Drug Information

Drug General Information
Drug ID
D0WC5L
Former ID
DNC012991
Drug Name
3-butylaminocarbonyl-6-ethyl-4-quinolone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528134]
Structure
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2D MOL

3D MOL
Formula
C16H20N2O2
Canonical SMILES
CCCCNC(=O)C1=CNC2=C(C1=O)C=C(C=C2)CC
InChI
1S/C16H20N2O2/c1-3-5-8-17-16(20)13-10-18-14-7-6-11(4-2)9-12(14)15(13)19/h6-7,9-10H,3-5,8H2,1-2H3,(H,17,20)(H,18,19)
InChIKey
QHHMSXBSEWIFOB-UHFFFAOYSA-N
PubChem Compound ID
11673471
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528134]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
Serotonergic synapse
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 528134J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
Ref 528134J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

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