Target Information

Target General Infomation
Target ID
T22655
Former ID
TTDC00248
Target Name
Mucosal addressin cell adhesion molecule 1
Gene Name
MADCAM1
Synonyms
MAdCAM-1; hMAdCAM-1; MADCAM1
Target Type
Clinical Trial
Disease Ulcerative colitis; Inflammatory bowel disease [ICD9: 555, 556, 556.9; ICD10: K50, K50-K52, K51]
Function
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
Target Validation
T22655
UniProt ID
Q13477
Sequence
MDFGLALLLAGLLGLLLGQSLQVKPLQVEPPEPVVAVALGASRQLTCRLACADRGASVQW
RGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHTVQLLVYAFPDQLTV
SPAALVPGDPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGDED
VLFRVTERWRLPPLGTPVPPALYCQATMRLPGLELSHRQAIPVLHSPTSPEPPDTTSPES
PDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGP
TQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLLALPTYHLWKRCRHLAEDDTHPPASLR
LLPQVSAWAGLRGTGQVGISPS
Drugs and Mode of Action
Drug(s) PF-00547659 Drug Info Phase 2 Ulcerative colitis; Inflammatory bowel disease [536371]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cell adhesion molecules (CAMs)
Intestinal immune network for IgA production
NetPath Pathway TNFalpha Signaling Pathway
Pathway Interaction Database a4b7 Integrin signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
References
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.

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