Target Information
Target General Infomation | |||||
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Target ID |
T80165
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Former ID |
TTDR00988
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Target Name |
Short transient receptor potential channel 6
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Gene Name |
TRPC6
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Synonyms |
STrpC6; TRP6; TRPC6
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Target Type |
Research
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Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
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BioChemical Class |
Transient receptor potential catioin channel
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UniProt ID | |||||
Sequence |
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE EKSQNTEDLAELIRELGEKLSMEPNQEETNR |
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Blocker (channel blocker) | 2-APB | Drug Info | [543855] | ||
ACAA | Drug Info | [543855] | |||
KB-R7943 | Drug Info | [543855] | |||
ML9 | Drug Info | [543855] | |||
Activator | 20-HETE | Drug Info | [543855] | ||
flufenamate | Drug Info | [543855] | |||
hyp 9 | Drug Info | [530580] | |||
lysophosphatidylcholine | Drug Info | [543855] | |||
OAG | Drug Info | [534828] | |||
SAG | Drug Info | [534828] | |||
SLG | Drug Info | [534828] | |||
Pathways | |||||
PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
Pathway Interaction Database | Endothelins | ||||
Nephrin/Neph1 signaling in the kidney podocyte | |||||
EPO signaling pathway | |||||
PAR1-mediated thrombin signaling events | |||||
Reactome | Effects of PIP2 hydrolysis | ||||
TRP channels | |||||
Role of second messengers in netrin-1 signaling | |||||
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Platelet homeostasis | |||||
Netrin-1 signaling | |||||
GPCR downstream signaling | |||||
Effects of PIP2 hydrolysis | |||||
References |
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