Drug General Information
Drug ID	D0V4GI
Former ID	DNC011501
Drug Name	CGS-9896
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[544687]
Structure		Download 2D MOL 3D MOL
Formula	C16H10ClN3O
Canonical SMILES	C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
InChI	1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H
InChIKey	QCBUAKLOWCOUCR-UHFFFAOYSA-N
PubChem Compound ID	108030
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528080]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Iron uptake and transport
References
Ref 544687	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000585)
Ref 528080	J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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