Target Validation Information
TTD ID	T49526
Target Name	Voltage-gated potassium channel Kv7.1 (KCNQ1)
Type of Target	Successful
Drug Potency against Target	Indapamide	Drug Info	IC50 = 100 nM/mL	[4]
	HMR-1556	Drug Info	IC50 = 120 nM	[2]
	L-365260	Drug Info	IC50 = 214 nM	[3]
	L-768673	Drug Info	IC50 = 6 nM	[3]
	N-(2-Diethylamino-ethyl)-4-hexyloxy-benzamide	Drug Info	IC50 = 3500 nM	[1]
	N-(3,3-Dimethyl-butyl)-4-hexyloxy-benzamide	Drug Info	IC50 = 250 nM	[1]
	N-(3,3-Dimethyl-butyl)-4-indol-1-yl-benzamide	Drug Info	IC50 = 260 nM	[1]
	N-(3,3-Dimethyl-cyclopentyl)-4-hexyloxy-benzamide	Drug Info	IC50 = 360 nM	[1]
References
REF 1	Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. J Med Chem. 2001 Nov 8;44(23):3764-7.
REF 2	Selective optimization of side activities: another way for drug discovery. J Med Chem. 2004 Mar 11;47(6):1303-14.
REF 3	Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(... J Med Chem. 1997 Nov 21;40(24):3865-8.
REF 4	Concomitant Block of the Rapid (I(Kr)) and Slow (I(Ks)) Components of the Delayed Rectifier Potassium Current is Associated With Additional Drug Effects on Lengthening of Cardiac Repolarization. J Cardiovasc Pharmacol Ther. 1999 Jul;4(3):143-150.

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