Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15571 | Target Info | |||
| Target Name | 5-HT 5A receptor (HTR5A) | ||||
| Synonyms | Serotonin receptor 5A; 5-hydroxytryptamine receptor 5A; 5-HT5A; 5-HT-5A; 5-HT-5; 5-HT 5A | ||||
| Target Type | Successful Target | ||||
| Gene Name | HTR5A | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Methylergonovine | Ligand Info | |||||
| Structure Description | CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine | PDB:7UM7 | ||||
| Method | Electron microscopy | Resolution | 2.75 Å | Mutation | No | [1] |
| PDB Sequence |
GVLILTLLGF
49 LVAATFAWNL59 LVLATILRVR69 TFHRVPHNLV79 ASMAVSDVLV89 AALVMPLSLV 99 HELSGRRWQL109 GRRLCQLWIA119 CDVLCCTASI129 WNVTAIALDR139 YWSITRPMEY 149 TLRTRKCVSN159 VMIALTWALS169 AVISLAPLLF179 GEECQVSREP198 SYAVFSTVGA 208 FYLPLCVVLF218 VYWKIYKAAK228 FRVEQKEQRA283 ALMVGILIGV293 FVLCWIPFFL 303 TELISPLCSC313 DIPAIWKSIF323 LWLGYSNSFF333 NPLIYTAFNK343 NYNSAF |
|||||
|
|
||||||
| Ligand Name: Lisuride | Ligand Info | |||||
| Structure Description | CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | PDB:7UM6 | ||||
| Method | Electron microscopy | Resolution | 2.79 Å | Mutation | Yes | [1] |
| PDB Sequence |
GVLILTLLGF
49 LVAATFAWNL59 LVLATILRVR69 TFHRVPHNLV79 ASMAVSDVLV89 AALVMPLSLV 99 HELSGRRWQL109 GRRLCQLWIA119 CDVLCCTASI129 WNVTAIALDR139 YWSITRPMEY 149 TLRTRKCVSN159 VMIALTWALS169 AVISLAPLLF179 GEECQVSREP198 SYAVFSTVGA 208 FYLPLCVVLF218 VYWKIYKAAK228 FRVWREQKEQ281 RAALMVGILI291 GVFVLCWIPF 301 FLTELISPLC311 SCDIPAIWKS321 IFLWLGYSNS331 FFNPLIYTAF341 NKNYNSAF |
|||||
|
|
||||||
| Ligand Name: 5-CT | Ligand Info | |||||
| Structure Description | CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT | PDB:7UM5 | ||||
| Method | Electron microscopy | Resolution | 2.73 Å | Mutation | Yes | [1] |
| PDB Sequence |
GVLILTLLGF
49 LVAATFAWNL59 LVLATILRVR69 TFHRVPHNLV79 ASMAVSDVLV89 AALVMPLSLV 99 HELSGRRWQL109 GRRLCQLWIA119 CDVLCCTASI129 WNVTAIALDR139 YWSITRPMEY 149 TLRTRKCVSN159 VMIALTWALS169 AVISLAPLLF179 GWGETYSEGS189 EECQVSREPS 199 YAVFSTVGAF209 YLPLCVVLFV219 YWKIYKAAKF229 RVEQKEQRAA284 LMVGILIGVF 294 VLCWIPFFLT304 ELISPLCSCD314 IPAIWKSIFL324 WLGYSNSFFN334 PLIYTAFNKN 344 YNSAFKNF
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8K3 or .8K32 or .8K33 or :38K3;style chemicals stick;color identity;select .A:121 or .A:122 or .A:125 or .A:126 or .A:194 or .A:200 or .A:201 or .A:204 or .A:205 or .A:208 or .A:298 or .A:301 or .A:302 or .A:305 or .A:324 or .A:328; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: ~{N}-[azanyl(azanylidene)methylidene]-5-fluoranyl-8-[2,4,6-tris(fluoranyl)phenyl]-3,4-dihydro-1~{H}-isoquinoline-2-carboxamide | Ligand Info | |||||
| Structure Description | Crystal structure of inactive 5-HT5AR in complex with AS2674723 | PDB:7UM4 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
LLSVFGVLIL
44 TLLGFLVAAT54 FAWNLLVLAT64 ILPHNLVASM82 AVSNVLVAAL92 VMPLSLVHEL 102 SGRRWQLGRR112 LCQLWIACDV122 LCCTASIWNV132 TAIALDRYWS142 ITRHMEYTLR 152 TRKCVSNVMI162 ALTWALSAVI172 SLAPLLFGWG182 ETYSEGSEEC192 QVSREPSYAV 202 FSTVGAFYLP212 LCVVLFVYWK222 IYKAAKFRVE277 QKEQRAALMV287 GILIGVFVLC 297 WAPFFLTELI307 SPLCSCDIPA317 IWKSIFLWLG327 YSNSFFNPLI337 YTAF |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NN6 or .NN62 or .NN63 or :3NN6;style chemicals stick;color identity;select .A:97 or .A:101 or .A:117 or .A:121 or .A:122 or .A:125 or .A:126 or .A:193 or .A:194 or .A:195 or .A:196 or .A:200 or .A:201 or .A:204 or .A:205 or .A:208 or .A:298 or .A:301 or .A:302 or .A:305 or .A:320 or .A:324 or .A:328; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER97
4.248
GLU101
2.328
TRP117
3.791
ASP121
2.716
VAL122
3.555
CYS125
3.180
THR126
3.467
GLN193
4.216
VAL194
3.311
SER195
3.566
ARG196
3.927
TYR200
3.583
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inactive and active state structures template selective tools for the human 5-HT(5A) receptor. Nat Struct Mol Biol. 2022 Jul;29(7):677-687. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.