Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T01003 Target Info
Target Name Endoplasmic reticulum to nucleus signaling 1 (ERN1)
Synonyms Serine/threonine-protein kinase/endoribonuclease IRE1; Ire1-alpha; IRE1a; IRE1; Inositol-requiring protein 1; hIRE1p; Endoplasmic reticulum-to-nucleus signaling 1
Target Type Clinical trial Target
Gene Name ERN1
Biochemical Class Kinase
UniProt ID
O75460
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-1291 miRNA Info
miRNA Mature AC
MIMAT0005881
Sequence uggcccugacugaagaccagcagu
miRNA Species Homo sapiens
Regulation Mechanism miR-1291 targets and destabilizes IRE1alpha mRNA through its 5'UTR. [1]
Evidence Score (E-score) 1 +
1 GFP Reporter Assay [1]
Representative Target(s) Regulated by This miRNA Endoplasmic reticulum to nucleus signaling 1 (ERN1) Target Info
ERN1_HUMAN
HepG2 glucose transporter (SLC2A1) Target Info
GTR1_HUMAN
References  Top
REF 1 MicroRNA-1291-mediated silencing of IRE1 enhances Glypican-3 expression. RNA. 2013 Jun;19(6):778-88.

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