Drug General Information
Drug ID	D0O9SG
Former ID	DNC012973
Drug Name	2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528080]
Structure		Download 2D MOL 3D MOL
Formula	C15H10ClNO2
Canonical SMILES	C1=CC=C(C=C1)C2=CC(=O)N(O2)C3=CC=C(C=C3)Cl
InChI	1S/C15H10ClNO2/c16-12-6-8-13(9-7-12)17-15(18)10-14(19-17)11-4-2-1-3-5-11/h1-10H
InChIKey	DWRJXWOCTFGHCE-UHFFFAOYSA-N
PubChem Compound ID	11543610
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528080]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528080]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 528080	J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Ref 528080	J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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