Drug General Information
Drug ID	D01UAS
Former ID	DNC006401
Drug Name	6-bromo-3-ethoxycarbonyl-4-quinolone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[1]
Structure		Download 2D MOL 3D MOL
Formula	C12H10BrNO3
Canonical SMILES	CCOC(=O)C1=CNC2=C(C1=O)C=C(C=C2)Br
InChI	1S/C12H10BrNO3/c1-2-17-12(16)9-6-14-10-4-3-7(13)5-8(10)11(9)15/h3-6H,2H2,1H3,(H,14,15)
InChIKey	IVZIOBTVAJBBAS-UHFFFAOYSA-N
PubChem Compound ID	689824
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[1]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[1]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[1]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[1]
	Gamma-aminobutyric-acid receptor alpha-3 subunit	Target Info	Inhibitor	[1]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
REF 1	J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

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