Drug Information

Drug General Information
Drug ID
D02FUY
Former ID
DAP000862
Drug Name
Diethylpropion
Synonyms
Adiposon; Amfepramon; Amfepramone; Amfepramonum; Amphepramon; Amphepramone; Anfamon; Anfepramona; Anorex; Cegramine; Danylen; Derfon; Diethylcathinone; Diethylpropione; Dobesin; Frekentine; Keramik; Keramin; Magrene; Modulor; Neobes; Nopropiophenone; Obesitex; Parabolin; Phepranon; Prefamone; Regenon; Reginon; Silutin; Tepanil; Tylinal; Amfepramone HCL; Amfepramone [INN]; Amfepramone hydrochloride; Amphepramonum hydrochloride; Diethylpropion HCL; Diethylpropione hydrochloride; Tenuate hydrochloride; UR 1423; Alpha-Benzoyltriethylamine; Alpha-Diethylaminopropiophenone; Amfepramone (INN); Amfepramone (TN); Amfepramonum [INN-Latin]; Anfepramona [INN-Spanish]; Diethylpropion (BAN); Tenuate (TN); Tenuate Dospan(TN); Fenyl-(1-diethylaminoethyl)keton; Fenyl-(1-diethylaminoethyl)keton [Czech]; (+-)-diethylpropion; 1-Phenyl-2-diethylamino-1-propanone; 2-(Diethylamino)-1-phenyl-1-propanone; 2-(Diethylamino)propiophenone; 2-(diethylamino)-1-phenylpropan-1-one; 2-Diethylaminopropiophenone
Drug Type
Small molecular drug
Indication Migraine; Obisity [ICD9: 278, 346; ICD10:E66, G43] Approved [536661], [542170]
Therapeutic Class
Appetite Depressants
Company
Sanofi Aventis Us Llc
Structure
Download
2D MOL

3D MOL
Formula
C13H19NO
InChI
InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3
InChIKey
XXEPPPIWZFICOJ-UHFFFAOYSA-N
CAS Number
CAS 134-80-5
PubChem Compound ID
7029
PubChem Substance ID
9169, 7423973, 7979076, 8154628, 10537732, 15438771, 29225940, 46506622, 48415889, 50026103, 51091775, 57323894, 75750729, 92712255, 99319074, 104171409, 104313762, 126128656, 126408370, 126625720, 129753898, 134223602, 134338141, 134338651, 134971122, 136936798, 137021040, 160964276, 168991721, 176267120, 177749275, 178103736, 179151422, 226414949, 249966592, 252089217, 252089218, 252163992, 252164026
SuperDrug ATC ID
A08AA03
SuperDrug CAS ID
cas=000090846
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [536130]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [536130]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536661Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci. 2008 Apr;29(4):208-17. Epub 2008 Mar 18.
Ref 542170(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7161).
Ref 536130Phentermine and anaesthesia. Anaesth Intensive Care. 2005 Aug;33(4):525-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.