Target Regulator(s) Information (Transcription Factor)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88304 | Target Info | |||
| Target Name | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | ||||
| Synonyms | MCMT; M.HsaI; Dnmt1; DNMT; DNA methyltransferase HsaI; DNA MTase HsaI; DNA (cytosine5)methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; CXXCtype zinc finger protein 9; CXXC9; CXXC-type zinc finger protein 9; AIM | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | DNMT1 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| The Transcription Factors (TFs) Regulating This Target | Top | ||||
|---|---|---|---|---|---|
| TF Name | Tumor suppressor p53 (TP53) homotetramer | ||||
| Classification | Superclass | beta-Scaffold Factors with Minor Groove Contacts | |||
| Class | p53 | ||||
| Family | p53 | ||||
| Regulation Type | Decrease | ||||
| Regulation Mechanism | Deletion of p53 in HCT116 human colon carcinoma cells and primary mouse astrocytes resulted in a 6-fold increase of Dnmt1 mRNA and protein, suggesting relief of p53-mediated Dnmt1 repression, and a p53 consensus binding site in exon 1 of the human Dnmt1 gene bound recombinant p53 in vitro and endogenous p53 in vivo in the absence of stimuli that activate p53, implying that p53 controls Dnmt1transcription through direct DNA binding. | [1] | |||
| Evidence Score (E-score) | 2 | + | |||
| 1 | Chromatin Immunoprecipitation Assay | [2] | |||
| 2 | Electrophoretic Mobility Shift Assay, Chromatin Immunoprecipitation Assay | [1] | |||
| UniProt ID | |||||
| Sequence |
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD |
||||
| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Acyltransferases | [+] 1 Acyltransferases Co-regulated By This TF | + | |||
| 1 | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Target Info | [3] | |
| Apoptosis regulators | [+] 1 Apoptosis regulators Co-regulated By This TF | + | |||
| 1 | Apoptosis regulator Bcl-2 (BCL-2) | Successful Target | Target Info | [4] | |
| Caveolin proteins | [+] 1 Caveolin proteins Co-regulated By This TF | + | |||
| 1 | Caveolin 1 (CAV1) | Literature-reported Target | Target Info | [5] | |
| Cyclins | [+] 1 Cyclins Co-regulated By This TF | + | |||
| 1 | Proliferating cell nuclear antigen (PCNA) | Clinical trial Target | Target Info | [6] | |
| Ester hydrolases | [+] 2 Ester hydrolases Co-regulated By This TF | + | |||
| 1 | M-phase inducer phosphatase 3 (MPIP3) | Literature-reported Target | Target Info | [7] | |
| 2 | Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [8] | |
| Growth factor binding | [+] 1 Growth factor binding Co-regulated By This TF | + | |||
| 1 | Insulin-like growth factor-binding protein 3 (IGFBP3) | Clinical trial Target | Target Info | [9] | |
| Methyltransferases | [+] 1 Methyltransferases Co-regulated By This TF | + | |||
| 1 | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Target Info | [1] | |
| Peptidases | [+] 2 Peptidases Co-regulated By This TF | + | |||
| 1 | Caspase-6 (CASP6) | Patented-recorded Target | Target Info | [10] | |
| 2 | Matrix metalloproteinase-2 (MMP-2) | Successful Target | Target Info | [11] | |
| Small GTPases | [+] 1 Small GTPases Co-regulated By This TF | + | |||
| 1 | GTPase HRas (HRAS) | Literature-reported Target | Target Info | [12] | |
| Transcription factors | [+] 1 Transcription factors Co-regulated By This TF | + | |||
| 1 | Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) | Literature-reported Target | Target Info | [13] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res. 2003 Oct 15;63(20):6579-82. | ||||
| REF 2 | Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res. 2010 Jul 15;70(14):5807-17. | ||||
| REF 3 | A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 1995 Jul 25;23(14):2584-92. | ||||
| REF 4 | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene. 2001 Jan 11;20(2):240-51. | ||||
| REF 5 | p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism. Biochemistry. 2000 Feb 29;39(8):1966-72. | ||||
| REF 6 | Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter. Mol Cell Biol. 1995 Dec;15(12):6785-93. | ||||
| REF 7 | Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev. 1998 Jul 15;12(14):2102-7. | ||||
| REF 8 | Regulation of PTEN transcription by p53. Mol Cell. 2001 Aug;8(2):317-25. | ||||
| REF 9 | Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature. 1995 Oct 19;377(6550):646-9. | ||||
| REF 10 | Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9492-7. | ||||
| REF 11 | Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol Cell Biol. 1997 Nov;17(11):6330-8. | ||||
| REF 12 | Transcriptional regulation of the c-H-ras1 gene by the P53 protein is implicated in the development of human endometrial and ovarian tumours. Oncogene. 1998 Jun 11;16(23):3013-7. | ||||
| REF 13 | Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1302-10. | ||||
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