Drug General Information
Drug ID
D08YLW
Former ID
DNC013103
Drug Name
3-demethoxy-3-L-fucopyranosylaminothiocolchicine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528408]
Structure
Download
2D MOL

3D MOL

Formula
C27H34N2O8S
Canonical SMILES
CC1C(C(C(C(O1)NC2=C(C(=C3C(=C2)CCC(C4=CC(=O)C(=CC=C43)S<br />C)NC(=O)C)OC)OC)O)O)O
InChI
1S/C27H34N2O8S/c1-12-22(32)23(33)24(34)27(37-12)29-18-10-14-6-8-17(28-13(2)30)16-11-19(31)20(38-5)9-7-15(16)21(14)26(36-4)25(18)35-3/h7,9-12,17,22-24,27,29,32-34H,6,8H2,1-5H3,(H,28,30)/t12-,17-,22+,23+,24-,27+/m0/s1
InChIKey
ZYVFSIDQHJSZKV-MPHDHXMWSA-N
PubChem Compound ID
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528408]
Glycine receptor alpha-1 chain Target Info Inhibitor [528408]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528408]
Glycine receptor Target Info Inhibitor [528408]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528408]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528408]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2670:Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.

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