Drug General Information
Drug ID	D05SVA
Former ID	DNC007222
Drug Name	5-(piperidin-4-yl)isoxazol-3-ol
Synonyms	5-Piperidin-4-yl-isoxazol-3-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527382]
Structure		Download 2D MOL 3D MOL
Formula	C8H12N2O2
Canonical SMILES	C1CNCCC1C2=CC(=O)NO2
InChI	1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)
InChIKey	YYOYGSTYWVHCJR-UHFFFAOYSA-N
PubChem Compound ID	125520
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[527382]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528744]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[527382]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[527382]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Iron uptake and transport
References
Ref 527382	J Med Chem. 2005 Jan 27;48(2):427-39.Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Ref 527382	J Med Chem. 2005 Jan 27;48(2):427-39.Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Ref 528744	J Med Chem. 2007 Apr 19;50(8):1988-92. Epub 2007 Mar 22.4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.

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