Drug General Information
Drug ID	D03YLX
Former ID	DNC011843
Drug Name	3-Methyl-9H-beta-carboline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[1]
Structure		Download 2D MOL 3D MOL
Formula	C12H10N2
Canonical SMILES	CC1=NC=C2C(=C1)C3=CC=CC=C3N2
InChI	1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,14H,1H3
InChIKey	XOHBPUCYRSORIZ-UHFFFAOYSA-N
PubChem Compound ID	13315103
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[1]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[1]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[1]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[1]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Iron uptake and transport
References
REF 1	J Med Chem. 1994 Dec 23;37(26):4576-80.Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor.

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