| Drug General Information |
| Drug ID |
D0ZU5W
|
| Former ID |
DNC010045
|
| Drug Name |
1-(2-(benzyloxy)phenyl)piperazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H20N2O
|
| Canonical SMILES |
C1CN(CCN1)C2=CC=CC=C2OCC3=CC=CC=C3
|
| InChI |
1S/C17H20N2O/c1-2-6-15(7-3-1)14-20-17-9-5-4-8-16(17)19-12-10-18-11-13-19/h1-9,18H,10-14H2
|
| InChIKey |
PPQUPQGZDGZYJI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
|---|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Serotonergic synapsehsa04024:cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapse
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathway
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling events
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WikiPathways
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Monoamine Transport
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NRF2 pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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| References |
| REF 1 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. Epub 2009 Oct 12.Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |
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