Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T71367 Target Info
Target Name MEK kinase kinase 4 (MAP4K4)
Synonyms Nckinteracting kinase; Nck-interacting kinase; Mitogenactivated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; MEKKK 4; MAPK/ERK kinase kinase kinase 4; KIAA0687; HPK/GCKlike kinase HGK; HPK/GCK-like kinase HGK; HGK
Target Type Patented-recorded Target
Gene Name MAP4K4
Biochemical Class Kinase
UniProt ID
O95819
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-141-3p miRNA Info
miRNA Mature AC
MIMAT0000432
Sequence uaacacugucugguaaagaugg
miRNA Species Homo sapiens
Regulation Mechanism miRNA-141 inhibits cell proliferation and invasion by directly targeting MAP4K4. [1]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [1]
2 Western Blot; qPCR; Immunohistochemistry [2]
Representative Target(s) Regulated by This miRNA Activin receptor type IIB (ACVR2B) Target Info
AVR2B_HUMAN
Bromodomain-containing protein 3 (BRD3) Target Info
BRD3_HUMAN
miRNA Mature ID hsa-miR-30d-5p miRNA Info
miRNA Mature AC
MIMAT0000245
Sequence uguaaacauccccgacuggaag
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [3]
2 qRT-PCR; Western Blot [4]
Representative Target(s) Regulated by This miRNA Autophagy-related 2B (ATG2B) Target Info
ATG2B_HUMAN
Beclin-1 (BECN1) Target Info
BECN1_HUMAN
miRNA Mature ID hsa-miR-31-5p miRNA Info
miRNA Mature AC
MIMAT0000089
Sequence aggcaagaugcuggcauagcu
miRNA Species Homo sapiens
Regulation Mechanism miR-31 targets melanoma oncogenes NIK. [5]
Evidence Score (E-score) 1 +
1 Immunoblot; Immunohistochemistry; Luciferase Reporter Assay [5]
Representative Target(s) Regulated by This miRNA Cyclin-dependent kinase 1 (CDK1) Target Info
CDK1_HUMAN
Dickkopf-related protein 1 (DKK1) Target Info
DKK1_HUMAN
miRNA Mature ID hsa-miR-302c-5p miRNA Info
miRNA Mature AC
MIMAT0000716
Sequence uuuaacauggggguaccugcug
miRNA Species Homo sapiens
Regulation Mechanism miR-302 mimics suppress MAP4K4 3'UTR luciferase activity, MAP4K4 3'UTR activity was upregulated following miR-302c silencing. [6]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [6]
Representative Target(s) Regulated by This miRNA MEK kinase kinase 4 (MAP4K4) Target Info
M4K4_HUMAN
References  Top
REF 1 miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. Mol Cancer Ther. 2013 Nov;12(11):2569-80.
REF 2 Chemotherapy-induced miR-141/MAP4K4 signaling suppresses progression of colorectal cancer. Biosci Rep. 2018 Dec 21;38(6). pii: BSR20180978.
REF 3 MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancrea... J Biol Chem. 2012 Sep 7;287(37):31155-64.
REF 4 Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. Circulation. 2015 Jun 23;131(25):2202-2216.
REF 5 Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. Oncotarget. 2012 Sep;3(9):1011-25.
REF 6 Mir-302c mediates influenza A virus-induced IFN expression by targeting NF-B inducing kinase. FEBS Lett. 2015 Dec 21;589(24 Pt B):4112-8.

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