Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87023 | Target Info | |||
| Target Name | Platelet-activating factor receptor (PTAFR) | ||||
| Synonyms |
PTAFR; PAF-R
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| Target Type | Successful Target | ||||
| Gene Name | PTAFR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Loratadine
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Approved | Compound Info | ||
| Synonyms |
Aerotina; Alarin; Alavert; Alerpriv; Allertidin; Anhissen; Biloina; Bonalerg; Civeran; Claratyne; Clarinase; Claritin; Claritine; Clarityn; Clarityne; Clarium; Fristamin; Histaloran; Lergy; Lertamine; Lesidas; Lisino; Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina; Loratadinum; Loratidine; Loratyne; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinomex; Roletra; Sanelor; Sensibit; Sohotin; Tadine; Velodan; Versal; Zeos; Bedix Loratadina; Claratyne Cold; Claratyne Decongestant; Clarinase Reperabs; Claritin D; Claritin Hives Relief; Claritin Hives Relief Reditab; Claritin Reditabs; Claritin reditab; Clarityne Dy Repetabs; Loratadina [Spanish]; Loratadine Redidose; Loratadine Wyeth Brand; Loratadinum [Latin]; Sinhistan Dy; Talorat Dy; Wyeth Brand of Loratadine; L 9664; Sch 29851; Sch29851; Alavert (TN); AllergyX (TN); Children's Claritin; Claritin (TN); Claritine (TN); Clarityn (TN); Clarityne (TN); Clarityne-D; Flonidan (TN); Fristamin (TN); Lomilan (TN); Lorfast (TN); Rinolan (TN); Roletra (TN); Sch-29851; Symphoral (TN); Tidilor (TN); Alavert, Claritin, Loratadine; Loratadine [USAN:BAN:INN]; Loratadine (JAN/USAN/INN); Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate; 1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester; 1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester; 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester; 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acidethyl ester; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Azatadine
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Approved | Compound Info | ||
| Synonyms |
Azatadina; Azatadinum; Azatidine; Azatadine maleate; Azatadina [INN-Spanish]; Azatadine (INN); Azatadine [INN:BAN]; Azatadinum [INN-Latin]; 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
5,6-Dihydro-11-(1-pivaloyl-4-piperidinylidene)-8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL342455; SCHEMBL8889578; BDBM50007454
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexyl]-ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341584; BDBM50007472; 11-(4-Acetylcyclohexylidene)-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
[4-(8-Chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]-phenylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL140924; SCHEMBL8879257; BDBM50007466; 5,6-Dihydro-11-(1-benzoyl-4-piperidinylidene)-8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[(3E)-3-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)propyl]-N-methylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124466; BDBM50007463
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
N-[(3Z)-3-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)propyl]-N-methylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL141432; BDBM50007474
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Chlorpheniramine
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Investigative | Compound Info | ||
| Synonyms |
Chlorphenamine; Teldrin; Chlor-trimeton; Chlorophenylpyridamine; Clorfeniramina; Phenetron; Haynon; Chloropheniramine; Chlorprophenpyridamine; Clorfenamina; Allergican; Chloropiril; Cloropiril; Histadur; Kloromin; Chloroprophenpyridamine; Chlorpheniraminum; Allergisan; Polaronil; Chlorphenaminum; Chlo-amine; Chlorpheniramine polistirex; Antagonate; Chlor-tripolon; D-Chlorpheniramine; Pyridamal 100; CHEMBL505; Dexchlorpheniramine free base; Chlor-Trimeton Allergy; 25523-97-1 (free base); Chlorphenamine hydrogen maleate; Efidac 24 Chlorpheniramine Maleate; Aller-Chlor; Chlorphenamine Maleate; 4-Chloropheniramine; Chloropheniramine maleate; Chlorphenamin; Telachlor; Chlorprophenpyridamine maleate; Clorfeniramina [Italian]; Clorfenamina [INN-Spanish]; Chlorphenaminum [INN-Latin]; HSDB 3032; EINECS 205-054-0; Chlorphenamine [INN:BAN]; Clofeniramina; PiriIton; Chlor-Pro; [3H]Chlorphenamine; Clofeniramina (TN); [3H]Chlorpheniramine; Chlorphenamine (INN); chlorpheniaramine maleate; S-(+)-Chlorpheniramine; Prestwick0_000117; Prestwick1_000117; Prestwick2_000117; Prestwick3_000117; NCGC00015227-04; 5-HT,N-ACETYL; SCHEMBL4219; Lopac0_000261; Oprea1_779072; BSPBio_000134; DivK1c_000596; Chlorpheniramine Maleate B.P.; SPBio_002073; BPBio1_000148; GTPL6976; DTXSID0022804; BDBM35938; KBio1_000596; Chlorpheniramine-d6see c424303; NINDS_000596; HMS2090M21; HMS3428J07; Chlorpheniramine polistirex [USAN]; Chlorpheniramine-d6 Maleate (salt); BBL012285; SBB017260; STK736174; AKOS001650136; CCG-108982; DB01114; MCULE-2363896855; SB19135; SDCCGSBI-0050249.P002; IDI1_000596; NCGC00015227-03; NCGC00015227-05; NCGC00015227-06; NCGC00015227-09; NCGC00015227-19; NCGC00162108-01; NCGC00162108-02; ST076791; FT-0665002; FT-0772034; T7375; C06905; D07398; L000003; Q420133; W-108317; BRD-A04553218-050-03-0; BRD-A04553218-050-08-9
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
5-(4-Methoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL309194; SCHEMBL9694184; BDBM50035541; 5-(4-methoxyphenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline
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| Activity |
IC50 = 55000 nM
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[2] | |||
| Compound Name |
5-(4-Pyrrolidin-1-ylmethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78642; SCHEMBL10397059; BDBM50035545; 5-[4-(pyrrolidin-1-ylmethyl)phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline
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| Activity |
IC50 = 59400 nM
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[2] | |||
| Compound Name |
5-(2,4-Dichloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL312268; SCHEMBL9693687; BDBM50035551; 5-(2,4-dichlorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline
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| Activity |
IC50 = 82000 nM
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[2] | |||
| Compound Name |
5-{4-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-phenyl}-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL320577; BDBM50041922
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| Activity |
IC50 = 89000 nM
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[3] | |||
| Compound Name |
5-Pyridin-3-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL80505; BDBM50035567
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
5-Furan-2-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310425; SCHEMBL10442256; BDBM50035538
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
5-(3,4,5-Trimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL81384; BDBM50035561
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. J Med Chem. 1991 Jan;34(1):457-61. | ||||
| REF 2 | Antitumor activity of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinolines. J Med Chem. 1995 Jan 20;38(2):234-40. | ||||
| REF 3 | Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. J Med Chem. 1993 Oct 15;36(21):3098-102. | ||||
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