Drug Information
Drug General Information | |||||
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Drug ID |
D08RVN
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Former ID |
DNC004399
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Drug Name |
NSC-19028
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [526416] | ||
Structure |
Download2D MOL |
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Formula |
C15H10O2
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Canonical SMILES |
C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
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InChI |
1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
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InChIKey |
VHBFFQKBGNRLFZ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Adenosine A3 receptor | Target Info | Inhibitor | [534098] | |
Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [526416] | ||
Cytochrome P450 19 | Target Info | Inhibitor | [530867] | ||
Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [551323] | ||
mRNA of androgen receptor | Target Info | Inhibitor | [530256] | ||
PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Coregulation of Androgen receptor activity | |||||
Regulation of Androgen receptor activity | |||||
Nongenotropic Androgen signaling | |||||
Regulation of nuclear beta catenin signaling and target gene transcription | |||||
FOXA1 transcription factor network | |||||
Notch-mediated HES/HEY network | |||||
PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
Reactome | Adenosine P1 receptors | ||||
G alpha (i) signalling eventsR-HSA-211976:Endogenous sterolsR-HSA-975298:Ligand-gated ion channel transport | |||||
GABA A receptor activationR-HSA-383280:Nuclear Receptor transcription pathway | |||||
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
WikiPathways | Nucleotide GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCRs, OtherWP702:Metapathway biotransformation | |||||
Tryptophan metabolism | |||||
Oxidation by Cytochrome P450 | |||||
Ovarian Infertility Genes | |||||
Metabolism of steroid hormones and vitamin D | |||||
FSH signaling pathway | |||||
Integrated Breast Cancer Pathway | |||||
Phase 1 - Functionalization of compoundsWP706:SIDS Susceptibility Pathways | |||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
Integrated Pancreatic Cancer Pathway | |||||
Prostate Cancer | |||||
Nuclear Receptors | |||||
Androgen receptor signaling pathway | |||||
References | |||||
Ref 526416 | J Med Chem. 2002 Sep 12;45(19):4188-201.Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. | ||||
Ref 530256 | Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. Epub 2009 Jun 23.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. | ||||
Ref 530867 | Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. Epub 2010 Apr 8.Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). | ||||
Ref 534098 | J Med Chem. 1996 Feb 2;39(3):781-8.Interactions of flavonoids and other phytochemicals with adenosine receptors. | ||||
Ref 551323 | Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). |
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