Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82543 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor beta-2 (CHRNB2) | ||||
| Synonyms | Nicotinic acetylcholine receptor beta2; Nicotinic acetylcholine receptor beta 2-subunit protein; CHRNB2; Beta-2 nAChR; Alpha-4/beta-2 nicotinic receptor | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CHRNB2 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Nicotine | Ligand Info | |||||
| Structure Description | Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor | PDB:6CNJ | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
| PDB Sequence |
DTEERLVEHL
11 LDPSRYNKLI21 RPATNGSELV31 TVQLMVSLAQ41 LISVHEREQI51 MTTNVWLTQE 61 WEDYRLTWKP71 EEFDNMKKVR81 LPSKHIWLPD91 VVLYNNADGM101 YEVSFYSNAV 111 VSYDGSIFWL121 PPAIYKSACK131 IEVKHFPFDQ141 QNCTMKFRSW151 TYDRTEIDLV 161 LKSEVASLDD171 FTPSGEWDIV181 ALPGRRNENP191 DDSTYVDITY201 DFIIRRKPLF 211 YTINLIIPCV221 LITSLAILVF231 YLPSDCGEKM241 TLCISVLLAL251 TVFLLLISKI 261 VPPTSLDVPL271 VGKYLMFTMV281 LVTFSIVTSV291 CVLNVHHRSP301 TTHTMAPWVK 311 VVFLEKLPAL321 LFMQQSVSED341 WKYVAMVIDR351 LFLWIFVFVC361 VFGTIGMF |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Varenicline | Ligand Info | |||||
| Structure Description | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | PDB:6UR8 | ||||
| Method | Electron microscopy | Resolution | 3.71 Å | Mutation | No | [2] |
| PDB Sequence |
DTEERLVEHL
11 LDPSRYNKLI21 RPATNGSELV31 TVQLMVSLAQ41 LISVHEREQI51 MTTNVWLTQE 61 WEDYRLTWKP71 EEFDNMKKVR81 LPSKHIWLPD91 VVLYNNADGM101 YEVSFYSNAV 111 VSYDGSIFWL121 PPAIYKSACK131 IEVKHFPFDQ141 QNCTMKFRSW151 TYDRTEIDLV 161 LKSEVASLDD171 FTPSGEWDIV181 ALPGRRNENP191 DDSTYVDITY201 DFIIRRKPLF 211 YTINLIIPCV221 LITSLAILVF231 YLPSDCGEKM241 TLCISVLLAL251 TVFLLLISKI 261 VPPTSLDVPL271 VGKYLMFTMV281 LVTFSIVTSV291 CVLNVHHRSP301 TTHTMAPWVK 311 VVFLEKLPAL321 LFMQQSVSED337 WKYVAMVIDR347 LFLWIFVFVC357 VFGTIGMF |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor | PDB:6CNJ | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
| PDB Sequence |
DTEERLVEHL
11 LDPSRYNKLI21 RPATNGSELV31 TVQLMVSLAQ41 LISVHEREQI51 MTTNVWLTQE 61 WEDYRLTWKP71 EEFDNMKKVR81 LPSKHIWLPD91 VVLYNNADGM101 YEVSFYSNAV 111 VSYDGSIFWL121 PPAIYKSACK131 IEVKHFPFDQ141 QNCTMKFRSW151 TYDRTEIDLV 161 LKSEVASLDD171 FTPSGEWDIV181 ALPGRRNENP191 DDSTYVDITY201 DFIIRRKPLF 211 YTINLIIPCV221 LITSLAILVF231 YLPSDCGEKM241 TLCISVLLAL251 TVFLLLISKI 261 VPPTSLDVPL271 VGKYLMFTMV281 LVTFSIVTSV291 CVLNVHHRSP301 TTHTMAPWVK 311 VVFLEKLPAL321 LFMQQSVSED341 WKYVAMVIDR351 LFLWIFVFVC361 VFGTIGMF |
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Click to Show 3D Structure of This Binding Site
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural principles of distinct assemblies of the human Alpha4beta2 nicotinic receptor. Nature. 2018 May;557(7704):261-265. | ||||
| REF 2 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun. 2020 Mar 27;11(1):1598. | ||||
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