Drug General Information
Drug ID
Former ID
Drug Name
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]


Canonical SMILES
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Placenta growth factor Target Info Inhibitor [551393]
Glucosamine-6-phosphate synthase Target Info Inhibitor [551393]
Phosphopantetheine adenylyltransferase Target Info Inhibitor [551393]
mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [551393]
P-selectin Target Info Inhibitor [551393]
CTP synthase Target Info Inhibitor [551393]
Nitric-oxide synthase, endothelial Target Info Inhibitor [551393]
Presynaptic density protein 95 Target Info Inhibitor [551393]
Heat shock protein HSP 90 Target Info Inhibitor [551393]
Calmodulin Target Info Inhibitor [551393]
Aldo-keto reductase family 1 member C3 Target Info Inhibitor [551393]
Phospholipase A2 Target Info Inhibitor [551393]
Beta-lactamase Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-7305:Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesisLIPASYN-PWY:Phospholipases
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Pathways in cancerhsa00770:Pantothenate and CoA biosynthesis
Metabolic pathwayshsa04520:Adherens junction
Insulin signaling pathwayhsa04514:Cell adhesion molecules (CAMs)
Staphylococcus aureus infectionhsa00240:Pyrimidine metabolism
Metabolic pathwayshsa00330:Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathwayhsa04390:Hippo signaling pathway
Glutamatergic synapse
Huntington's disease
Cocaine addictionhsa04141:Protein processing in endoplasmic reticulum
Antigen processing and presentation
NOD-like receptor signaling pathway
Progesterone-mediated oocyte maturation
Pathways in cancer
Prostate cancerhsa04014:Ras signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Salivary secretion
Gastric acid secretion
Alzheimer's disease
Amphetamine addiction
Gliomahsa00140:Steroid hormone biosynthesis
Arachidonic acid metabolism
Ovarian steroidogenesishsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Pancreatic secretion
Fat digestion and absorption
NetPath Pathway TSH Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_8:Wnt Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling PathwayNetPath_21:RANKL Signaling Pathway
TSH Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Cadherin signaling pathwayP02740:De novo pyrimidine ribonucleotides biosythesisP00005:Angiogenesis
Endothelin signaling pathway
Interleukin signaling pathway
PI3 kinase pathway
VEGF signaling pathwayP00029:Huntington diseaseP06959:CCKR signaling map ST
Pathway Interaction Database VEGFR1 specific signalsinsulin_pathway:Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling eventsil4_2pathway:IL4-mediated signaling events
amb2 Integrin signalinger_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
SHP2 signaling
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling eventserbb4_pathway:ErbB4 signaling eventshdac_classii_pathway:Signaling events mediated by HDAC Class II
Validated targets of C-MYC transcriptional activation
Integrin-linked kinase signaling
LKB1 signaling events
Regulation of Telomerase
Glucocorticoid receptor regulatory network
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
Regulation of Androgen receptor activity
Integrins in angiogenesis
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
ErbB receptor signaling network
Class I PI3K signaling events mediated by Aktbcr_5pathway:BCR signaling pathway
p38 MAPK signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IFN-gamma pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ErbB1 downstream signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Calcium signaling in the CD4+ TCR pathway
Insulin-mediated glucose transport
N-cadherin signaling events
Cellular roles of Anthrax toxin
Regulation of Ras family activation
Downstream signaling in na&#xef
Fc-epsilon receptor I signaling in mast cells
PathWhiz Pathway Pyrimidine MetabolismPW000564:Muscle/Heart ContractionPW000044:Arachidonic Acid Metabolism
Reactome VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-354192:Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signalingR-HSA-114608:Platelet degranulation
Cell surface interactions at the vascular wallR-HSA-1222556:ROS production in response to bacteria
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeabilityR-HSA-399719:Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RHO GTPases activate CIT
RAF/MAP kinase cascadeR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Regulation of actin dynamics for phagocytic cup formation
Regulation of PLK1 Activity at G2/M Transition
Attenuation phase
HSF1-dependent transactivation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
EPHA-mediated growth cone collapse
VEGFR2 mediated vascular permeability
Anchoring of the basal body to the plasma membrane
Constitutive Signaling by EGFRvIIIR-HSA-111933:Calmodulin induced events
Platelet degranulation
Translocation of GLUT4 to the plasma membrane
DARPP-32 events
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Smooth Muscle Contraction
VEGFR2 mediated cell proliferation
RHO GTPases activate IQGAPs
RAF/MAP kinase cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-975634:Retinoid metabolism and transportR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Focal Adhesion
Signaling by VEGFWP1857:Metabolism of water-soluble vitamins and cofactorsWP481:Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signalingWP2806:Human Complement System
Spinal Cord Injury
Cell surface interactions at the vascular wallWP1851:Metabolism of nucleotidesWP554:ACE Inhibitor Pathway
EGF/EGFR Signaling Pathway
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
AGE/RAGE pathway
Endothelin Pathways
Effects of Nitric Oxide
Metabolism of nitric oxide
AngiogenesisWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
L1CAM interactionsWP2884:NRF2 pathway
Nuclear Receptors Meta-Pathway
Aryl Hydrocarbon Receptor Pathway
Binding and Uptake of Ligands by Scavenger Receptors
Signaling by ERBB2
Fcgamma receptor (FCGR) dependent phagocytosis
Influenza Life Cycle
EBV LMP1 signaling
Aryl Hydrocarbon Receptor
TNF alpha Signaling Pathway
Arylhydrocarbon receptor (AhR) signaling pathway
Signaling by EGFR
Semaphorin interactions
Mitotic G2-G2/M phases
NOD pathwayWP2777:Translocation of GLUT4 to the Plasma Membrane
Visual phototransduction
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by the B Cell Receptor (BCR)
Inositol phosphate metabolism
DAG and IP3 signaling
Opioid Signalling
Muscle contraction
Metabolism of carbohydratesWP702:Metapathway biotransformation
Benzo(a)pyrene metabolism
Arachidonic acid metabolismWP2740:Glycerophospholipid biosynthesis
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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