Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T96972 Target Info
Target Name DNA replication licensing factor MCM7 (MCM7)
Synonyms P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47
Target Type Literature-reported Target
Gene Name MCM7
Biochemical Class Acid anhydride hydrolase
UniProt ID
MCM7_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 5 Acid anhydride hydrolases +
Interacting Protein Name DNA replication licensing factor MCM2 (MCM2) Interacting Protein Interacting Protein Info
UniProt ID
MCM2_HUMAN 
Synonyms BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-fractionation [5]
6 Reconstituted Complex [6]
7 Reconstituted Complex [7]
8 Yeast two hybrid [8]
Interacting Target Name DNA replication licensing factor MCM6 (MCM6) Literature-reported Target Interacting Protein Info
UniProt ID
MCM6_HUMAN 
Synonyms p105MCM; Minichromosome maintenanceprotein 6
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Co-fractionation [9]
4 Reconstituted Complex [6]
5 Yeast two hybrid [8]
Interacting Protein Name DNA replication licensing factor MCM4 (MCM4) Interacting Protein Interacting Protein Info
UniProt ID
MCM4_HUMAN 
Synonyms CDC21; CDC54; NKCD; NKGCD; P1.CDC21; hCdc21
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Co-fractionation [5]
5 Reconstituted Complex [7]
Interacting Protein Name Structural maintenance of chromosomes protein 1A (SMC1A) Interacting Protein Interacting Protein Info
UniProt ID
SMC1A_HUMAN 
Synonyms CDLS2; DXS423E; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-fractionation [11]
3 Reconstituted Complex [10]
Interacting Protein Name DNA replication licensing factor MCM3 (MCM3) Interacting Protein Interacting Protein Info
UniProt ID
MCM3_HUMAN 
Synonyms HCC5; P1.MCM3; P1.h; RLFB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [3]
3 Yeast two hybrid [8]
Cell division cycle proteins [+] 3 Cell division cycle proteins +
Interacting Protein Name Cell division control protein 6 homolog (CDC6) Interacting Protein Interacting Protein Info
UniProt ID
CDC6_HUMAN 
Synonyms CDC18L; HsCDC18; HsCDC6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [12]
3 Co-localization [13]
4 Yeast two hybrid [8]
Interacting Protein Name Cell division control protein 45 homolog (CDC45) Interacting Protein Interacting Protein Info
UniProt ID
CDC45_HUMAN 
Synonyms CDC45L; CDC45L2; PORC.PI.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
3 Yeast two hybrid [8]
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Affinity Capture-Western [16]
3 Yeast two hybrid [17]
Kinases [+] 1 Kinases +
Interacting Target Name CDC7-related kinase (CDC7) Clinical trial Target Interacting Protein Info
UniProt ID
CDC7_HUMAN 
Synonyms huCdc7; HsCdc7; Cell division cycle 7-related protein kinase; Cell division cycle 7related protein kinase; CDC7related kinase; CDC7L1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [18]
2 Yeast two hybrid [8]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-Western [20]
3 Yeast two hybrid [20]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Reconstituted Complex [22]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Mini-chromosome maintenance complex-binding protein (MCMBP) Interacting Protein Interacting Protein Info
UniProt ID
MCMBP_HUMAN 
Synonyms C10orf119; MCM.BP
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [9]
2 Yeast two hybrid [23]
3 Yeast two hybrid [24]
Interacting Target Name Facilitates chromatin transcription complex (FACT) Clinical trial Target Interacting Protein Info
UniProt ID
SSRP1_HUMAN 
Synonyms T160; Structure-specific recognition protein 1; Recombination signal sequence recognition protein 1; hSSRP1; FACTp80; FACT80; FACT complex subunit SSRP1; FACT 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; Facilitates chromatin transcription complex 80 kDa subunit; Chromatin-specific transcription elongation factor 80 kDa subunit
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-Western [26]
References  Top
REF 1 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. J Biol Chem. 1997 Apr 18;272(16):10928-35.
REF 4 Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. J Biol Chem. 2002 Nov 8;277(45):42471-9.
REF 5 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 6 Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Genes Cells. 2003 May;8(5):413-21.
REF 7 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 8 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J Mol Biol. 2003 Mar 14;327(1):111-28.
REF 9 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 10 Direct interaction between cohesin complex and DNA replication machinery. Biochem Biophys Res Commun. 2006 Mar 17;341(3):770-5.
REF 11 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 12 Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. J Biol Chem. 1999 Sep 3;274(36):25927-32.
REF 13 Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. Nucleic Acids Res. 2015 Jul 13;43(12):5898-911.
REF 14 The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. J Biol Chem. 2006 Oct 13;281(41):30631-44.
REF 15 Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. Eur J Biochem. 1999 Nov;265(3):936-43.
REF 16 The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. J Biol Chem. 2003 Mar 14;278(11):9754-60.
REF 17 Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol Cell Biol. 1998 May;18(5):2748-57.
REF 18 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem. 2000 Sep 15;275(37):29042-52.
REF 19 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 20 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle. 2007 Jan 15;6(2):205-17.
REF 21 The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 Jun 28;16(1):37-47.
REF 22 MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011 Jun 10;42(5):700-12.
REF 23 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 24 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 25 A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57.
REF 26 Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 2006 Sep 6;25(17):3975-85.

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