Resistance mutation info of target
| Target General Information | |||||||||||||||||||||||
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| Target ID | T56556 | ||||||||||||||||||||||
| Target Name | ATP-binding cassette sub-family G member 2 (ABCG2) | Target Info | |||||||||||||||||||||
| Gene Name | ABCG2 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Uniprot ID | ABCG2_HUMAN | ||||||||||||||||||||||
| Sequence | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS [Hom o sapiens] |
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| Drug Resistance Mutation and Corresponding Drugs | |||||||||||||||||||||||
| Mutation Info | Missense: R482* | ||||||||||||||||||||||
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| Mutation Info | Missense: R482G | ||||||||||||||||||||||
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| Mutation Info | Missense: R482M | ||||||||||||||||||||||
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| Mutation Info | Missense: R482T | ||||||||||||||||||||||
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| Reference | |||||||||||||||||||||||
| REF 1 | Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. | ||||||||||||||||||||||
| REF 2 | Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. | ||||||||||||||||||||||
| REF 3 | Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). | ||||||||||||||||||||||
| REF 4 | Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein. | ||||||||||||||||||||||
| REF 5 | Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. | ||||||||||||||||||||||
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