Target Regulator(s) Information (MicroRNA)

Content Navigation (  All   None )                                      
Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T76093 Target Info
Target Name Proheparin-binding EGF-like growth factor (HBEGF)
Synonyms Proheparinbinding EGFlike growth factor; Heparinbinding EGFlike growth factor; Heparin-binding EGF-like growth factor; HEGFL; HB-EGF; Diphtheria toxin receptor; DTS; DTR; DT-R
Target Type Clinical trial Target
Gene Name HBEGF
Biochemical Class Growth factor
UniProt ID
Q99075
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-132-3p miRNA Info
miRNA Mature AC
MIMAT0000426
Sequence uaacagucuacagccauggucg
miRNA Species Homo sapiens
Regulation Mechanism miR-132 targets HB-EGF in mast cells. [3]
Evidence Score (E-score) 3 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay; Microarray; qRT-PCR; Western Blot [2]
3 Microarray [3]
Representative Target(s) Regulated by This miRNA Brain-derived neurotrophic factor (BDNF) Target Info
BDNF_HUMAN
Cyclin A2 (CCNA2) Target Info
CCNA2_HUMAN
References  Top
REF 1 DNA methylation silences miR-132 in prostate cancer. Oncogene. 2013 Jan 3;32(1):127-34.
REF 2 MicroRNA-132 targets HB-EGF upon IgE-mediated activation in murine and human mast cells. Cell Mol Life Sci. 2012 Mar;69(5):793-808.
REF 3 MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007 Jul 6;27(1):91-105.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.