Drug Information

Drug General Information
Drug ID
D0VK7M
Former ID
DIB018933
Drug Name
AZD5582
Synonyms
AZD 5582; AZD-5582
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532581]
Structure
Download
2D MOL
Formula
C58H78N8O8
InChI
InChI=1S/C58H78N8O8/c1-37(59-3)53(67)61-49(39-21-9-7-10-22-39)57(71)65-31-19-29-45(65)55(69)63-51-43-27-15-13-25-41(43)35-47(51)73-33-17-5-6-18-34-74-48-36-42-26-14-16-28-44(42)52(48)64-56(70)46-30-20-32-66(46)58(72)50(40-23-11-8-12-24-40)62-54(68)38(2)60-4/h13-16,25-28,37-40,45-52,59-60H,7-12,19-24,29-36H2,1-4H3,(H,61,67)(H,62,68)(H,63,69)(H,64,70)/t37-,38-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1
InChIKey
WLMCRYCCYXHPQF-ZVMUOSSASA-N
PubChem Compound ID
49847690
PubChem Substance ID
104175937, 121139440, 141358985, 194160010, 223366043, 228810396, 245412759, 252451079
Target and Pathway
Target(s) Inhibitor of apoptosis protein 2 Target Info Antagonist [532581]
mRNA of Inhibitor of apoptosis protein Target Info Antagonist [532581]
Inhibitor of apoptosis protein 1 Target Info Antagonist [532581]
KEGG Pathway NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
Apoptosis
Hippo signaling pathway
Focal adhesion
NOD-like receptor signaling pathway
TNF signaling pathway
Toxoplasmosis
Pathways in cancer
Small cell lung cancerhsa04064:NF-kappa B signaling pathway
HTLV-I infection
Transcriptional misregulation in cancer
Small cell lung cancer
NetPath Pathway TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL1 Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Notch Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
CCKR signaling map STP00006:Apoptosis signaling pathwayP00006:Apoptosis signaling pathway
CCKR signaling map ST
Pathway Interaction Database Canonical NF-kappaB pathway
CD40/CD40L signaling
FAS (CD95) signaling pathway
TNF receptor signaling pathway
p75(NTR)-mediated signalingp75ntrpathway:p75(NTR)-mediated signaling
BMP receptor signaling
Caspase Cascade in Apoptosis
TGF-beta receptor signalingcd40_pathway:CD40/CD40L signaling
Ceramide signaling pathway
p75(NTR)-mediated signaling
C-MYB transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Reactome Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
IKK complex recruitment mediated by RIP1R-HSA-111463:SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Deactivation of the beta-catenin transactivating complex
Regulation of necroptotic cell deathR-HSA-168638:NOD1/2 Signaling Pathway
IKK complex recruitment mediated by RIP1
WikiPathways Focal Adhesion
Apoptosis
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
Apoptotic execution phase
Apoptosis Modulation and SignalingWP3286:Copper homeostasis
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
NOD pathwayWP306:Focal Adhesion
References
Ref 532581Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
Ref 532581Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.

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