase 2 |
IC50 > 250000 nM
|
[107] | |||
| Compound Name |
2-Amino-3-(4-methoxyphenylsulfonyl)propanehydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90057; BDBM50105432; 2-Amino-N-hydroxy-3-(4-methoxy-benzenesulfonyl)-propionamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 250000 nM
|
[118] | ||
| Compound Name |
(3S)-N-[4-(Hydroxyamino)-4-oxobutyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830510
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 251910 nM
|
[156] | ||
| Compound Name |
(S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-(isopropylamino)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490438; BDBM50267528
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 256100 nM
|
[94] | ||
| Compound Name |
(S)-N-Hydroxy-2-[methyl-(2-pyridin-4-yl-acetyl)-amino]-3-(4-phenoxy-benzenesulfonyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327202; BDBM50105430
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 258000 nM
|
[118] | ||
| Compound Name |
N-[1-(Phenoxymethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41485; SCHEMBL7504451; BDBM50100907; N-[1-[4-(4-cyanophenyl)phenoxy]-3-phenoxypropan-2-yl]-N-hydroxyformamide; N-[2-(4''-Cyano-biphenyl-4-yloxy)-1-phenoxymethyl-ethyl]-N-hydroxy-formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 260000 nM
|
[26] | ||
| Compound Name |
Chembl4203044
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455775
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 260000 nM
|
[50] | ||
| Compound Name |
(3S)-N-[(2S)-3-Hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830655
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 267730 nM
|
[156] | ||
| Compound Name |
(4S)-5-[[(2S)-5-[[Amino(nitramido)methylidene]amino]-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-4-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372451; BDBM50013121
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 270000 nM
|
[40] | ||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-L-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501715; BDBM50272134
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 270000 nM
|
[96] | ||
| Matrix metalloproteinase 3 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 7 |
IC50 > 300000 nM
|
[96] | |||
| Compound Name |
Dibenzyl (2S)-2-[[2-[(3S)-3-[[(2S)-2-amino-3-phenylpropanoyl]amino]-2,6-dioxopiperidin-1-yl]acetyl]amino]pentanedioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213731; BDBM50323949
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 272000 nM
|
[99] | ||
| Compound Name |
(2S,4R)-N,4-Dihydroxy-1-[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830658
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 276440 nM
|
[156] | ||
| Compound Name |
(S,E)-4-(3-(3,4-Dimethoxyphenyl)acrylamido)-5-oxo-5-(propylamino)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491651; BDBM50267527
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 283600 nM
|
[94] | ||
| Compound Name |
(R)-5-(3-Bromobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477251; BDBM50267318
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 287300 nM
|
[69] | ||
| Compound Name |
5-[(2-Furylmethyl)amino]-1,3,4-thiadiazole-2-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL38604; 5-[(furan-2-ylmethyl)amino]-1,3,4-thiadiazole-2-thiol; 5-((Furan-2-ylmethyl)amino)-1,3,4-thiadiazole-2-thiol; CTK8A8705; CTK8F6619; BDBM50076381; MFCD07313349; ZINC13796895; AKOS009013145; MCULE-5750175915; NE13509; EN300-13626; AB00734316-01; SR-01000070796; SR-01000070796-1; Z90668292; 5-{[(furan-2-yl)methyl]amino}-1,3,4-thiadiazole-2-thiol; 5-[(Furan-2-ylmethyl)-amino]-3H-[1,3,4]thiadiazole-2-thione
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 289000 nM
|
[63] | ||
| Compound Name |
(2R)-5-Oxo-1-[(4-phenylphenyl)methyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957576; BDBM50366177
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 290000 nM
|
[45] | ||
| Compound Name |
MMP-2/MMP-9 Inhibitor V
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445971; N-[4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanesulfonamide; SB-3CT, pMS; N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)methanesulfonamide; SCHEMBL315716; CTK8G1146; (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane; BDBM50264810
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
Ki = 295000 nM
|
[8] | ||
| Compound Name |
(2R)-2-[[(E)-3-(4-Methoxyphenyl)prop-2-enoyl]amino]-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL481704; BDBM50251877; (2R)-N-[5-(4-Nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(pmethoxycinnamoyl)amino]-propanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 297300 nM
|
[160] | ||
| Compound Name |
Chembl4164016
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278389
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 298500 nM
|
[112] | ||
| Compound Name |
[(4S,5S)-2-(4-Bromo-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181707; BDBM50152634
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[101] | ||
| Compound Name |
Ethyl 3-[5-(2-oxochromen-3-yl)-2-sulfanylidene-1H-imidazol-3-yl]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927203; BDBM50359727
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 300000 nM
|
[57] | ||
| Compound Name |
2-(Acetylamino)-3-(4-methoxyphenylsulfonyl)propanehydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329686; SCHEMBL7181926; BDBM50105444; 2-acetamido-N-hydroxy-3-(4-methoxyphenyl)sulfonylpropanamide; 2-Acetylamino-N-hydroxy-3-(4-methoxy-benzenesulfonyl)-propionamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 300000 nM
|
[118] | ||
| Compound Name |
2-(Benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234737; BDBM50241254; N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 > 300000 nM
|
[135] | ||
| Compound Name |
L-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445994; h-leu-phe-nhme, AldrichCPR; SCHEMBL7330972; ZINC2386645; BDBM50245250; MFCD01862383; L-leucyl-L-phenylalanine N-methylamide; (2S)-2-AMINO-4-METHYL-N-[(1S)-1-(METHYLCARBAMOYL)-2-PHENYLETHYL]PENTANAMIDE; (2S)-2-amino-4-methyl-N-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]pentanamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 7 |
IC50 > 300000 nM
|
[96] | ||
| Matrix metalloproteinase 9 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 2 |
IC50 > 300000 nM
|
[96] | |||
| Compound Name |
[(4S,5S)-2-(4-Chloro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424792; BDBM50152640
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 300000 nM
|
[101] | ||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452082; BDBM50245247
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 300000 nM
|
[96] | ||
| Matrix metalloproteinase 7 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 1 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 2 |
IC50 > 300000 nM
|
[96] | |||
| Compound Name |
D-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510082; BDBM50245251
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 300000 nM
|
[96] | ||
| Matrix metalloproteinase 7 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 8 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 9 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 1 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 2 |
IC50 > 300000 nM
|
[96] | |||
| Compound Name |
{(4S,5S)-2-[2-(4-Bromo-phenyl)-vinyl]-5-vinyl-4,5-dihydro-oxazol-4-yl}-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186648; BDBM50152650
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 300000 nM
|
[101] | ||
| Compound Name |
3,2-Diguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,2'-diguanidinoneamine; CHEMBL215074; BDBM12005; Neamine guanidinylated deriv. 21
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[161] | ||
| Matrix metalloproteinase 14 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 3 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 9 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 1 |
Ki > 300000 nM
|
[161] | |||
| Compound Name |
Neamine guanidinylated deriv. 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215715; BDBM12012; 1,3,2,6-Tetraguanidino-5,6,3,4-tetramethoxylneamine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[161] | ||
| Matrix metalloproteinase 14 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 3 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 9 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 1 |
Ki > 300000 nM
|
[161] | |||
| Compound Name |
(4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362099; BDBM50152637
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[101] | ||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364212; BDBM50152631
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[101] | ||
| Compound Name |
Neamine guanidinylated deriv. 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215269; 1,3,2,6-Tetraguanidinoneamine; BDBM11997; 1,3,2',6'-tetraguanidinoneamine
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[161] | ||
| Matrix metalloproteinase 14 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 3 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 9 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 1 |
Ki > 300000 nM
|
[161] | |||
| Compound Name |
N-[2-[4-(4-Cyanophenyl)phenoxy]-1-(4-fluorophenyl)ethyl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39035; SCHEMBL7505043; BDBM50100906; N-[2-(4''-Cyano-biphenyl-4-yloxy)-1-(4-fluoro-phenyl)-ethyl]-N-hydroxy-formamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 300000 nM
|
[26] | ||
| Matrix metalloproteinase 2 |
IC50 = 480000 nM
|
[26] | |||
| Compound Name |
Z-L-Leu-L-Phe-OMe
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452584; SCHEMBL7326037; BDBM50245249; N-benzyloxycarbonyl-L-leucyl-L-phenylalanine methyl ester; N-(Benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester; methyl (2S)-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 300000 nM
|
[96] | ||
| Matrix metalloproteinase 7 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 8 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 9 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 1 |
IC50 > 300000 nM
|
[96] | |||
| Matrix metalloproteinase 2 |
IC50 > 300000 nM
|
[96] | |||
| Compound Name |
1,3,2-Triguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3,2'-triguanidinoneamine; CHEMBL438810; BDBM12008; Neamine guanidinylated deriv. 23
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
Ki > 300000 nM
|
[161] | ||
| Matrix metalloproteinase 14 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 3 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 9 |
Ki > 300000 nM
|
[161] | |||
| Matrix metalloproteinase 1 |
Ki > 300000 nM
|
[161] | |||
| Compound Name |
Chembl4170455
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278367
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 301100 nM
|
[112] | ||
| Matrix metalloproteinase 12 |
IC50 = 493200 nM
|
[112] | |||
| Compound Name |
(3S)-N-[(2S)-1-(Hydroxyamino)-3-methyl-1-oxobutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830648
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 307270 nM
|
[156] | ||
| Compound Name |
Chembl4167291
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278365
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 309300 nM
|
[112] | ||
| Matrix metalloproteinase 8 |
IC50 = 483100 nM
|
[112] | |||
| Compound Name |
(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927186; ZINC2698193; BDBM50359724; STK711873; AKOS002386597; ST50326453; AB00674549-01; F1542-0089
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 310000 nM
|
[57] | ||
| Matrix metalloproteinase 2 |
IC50 = 350000 nM
|
[57] | |||
| Compound Name |
(2S)-1-[(2-Chlorophenyl)methyl]-5-oxopyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243307; ZINC266791; BDBM50366189; AKOS024405262
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 315000 nM
|
[45] | ||
| Compound Name |
(S)-2-(2-((S)-3-((S)-2-Amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl)acetamido)-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213796; BDBM50323955
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 315650 nM
|
[99] | ||
| Compound Name |
5-(4-Phenyl-butylamino)-3H-[1,3,4]thiadiazole-2-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290050; BDBM50076379
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 318000 nM
|
[63] | ||
| Compound Name |
2-Cinnamamido-N1-hydroxy-N4-phenylsuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594936; BDBM50304544
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 324400 nM
|
[18] | ||
| Compound Name |
(2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-(3,4-hydroxy)-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445758; BDBM50273697
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 328500 nM
|
[115] | ||
| Compound Name |
(S)-N-Hydroxy-2,5-bis(4-(trifluoromethyl)phenylsulfonamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496702; BDBM50260913
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 329000 nM
|
[151] | ||
| Matrix metalloproteinase 10 |
Ki = 337000 nM
|
[151] | |||
| Compound Name |
(4R)-N-Hydroxy-3-[(4-phenylphenyl)methyl]-1,3-thiazolidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957593; BDBM50366195
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 330000 nM
|
[45] | ||
| Compound Name |
(2S)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-3-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819320; BDBM50351021
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 331100 nM
|
[71] | ||
| Compound Name |
(2S)-5-Oxo-1-[(4-phenylphenyl)methyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957585; BDBM50366186
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 340000 nM
|
[45] | ||
| Compound Name |
Dimethyl 2-[[(4S)-5-[(1,4-dimethoxy-1,4-dioxobutan-2-yl)amino]-4-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]-5-oxopentanoyl]amino]butanedioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451393; BDBM50267680; (S,E)-2-[3-(3,4-Dimethoxyphenyl)acrylamido]-N1,N5-[(R)-1,4-dimethoxy-1,4-dioxobutan]pentanediamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 340800 nM
|
[94] | ||
| Compound Name |
Chembl4162521
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278366
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 345800 nM
|
[112] | ||
| Compound Name |
(4s)-3-{[4-(4-Cyano-2-Methylphenyl)piperazin-1-Yl]sulfonyl}-N-Hydroxy-1,3-Thiazolidine-4-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770935; Q27462716
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 346000 nM
|
[20] | ||
| Compound Name |
N-[(S)-1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-ethyl]-2,6-dimethoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316293; BDBM50105436
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 350000 nM
|
[118] | ||
| Compound Name |
6-Methyl-2H-1,4-benzoxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one; 6-methyl-4H-1,4-benzoxazin-3-one; CHEMBL485691; 2H-1,4-Benzoxazine-3(4H)-one, 6-methyl-; 6-METHYL-4H-BENZO[1,4]OXAZIN-3-ONE; 6-Methyl-2H-1,4-benzoxazine-3(4H)-one; 6-methyl-2,4-dihydro-1,4-benzoxazin-3-one; SCHEMBL279594; CTK4I1476; DTXSID20192653; KS-00001W0X; ZINC3883825; 2427AE; BDBM50270676; MFCD01321311; SBB087684; STK317994; AKOS003392315; AB09061; CCG-321495; MCULE-8315381896; ST095737; 2H-1,4-Benzoxazin-3(4H)-one,6-methyl-; 6-Methyl-2H-1,4-benzooxazine-3(4H)-one; CS-0085207; EU-0063551; FT-0680323; 6-methyl-2H,4H-benzo[e]1,4-oxazin-3-one; A-8067; 3W-0266; 6-Methyl-2H-1,4-benzoxazin-3(4H)-one, 98%; 6-methyl-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one; J-518885; 6-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-3-ONE
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 12 |
IC50 = 355000 nM
|
[162] | ||
| Compound Name |
(R)-2-(((Benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Z-D-Tyr-OH; Z-D-tyrosine; N-Carbobenzoxy-D-tyrosine; N-ALPHA-CBZ-D-TYROSINE; CHEMBL305478; (2R)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoic acid; Cbz-Tyr-OH; CBZ-D-TYROSINE; benzyloxycarbonyl-d-tyrosine; MFCD00063031; N-Cbz-D-tyrosine; Cbz-D-Tyr; UPCMLD00WV-86; SCHEMBL6118298; UPCMLD00WV-86:002; ZINC155939; BDBM50043797; KM0825; AKOS016842947; AB02491; AM82313; MCULE-9896876377; N-ALPHA-CARBOBENZOXY-D-TYROSINE; AK-50005; AS-72357; SC-09945; Z-D-Tyr-OH, >=98.0% (TLC); V7079; 205Z125; Q-101735; (R)-2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoic acid; (R)-2-Benzyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid; (2R)-2-{[(BENZYLOXY)CARBONYL]AMINO}-3-(4-HYDROXYPHENYL)PROPANOIC ACID
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
Ki = 356000 nM
|
[65] | ||
| Compound Name |
N-[1-(2,6-Dioxo-4,4-dimethylpiperidinomethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288701; SCHEMBL7448709; BDBM50100916
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 360000 nM
|
[26] | ||
| Compound Name |
(S,E)-2-(3-(3,4-Dimethoxyphenyl)acrylamido)-N1,N5-bis(4-fluorophenyl)pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489238; BDBM50267610
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 368100 nM
|
[94] | ||
| Compound Name |
(R)-5-Oxo-5-(thiazol-2-ylamino)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491854; BDBM50267879
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 369400 nM
|
[69] | ||
| Compound Name |
N-Sec-Butyl-N-hydroxycarbamoylmethyl-2-[3-(4-phenoxy-phenyl)-1-(3-phenyl-propyl)-ureido]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93768; BDBM50081795; N-Hydroxy-2-[sec-butyl[1-(3-phenylpropyl)-3-(4-phenoxyphenyl)ureidoacetyl]amino]acetamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 370000 nM
|
[47] | ||
| Compound Name |
2,3-Bis(2,4-dimethoxyphenylsulfonamido)-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521689; BDBM50260884
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 10 |
Ki = 372000 nM
|
[151] | ||
| Compound Name |
1-(4-Phenoxyphenethyl)-3-hydroxy-1-methylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200385; BDBM50175782
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 = 380000 nM
|
[90] | ||
| Compound Name |
1-(4-Phenoxyphenethyl)-3-hydroxyurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197921; BDBM50175781
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 3 |
IC50 > 380000 nM
|
[90] | ||
| Matrix metalloproteinase 8 |
IC50 > 380000 nM
|
[90] | |||
| Matrix metalloproteinase 2 |
IC50 > 380000 nM
|
[90] | |||
| Compound Name |
L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-((4-Chlorophenyl)methyl)-5-oxo-L-proline; CHEMBL1957590; Acide N-(p-chlorobenzyl)pyroglutamique [French]; Acide N-(p-chlorobenzyl)pyroglutamique; SCHEMBL16601331; CTK3I9291; DTXSID40208467; ZINC6092884; (2S)-1-[(4-chlorophenyl)methyl]-5-oxopyrrolidine-2-carboxylic acid; BDBM50366192; 1-(4-Chlorobenzyl)-5-oxo-L-proline; (S)-1-(4-Chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 383000 nM
|
[45] | ||
| Compound Name |
3-Aminosalicylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Amino-2-hydroxybenzoic acid; 3-amino salicylic acid; Benzoic acid, 3-amino-2-hydroxy-; MFCD00010299; 3-amino-2-hydroxy-benzoic acid; UNII-WN7T1GM9RM; WN7T1GM9RM; Salicylic acid, 3-amino-; 3-Aminosalicylic acid, 97%; CHEMBL1650630; 3-Amino-2-hydroxybenzoic acid (3-Aminosalicylic acid); 3-amino-2-hydroxybenzoate; Benzoic acid, amino-2-hydroxy-; 3-Aminosalicylate; 3-amino-salicylate; 3-Amino Salicylate; EINECS 209-328-0; Mesalamine Impurity F; NSC 285111; 3-aminosalicyclic acid; 3-amino-salicylic acid; PubChem14474; 3-amino-(8CI)salicylate; ACMC-1B1LK; 3-amino-2-hydroxy-benzoate; Oprea1_451884; Benzoicacid,amino-2-hydroxy-; 3-amino-(8CI)salicylic acid; SCHEMBL204392; 2-hydroxy 3-aminobenzoic acid; 3-AMINOSALICYLIC ACID,; 2-hydroxy 3-amino benzoic acid; CTK0J2212; ZINC88619; DTXSID90862215; 3-Amino-2-hydroxybenzoic acid #; KUC106692N; 3-amino-2-hydroxy-(9CI)benzoate; Salicylic acid, 3-amino- (8CI); ANW-32621; BDBM50335811; NSC285111; SBB001895; STK677269; 3-amino-2-hydroxy-(9CI)benzoic acid; AKOS005594690; AB01026; MCULE-1378878669; NSC-285111; PS-5956; VZ26258; AC-23862; SC-14094; Benzoic acid, 3-amino-2-hydroxy- (9CI); KSC-11-207-24; ST4062832; A0421; AM20080689; FT-0615072; FT-0619948; X8030; A-8661; 088A644; 570A230; W-105491; Q27161513
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 389000 nM
|
[17] | ||
| Compound Name |
(3S)-N-[(1S)-2-(Hydroxyamino)-2-oxo-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830651
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 393140 nM
|
[156] | ||
| Compound Name |
(S,E)-2-(3-(3,4-Dimethoxyphenyl)acrylamido)-N1,N5-dip-tolylpentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489237; BDBM50267609
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 397600 nM
|
[94] | ||
| Compound Name |
N-[3-(Dimethylamino)propyl]-4-(4-methylphenoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796286; BDBM50418819
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 398107.17 nM
|
[54] | ||
| Compound Name |
4-(3-Methoxy-4-nitrophenoxy)-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796292; BDBM50418828
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 398107.17 nM
|
[54] | ||
| Compound Name |
4-(2-Cyanophenoxy)-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796293; BDBM50418818
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 398107.17 nM
|
[54] | ||
| Compound Name |
N-Benzyl-4-(4-methylphenoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796280; BDBM50418820; AKOS003061839
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 398107.17 nM
|
[54] | ||
| Compound Name |
4-(4-Methylphenoxy)-N-(2-pyridin-4-ylethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796283; BDBM50418823
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 13 |
IC50 > 398107.17 nM
|
[54] | ||
| Compound Name |
(2R)-1-[(4-Chlorophenyl)methyl]-N-hydroxy-5-oxopyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957581; BDBM50366182
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 400000 nM
|
[45] | ||
| Matrix metalloproteinase 9 |
IC50 = 430000 nM
|
[45] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]-4-(benzyloxycarbonylamino)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431026; BDBM50441214
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 400000 nM
|
[59] | ||
| Compound Name |
3-(4-(2-Oxo-2H-chromen-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927183; ZINC2957866; BDBM50359721; AKOS024602290; MCULE-4659831116; F0920-6501
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 400000 nM
|
[57] | ||
| Compound Name |
2-(Tosylamino)-3-(4-phenoxyphenylsulfonyl)propanehydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90764; BDBM50105437; N-Hydroxy-3-(4-phenoxy-benzenesulfonyl)-2-(toluene-4-sulfonylamino)-propionamide
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 400000 nM
|
[118] | ||
| Compound Name |
(2R)-2-[[4-[4-[(5-Bromo-4-methoxy-3-methyl-1-benzofuran-2-yl)methoxy]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497772; SCHEMBL8287194; BDBM50265076
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 > 400000 nM
|
[8] | ||
| Compound Name |
Thioacetic acid S-((4S,5S)-2-biphenyl-4-yl-5-vinyl-4,5-dihydro-oxazol-4-yl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363953; BDBM50152633
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki > 400000 nM
|
[101] | ||
| Compound Name |
Chembl4171886
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278388
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 8 |
IC50 = 401100 nM
|
[112] | ||
| Compound Name |
(4S)-5-[[(2S)-1-(Carboxymethylamino)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160644
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 403000 nM
|
[40] | ||
| Compound Name |
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 33 [PMID: 19908842]; CHEMBL578159; MLS002471784; GTPL8874; SCHEMBL3346407; HMS2213P07; HMS3348G08; BDBM50303436; NCGC00182115-01; NCGC00182115-02; SMR001395198; Q27076570; 9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 426579.52 nM
|
[110] | ||
| Compound Name |
(8S)-7-(4-Methylphenyl)sulfonyl-1,4-dithia-7-azaspiro[4.4]nonane-8-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092092; BDBM50155524; (2S)-3-(p-tolylsulfonyl)-6,9-dithia-3-azaspiro[4.4]nonane-2-carbohydrazide
Click to Show/Hide
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||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 428990 nM
|
[113] | ||
| Compound Name |
Chembl4175156
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278390
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 14 |
IC50 = 435800 nM
|
[112] | ||
| Matrix metalloproteinase 12 |
IC50 = 493250 nM
|
[112] | |||
| Compound Name |
(S)-N-Hydroxy-2-methylamino-3-(4-phenoxy-benzenesulfonyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93993; BDBM50105445
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 440000 nM
|
[118] | ||
| Compound Name |
N4-Benzyl-2-cinnamamido-N1-hydroxysuccinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594961; BDBM50304537
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 447200 nM
|
[18] | ||
| Compound Name |
Benzyl 2-[[2-[(3S)-3-[[(2S)-2-amino-3-phenylpropanoyl]amino]-2,6-dioxopiperidin-1-yl]acetyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214593; BDBM50323943; (S)-Benzyl-2-(2-(3-((S)-2-amino-3-phenylpropanamido)-2,6-dioxopiperidin-1-yl))acetate
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 454000 nM
|
[99] | ||
| Compound Name |
(2R)-2-[(3R)-3-Amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hydroxy-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630098; BDBM50332481
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
IC50 = 460000 nM
|
[163] | ||
| Compound Name |
2-[[(2S)-2-[[(2S)-5-Amino-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160626
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
Ki = 460000 nM
|
[40] | ||
| Compound Name |
(3S)-N-[(2S)-1-(Hydroxyamino)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1830512
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 463380 nM
|
[156] | ||
| Compound Name |
(S,E)-N1,N5-Bis(4-chlorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490452; BDBM50267643
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 470600 nM
|
[94] | ||
| Compound Name |
(S,E)-2-(3-(3,4-Dimethoxyphenyl)acrylamido)-N1,N5-bis(2-fluorophenyl)pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490647; BDBM50267645
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 2 |
IC50 = 470700 nM
|
[94] | ||
| Compound Name |
(S)-2-(Benzyl-methyl-amino)-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93725; BDBM50105425
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 1 |
IC50 = 475000 nM
|
[118] | ||
| Compound Name |
2-Amino-5-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834423; SCHEMBL2369869; BDBM50354625; 2-amino-5-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenol
Click to Show/Hide
|
||||
| Activity | Matrix metalloproteinase 9 |
Ki = 490000 nM
|
[114] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 3 | A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose. J Med Chem. 2017 Jul 13;60(13):5933-5939. | ||||
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| REF 13 | Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors. Eur J Med Chem. 2016 Jan 27;108:141-153. | ||||
| REF 14 | Small molecule inhibitors of anthrax lethal factor toxin. Bioorg Med Chem. 2014 Jan 1;22(1):419-34. | ||||
| REF 15 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment ... Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. | ||||
| REF 16 | Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2585-8. | ||||
| REF 17 | Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54(2):591-602. | ||||
| REF 18 | Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2009 Oct 15;17(20):7398-404. | ||||
| REF 19 | Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors. J Med Chem. 2002 Jan 3;45(1):219-32. | ||||
| REF 20 | Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models. Eur J Med Chem. 2016 Mar 23;111:193-201. | ||||
| REF 21 | Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem. 2009 Jun 1;17(11):3857-65. | ||||
| REF 22 | Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50. | ||||
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