Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04OVJ
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| Former ID |
DNC003516
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| Drug Name |
Ro-154513
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C15H14N6O3
|
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| InChI |
InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3
|
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| InChIKey |
CFSOJZTUTOQNIA-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7380059, 8153126, 12013972, 14924107, 24899343, 26753182, 29224150, 48110695, 48334739, 49978810, 53790684, 56464704, 56464705, 57322599, 77036011, 91722218, 103164360, 104308223, 125541711, 127618661, 134340721, 134961914, 135062199, 135697913, 162023141, 162228348, 163201388, 177748542, 178101113, 178101180, 184581957, 198958950, 239972838, 241375734, 252156245
|
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| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [2] | |
| Gamma-aminobutyric-acid receptor alpha-5 subunit | Target Info | Inhibitor | [3] | ||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [2] | ||
| Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [4] | ||
| Gamma-aminobutyric-acid receptor alpha-2 subunit | Target Info | Inhibitor | [3] | ||
| Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [3] | ||
| Gamma-aminobutyric-acid receptor alpha-3 subunit | Target Info | Inhibitor | [3] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport | |||||
| GABA A receptor activation | |||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4296). | ||||
| REF 2 | J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors. | ||||
| REF 3 | J Med Chem. 1996 Apr 26;39(9):1928-34.Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. | ||||
| REF 4 | J Med Chem. 1994 Mar 18;37(6):758-68.Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. | ||||
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