Target Information

Target General Infomation
Target ID
T30356
Former ID
TTDI01992
Target Name
Blood group Rh(D) polypeptide
Gene Name
RHD
Synonyms
CD240D; RHXIII; Rh polypeptide 2; RhPII; Rhesus D antigen; RHD
Target Type
Clinical Trial
Disease Anemia [ICD9: 280-285; ICD10: D50-D64]
Function
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
BioChemical Class
Ammonia transporter channel
UniProt ID
Q02161
Sequence
MSSKYPRSVRRCLPLWALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAI
GLGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPSGKVVITLFSIRLATMSA
LSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAYFG
LSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFN
TYYAVAVSVVTAISGSSLAHPQGKISKTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLV
AGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIG
FQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF
Drugs and Mode of Action
Drug(s) Roledumab Drug Info Phase 2/3 Anemia [524990]
Rozrolimupab Drug Info Discontinued in Phase 2 Anemia [548490]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 524990ClinicalTrials.gov (NCT02287896) Pharmacokinetics and Safety of Roledumab, in RhD-negative Pregnant Women Carrying an RhD-positive Foetus. U.S. National Institutes of Health.
Ref 548490Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025976)
Ref 531295Rozrolimupab, symphobodies against rhesus D, for the potential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura. Curr Opin Mol Ther. 2010 Dec;12(6):734-40.
Ref 531898Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCgammaRIII, in healthy volunteers. Vox Sang. 2012 Oct;103(3):213-22.

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