Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T00938
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| Former ID |
TTDI02203
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| Target Name |
DHICA oxidase
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| Gene Name |
TYRP1
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| Synonyms |
5,6dihydroxyindole2carboxylic acid oxidase; Catalase B; Glycoprotein 75; Melanoma antigen gp75; TRP; TRP1; Tyrosinaserelated protein 1; TYRP1
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| Target Type |
Clinical Trial
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| Disease | Melanoma [ICD9: 172; ICD10: C43] | ||||
| Function |
Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA)into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
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| BioChemical Class |
Tyrosinase
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| UniProt ID | |||||
| EC Number |
EC 1.14.18.-
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| Sequence |
MSAPKLLSLGCIFFPLLLFQQARAQFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSS
GRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGA ACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFE NISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQ EPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLG TLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVE GYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNA DISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSREFSVPEIIA IAVVGALLLVALIFGTASYLIRARRSMDEANQPLLTDQYQCYAEEYEKLQNPNQSVV |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Eumelanin biosynthesis | ||||
| KEGG Pathway | Tyrosine metabolism | ||||
| Metabolic pathways | |||||
| Melanogenesis | |||||
| Pathway Interaction Database | Direct p53 effectors | ||||
| PathWhiz Pathway | Degradation of Superoxides | ||||
| References | |||||
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