Drug Information
Drug General Information | |||||
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Drug ID |
D05EVI
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Former ID |
DNC011862
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Drug Name |
U-78875
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Drug Type |
Small molecular drug
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Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Discontinued in Phase 1 | [544810] | ||
Structure |
Download2D MOL |
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Formula |
C18H17N5O2
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Canonical SMILES |
CC(C)N1C2=CC=CC=C2N3C=NC(=C3C1=O)C4=NOC(=N4)C5CC5
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InChI |
1S/C18H17N5O2/c1-10(2)23-13-6-4-3-5-12(13)22-9-19-14(15(22)18(23)24)16-20-17(25-21-16)11-7-8-11/h3-6,9-11H,7-8H2,1-2H3
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InChIKey |
ZGEGOFCLSWVVKG-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [525465] | |
Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [534209] | ||
Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [534271] | ||
Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [525465] | ||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
Iron uptake and transport | |||||
References | |||||
Ref 525465 | J Med Chem. 1999 Apr 8;42(7):1123-44.Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. | ||||
Ref 534209 | J Med Chem. 1996 Sep 13;39(19):3820-36.3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. | ||||
Ref 534271 | J Med Chem. 1996 Nov 8;39(23):4654-66.High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. |
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