Target Information

Target General Infomation
Target ID
T64382
Former ID
TTDS00018
Target Name
Gamma-aminobutyric acid receptor
Synonyms
GABA receptor
Target Type
Successful
Disease Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Ascariasis; Enterobiasis [ICD9: 127.0, 127.4; ICD10: B77, B80]
Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F31, F40-F42]
Epilepsy [ICD10: G40]
Epileptic seizures [ICD9: 345.9, 780.3; ICD10: G40, P90, R56]
Inflammation [ICD10: E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89]
Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10: A09, K58, K59.1]
Muscle spasm [ICD10: M62.838]
Obesity [ICD9: 278; ICD10: E66]
Premenstrual syndrome [ICD10: N94.3]
Schizophrenia [ICD9: 295; ICD10: F20]
Seizures [ICD9: 345.9, 780.3; ICD10: G40, P90, R56]
Urea cycle disorders [ICD9: 270.6; ICD10: E72.2]
BioChemical Class
Chloride channel
Target Validation
T64382
Drugs and Mode of Action
Drug(s) ALPIDEM Drug Info Approved Anxiety disorder [551871]
Clonazepam Drug Info Approved Epilepsy [538277], [541998]
DP-VPA Drug Info Approved Bipolar disorder [546558]
Phenobarbital Drug Info Approved Seizures [539845], [550627]
Piperazine Drug Info Approved Ascariasis; Enterobiasis [538341], [551871]
THIOCOLCHICOSIDE Drug Info Approved Muscle spasm [551871]
ANDROSTERONE Drug Info Phase 3 Discovery agent [524778]
Phentermine+topiramate Drug Info Phase 3 Obesity [536869]
ZK-93423 Drug Info Phase 3 Epileptic seizures [467683], [533661]
ALLOPREGNANOLONE Drug Info Phase 2 Discovery agent [467451], [524035]
BL-1020 Drug Info Phase 2 Schizophrenia [536463]
BNC-210 Drug Info Phase 2 Anxiety disorder [548927]
Clonazepam Drug Info Phase 2 Seizures [529439], [534170], [541998]
Dextofisopam Drug Info Phase 2 Irritable bowel syndrome [536224]
Phenylbutyrate Drug Info Phase 2 Urea cycle disorders [536447], [543164]
PIKAMILONE Drug Info Phase 2 Anxiety disorder [522726]
Muscimol Drug Info Phase 1 Discovery agent [467594], [522693]
ELTANOLONE Drug Info Discontinued in Phase 3 Premenstrual syndrome [546011]
Dezinamide Drug Info Discontinued in Phase 2 Epileptic seizures [544536]
Gedocarnil Drug Info Discontinued in Phase 1 Anxiety disorder [545942]
U-78875 Drug Info Discontinued in Phase 1 Anxiety disorder [544810]
C-202 Drug Info Terminated Epilepsy [548090]
CGS-17867A Drug Info Terminated Alcohol use disorders [544711]
CGS-9896 Drug Info Terminated Discovery agent [544687]
Divaplon Drug Info Terminated Discovery agent [544692]
U-90042 Drug Info Terminated Anxiety disorder [544907]
XR-368 Drug Info Terminated Anxiety disorder [545635]
Inhibitor ((E)-3-Amino-propenyl)-methyl-phosphinic acid Drug Info [529517]
(2-Amino-4,5-dihydro-thiazol-4-yl)-acetic acid Drug Info [551228]
(2E,4S)-4-ammoniopent-2-enoate Drug Info [533514]
(4R)-4-ammoniopentanoate Drug Info [533514]
(4S)-4-ammoniopentanoate Drug Info [533514]
(6-Benzylamino-9H-beta-carbolin-3-yl)-methanol Drug Info [533414]
(9-Benzyl-9H-purin-6-yl)-cyclopropyl-amine Drug Info [533033]
(9H-beta-Carbolin-3-yl)-carbamic acid ethyl ester Drug Info [533400]
(9H-beta-Carbolin-3-yl)-ethyl-amine Drug Info [533400]
(9H-beta-Carbolin-3-yl)-methanol Drug Info [533414]
(beta-CCE)9H-beta-Carboline-3-carboxylic acid Drug Info [526738]
(R)-4-amino-2-methylbutanoic acid Drug Info [529135]
1,1-Dimethyl-5-oxa-spiro[2.4]heptan-4-one Drug Info [533975]
1,3-Diphenyl-1H-chromeno[4,3-c]pyrazol-4-one Drug Info [533354]
1-(4-chlorophenyl)-4-phenyl-1H-imidazole Drug Info [528080]
1-(9H-beta-Carbolin-3-yl)-butan-1-one Drug Info [526755]
1-(9H-beta-Carbolin-3-yl)-ethanone Drug Info [533414]
1-Methyl-5-oxa-spiro[2.4]heptan-4-one Drug Info [533975]
2,4-Diamino-butyric acid(GABA) Drug Info [533404]
2,6-Diisopropyl-4-nitro-phenol Drug Info [534629]
2-(1H-Indol-3-yl)-2-oxo-N-phenethyl-acetamide Drug Info [526738]
2-(2-Amino-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(2-Hydroxy-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(2-Methoxy-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(3-Amino-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(3-Bromo-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(3-Bromo-phenyl)-6-nitro-chromen-4-one Drug Info [551323]
2-(3-Bromo-phenyl)-chromen-4-one Drug Info [551323]
2-(3-Butoxy-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(3-Chloro-phenyl)-chromen-4-one Drug Info [551323]
2-(3-Hydroxy-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(3-Methoxy-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(4-Amino-phenyl)-6-methyl-chromen-4-one Drug Info [526416]
2-(4-Chloro-phenyl)-3H-imidazo[4,5-c]quinoline Drug Info [534155]
2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one Drug Info [528080]
2-(9-Benzyl-9H-purin-6-ylamino)-ethanol Drug Info [533033]
2-Furan-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one Drug Info [534157]
2-Isoxazol-3-yl-3H-imidazo[4,5-c]quinoline Drug Info [534155]
2-Isoxazol-5-yl-3H-imidazo[4,5-c]quinoline Drug Info [534155]
2-Oxa-spiro[4.4]nonan-1-one Drug Info [533975]
2-p-Tolyl-6H-pyrazolo[1,5-c]quinazolin-5-one Drug Info [534157]
2-Phenyl-3H-imidazo[4,5-c]quinoline Drug Info [534155]
2-Phenyl-5,6-dihydro-pyrazolo[1,5-c]quinazoline Drug Info [534157]
2-Phenyl-6-propyl-chromen-4-one Drug Info [526416]
2-Phenyl-6H-pyrazolo[1,5-c]quinazolin-5-one Drug Info [534157]
2-Pyridin-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one Drug Info [534157]
2-Thiophen-2-yl-3H-imidazo[4,5-c]quinoline Drug Info [534155]
3,3-Diethyl-dihydro-furan-2-one Drug Info [533975]
3,3-Diisopropyl-dihydro-furan-2-one Drug Info [533975]
3,3-Dimethyl-dihydro-furan-2-one Drug Info [533975]
3-(2,2-Dimethyl-propoxy)-9H-beta-carboline Drug Info [526755]
3-(3-Methyl-butoxy)-9H-beta-carboline Drug Info [526755]
3-(benzyloxy)-9H-pyrido[3,4-b]indole Drug Info [531188]
3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole Drug Info [531188]
3-(isopentyloxy)-9H-pyrido[3,4-b]indole Drug Info [531188]
3-amino-3-demethoxythiocolchicine Drug Info [528408]
3-Amino-propane-1-sulfonic acid Drug Info [551302]
3-ammoniopropane-1-sulfinate Drug Info [551302]
3-Butoxy-9H-beta-carboline Drug Info [526755]
3-butoxy-9H-pyrido[3,4-b]indole Drug Info [531188]
3-butoxycarbonyl-4-quinolone Drug Info [528134]
3-butoxycarbonyl-6-ethyl-4-quinolone Drug Info [528134]
3-butylaminocarbonyl-6-ethyl-4-quinolone Drug Info [528134]
3-carboxy-6-ethyl-4-quinolone Drug Info [528134]
3-Chloro-9H-beta-carboline Drug Info [533363]
3-cyclopentoxycarbonyl-6-ethyl-4-quinolone Drug Info [528134]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine Drug Info [528408]
3-demethoxy-3-D-mannopyranosylaminothiocolchicine Drug Info [528408]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine Drug Info [528408]
3-demethoxy-3-L-fucopyranosylaminothiocolchicine Drug Info [528408]
3-demethoxy-3D-glucopyranosylaminothiocolchicine Drug Info [528408]
3-Ethoxy-9H-beta-carboline Drug Info [534660]
3-ethoxy-9H-pyrido[3,4-b]indole Drug Info [531188]
3-ethoxycarbonyl-4-quinolone Drug Info [528134]
3-ethoxycarbonyl-6-ethyl-2-methyl-4-quinolone Drug Info [528134]
3-ethoxycarbonyl-6-propyl-4-quinolone Drug Info [528134]
3-Ethyl-3-isopropyl-dihydro-furan-2-one Drug Info [533975]
3-Ethyl-3-methyl-dihydro-furan-2-one Drug Info [533975]
3-Hydroxy-piperidine-4-carboxylic acid Drug Info [533544]
3-Isobutoxy-9H-beta-carboline Drug Info [526755]
3-isobutoxy-9H-pyrido[3,4-b]indole Drug Info [531188]
3-Isopropoxy-9H-beta-carboline Drug Info [526755]
3-Isopropyl-3-methyl-dihydro-furan-2-one Drug Info [533975]
3-Isothiocyanato-9H-beta-carboline Drug Info [531518]
3-Methoxy-9H-beta-carboline Drug Info [533363]
3-Methoxycarbonyl-2-methyl-9H-beta-carbolin-2-ium Drug Info [551248]
3-Methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-one Drug Info [533354]
3-Methyl-2-phenyl-2H-chromeno[4,3-c]pyrazol-4-one Drug Info [533354]
3-Methyl-9H-beta-carboline Drug Info [533745]
3-Nitro-9H-beta-carboline Drug Info [533363]
3-Propoxy-9H-beta-carboline Drug Info [533363]
3-propoxy-9H-pyrido[3,4-b]indole Drug Info [531188]
3-sec-Butoxy-9H-beta-carboline Drug Info [526755]
3-tert-Butyl-3-ethyl-dihydro-furan-2-one Drug Info [533975]
4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol Drug Info [528295]
4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole Drug Info [528080]
4-(5-tert-Butyl-[1,3]dithian-2-yl)-benzonitrile Drug Info [533668]
4-Amino-3-hydroxy-butyric acid Drug Info [533403]
4-benzyl-5-(4-piperidyl)isothiazol-3-ol Drug Info [528034]
4-Benzyl-5-piperidin-4-yl-isoxazol-3-ol Drug Info [527382]
4-Bromo-2,6-diisopropyl-phenol Drug Info [534629]
4-Chloro-2,6-diisopropyl-phenol Drug Info [534629]
4-Dimethylamino-2,6-diisopropyl-phenol Drug Info [534629]
4-Ethyl-5-piperidin-4-yl-isoxazol-3-ol Drug Info [525949]
4-Hydroxy-3,5-diisopropyl-benzaldehyde Drug Info [534629]
4-Iodo-2,6-diisopropyl-phenol Drug Info [534629]
4-Methoxymethyl-3,6-dipropoxy-9H-beta-carboline Drug Info [534660]
4-Methyl-5-(4-piperidyl)isothiazol-3-ol Drug Info [528034]
4-Methyl-5-piperidin-4-yl-isoxazol-3-ol Drug Info [525949]
4-Naphthalen-1-yl-5-piperidin-4-yl-isoxazol-3-ol Drug Info [527382]
4-Naphthalen-2-yl-5-piperidin-4-yl-isoxazol-3-ol Drug Info [527382]
4-Phenyl-5-piperidin-4-yl-isoxazol-3-ol Drug Info [528744]
5-(4-piperidyl)-4-propylisothiazol-3-ol Drug Info [528034]
5-(piperidin-4-yl)isothiazol-3-ol Drug Info [528034]
5-(piperidin-4-yl)isoxazol-3-ol Drug Info [528744]
5-Aminomethyl-4,5-dihydro-isoxazol-3-ol Drug Info [533403]
5-tert-Butyl-2-(4-ethynyl-phenyl)-[1,3]dithiane Drug Info [533668]
5-tert-Butyl-2-(4-fluoro-phenyl)-[1,3]dithiane Drug Info [533668]
5-[(1R)-1-ammonioethyl]isoxazol-3-olate Drug Info [533514]
5-[(1S)-1-ammonioethyl]isoxazol-3-olate Drug Info [533514]
6,6-Dimethyl-2-oxa-spiro[4.4]nonan-1-one Drug Info [533975]
6,9-Dimethyl-2-oxa-spiro[4.4]nonan-1-one Drug Info [533975]
6-benzyl-3-ethoxycarbonyl-4-quinolone Drug Info [528134]
6-benzyl-3-propoxycarbonyl-4-quinolone Drug Info [528134]
6-benzyl-3-propylaminocarbonyl-4-quinolone Drug Info [528134]
6-Bromo-2-(2-nitro-phenyl)-chromen-4-one Drug Info [551336]
6-Bromo-2-(3-bromo-phenyl)-chromen-4-one Drug Info [551323]
6-Bromo-2-(3-nitro-phenyl)-chromen-4-one Drug Info [551336]
6-Bromo-2-(4-nitro-phenyl)-chromen-4-one Drug Info [551336]
6-Bromo-2-phenyl-chromen-4-one Drug Info [551323]
6-bromo-3-ethoxycarbonyl-2-methyl-4-quinolone Drug Info [528134]
6-bromo-3-ethoxycarbonyl-4-quinolone Drug Info [528134]
6-Chloro-2-(3-nitro-phenyl)-chromen-4-one Drug Info [551323]
6-Chloro-2-phenyl-chromen-4-one Drug Info [551323]
6-Ethyl-2-phenyl-chromen-4-one Drug Info [526416]
6-ethyl-3-(2-ethylbutoxycarbonyl)-4-quinolone Drug Info [528134]
6-ethyl-3-(2-methylbutoxycarbonyl)-4-quinolone Drug Info [528134]
6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone Drug Info [528134]
6-ethyl-3-(3-pentoxycarbonyl)-4-quinolone Drug Info [528134]
6-ethyl-3-i-propoxycarbonyl-4-quinolone Drug Info [528134]
6-ethyl-3-pentoxycarbonyl-4-quinolone Drug Info [528134]
6-ethyl-3-propoxycarbonyl-4-quinolone Drug Info [528134]
6-ethyl-3-propylaminocarbonyl-4-quinolone Drug Info [528134]
6-Fluoro-2-(3-nitro-phenyl)-chromen-4-one Drug Info [551323]
6-Isopropyl-2-phenyl-chromen-4-one Drug Info [526416]
6-Methyl-2-oxa-spiro[4.4]nonan-1-one Drug Info [533975]
6-Methyl-2-p-tolyl-chromen-4-one Drug Info [526416]
6-Methyl-2-phenyl-chromen-4-one Drug Info [526416]
6-Methyl-2-pyridin-3-yl-chromen-4-one Drug Info [526416]
6-Nitro-2-(3-nitro-phenyl)-chromen-4-one Drug Info [551290]
6-Nitro-2-(4-nitro-phenyl)-chromen-4-one Drug Info [551290]
6-Nitro-2-phenyl-chromen-4-one Drug Info [551323]
7,12-Dihydro-5,7,12-triaza-indeno[1,2-a]fluorene Drug Info [533412]
7,12-Dihydro-7,12-diaza-indeno[1,2-a]fluorene Drug Info [533363]
7-Diazonium-naphthalene-1-sulfonic acid anion Drug Info [533352]
8-Diazonium-naphthalene-1-sulfonic acid anion Drug Info [533352]
9H-beta-Carbolin-3-ol Drug Info [533363]
9H-beta-Carbolin-6-ylamine Drug Info [533414]
9H-beta-Carboline-3-carboxylic acid butyl ester Drug Info [533546]
9H-beta-Carboline-3-carboxylic acid ethyl ester Drug Info [533546]
9H-beta-Carboline-3-carboxylic acid propyl ester Drug Info [533546]
Acetic acid 2,6-diisopropyl-phenyl ester Drug Info [534629]
AFLATREME Drug Info [551293]
ALFAXALONE Drug Info [534629]
ALLOPREGNANOLONE Drug Info [528321]
ALPIDEM Drug Info [534470]
AMENTOFLAVONE Drug Info [526653]
ANDROSTERONE Drug Info [528321]
Benzoic acid 2,6-diisopropyl-phenyl ester Drug Info [534629]
Benzyl-(9H-beta-carbolin-6-yl)-amine Drug Info [533363]
Beta-Carboline-3-carboxylic acid t-butyl ester Drug Info [531188]
BETA-CCM Drug Info [533763]
BRL-54504AX Drug Info [551288]
CGP-27492 Drug Info [533678]
CGS-13767 Drug Info [529466]
CGS-17867A Drug Info [527100]
CGS-8216 Drug Info [529466]
CGS-9895 Drug Info [533348]
CGS-9896 Drug Info [528080]
CI-218872 Drug Info [531188]
Divaplon Drug Info [533379]
ELTANOLONE Drug Info [528321]
Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate Drug Info [531188]
Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate Drug Info [531188]
ETIOCHOLANOLONE Drug Info [528321]
GABAZINE Drug Info [528034]
GAMMA-AMINO-BUTANOIC ACID Drug Info [528408]
GNF-PF-3645 Drug Info [528134]
GNF-PF-4421 Drug Info [528134]
Isoquinoline-3-carboxylic acid methyl ester Drug Info [533363]
L-655708 Drug Info [527005]
N-(9H-beta-Carbolin-3-yl)-acetamide Drug Info [533400]
N-(9H-beta-Carbolin-3-yl)-formamide Drug Info [533400]
N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide Drug Info [534710]
N-butyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide Drug Info [528709]
N-Indan-1-yl-2-(1H-indol-3-yl)-2-oxo-acetamide Drug Info [526094]
NIPECOTIC ACID Drug Info [533396]
NORHARMANE Drug Info [533363]
NSC-19028 Drug Info [526416]
NSC-73613 Drug Info [551323]
NSC-93394 Drug Info [551323]
Piperidine-4-carboxylic acid Drug Info [533544]
PITRAZEPINE Drug Info [526735]
Pyrrolidin-3-yl-acetic acid Drug Info [533396]
Ridine-5-carboxylic acid ethyl ester Drug Info [533164]
RIPAZEPAM Drug Info [533397]
RO-054520 Drug Info [533368]
RO-145974 Drug Info [534008]
RO-145975 Drug Info [534008]
RO-147437 Drug Info [534008]
Ro-151310 Drug Info [531044]
Ro-154513 Drug Info [534122]
RO-194603 Drug Info [534008]
Ro-4938581 Drug Info [530391]
RWJ-16979 Drug Info [533762]
RY-066 Drug Info [534718]
Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate Drug Info [531188]
THIOCOLCHICOSIDE Drug Info [528408]
Toluene-1-diazonium-3-sulfonic acid anion Drug Info [533352]
U-78875 Drug Info [525465]
U-89267 Drug Info [533912]
WEDELOLACTONE Drug Info [525981]
ZK-93423 Drug Info [530319]
Antagonist Bicuculline Drug Info [534920]
Phenobarbital Drug Info [536555], [537706]
Piperazine Drug Info [535818]
SR95531 Drug Info [534920]
Agonist BL-1020 Drug Info [536463]
Clonazepam Drug Info [535248], [536166]
Dextofisopam Drug Info [536224]
Muscimol Drug Info [537788]
Phenylbutyrate Drug Info [536447]
Modulator BNC-210 Drug Info [525395]
C-202 Drug Info [551657]
Dezinamide Drug Info [534194]
DP-VPA Drug Info [526386]
Gedocarnil Drug Info [551901]
Phentermine+topiramate Drug Info [536710]
PIKAMILONE Drug Info [551871]
U-90042 Drug Info [533584]
XR-368 Drug Info [534442]
References
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Ref 544687Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000585)
Ref 544692Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000631)
Ref 544711Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000696)
Ref 544810Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001194)
Ref 544907Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001470)
Ref 545635Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004007)
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