| Drug General Information |
| Drug ID |
D06HRX
|
| Former ID |
DNC003853
|
| Drug Name |
AMENTOFLAVONE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C30H18O10
|
| Canonical SMILES |
C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4<br />)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O
|
| InChI |
1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
|
| InChIKey |
YUSWMAULDXZHPY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Gamma-aminobutyric acid receptor subunit beta-2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 |
Target Info |
Inhibitor |
[2]
|
| Gamma-aminobutyric-acid receptor alpha-5 subunit |
Target Info |
Inhibitor |
[1]
|
| Gamma-aminobutyric acid receptor subunit alpha-1 |
Target Info |
Inhibitor |
[1]
|
| Gamma-aminobutyric acid receptor subunit gamma-2 |
Target Info |
Inhibitor |
[1]
|
| Gamma-aminobutyric-acid receptor alpha-2 subunit |
Target Info |
Inhibitor |
[1]
|
| Gamma-aminobutyric-acid receptor alpha-3 subunit |
Target Info |
Inhibitor |
[1]
|
| Xanthine dehydrogenase/oxidase |
Target Info |
Inhibitor |
[3]
|
| Gamma-aminobutyric acid receptor |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Purine nucleotides degradation
|
|
Urate biosynthesis/inosine 5'-phosphate degradation
|
|
Guanosine nucleotides degradation
|
|
Adenosine nucleotides degradation
|
|
Retinoate biosynthesis II
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Retrograde endocannabinoid signaling
|
|
Serotonergic synapse
|
|
GABAergic synapse
|
|
Morphine addiction
|
|
Nicotine addictionhsa04151:PI3K-Akt signaling pathway
|
|
MicroRNAs in cancerhsa04080:Neuroactive ligand-receptor interaction
|
|
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
|
|
Nicotine addictionhsa00230:Purine metabolism
|
|
Caffeine metabolism
|
|
Drug metabolism - other enzymes
|
|
Metabolic pathways
|
|
Peroxisome
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Apoptosis signaling pathway
|
|
CCKR signaling map STP02723:Adenine and hypoxanthine salvage pathway
|
|
Purine metabolism
|
|
Pathway Interaction Database
|
E2F transcription factor network
|
|
Direct p53 effectors
|
|
IL6-mediated signaling events
|
|
HIF-1-alpha transcription factor network
|
|
PathWhiz Pathway
|
Caffeine Metabolism
|
|
Purine Metabolism
|
|
Reactome
|
Ligand-gated ion channel transport
|
|
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
|
|
GABA A receptor activationR-HSA-74259:Purine catabolism
|
|
WikiPathways
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Iron uptake and transportWP254:Apoptosis
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in leukocytes - TarBase
|
|
Apoptosis Modulation and SignalingWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Iron uptake and transportWP706:SIDS Susceptibility Pathways
|
|
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Iron uptake and transportWP408:Oxidative Stress
|
|
Effects of Nitric Oxide
|
|
Metabolism of nucleotides
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4.Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). |
|---|
| REF 3 | Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. |
|---|
