Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95736 | Target Info | |||
| Target Name | Serine/threonine-protein kinase NIK (MAP3K14) | ||||
| Synonyms |
NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14; HsNIK
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MAP3K14 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 58 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
IMD-0354
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
IMD-2560; IMD-2560); I-kappaB kinase beta inhibitor (dermatological, atopic dermatitis/acne), Institute of Medicinal MolecularDesign; I-kappaB kinase beta inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD; IKK-beta inhibitor (dermatological, atopic dermatitis/acne), IMMD; IL-6 release inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
PS-1145
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PS-1145; 431898-65-6; PS 1145; CHEMBL79004; N-(6-Chloro-9H-beta-carbolin-8-yl)-nicotinamide; MLS006010310; ZINC9090; SCHEMBL1420453; CTK1D2755; KS-00000TTM; CHEBI:94801; DTXSID00433238; EX-A786; MolPort-042-665-715; JZRMBDHPALEPDM-UHFFFAOYSA-N; HMS3229F21; BCP24095; s7691; BDBM50130248; AKOS030526812; CS-5415; ACN-053038; NCGC00165873-02; NCGC00165873-01; SMR004701376; HY-18008; AK547800; FT-0700478; J-690297; BRD-K93023739-001-02-9; N-{6-chloro-9H-pyrido[3,4-b]indol-8-yl}pyridine-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Plumbagin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Plumbagin; 481-42-5; Plumbagine; 5-Hydroxy-2-methyl-1,4-naphthoquinone; Plumbaein; Plumbagone; 2-Methyljuglone; 5-hydroxy-2-methylnaphthalene-1,4-dione; 5-Hydroxy-2-methyl-1,4-naphthalenedione; 5-Hydroxy-2-methyl-[1,4]naphthoquinone; 1,4-Naphthalenedione, 5-hydroxy-2-methyl-; 2-Methyl-5-hydroxy-1,4-naphthoquinone; UNII-YAS4TBQ4OQ; NSC 688284; NSC 236613; CCRIS 6671; YAS4TBQ4OQ; EINECS 207-569-6; BRN 1870475; AI3-38055; CHEBI:8273; CHEMBL295316; VCMMXZQDRFWYSE-UHFFFAOYSA-N; 1,4-NAPHTHOQUINONE, 5-HYDROXY-2-METHYL-; NSC688284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(Ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1210773; (4Z)-4-(ethoxymethylene)isoquinoline-1,3(2H,4H)-dione; 4-(ethoxymethylene)isoquinoline-1,3(2H,4H)-dione; HMS1733A12; BDBM50322999; NE18631; J-011957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Isoquinoline-1,3(2H,4H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3[2H,4H]-Isoquinolinedione; Homophthalimide; 4H-isoquinoline-1,3-dione; 1,2,3,4-TETRAHYDROISOQUINOLINE-1,3-DIONE; 1,3(2H,4H)-Isoquinolinedione; 2,4-dihydroisoquinoline-1,3-dione; MLS003373813; CHEMBL1210769; 1,4H)-Isoquinolinedione; SCHEMBL422023; cid_349435; CTK1D6514; KS-00000HCL; DTXSID50325194; HMS1734A04; 1,3 (2H, 4H)-Isoquinolinedione; ZINC1601221; ANW-52281; BBL100072; BDBM50322995; MFCD00234966; NSC409146; SBB079065; STL214583; AKOS001174017; AB05280; CS-W006004; MCULE-1752890442; NSC-409146; 1,2,3,4-4H-Isoquinolin-1,3-dione; 1,3,4-Tetrahydro-1,3-dioxoisoquinoline; AK-24472; AS-18364; BR-24472; SC-21766; SMR002048609; 1,2,3,4-Tetrahydro-1,3-dioxoisoquinoline; AB0024966; DB-081850; AM20061083; FT-0647852; ST45237322; W6338; EN300-15352; A18787; S-4681; SR-01000902235; J-503856; J-650194; SR-01000902235-2
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[2] | |||
| Compound Name |
Chembl4283047
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 = 58200 nM
|
[3] | |||
| Compound Name |
4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(4-Chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamine; 4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-amine; 4-(4-chlorophenyl)-3-methylpyrazole-5-ylamine; Cambridge id 5679811; Oprea1_349134; MLS000719160; SCHEMBL1248139; CHEMBL1885200; CTK6G9598; CTK8F5367; DTXSID10341799; HMS2712J14; HMS3535D16; ALBB-007578; ZINC4660540; 7274AD; BBL012526; MFCD00737209; SBB011182; STK234817; AKOS000270520; AKOS022304211; CCG-200054; MCULE-2044086228; SMR000291428; ST064643; VS-03371; AB0169146; BB 0219143; Y-7651; AB00093218-01; Pyrazol-5-amine, 4-(4-chlorophenyl)-3-methyl-; 3-Methyl-4-(4-chlorophenyl)-1H-pyrazol-5-amine; 4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-ylamine; 4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-ylamine #; F2130-0219; 4-(4-Chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 61100 nM
|
[3] | |||
| Compound Name |
4-(2,7-Dimethylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334575; BDBM50429628
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 80000 nM
|
[4] | |||
| Compound Name |
4-(2-Methylimidazo[1,2-a]pyridin-3-yl)-2-pyrimidinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine; 4-{2-methylimidazo[1,2-a]pyridin-3-yl}pyrimidin-2-amine; Imidazo[1,2-a]pyridine deriv. 1; BDBM7641; CHEMBL100979; SCHEMBL7964840; DTXSID20424880; ZINC12354765; AKOS016352827; MCULE-1146797470; NS-02807; DB-072903; FT-0755349; 239M373; 2-Methyl-3-(2-amino-4-pyrimidinyl)imidazo[1,2-a]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 80000 nM
|
[4] | |||
| Compound Name |
4-(2,8-Dimethylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334576; BDBM50429627
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 80000 nM
|
[4] | |||
| Compound Name |
2,7-Naphthyridine-1,3,6,8-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1210770; BDBM50322996
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
4-(4-Bromophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(4-bromophenyl)-5-methyl-1H-pyrazol-3-amine; 5-Amino-4-(4-bromophenyl)-3-methylpyrazole; 4-(4-bromophenyl)-5-methyl-2H-pyrazol-3-amine; CHEMBL4294454; SCHEMBL13310491; CTK5I7189; CTK8F6718; DTXSID80589429; ZINC8701292; KM3347; AKOS009142305; AS-65477; CS-0119878; V9624; 4-(4-bromophenyl)-5-methyl-2h-pyrazol-3-ylamine; 5-Amino-4-(4-bromophenyl)-3-methylpyrazole, 96%; Z274574824
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1,4-Dihydro-3(2H)-isoquinolinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,4-dihydroisoquinolin-3(2H)-one; 1,4-Dihydro-2H-isoquinolin-3-one; 1,2-dihydroisoquinolin-3(4H)-one; 2,4-dihydro-1H-isoquinolin-3-one; 1,2,3,4-tetrahydroisoquinolin-3-one; CHEMBL1210771; 3(2H)-Isoquinolinone,1,4-dihydro-; EINECS 246-174-3; NSC134509; ACMC-209gax; SCHEMBL89023; SCHEMBL2490656; CTK4F3406; DTXSID90179072; 1,4-dihydro-3-hydroxyisoquinoline; ZINC4202815; ANW-25399; BDBM50322997; MFCD03460354; STL265913; 1,2-dihydroisoquinolin-3-(4H)-one; AKOS006344960; AB15535; MCULE-7313339331; NSC-134509; 3-oxo-1,2,3,4-tetrahydroisoquinoline; SC-90927; 1,4-Dihydro-3(2H)-isoquinolinone, 95%; AM20030439; CS-0120025; FT-0648811; V4626; A-7423; 331D940; J-503994; F1285-0717; Z2230911536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4286561
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(3-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(3-Chlorophenyl)-5-methyl-1H-pyrazol-3-amine; 1H-Pyrazol-3-amine, 4-(3-chlorophenyl)-5-methyl-; 4-(3-chlorophenyl)-3-methylpyrazole-5-ylamine; 3-Amino-4-(3-chlorophenyl)-5-methyl pyrazole; CHEMBL4292952; CTK2B7901; DTXSID20490520; ALBB-032828; ZINC8701428; MFCD09438994; SBB082624; AKOS000302222; AKOS008124417; AKOS022304209; MCULE-3974962278; BB 0260654; ST50532394; EN300-88760; Y-5281; Z1262237268; 4-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-amine(SALTDATA; 4-(3-CHLOROPHENYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4281464
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280454
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AKOS012196576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4292701
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4281692; CTK6C0953; CTK8F5130; ALBB-006919; MFCD12027287; STK504195; ZINC32919530; AKOS000264664; 3-Methyl-4-(m-tolyl)-1H-pyrazol-5-amine; 5-methyl-4-(3-methylphenyl)-1H-pyrazol-3-amine; Z2680629344
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283909
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL15742048; ZINC41286240; AKOS011268000; 4-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4166474
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4284120
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4294749
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4279494
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4288356
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280373
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 3-Methyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine; SCHEMBL7888487; CHEMBL4293369; CTK6C3912; CTK8F5132; KS-00001RBI; DTXSID00382373; ZINC3883286; 0710AF; KM2296; MFCD03791147; SBB099416; AKOS005069280; MCULE-7916739921; 10T-0382; 3-methyl-4-[3-(trifluoromethyl)phenyl]pyrazole-5-ylamine; 3-Methyl-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4284415
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4286012
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4284828
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-phenyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Methyl-4-phenyl-2H-pyrazol-3-ylamine; 5-amino-3-methyl-4-phenylpyrazole; 5-methyl-4-phenyl-1H-pyrazol-3-amine; 3-Amino-5-Methyl-4-Phenylpyrazole; 5-methyl-4-phenyl-2H-pyrazol-3-amine; UNII-OC0W48DG01; OC0W48DG01; 1H-Pyrazol-3-amine,5-methyl-4-phenyl-; 1H-Pyrazol-5-amine,3-methyl-4-phenyl-; 3-methyl-4-phenylpyrazole-5-ylamine; Pyrazole, 5-amino-3-methyl-4-phenyl-; 1H-Pyrazol-3-amine, 5-methyl-4-phenyl-; Maybridge3_005336; Oprea1_166909; MLS000718547; SCHEMBL544723; Pyrazole, 3(OR 5)-amino-5(OR 3)-methyl-4-phenyl-; CHEMBL1609052; CTK4G7923; CTK5B1468; DTXSID80975823; HMS1446C12; HMS2678A07; ALBB-006621; KS-00003KC6; ZINC8743937; BBL007578; CCG-48710; KM0404; MFCD00831955; SBB010561; STK161389; AKOS000265012; AKOS015898914; FS-1252; MCULE-5899288516; SB21940; IDI1_016723; 3-Amino-5-methyl-4-phenyl-1H-pyrazole; 3-Methyl-4-phenyl-1H-pyrazole-5-amine; 5-Methyl-4-phenyl-1H-pyrazol-3-ylamine; SMR000290815; ST037469; AB0131798; DB-053614; A5753; BB 0219097; FT-0640686; V6864; EN300-41461; AB00583018-02; SR-01000530901; 5-Methyl-4-phenyl-1,2-dihydro-3H-pyrazol-3-imine; SR-01000530901-1; SR-01000530901-2; 5-Methyl-4-phenyl-2H-pyrazol-3-ylamine, AldrichCPR; Q27285561; F0912-0735
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4292088
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4294725
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4287493
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4290916
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4291313
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4284710
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL21586252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4283382
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4290266
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4288230
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(3-Bromophenyl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(3-bromophenyl)-5-methyl-1H-pyrazol-3-amine; CHEMBL4285123; ZINC37504468; AKOS009590873; AKOS022316431; MCULE-7105794193; NE43735; Y2624; EN300-75549; Z1255523429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4280067
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Thiophen-2-ylmethylene)isoquinoline-1,3(2H,4H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1210772; BDBM50322998
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4291646
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AKOS011267413
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-methyl-4-(4-methylphenyl)pyrazole-5-ylamine; SCHEMBL842957; CHEMBL4286140; SBB079697; ZINC12880096; AKOS000687244; MCULE-6721632026; 3-Methyl-4-p-tolyl-1H-pyrazol-5-amine; BB 0219346; ST50530128; J3.614.174C; 5-methyl-4-(4-methylphenyl)-1H-pyrazol-3-amine; 3-Methyl-4-(4-methylphenyl)-1H-pyrazol-5-a mine; 4-(4-Methylphenyl)-3-methyl-1H-pyrazole-5-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2H-1,3-Benzodioxol-5-yl)-5-methyl-1H-pyrazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4289568; SCHEMBL15020886; ZINC36936208; AKOS022774009; MCULE-8451113259; NE45413; 4-(1,3-benzodioxol-5-yl)-5-methyl-1H-pyrazol-3-amine; Z1278581691; 3-Methyl-4-(3,4-methylenedioxyphenyl)-1H-pyrazol-5-amine; 4-(2H-1,3-benzodioxol-5-yl)-3-methyl-1H-pyrazol-5-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4278086
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283501
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4287264
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4283080
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5,7-Dichloro-1H-quinazoline-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1210774; 5,7-dichloroquinazoline-2,4(1H,3H)-dione; SCHEMBL3669227; 5,7-dichloro-1,2,3,4-tetrahydroquinazoline-2,4-dione; ZINC1428744; BDBM50323000; STK685222; AKOS005598938; MCULE-5318445429; ST084286; 5,7-dichloroquinazolin-2,4(1H,3H)-dione; DB-107266; 5,7-dichloro-1,3-dihydroquinazoline-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4279585
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4277586
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4287256
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4282760
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4281003
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4293673
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4177097
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50277996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 4-Hydroxy- N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-B cascade. Medchemcomm. 2017 Aug 25;8(9):1850-1855. | ||||
| REF 2 | NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4515-20. | ||||
| REF 3 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 4 | Inhibiting NF- B-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1238-44. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.