Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T33489 | ||||
Target Name | Steryl-sulfatase (STS) | ||||
Type of Target |
Successful |
||||
Drug Potency against Target | STX 64 | Drug Info | IC50 = 8 nM | [9] | |
2',4'-dicyanobiphenyl-4-yl sulfamate | Drug Info | IC50 = 16.3 nM | [8] | ||
2-(4-cyclohexylthiosemicarbazono)methyl-phenol | Drug Info | IC50 = 8000 nM | [6] | ||
2-Adamantan-2-ylidenemethyl-benzooxazol-6-ol | Drug Info | IC50 = 260 nM | [4] | ||
2-ethylestradiol 3,17-O,O-bis-sulfamate | Drug Info | IC50 = 1000 nM | [5] | ||
2-methylsulfanylestradiol 3,17-O,O-bis-sulfamate | Drug Info | IC50 = 320 nM | [5] | ||
3-(4-cyclohexylthiosemicarbazono)methyl-phenol | Drug Info | IC50 = 4000 nM | [6] | ||
3-(4-hexylthiosemicarbazono)methyl-benzoic acid | Drug Info | IC50 = 12000 nM | [6] | ||
3-{3-[(aminosulfonyl)oxy]benzoyl}phenyl sulfamate | Drug Info | IC50 = 3200 nM | [1] | ||
3-{4-[(aminosulfonyl)oxy]benzoyl}phenyl sulfamate | Drug Info | IC50 = 780 nM | [1] | ||
4-(4-cyclohexylthiosemicarbazono)methyl-phenol | Drug Info | IC50 = 2300 nM | [6] | ||
4-Sulfamoyloxy-benzoic acid butyl ester | Drug Info | IC50 = 10500 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid cycloheptyl ester | Drug Info | IC50 = 500 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid cyclohexyl ester | Drug Info | IC50 = 1700 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid cyclooctyl ester | Drug Info | IC50 = 170 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid cyclopentyl ester | Drug Info | IC50 = 9300 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid heptyl ester | Drug Info | IC50 = 3400 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid hexyl ester | Drug Info | IC50 = 3800 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid nonyl ester | Drug Info | IC50 = 4800 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid octyl ester | Drug Info | IC50 = 5000 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid pentyl ester | Drug Info | IC50 = 5900 nM | [3] | ||
4-Sulfamoyloxy-benzoic acid propyl ester | Drug Info | IC50 = 13200 nM | [3] | ||
4-{4-[(aminosulfonyl)oxy]benzoyl}phenyl sulfamate | Drug Info | IC50 = 190 nM | [7] | ||
Coumate | Drug Info | IC50 = 1.5 nM | [8] | ||
EMATE | Drug Info | IC50 = 80 nM | [6] | ||
Estradiol 3,17-O,O-bis-sulfamate | Drug Info | IC50 = 18 nM | [5] | ||
MHL cyclohexylthiosemicarbazone | Drug Info | IC50 = 460 nM | [6] | ||
STX-140 | Drug Info | IC50 = 39 nM | [5] | ||
Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester | Drug Info | IC50 = 403 nM | [2] | ||
Sulfamic acid 3-(3-hydroxy-benzoyl)-phenyl ester | Drug Info | IC50 = 6900 nM | [1] | ||
Sulfamic acid 3-(3-methoxy-benzoyl)-phenyl ester | Drug Info | IC50 = 7100 nM | [1] | ||
Sulfamic acid 3-(4-hydroxy-benzoyl)-phenyl ester | Drug Info | IC50 = 5000 nM | [1] | ||
Sulfamic acid 3-(4-methoxy-benzoyl)-phenyl ester | Drug Info | IC50 = 6900 nM | [1] | ||
Sulfamic acid 3-benzoyl-phenyl ester | Drug Info | IC50 = 5700 nM | [1] | ||
Sulfamic acid 4-(2-hydroxy-benzoyl)-phenyl ester | Drug Info | IC50 = 4600 nM | [1] | ||
Sulfamic acid 4-(2-methoxy-benzoyl)-phenyl ester | Drug Info | IC50 = 4800 nM | [1] | ||
Sulfamic acid 4-(3-methoxy-benzoyl)-phenyl ester | Drug Info | IC50 = 5200 nM | [1] | ||
Sulfamic acid 4-benzoyl-phenyl ester | Drug Info | IC50 = 5100 nM | [1] | ||
Action against Disease Model | STX 64 | Drug Info | The IC50 value of STX64, a potent STS inhibitor, against STS activity in JEG-3 cell line is 0.5 nmol/L. | [10] | |
References | |||||
REF 1 | 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. | ||||
REF 2 | Estrogenic potential of 2-alkyl-4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase. J Med Chem. 2003 Nov 6;46(23):5091-4. | ||||
REF 3 | Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. | ||||
REF 4 | Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4999-5002. | ||||
REF 5 | 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. | ||||
REF 6 | Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. | ||||
REF 7 | Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activ... J Med Chem. 2008 Jul 24;51(14):4226-38. | ||||
REF 8 | Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70. | ||||
REF 9 | Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates. Chem Biol. 2000 Oct;7(10):773-91. | ||||
REF 10 | A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor. Clin Cancer Res. 2008 Oct 15;14(20):6469-77. | ||||
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