Target Information

Target General Infomation
Target ID
T15344
Former ID
TTDI02197
Target Name
Activation-inducible TNFR family receptor
Gene Name
TNFRSF18
Synonyms
CD357; Glucocorticoid-induced TNFR-related protein; Tumor necrosis factor receptor superfamily member 18; TNFRSF18
Target Type
Clinical Trial
Disease Melanoma [ICD9: 172; ICD10: C43]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
BioChemical Class
Cytokine receptor
UniProt ID
Q9Y5U5
Sequence
MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRD
YPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTF
SGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPAEPLGWLTVVLLAVAACVLLL
TSAQLGLHIWQLRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLW
V
Drugs and Mode of Action
Drug(s) MK-4166 Drug Info Phase 1 Solid tumours [524744]
TRX-518 Drug Info Phase 1 Melanoma [523249]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway TCR Signaling Pathway
Pathway Interaction Database Downstream signaling in na&amp
#xef
ve CD8+ T cells
Reactome TNFs bind their physiological receptors
References
Ref 523249ClinicalTrials.gov (NCT01239134) Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid Tumors. U.S. National Institutes of Health.
Ref 524744ClinicalTrials.gov (NCT02132754) Study of MK-4166 in Participants With Advanced Solid Tumors (MK-4166-001). U.S. National Institutes of Health.
Ref 525419Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5. doi: 10.1038/nbt0715-673.
Ref 533281Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.