Target Regulator(s) Information (Transcription Factor)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56365 | Target Info | |||
| Target Name | B-lymphocyte surface antigen B4 (CD19) | ||||
| Synonyms | T-cell surface antigen Leu-12; Leu-12; Differentiation antigen CD19; B-lymphocyte antigen CD19 | ||||
| Target Type | Successful Target | ||||
| Gene Name | CD19 | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| The Transcription Factors (TFs) Regulating This Target | Top | ||||
|---|---|---|---|---|---|
| TF Name | Paired box protein Pax-5 (PAX5) | ||||
| Classification | Superclass | Helix-turn-helix | |||
| Class | Paired box | ||||
| Family | Paired domain only | ||||
| Regulation Type | Increase | ||||
| Regulation Mechanism | The regulation of mouse CD19 expression has been suggested to rely on a stage specific promoter that interacts with the PAX5. | [1] | |||
| Evidence Score (E-score) | 3 | + | |||
| 1 | DNA Binding Assay, DNase I Footprint Analysis | [5] | |||
| 2 | Electrophoretic Mobility Shift Assay | [1] | |||
| 3 | Electrophoretic Mobility Shift Assay | [4] | |||
| UniProt ID | |||||
| Sequence |
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV
SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYP IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF PNPGLLGSPYYYSAAARGAAPPAAATAYDRH |
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| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
| 1 | B-lymphocyte surface antigen B4 (CD19) | Successful Target | Target Info | [1] | |
| Transcription factors | [+] 1 Transcription factors Co-regulated By This TF | + | |||
| 1 | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [6] | |
| TF Name | Paired box protein Pax-6 (PAX6) | ||||
| Classification | Superclass | Helix-turn-helix | |||
| Class | Paired box | ||||
| Family | Paired plus homeo domain | ||||
| Regulation Type | Increase | ||||
| Evidence Score (E-score) | 2 | + | |||
| 1 | Electrophoretic Mobility Shift Assay | [4] | |||
| 2 | Electrophoretic Mobility Shift Assay, DNase I Footprint Analysis | [2] | |||
| UniProt ID | |||||
| Sequence |
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY
YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR LQ |
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| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
| 1 | B-lymphocyte surface antigen B4 (CD19) | Successful Target | Target Info | [2] | |
| TF Name | Early growth response protein 1 (EGR1) | ||||
| Classification | Superclass | Zinc-coordinating DNA-binding domains | |||
| Class | Cys2His2 zinc finger domain | ||||
| Family | Developmental / cell cycle regulators | ||||
| Subfamily | Egr/Krox | ||||
| Regulation Type | Increase | ||||
| Regulation Mechanism | Gel shift assays demonstrated SP1 andEGR1 binding to theCD19GC box, while unknown nuclear proteins bound the PyG and AT boxes.. | [3] | |||
| Evidence Score (E-score) | 1 | + | |||
| 1 | Electrophoretic Mobility Shift Assay, DNase I Footprint Analysis | [3] | |||
| UniProt ID | |||||
| Sequence |
MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGS
NSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETS YPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAAS SASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAY PAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSG SQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIR IHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR QKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSS TYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTI EIC |
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| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Apolipoproteins | [+] 1 Apolipoproteins Co-regulated By This TF | + | |||
| 1 | Apolipoprotein A-I (APOA1) | Clinical trial Target | Target Info | [7] | |
| Growth factors | [+] 2 Growth factors Co-regulated By This TF | + | |||
| 1 | Platelet-derived growth factor A (PDGFA) | Clinical trial Target | Target Info | [8] | |
| 2 | Platelet-derived growth factor B (PDGFB) | Clinical trial Target | Target Info | [9] | |
| Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
| 1 | B-lymphocyte surface antigen B4 (CD19) | Successful Target | Target Info | [3] | |
| Kinases | [+] 1 Kinases Co-regulated By This TF | + | |||
| 1 | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [10] | |
| Oxidoreductases | [+] 1 Oxidoreductases Co-regulated By This TF | + | |||
| 1 | Superoxide dismutase Cu-Zn (SOD Cu-Zn) | Clinical trial Target | Target Info | [11] | |
| Transcription factors | [+] 2 Transcription factors Co-regulated By This TF | + | |||
| 1 | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [12] | |
| 2 | Early growth response protein 1 (EGR-1) | Clinical trial Target | Target Info | [13] | |
| TF Name | Paired box protein Pax-2 (PAX2) | ||||
| Classification | Superclass | Helix-turn-helix | |||
| Class | Paired box | ||||
| Family | Paired domain only | ||||
| Regulation Type | Increase | ||||
| Evidence Score (E-score) | 1 | + | |||
| 1 | Electrophoretic Mobility Shift Assay, DNase I Footprint Analysis | [2] | |||
| UniProt ID | |||||
| Sequence |
MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV
SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND PVGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDS QSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGL DEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAG MVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH |
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| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
| 1 | B-lymphocyte surface antigen B4 (CD19) | Successful Target | Target Info | [2] | |
| Transcription factors | [+] 2 Transcription factors Co-regulated By This TF | + | |||
| 1 | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [6] | |
| 2 | Wilms tumor protein (WT1) | Clinical trial Target | Target Info | [14] | |
| TF Name | Early B-cell factor 3 (COE3) homodimer | ||||
| Classification | Superclass | Basic Domains | |||
| Class | Helix-loop-helix factors (bHLH) | ||||
| Family | HLH domain only | ||||
| Regulation Type | Increase | ||||
| Regulation Mechanism | A human homologue of mouse COE3 participate in transcriptional regulation of the human CD19 promoter. | [1] | |||
| Evidence Score (E-score) | 1 | + | |||
| 1 | Electrophoretic Mobility Shift Assay | [1] | |||
| UniProt ID | |||||
| Sequence |
MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPS
NLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGV RTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDP VIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKH GRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTML VWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRL QKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHN QIPTLGNNPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYVPSSTPQQ SNYNTVSTSMNGYGSGAMASLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCS STHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSANGNGLQAMSGLVVPPM |
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| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
| 1 | B-lymphocyte surface antigen B4 (CD19) | Successful Target | Target Info | [1] | |
| TF Name | Paired box protein Pax-1 (PAX1) | ||||
| Classification | Superclass | Helix-turn-helix | |||
| Class | Paired box | ||||
| Family | Paired domain only | ||||
| Regulation Type | Increase | ||||
| Evidence Score (E-score) | 1 | + | |||
| 1 | Electrophoretic Mobility Shift Assay | [4] | |||
| UniProt ID | |||||
| Sequence |
MKFTLGLGSRAWRVSWEGAAAAAAGPGAGGSALRCRAQRVSSPRLGRRGSRLSGALPLCL
SRGGGGAQALPDCAGPSPGHPGHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIR LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKH IRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQP PSQPTLPYNHIYQYPYPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRT FMEQTGALAGSEGTAYSPKMEDWAGVNRTAFPATPAVNGLEKPALEADIKYTQSASTLSA VGGFLPACAYPASNQHGVYSAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMT FKHPSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQVCAAAP AIGTGRIGGLAEEEASAGPRGARPASPQAQPCLWPDPPHFLYWSGFLGFSELGF |
||||
| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
| 1 | B-lymphocyte surface antigen B4 (CD19) | Successful Target | Target Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A human early B-cell factor-like protein participates in the regulation of the human CD19 promoter. Mol Immunol. 1999 Oct-Nov;36(15-16):1067-77. | ||||
| REF 2 | Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J Biol Chem. 1994 Mar 18;269(11):8355-61. | ||||
| REF 3 | In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. J Immunol. 1997 Aug 1;159(3):1284-92. | ||||
| REF 4 | DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 1993 Oct;7(10):2048-61. | ||||
| REF 5 | The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol Cell Biol. 1992 Jun;12(6):2662-72. | ||||
| REF 6 | Loss of p53 function through PAX-mediated transcriptional repression. EMBO J. 1995 Nov 15;14(22):5638-45. | ||||
| REF 7 | Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription. J Biol Chem. 1995 Mar 24;270(12):7004-10. | ||||
| REF 8 | The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene. J Biol Chem. 1992 Nov 5;267(31):21999-2002. | ||||
| REF 9 | c-sis/PDGF-B promoter transactivation by the Yax protein of human T-cell leukemia virus type 1. J Biol Chem. 1996 Jun 14;271(24):14584-90. | ||||
| REF 10 | Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia. Cancer Res. 2002 Feb 1;62(3):827-34. | ||||
| REF 11 | The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. J Biol Chem. 1999 Jan 1;274(1):503-9. | ||||
| REF 12 | Early growth response-1-dependent apoptosis is mediated by p53. J Biol Chem. 1997 Aug 8;272(32):20131-8. | ||||
| REF 13 | Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter. Mol Cell Biol. 1994 Sep;14(9):5975-85. | ||||
| REF 14 | Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene. 1997 Jun 5;14(22):2689-700. | ||||
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