Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T62460 Target Info
Target Name Janus kinase 1 (JAK-1)
Synonyms Tyrosine-protein kinase JAK1; JAK1B; JAK1A
Target Type Successful Target
Gene Name JAK1
Biochemical Class Kinase
UniProt ID
JAK1_HUMAN 
Target Interacting Proteins  Top
Cytokine receptors [+] 2 Cytokine receptors +
Interacting Target Name Interleukin 4 receptor alpha (IL4R) Successful Target Interacting Protein Info
UniProt ID
IL4RA_HUMAN 
Synonyms Interleukin-4 receptor subunit alpha; IL-4R-alpha; IL-4RA; IL4RA; IL-4R subunit alpha; IL-4 receptor subunit alpha; CD124 antigen; CD124; 582J2.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Interacting Target Name Interferon alpha/beta receptor 2 (IFNAR2) Successful Target Interacting Protein Info
UniProt ID
INAR2_HUMAN 
Synonyms Type I interferon receptor 2; Type I interferon receptor; Interferon alpha/beta receptor; Interferon alpha binding protein; IFN-R-2; IFN-R; IFNARB; IFN-alpha-REC; IFN-alpha/beta receptor 2; IFN-alpha binding protein; IFNABR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Putative transporters [+] 1 Putative transporters +
Interacting Target Name Interleukin 2 receptor beta (IL2RB) Clinical trial Target Interacting Protein Info
UniProt ID
IL2RB_HUMAN 
Synonyms P70-75; Interleukin-2 receptor subunit beta; Interleukin-15 receptor subunit beta; IL-2RB; IL-2R subunit beta; IL-2 receptor subunit beta; IL-2 receptor; IL15RB; High affinity IL-2 receptor subunit beta; CD122
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [3]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [10]
Other proteins [+] 2 Other proteins +
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
Interacting Target Name Suppressor of cytokine signaling 3 (SOCS3) Literature-reported Target Interacting Protein Info
UniProt ID
SOCS3_HUMAN 
Synonyms STAT-induced STAT inhibitor 3; STAT induced STAT inhibitor 3; SSI-3; SSI3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; CIS3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [14]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13003-8.
REF 3 Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. J Immunol. 2002 Aug 1;169(3):1302-8.
REF 4 UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J. 2006 Jun 7;25(11):2358-67.
REF 5 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem. 2003 Jan 3;278(1):661-71.
REF 6 Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. J Biol Chem. 1997 Jan 10;272(2):1032-7.
REF 7 Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta. J Biol Chem. 1998 Apr 24;273(17):10719-25.
REF 8 Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur J Haematol. 2001 Aug;67(2):63-71.
REF 9 EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1227-37.
REF 10 Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem. 2002 Mar 1;277(9):7076-85.
REF 11 Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells. Cell Growth Differ. 2002 Jan;13(1):13-8.
REF 12 Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J Immunol. 1998 Mar 15;160(6):2742-50.
REF 13 Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Mol Endocrinol. 2000 Mar;14(3):440-8.
REF 14 SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol. 1999 Jul;19(7):4980-8.

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