Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T13175 Target Info
Target Name Wnt-5a protein (WNT5A)
Synonyms Protein Wnt-5a
Target Type Literature-reported Target
Gene Name WNT5A
UniProt ID
P41221
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-374a-5p miRNA Info
miRNA Mature AC
MIMAT0000727
Sequence uuauaauacaaccugauaagug
miRNA Species Homo sapiens
Regulation Mechanism Overexpression of miR-374a by p-miR-374a in HCC827 cells significantly decreased the protein expression of WNT5A. [1]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Immunofluorescence [1]
2 Western Blot [2]
Representative Target(s) Regulated by This miRNA ATM serine/threonine kinase (ATM) Target Info
ATM_HUMAN
CCAAT/enhancer binding protein beta (CEBPB) Target Info
CEBPB_HUMAN
miRNA Mature ID hsa-miR-487b-3p miRNA Info
miRNA Mature AC
MIMAT0003180
Sequence aaucguacagggucauccacuu
miRNA Species Homo sapiens
Regulation Mechanism miR-487b directly targeted WNT5A. [3]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Metabotropic glutamate receptor 3 (mGluR3) Target Info
GRM3_HUMAN
Polycomb complex protein BMI-1 (BMI1) Target Info
BMI1_HUMAN
miRNA Mature ID hsa-miR-154-5p miRNA Info
miRNA Mature AC
MIMAT0000452
Sequence uagguuauccguguugccuucg
miRNA Species Homo sapiens
Regulation Mechanism miR-154 functions as a tumor suppressor in glioblastoma by targeting WNT5A. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA High mobility group protein HMGI-C (HMGA2) Target Info
HMGA2_HUMAN
Toll-like receptor 2 (TLR2) Target Info
TLR2_HUMAN
miRNA Mature ID hsa-miR-154-3p miRNA Info
miRNA Mature AC
MIMAT0000453
Sequence aaucauacacgguugaccuauu
miRNA Species Homo sapiens
Regulation Mechanism miR-54 functions as a tumor suppressor in OS by partially suppressing WNT5A expression. [5]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [5]
Representative Target(s) Regulated by This miRNA Wnt-5a protein (WNT5A) Target Info
WNT5A_HUMAN
References  Top
REF 1 Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. Cell Death Dis. 2014 May 15;5:e1227.
REF 2 MicroRNA-374a Inhibits Aggressive Tumor Biological Behavior in Bladder Carcinoma by Suppressing Wnt/-Catenin Signaling. Cell Physiol Biochem. 2018;48(2):815-826.
REF 3 Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis. J Clin Invest. 2013 Mar;123(3):1241-61.
REF 4 MiR-154 Functions as a Tumor Suppressor in Glioblastoma by Targeting Wnt5a. Mol Neurobiol. 2017 May;54(4):2823-2830.
REF 5 MicroRNA-154 functions as a tumor suppressor in osteosarcoma by targeting Wnt5a. Oncol Rep. 2016 Mar;35(3):1851-8.

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